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Namkung, Yoon, LeGouill, Christian, Kumar, Sahil, Cao, Yubo, Teixeira, Larissa B, Lukasheva, Viktoriya, Giubilaro, Jenna, Simões, Sarah C, Longpré, Jean-Michel, Devost, Dominic, Hébert, Terence E, Piñeyro, Graciela, Leduc, Richard, Costa-Neto, Claudio M, Bouvier, Michel, Laporte, Stéphane A
Published in Science signaling (04.12.2018)
Published in Science signaling (04.12.2018)
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Design, Structural Optimization, and Characterization of the First Selective Macrocyclic Neurotensin Receptor Type 2 Non-opioid Analgesic
Chartier, Magali, Desgagné, Michael, Sousbie, Marc, Côté, Jérôme, Longpré, Jean-Michel, Marsault, Eric, Sarret, Philippe
Published in Journal of medicinal chemistry (25.02.2021)
Published in Journal of medicinal chemistry (25.02.2021)
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Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors
Gusach, Anastasiia, Luginina, Aleksandra, Marin, Egor, Brouillette, Rebecca L, Besserer-Offroy, Élie, Longpré, Jean-Michel, Ishchenko, Andrii, Popov, Petr, Patel, Nilkanth, Fujimoto, Taku, Maruyama, Toru, Stauch, Benjamin, Ergasheva, Margarita, Romanovskaia, Daria, Stepko, Anastasiia, Kovalev, Kirill, Shevtsov, Mikhail, Gordeliy, Valentin, Han, Gye Won, Katritch, Vsevolod, Borshchevskiy, Valentin, Sarret, Philippe, Mishin, Alexey, Cherezov, Vadim
Published in Nature communications (06.12.2019)
Published in Nature communications (06.12.2019)
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Brain irradiation leads to persistent neuroinflammation and long-term neurocognitive dysfunction in a region-specific manner
Constanzo, Julie, Midavaine, Élora, Fouquet, Jérémie, Lepage, Martin, Descoteaux, Maxime, Kirby, Karyn, Tremblay, Luc, Masson-Côté, Laurence, Geha, Sameh, Longpré, Jean-Michel, Paquette, Benoit, Sarret, Philippe
Published in Progress in neuro-psychopharmacology & biological psychiatry (30.08.2020)
Published in Progress in neuro-psychopharmacology & biological psychiatry (30.08.2020)
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The signaling signature of the neurotensin type 1 receptor with endogenous ligands
Besserer-Offroy, Élie, Brouillette, Rebecca L., Lavenus, Sandrine, Froehlich, Ulrike, Brumwell, Andrea, Murza, Alexandre, Longpré, Jean-Michel, Marsault, Éric, Grandbois, Michel, Sarret, Philippe, Leduc, Richard
Published in European journal of pharmacology (15.06.2017)
Published in European journal of pharmacology (15.06.2017)
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Ligand-dependent intracellular trafficking of the G protein-coupled P2Y6 receptor
Girard, Mélissa, Bellefeuille, Steve Dagenais, Eiselt, Émilie, Arguin, Guillaume, Longpré, Jean-Michel, Sarret, Philippe, Gendron, Fernand-Pierre
Published in Biochimica et biophysica acta. Molecular cell research (01.06.2023)
Published in Biochimica et biophysica acta. Molecular cell research (01.06.2023)
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Structural Optimization and Characterization of Potent Analgesic Macrocyclic Analogues of Neurotensin (8–13)
Sousbie, Marc, Vivancos, Mélanie, Brouillette, Rebecca L., Besserer-Offroy, Élie, Longpré, Jean-Michel, Leduc, Richard, Sarret, Philippe, Marsault, Éric
Published in Journal of medicinal chemistry (23.08.2018)
Published in Journal of medicinal chemistry (23.08.2018)
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Metabolically stable neurotensin analogs exert potent and long-acting analgesia without hypothermia
Vivancos, Mélanie, Fanelli, Roberto, Besserer-Offroy, Élie, Beaulieu, Sabrina, Chartier, Magali, Resua-Rojas, Martin, Mona, Christine E., Previti, Santo, Rémond, Emmanuelle, Longpré, Jean-Michel, Cavelier, Florine, Sarret, Philippe
Published in Behavioural brain research (07.05.2021)
Published in Behavioural brain research (07.05.2021)
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Structure-based mechanism of cysteinyl leukotriene receptor inhibition by antiasthmatic drugs
Luginina, Aleksandra, Gusach, Anastasiia, Marin, Egor, Mishin, Alexey, Brouillette, Rebecca, Popov, Petr, Shiriaeva, Anna, Besserer-Offroy, Élie, Longpré, Jean-Michel, Lyapina, Elizaveta, Ishchenko, Andrii, Patel, Nilkanth, Polovinkin, Vitaly, Safronova, Nadezhda, Bogorodskiy, Andrey, Edelweiss, Evelina, Hu, Hao, Weierstall, Uwe, Liu, Wei, Batyuk, Alexander, Gordeliy, Valentin, Han, Gye Won, Sarret, Philippe, Katritch, Vsevolod, Borshchevskiy, Valentin, Cherezov, Vadim
Published in Science advances (09.10.2019)
Published in Science advances (09.10.2019)
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Neurotensin Analogues Containing Cyclic Surrogates of Tyrosine at Position 11 Improve NTS2 Selectivity Leading to Analgesia without Hypotension and Hypothermia
Eiselt, Emilie, Gonzalez, Simon, Martin, Charlotte, Chartier, Magali, Betti, Cecilia, Longpré, Jean-Michel, Cavelier, Florine, Tourwé, Dirk, Gendron, Louis, Ballet, Steven, Sarret, Philippe
Published in ACS chemical neuroscience (20.11.2019)
Published in ACS chemical neuroscience (20.11.2019)
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Signal profiling of the β1AR reveals coupling to novel signalling pathways and distinct phenotypic responses mediated by β1AR and β2AR
Lukasheva, Viktoriya, Devost, Dominic, Le Gouill, Christian, Namkung, Yoon, Martin, Ryan D., Longpré, Jean-Michel, Amraei, Mohammad, Shinjo, Yuji, Hogue, Mireille, Lagacé, Monique, Breton, Billy, Aoki, Junken, Tanny, Jason C., Laporte, Stéphane A., Pineyro, Graciela, Inoue, Asuka, Bouvier, Michel, Hébert, Terence E.
