Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target
Wilson, Caroline, Ray, Peter, Zuccotto, Fabio, Hernandez, Jorge, Aggarwal, Anup, Mackenzie, Claire, Caldwell, Nicola, Taylor, Malcolm, Huggett, Margaret, Mathieson, Michael, Murugesan, Dinakaran, Smith, Alasdair, Davis, Susan, Cocco, Mattia, Parai, Maloy K, Acharya, Arjun, Tamaki, Fabio, Scullion, Paul, Epemolu, Ola, Riley, Jennifer, Stojanovski, Laste, Lopez-Román, Eva Maria, Torres-Gómez, Pedro Alfonso, Toledo, Ana Maria, Guijarro-Lopez, Laura, Camino, Isabel, Engelhart, Curtis A, Schnappinger, Dirk, Massoudi, Lisa M, Lenaerts, Anne, Robertson, Gregory T, Walpole, Chris, Matthews, David, Floyd, David, Sacchettini, James C, Read, Kevin D, Encinas, Lourdes, Bates, Robert H, Green, Simon R, Wyatt, Paul G
Published in Journal of medicinal chemistry (13.01.2022)
Published in Journal of medicinal chemistry (13.01.2022)
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Searching for New Leads for Tuberculosis: Design, Synthesis, and Biological Evaluation of Novel 2‑Quinolin-4-yloxyacetamides
Pitta, Eleni, Rogacki, Maciej K, Balabon, Olga, Huss, Sophie, Cunningham, Fraser, Lopez-Roman, Eva Maria, Joossens, Jurgen, Augustyns, Koen, Ballell, Lluis, Bates, Robert H, Van der Veken, Pieter
Published in Journal of medicinal chemistry (28.07.2016)
Published in Journal of medicinal chemistry (28.07.2016)
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Optimization of Hydantoins as Potent Antimycobacterial Decaprenylphosphoryl-β‑d‑Ribose Oxidase (DprE1) Inhibitors
Balabon, Olga, Pitta, Eleni, Rogacki, Maciej K, Meiler, Eugenia, Casanueva, Ruth, Guijarro, Laura, Huss, Sophie, Lopez-Roman, Eva Maria, Santos-Villarejo, Ángel, Augustyns, Koen, Ballell, Lluis, Aguirre, David Barros, Bates, Robert H, Cunningham, Fraser, Cacho, Monica, Van der Veken, Pieter
Published in Journal of medicinal chemistry (28.05.2020)
Published in Journal of medicinal chemistry (28.05.2020)
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Journal Article
Identification and Optimization of Novel Inhibitors of the Polyketide Synthase 13 Thioesterase Domain with Antitubercular Activity
Green, Simon R., Wilson, Caroline, Eadsforth, Thomas C., Punekar, Avinash S., Tamaki, Fabio K., Wood, Gavin, Caldwell, Nicola, Forte, Barbara, Norcross, Neil R., Kiczun, Michael, Post, John M., Lopez-Roman, Eva Maria, Engelhart, Curtis A., Lukac, Iva, Zuccotto, Fabio, Epemolu, Ola, Boshoff, Helena I. M., Schnappinger, Dirk, Walpole, Chris, Gilbert, Ian H., Read, Kevin D., Wyatt, Paul G., Baragana, Beatriz
Published in Journal of medicinal chemistry (23.11.2023)
Published in Journal of medicinal chemistry (23.11.2023)
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Design, Synthesis, and Evaluation of New Thiadiazole-Based Direct Inhibitors of Enoyl Acyl Carrier Protein Reductase (InhA) for the Treatment of Tuberculosis
Šink, Roman, Sosič, Izidor, Živec, Matej, Fernandez-Menendez, Raquel, Turk, Samo, Pajk, Stane, Alvarez-Gomez, Daniel, Lopez-Roman, Eva Maria, Gonzales-Cortez, Carolina, Rullas-Triconado, Joaquin, Angulo-Barturen, Inigo, Barros, David, Ballell-Pages, Lluís, Young, Robert J, Encinas, Lourdes, Gobec, Stanislav
Published in Journal of medicinal chemistry (22.01.2015)
Published in Journal of medicinal chemistry (22.01.2015)
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Discovery of heterocyclic replacements for the coumarin core of anti-tubercular FadD32 inhibitors
Fang, Chao, Lee, Katie K., Nietupski, Raymond, Bates, Robert H., Fernandez-Menendez, Raquel, Lopez-Roman, Eva Maria, Guijarro-Lopez, Laura, Yin, Yunxing, Peng, Zuozhong, Gomez, James E., Fisher, Stewart, Barros-Aguirre, David, Hubbard, Brian K., Serrano-Wu, Michael H., Hung, Deborah T.
