The contact activation inhibitor AB023 in heparin-free hemodialysis: results of a randomized phase 2 clinical trial
Lorentz, Christina U., Tucker, Erik I., Verbout, Norah G., Shatzel, Joseph J., Olson, Sven R., Markway, Brandon D., Wallisch, Michael, Ralle, Martina, Hinds, Monica T., McCarty, Owen J.T., Gailani, David, Weitz, Jeffrey I., Gruber, András
Published in Blood (02.12.2021)
Published in Blood (02.12.2021)
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Journal Article
Contact Activation Inhibitor and Factor XI Antibody, AB023, Produces Safe, Dose-Dependent Anticoagulation in a Phase 1 First-In-Human Trial
Lorentz, Christina U, Verbout, Norah G, Wallisch, Michael, Hagen, Matthew W, Shatzel, Joseph J, Olson, Sven R, Puy, Cristina, Hinds, Monica T, McCarty, Owen J.T, Gailani, David, Gruber, András, Tucker, Erik I
Published in Arteriosclerosis, thrombosis, and vascular biology (01.04.2019)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.04.2019)
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Journal Article
Cross-Talk between the Complement Pathway and the Contact Activation System of Coagulation: Activated Factor XI Neutralizes Complement Factor H
Puy, Cristina, Pang, Jiaqing, Reitsma, Stéphanie E, Lorentz, Christina U, Tucker, Erik I, Gailani, David, Gruber, András, Lupu, Florea, McCarty, Owen J T
Published in The Journal of immunology (1950) (15.04.2021)
Published in The Journal of immunology (1950) (15.04.2021)
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Journal Article
Role of platelet count in a murine stasis model of deep vein thrombosis
Mathews, Rick, Setthavongsack, Naly, Le-Cook, Anh, Kaempf, Andy, Loftis, Jennifer M, Woltjer, Randall L, Lorentz, Christina U, Revenko, Alexey, Hinds, Monica T, Nguyen, Khanh P
Published in Platelets (Edinburgh) (01.12.2024)
Published in Platelets (Edinburgh) (01.12.2024)
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Journal Article
Coagulation factor XI regulates endothelial cell permeability and barrier function in vitro and in vivo
Puy, Cristina, Moellmer, Samantha A., Pang, Jiaqing, Vu, Helen H., Melrose, Alexander R., Lorentz, Christina U., Tucker, Erik I., Shatzel, Joseph J., Keshari, Ravi S., Lupu, Florea, Gailani, David, McCarty, Owen J. T.
Published in Blood (16.08.2024)
Published in Blood (16.08.2024)
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Journal Article
Pharmacological targeting of coagulation factor XI mitigates the development of experimental atherosclerosis in low‐density lipoprotein receptor‐deficient mice
Ngo, Anh T. P., Jordan, Kelley R., Mueller, Paul A., Hagen, Matthew W., Reitsma, Stéphanie E., Puy, Cristina, Revenko, Alexey S., Lorentz, Christina U., Tucker, Erik I., Cheng, Quifang, Hinds, Monica T., Fazio, Sergio, Monia, Brett P., Gailani, David, Gruber, András, Tavori, Hagai, McCarty, Owen J. T.
Published in Journal of thrombosis and haemostasis (01.04.2021)
Published in Journal of thrombosis and haemostasis (01.04.2021)
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Journal Article
Role of platelets in regulating activated coagulation factor XI activity
Reitsma, Stéphanie E, Pang, Jiaqing, Raghunathan, Vikram, Shatzel, Joseph J, Lorentz, Christina U, Tucker, Erik I, Gruber, András, Gailani, David, McCarty, Owen J T, Puy, Cristina
Published in American Journal of Physiology: Cell Physiology (01.03.2021)
Published in American Journal of Physiology: Cell Physiology (01.03.2021)
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Journal Article
Factor XII plays a pathogenic role in organ failure and death in baboons challenged with Staphylococcus aureus
Silasi, Robert, Keshari, Ravi S., Regmi, Girija, Lupu, Cristina, Georgescu, Constantin, Simmons, Joe H., Wallisch, Michael, Kohs, Tia C.L., Shatzel, Joseph J., Olson, Sven R., Lorentz, Christina U., Puy, Cristina, Tucker, Erik I., Gailani, David, Strickland, Sidney, Gruber, András, McCarty, Owen J.T., Lupu, Florea
Published in Blood (15.07.2021)
Published in Blood (15.07.2021)
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Journal Article
Factor XI Inhibition for the Prevention of Catheter-Associated Thrombosis in Patients With Cancer Undergoing Central Line Placement: A Phase 2 Clinical Trial
Pfeffer, Michael A, Kohs, Tia C L, Vu, Helen H, Jordan, Kelley R, Wang, Jenny Si Han, Lorentz, Christina U, Tucker, Erik I, Puy, Cristina, Olson, Sven R, DeLoughery, Thomas G, Hinds, Monica T, Keshari, Ravi S, Gailani, David, Lupu, Florea, McCarty, Owen J T, Shatzel, Joseph J
Published in Arteriosclerosis, thrombosis, and vascular biology (01.01.2024)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.01.2024)
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Journal Article
The protein C activator AB002 rapidly interrupts thrombus development in baboons
Tucker, Erik I., Verbout, Norah G., Markway, Brandon D., Wallisch, Michael, Lorentz, Christina U., Hinds, Monica T., Shatzel, Joseph J., Pelc, Leslie A., Wood, David C., McCarty, Owen J.T., Di Cera, Enrico, Gruber, András
Published in Blood (27.02.2020)
Published in Blood (27.02.2020)
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Journal Article
Inhibition of contact-mediated activation of factor XI protects baboons against S aureus–induced organ damage and death
Silasi, Robert, Keshari, Ravi Shankar, Lupu, Cristina, Van Rensburg, Walter Janse, Chaaban, Hala, Regmi, Girija, Shamanaev, Aleksandr, Shatzel, Joseph J., Puy, Cristina, Lorentz, Christina U., Tucker, Erik I., Gailani, David, Gruber, András, McCarty, Owen J.T., Lupu, Florea
Published in Blood advances (26.02.2019)
Published in Blood advances (26.02.2019)
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Journal Article
Antibody inhibition of contact factor XII reduces platelet deposition in a model of extracorporeal membrane oxygenator perfusion in nonhuman primates
Wallisch, Michael, Lorentz, Christina U., Lakshmanan, Hari H.S., Johnson, Jennifer, Carris, Marschelle R., Puy, Cristina, Gailani, David, Hinds, Monica T., McCarty, Owen J.T., Gruber, András, Tucker, Erik I.