Published in Scientific reports (29.05.2020)
Published in Scientific reports (29.05.2020)
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The hypotensive effect of activated apelin receptor is correlated with β-arrestin recruitment
Besserer-Offroy, Élie, Bérubé, Patrick, Côté, Jérôme, Murza, Alexandre, Longpré, Jean-Michel, Dumaine, Robert, Lesur, Olivier, Auger-Messier, Mannix, Leduc, Richard, Marsault, Éric, Sarret, Philippe
Published in Pharmacological research (01.05.2018)
Published in Pharmacological research (01.05.2018)
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Synthesis and Characterization in Vitro and in Vivo of (l)‑(Trimethylsilyl)alanine Containing Neurotensin Analogues
Fanelli, Roberto, Besserer-Offroy, Élie, René, Adeline, Côté, Jérôme, Tétreault, Pascal, Collerette-Tremblay, Jasmin, Longpré, Jean-Michel, Leduc, Richard, Martinez, Jean, Sarret, Philippe, Cavelier, Florine
Published in Journal of medicinal chemistry (08.10.2015)
Published in Journal of medicinal chemistry (08.10.2015)
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Use of Molecular Modeling to Design Selective NTS2 Neurotensin Analogues
Fanelli, Roberto, Floquet, Nicolas, Besserer-Offroy, Élie, Delort, Bartholomé, Vivancos, Mélanie, Longpré, Jean-Michel, Renault, Pedro, Martinez, Jean, Sarret, Philippe, Cavelier, Florine
Published in Journal of medicinal chemistry (27.04.2017)
Published in Journal of medicinal chemistry (27.04.2017)
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Pain relief devoid of opioid side effects following central action of a silylated neurotensin analog
Tétreault, Pascal, Besserer-Offroy, Élie, Brouillette, Rebecca L., René, Adeline, Murza, Alexandre, Fanelli, Roberto, Kirby, Karyn, Parent, Alexandre J., Dubuc, Isabelle, Beaudet, Nicolas, Côté, Jérôme, Longpré, Jean-Michel, Martinez, Jean, Cavelier, Florine, Sarret, Philippe
Published in European journal of pharmacology (05.09.2020)
Published in European journal of pharmacology (05.09.2020)
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The P2Y6 receptor signals through Gαq/Ca2+/PKCα and Gα13/ROCK pathways to drive the formation of membrane protrusions and dictate cell migration
Girard, Mélissa, Dagenais Bellefeuille, Steve, Eiselt, Émilie, Brouillette, Rebecca, Placet, Morgane, Arguin, Guillaume, Longpré, Jean‐Michel, Sarret, Philippe, Gendron, Fernand‐Pierre
Published in Journal of cellular physiology (01.12.2020)
Published in Journal of cellular physiology (01.12.2020)
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Structure-activity relationship of novel macrocyclic biased apelin receptor agonists
Murza, Alexandre, Sainsily, Xavier, Cote, Jerome, Bruneau-Cossette, Laurent, Besserer-Offroy, Elie, Longpre, Jean-Michel, Leduc, Richard, Dumaine, Robert, Lesur, Olivier, Auger-Messier, Mannix, Sarret, Philippe, Marsault, Eric
Published in Organic & biomolecular chemistry (2017)
Published in Organic & biomolecular chemistry (2017)
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Dichotomic effects of clinically used drugs on tumor growth, bone remodeling and pain management
Barrière, David André, Midavaine, Élora, Doré-Savard, Louis, Kirby, Karyn, Tremblay, Luc, Beaudoin, Jean-François, Beaudet, Nicolas, Longpré, Jean-Michel, Lecomte, Roger, Lepage, Martin, Sarret, Philippe
Published in Scientific reports (27.12.2019)
Published in Scientific reports (27.12.2019)
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