The trispecific DARPin ensovibep inhibits diverse SARS-CoV-2 variants
Rothenberger, Sylvia, Hurdiss, Daniel L., Walser, Marcel, Malvezzi, Francesca, Mayor, Jennifer, Ryter, Sarah, Moreno, Hector, Liechti, Nicole, Bosshart, Andreas, Iss, Chloé, Calabro, Valérie, Cornelius, Andreas, Hospodarsch, Tanja, Neculcea, Alexandra, Looser, Thamar, Schlegel, Anja, Fontaine, Simon, Villemagne, Denis, Paladino, Maria, Schiegg, Dieter, Mangold, Susanne, Reichen, Christian, Radom, Filip, Kaufmann, Yvonne, Schaible, Doris, Schlegel, Iris, Zitt, Christof, Sigrist, Gabriel, Straumann, Marcel, Wolter, Julia, Comby, Marco, Sacarcelik, Feyza, Drulyte, Ieva, Lyoo, Heyrhyoung, Wang, Chunyan, Li, Wentao, Du, Wenjuan, Binz, H. Kaspar, Herrup, Rachel, Lusvarghi, Sabrina, Neerukonda, Sabari Nath, Vassell, Russell, Wang, Wei, Adler, Julia M., Eschke, Kathrin, Nascimento, Mariana, Abdelgawad, Azza, Gruber, Achim D., Bushe, Judith, Kershaw, Olivia, Knutson, Charles G., Balavenkatraman, Kamal K., Ramanathan, Krishnan, Wyler, Emanuel, Teixeira Alves, Luiz Gustavo, Lewis, Seth, Watson, Randall, Haeuptle, Micha A., Zürcher, Alexander, Dawson, Keith M., Steiner, Daniel, Weiss, Carol D., Amstutz, Patrick, van Kuppeveld, Frank J. M., Stumpp, Michael T., Bosch, Berend-Jan, Engler, Olivier, Trimpert, Jakob
Published in Nature biotechnology (01.12.2022)
Published in Nature biotechnology (01.12.2022)
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Abstract 525: Novel DARPin multi-specific T-cell engager with an improved therapeutic window to overcome dose limiting toxicities in AML therapies
Reschke, Nina, Looser, Thamar, Krieg, Jennifer, Bianchi, Matteo, Schildknecht, Patricia, Bassler, Nicole, Gruebler, Yvonne, Grimm, Sebastian, Jeanbart, Laura, Hospodarsch, Tanja, Neculcea, Alexandra, Steiner, Daniel, Schlereth, Bernd, Reichen, Christian
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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MP0533: A Multispecific Darpin CD3 Engager Targeting CD33, CD123, and CD70 for the Treatment of AML and MDS Designed to Selectively Target Leukemic Stem Cells
Bianchi, Matteo, Reichen, Christian, Fischer, Stefanie, Grübler, Yvonne, Eggenschwiler, Aline, Marpakwar, Rajlakshmi, Looser, Thamar, Spitzli, Patricia, Herzog, Christel, Villemagne, Denis, Kaufmann, Yvonne, Auge, Alienor, Hänggi, Martin, Ali, Waleed, Lekishvili, Tamara, Frasconi, Teresa, Wullschleger, Stephan, Zitt, Christof, Franchini, Marco, Croset, Amelie, Watson, Randall, Kirkin, Vladimir, Luethi, Ursina, Ochsenbein, Adrian, Riether, Carsten, Steiner, Daniel, Leupin, Nicolas, Goubier, Anne
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Avidity-Engineered CD3 Engaging DARPin ® Targeting Three Tumor Associated Antigens Induce Strong and Specific T Cell Dependent Killing of AML Cells with Potential for Improved Safety
Bianchi, Matteo, Reschke, Nina, Reichen, Christian, Fischer, Stefanie, Grübler, Yvonne, Eggenschwiler, Aline, Krieg, Jennifer, Ioannou, Kyriaki, Ragusa, Simone, Looser, Thamar, Spitzli, Patricia, Herzog, Christel, Villemagne, Denis, Kaufmann, Yvonne, Matzner, Mirela, Auge, Alienor, Hänggi, Martin, Ali, Waleed, Franchini, Marco, Kirkin, Vladimir, Schlereth, Bernd, Luethi, Ursina, Ochsenbein, Adrian, Riether, Carsten, Steiner, Daniel, Goubier, Anne
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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The CD33xCD123xCD70 Multispecific CD3-Engaging DARPin MP0533 Induces Selective T Cell-Mediated Killing of AML Leukemic Stem Cells