Published in Research and practice in thrombosis and haemostasis (01.02.2020)
Published in Research and practice in thrombosis and haemostasis (01.02.2020)
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Journal Article
Sympathetic denervation of peri-infarct myocardium requires the p75 neurotrophin receptor
Lorentz, Christina U., Parrish, Diana C., Alston, Eric N., Pellegrino, Michael J., Woodward, William R., Hempstead, Barbara L., Habecker, Beth A.
Published in Experimental neurology (01.11.2013)
Published in Experimental neurology (01.11.2013)
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Journal Article
Safety and tolerability of the protein C activator AB002 in end-stage renal disease patients on hemodialysis: a randomized phase 2 trial
Verbout, Norah G., Lorentz, Christina U., Markway, Brandon D., Wallisch, Michael, Marbury, Thomas C., Di Cera, Enrico, Shatzel, Joseph J., Gruber, András, Tucker, Erik I.
Published in Communications medicine (26.07.2024)
Published in Communications medicine (26.07.2024)
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Journal Article
ProNGF, a cytokine induced after myocardial infarction in humans, targets pericytes to promote microvascular damage and activation
Siao, Chia-Jen, Lorentz, Christina U, Kermani, Pouneh, Marinic, Tina, Carter, John, McGrath, Kelly, Padow, Victoria A, Mark, Willie, Falcone, Domenick J, Cohen-Gould, Leona, Parrish, Diana C, Habecker, Beth A, Nykjaer, Anders, Ellenson, Lora H, Tessarollo, Lino, Hempstead, Barbara L
Published in The Journal of experimental medicine (19.11.2012)
Published in The Journal of experimental medicine (19.11.2012)
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Journal Article
The contact activation system as a potential therapeutic target in patients with COVID‐19
Shatzel, Joseph J., DeLoughery, Emma P., Lorentz, Christina U., Tucker, Erik I., Aslan, Joseph E., Hinds, Monica T., Gailani, David, Weitz, Jeffrey I., McCarty, Owen J.T., Gruber, Andras
Published in Research and Practice in Thrombosis and Haemostasis (01.05.2020)
Published in Research and Practice in Thrombosis and Haemostasis (01.05.2020)
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Journal Article
Web Resource
BMP7‐induced dendritic growth in sympathetic neurons requires p75NTR signaling
Courter, Lauren A., Shaffo, Frances C., Ghogha, Atefeh, Parrish, Diana J., Lorentz, Christina U., Habecker, Beth A., Lein, Pamela J.
Published in Developmental neurobiology (Hoboken, N.J.) (01.09.2016)
Published in Developmental neurobiology (Hoboken, N.J.) (01.09.2016)
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Journal Article
BMP7-induced dendritic growth in sympathetic neurons requires p75(NTR) signaling
Courter, Lauren A, Shaffo, Frances C, Ghogha, Atefeh, Parrish, Diana J, Lorentz, Christina U, Habecker, Beth A, Lein, Pamela J
Published in Developmental neurobiology (Hoboken, N.J.) (01.09.2016)
Published in Developmental neurobiology (Hoboken, N.J.) (01.09.2016)
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Journal Article
Heterogeneous ventricular sympathetic innervation, altered beta-adrenergic receptor expression, and rhythm instability in mice lacking the p75 neurotrophin receptor
Lorentz, Christina U, Alston, Eric N, Belcik, Todd, Lindner, Jonathan R, Giraud, George D, Habecker, Beth A
Published in American journal of physiology. Heart and circulatory physiology (01.06.2010)
Published in American journal of physiology. Heart and circulatory physiology (01.06.2010)
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Journal Article
Activation of coagulation FXI promotes endothelial inflammation and amplifies platelet activation in a nonhuman primate model of hyperlipidemia
Kohs, Tia C.L., Vu, Helen H., Jordan, Kelley R., Parra-Izquierdo, Iván, Hinds, Monica T., Shatzel, Joseph J., Kievit, Paul, Morgan, Terry K., Yunga, Samuel Tassi, Ngo, Thuy T.M., Aslan, Joseph E., Wallisch, Michael, Lorentz, Christina U., Tucker, Erik I., Gailani, David, Lindner, Jonathan R., Puy, Cristina, McCarty, Owen J.T.
Published in Research and practice in thrombosis and haemostasis (01.01.2024)
Published in Research and practice in thrombosis and haemostasis (01.01.2024)
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Journal Article