Published in Bioorganic & medicinal chemistry letters (01.12.2018)
Published in Bioorganic & medicinal chemistry letters (01.12.2018)
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MymA Bioactivated Thioalkylbenzoxazole Prodrug Family Active against Mycobacterium tuberculosis
Moure, Abraham L, Narula, Gagandeep, Sorrentino, Flavia, Bojang, Adama, Tsui, Clement K. M, Sao Emani, Carine, Porras-De Francisco, Esther, Díaz, Beatriz, Rebollo-López, María José, Torres-Gómez, Pedro Alfonso, López-Román, Eva María, Camino, Isabel, Casado Castro, Patricia, Guijarro López, Laura, Ortega, Fátima, Ballell, Lluis, Barros-Aguirre, David, Remuiñán Blanco, Modesto, Av-Gay, Yossef
Published in Journal of medicinal chemistry (14.05.2020)
Published in Journal of medicinal chemistry (14.05.2020)
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Exploring the SAR of the β‑Ketoacyl-ACP Synthase Inhibitor GSK3011724A and Optimization around a Genotoxic Metabolite
Cunningham, Fraser, Esquivias, Jorge, Fernández-Menéndez, Raquel, Pérez, Arancha, Guardia, Ana, Escribano, Jaime, Rivero, Cristina, Vimal, Mythily, Cacho, Mónica, de Dios-Antón, Paco, Martínez-Martínez, María Santos, Jiménez, Elena, Huertas Valentín, Leticia, Rebollo-López, María José, López-Román, Eva María, Sousa-Morcuende, Verónica, Rullas, Joaquín, Neu, Margaret, Chung, Chun-wa, Bates, Robert H
Published in ACS infectious diseases (08.05.2020)
Published in ACS infectious diseases (08.05.2020)
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Journal Article
Identification and Profiling of HydantoinsA Novel Class of Potent Antimycobacterial DprE1 Inhibitors
Rogacki, Maciej K, Pitta, Eleni, Balabon, Olga, Huss, Sophie, Lopez-Roman, Eva Maria, Argyrou, Argyrides, Blanco-Ruano, Delia, Cacho, Monica, Vande Velde, Christophe M. L, Augustyns, Koen, Ballell, Lluis, Barros, David, Bates, Robert H, Cunningham, Fraser, Van der Veken, Pieter
Published in Journal of medicinal chemistry (27.12.2018)
Published in Journal of medicinal chemistry (27.12.2018)
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Pulmonary Mycobacterium bovis BCG vaccination confers dose-dependent superior protection compared to that of subcutaneous vaccination
Aguilo, Nacho, Toledo, Ana Maria, Lopez-Roman, Eva Maria, Perez-Herran, Esther, Gormley, Eamonn, Rullas-Trincado, Joaquin, Angulo-Barturen, Iñigo, Martin, Carlos
Published in Clinical and vaccine immunology (01.04.2014)
Published in Clinical and vaccine immunology (01.04.2014)
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Release of 50 new, drug-like compounds and their computational target predictions for open source anti-tubercular drug discovery
Rebollo-Lopez, María Jose, Lelièvre, Joël, Alvarez-Gomez, Daniel, Castro-Pichel, Julia, Martínez-Jiménez, Francisco, Papadatos, George, Kumar, Vinod, Colmenarejo, Gonzalo, Mugumbate, Grace, Hurle, Mark, Barroso, Vanessa, Young, Rob J, Martinez-Hoyos, María, González del Río, Rubén, Bates, Robert H, Lopez-Roman, Eva Maria, Mendoza-Losana, Alfonso, Brown, James R, Alvarez-Ruiz, Emilio, Marti-Renom, Marc A, Overington, John P, Cammack, Nicholas, Ballell, Lluís, Barros-Aguire, David
Published in PloS one (07.12.2015)
Published in PloS one (07.12.2015)
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