Bianchi, Matteo, Reichen, Christian, Croset, Amelie, Fischer, Stefanie, Eggenschwiler, Aline, Grübler, Yvonne, Marpakwar, Rajlakshmi, Looser, Thamar, Spitzli, Patricia, Herzog, Christel, Villemagne, Denis, Schiegg, Dieter, Abduli, Liridon, Iss, Chloé, Neculcea, Alexandra, Franchini, Marco, Lekishvili, Tamara, Ragusa, Simone, Zitt, Christof, Kaufmann, Yvonne, Auge, Alienor, Hänggi, Martin, Ali, Waleed, Frasconi, Teresa M, Wullschleger, Stephan, Schlegel, Iris, Matzner, Mirela, Lüthi, Ursina, Schlereth, Bernd, Dawson, Keith M, Kirkin, Vladimir, Ochsenbein, Adrian F, Grimm, Sebastian, Reschke, Nina, Riether, Carsten, Steiner, Daniel, Leupin, Nicolas, Goubier, Anne
Published in Cancer immunology research (02.07.2024)
Published in Cancer immunology research (02.07.2024)
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Ensovibep, a novel trispecific DARPin candidate that protects against SARS-CoV-2 variants
Rothenberger, Sylvia, Hurdiss, Daniel L, Walser, Marcel, Malvezzi, Francesca, Mayor, Jennifer, Ryter, Sarah, Moreno, Hector, Liechti, Nicole, Bosshart, Andreas, Iss, Chloe, Calabro, Valerie, Cornelius, Andreas, Hospodarsch, Tanja, Neculcea, Alexandra, Looser, Thamar, Schlegel, Anja, Fontaine, Simon, Villemagne, Denis, Paladino, Maria, Kaufmann, Yvonne, Schaible, Doris, Schlegel, Iris, Schiegg, Dieter, Zitt, Christof, Sigrist, Gabriel, Straumann, Marcel, Sacarcelik, Feyza, Wolter, Julia, Comby, Marco, Adler, Julia M, Eschke, Kathrin, Nascimento, Mariana, Abdelgawad, Azza, Gruber, Achim D, Bushe, Judith, Kershaw, Olivia, Lyoo, Heyrhyoung, Wang, Chunyan, Li, Wentao, Drulyte, Ieva, Du, Wenjuan, Binz, Kaspar, Herrup, Rachel, Lusvarghi, Sabrina, Neerukonda, Sabari N, Vassell, Russell, Wang, Wei, Mangold, Susanne, Reichen, Christian, Radom, Filip, Knutson, Charles G, Balavenkatraman, Kamal K, Ramanathan, Krishnan, Lewis, Seth, Watson, Randall, Haeuptle, Micha A, Zuercher, Alexander, Dawson, Keith M, Steiner, Daniel, Weiss, Carol D, Amstutz, Patrick, Van Kuppeveld, Frank Jm, Stumpp, Michael T, Bosch, Berend-Jan, Engler, Olivier, Trimpert, Jakob
Published in bioRxiv (26.02.2022)
Published in bioRxiv (26.02.2022)
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Highly potent anti-SARS-CoV-2 multivalent DARPin therapeutic candidates
Walser, Marcel, Rothenberger, Sylvia, Hurdiss, Daniel L, Schlegel, Anja, Calabro, Valerie, Fontaine, Simon, Villemagne, Denis, Paladino, Maria, Hospodarsch, Tanja, Neculcea, Alexandra, Cornelius, Andreas, Schildknecht, Patricia, Matzner, Mirela, Haenggi, Martin, Franchini, Marco, Kaufmann, Yvonne, Schaible, Doris, Schlegel, Iris, Iss, Chloe, Looser, Thamar, Mangold, Susanne, Herzog, Christel, Schiegg, Dieter, Reichen, Christian, Radom, Filip, Bosshart, Andreas, Lehmann, Andreas, Haeuptle, Micha A, Zuercher, Alexander, Vagt, Toni, Sigrist, Gabriel, Straumann, Marcel, Proba, Karl, Veitonmaki, Niina, Dawson, Keith M, Zitt, Christof, Mayor, Jennifer, Ryter, Sarah, Lyoo, Heyrhyoung, Wang, Chunyan, Li, Wentao, Drulyte, Ieva, Du, Wenjuan, H Kaspar Binz, Leon De Waal, Stittelaar, Koert J, Taplin, Sarah, Lewis, Seth, Steiner, Daniel, Van Kuppeveld, Frank Jm, Engler, Olivier, Bosch, Berend-Jan, Stumpp, Michael T, Amstutz, Patrick
Published in bioRxiv (21.07.2021)
Published in bioRxiv (21.07.2021)
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