A double-blind, randomised, placebo-controlled, phase 2b study evaluating sorafenib in combination with paclitaxel as a first-line therapy in patients with HER2-negative advanced breast cancer
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Published in European journal of cancer (1990) (01.01.2013)
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Sorafenib in Combination with Oxaliplatin, Leucovorin, and Fluorouracil (Modified FOLFOX6) as First-line Treatment of Metastatic Colorectal Cancer: The RESPECT Trial
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Published in Clinical cancer research (01.05.2013)
Published in Clinical cancer research (01.05.2013)
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Sorafenib or Placebo with Either Gemcitabine or Capecitabine in Patients with HER-2―Negative Advanced Breast Cancer That Progressed during or after Bevacizumab
SCHWARTZBERG, Lee S, TAUER, Kurt W, BELL-MCGUINN, Katherine, KIRSHNER, Jeffrey J, EISENBERG, Peter, EMANUELSON, Richard, KEATON, Mark, LEVINE, Ellis, MEDGYESY, Diana C, QAMAR, Rubina, STARR, Alexander, SUNHEE KWON RO, HERMANN, Robert C, LOKKER, Nathalie A, HUDIS, Clifford A, MAKARI-JUDSON, Grace, ISAACS, Claudine, THADDEUS BECK, J, KAKLAMANI, Virginia, STEPANSKI, Edward J, RUGO, Hope S, WEI WANG
Published in Clinical cancer research (15.05.2013)
Published in Clinical cancer research (15.05.2013)
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Platelet-derived growth factor (PDGF) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: Evidence that the novel PDGF-C and PDGF-D ligands may play a role in the development of brain tumors
LOKKER, Nathalie A, SULLIVAN, Carol M, HOLLENBACH, Stanley J, ISRAEL, Mark A, GIESE, Neill A
Published in Cancer research (Chicago, Ill.) (01.07.2002)
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Published in Cancer research (Chicago, Ill.) (01.07.2002)
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PDGF-D, a new protease-activated growth factor
LaRochelle, William J, Jeffers, Michael, McDonald, William F, Chillakuru, Rajeev A, Giese, Neill A, Lokker, Nathalie A, Sullivan, Carol, Boldog, Ferenc L, Yang, Meijia, Vernet, Corine, Burgess, Catherine E, Fernandes, Elma, Deegler, Lisa L, Rittman, Beth, Shimkets, Juliette, Shimkets, Richard A, Rothberg, Jonathan M, Lichenstein, Henri S
Published in Nature cell biology (01.05.2001)
Published in Nature cell biology (01.05.2001)
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CT53518, a novel selective FLT3 antagonist for the treatment of acute myelogenous leukemia (AML)
Kelly, Louise M, Yu, Jin-Chen, Boulton, Christina L, Apatira, Mutiah, Li, Jason, Sullivan, Carol M, Williams, Ifor, Amaral, Sonia M, Curley, David P, Duclos, Nicole, Neuberg, Donna, Scarborough, Robert M, Pandey, Anjali, Hollenbach, Stanley, Abe, Keith, Lokker, Nathalie A, Gilliland, D.Gary, Giese, Neill A
Published in Cancer cell (01.06.2002)
Published in Cancer cell (01.06.2002)
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Potent and Selective Inhibitors of Platelet-Derived Growth Factor Receptor Phosphorylation. 1. Synthesis, Structure−Activity Relationship, and Biological Effects of a New Class of Quinazoline Derivatives
Matsuno, Kenji, Ichimura, Michio, Nakajima, Takao, Tahara, Keiko, Fujiwara, Shigeki, Kase, Hiroshi, Ushiki, Junko, Giese, Neill A, Pandey, Anjali, Scarborough, Robert M, Lokker, Nathalie A, Yu, Jin-Chen, Irie, Junko, Tsukuda, Eiji, Ide, Shin-ichi, Oda, Shoji, Nomoto, Yuji
Published in Journal of medicinal chemistry (04.07.2002)
Published in Journal of medicinal chemistry (04.07.2002)
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PDGF C Is A Selective α Platelet-Derived Growth Factor Receptor Agonist That Is Highly Expressed in Platelet α Granules and Vascular Smooth Muscle
Fang, Li, Yan, Yibing, Komuves, Laszlo G, Yonkovich, Shirlee, Sullivan, Carol M, Stringer, Bradley, Galbraith, Sarah, Lokker, Nathalie A, Hwang, S Stuart, Nurden, Paquita, Phillips, David R, Giese, Neill A
Published in Arteriosclerosis, thrombosis, and vascular biology (01.04.2004)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.04.2004)
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Potent and Selective Inhibitors of PDGF Receptor Phosphorylation. 2. Synthesis, Structure Activity Relationship, Improvement of Aqueous Solubility, and Biological Effects of 4-[4-(N-Substituted (thio)carbamoyl)-1-piperazinyl]-6,7-dimethoxyquinazoline Derivatives
Matsuno, Kenji, Nakajima, Takao, Ichimura, Michio, Giese, Neill A, Yu, Jin-Chen, Lokker, Nathalie A, Ushiki, Junko, Ide, Shin-ichi, Oda, Shoji, Nomoto, Yuji
Published in Journal of medicinal chemistry (26.09.2002)
Published in Journal of medicinal chemistry (26.09.2002)
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Crystal structure of the NK1 fragment of human hepatocyte growth factor at 2.0 å resolution
Ultsch, Mark, Lokker, Nathalie A, Godowski, Paul J, de Vos, Abraham M
Published in Structure (London) (15.11.1998)
Published in Structure (London) (15.11.1998)
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Dissecting the Stromal Signaling and Regulation of Myeloid Cells and Memory Effector T Cells in Pancreatic Cancer
Blair, Alex B, Kim, Victoria M, Muth, Stephen T, Saung, May Tun, Lokker, Nathalie, Blouw, Barbara, Armstrong, Todd D, Jaffee, Elizabeth M, Tsujikawa, Takahiro, Coussens, Lisa M, He, Jin, Burkhart, Richard A, Wolfgang, Christopher L, Zheng, Lei
Published in Clinical cancer research (01.09.2019)
Published in Clinical cancer research (01.09.2019)
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Efficacy of the Novel Selective Platelet-Derived Growth Factor Receptor Antagonist CT52923 on Cellular Proliferation, Migration, and Suppression of Neointima following Vascular Injury
Yu, J C, Lokker, N A, Hollenbach, S, Apatira, M, Li, J, Betz, A, Sedlock, D, Oda, S, Nomoto, Y, Matsuno, K, Ide, S, Tsukuda, E, Giese, N A
Published in The Journal of pharmacology and experimental therapeutics (01.09.2001)
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Published in The Journal of pharmacology and experimental therapeutics (01.09.2001)
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Abstract OT1-1-14: A phase 2, 2-stage, 2-cohort study of the oral PARP inhibitor BMN 673 in patients with germline BRCA mutation and locally advanced and/or metastatic breast cancer (ABRAZO study)
Turner, Nicholas C, Balmana, Judith, Domchek, Susan M, Visco, Frances, Zhang, Charlie, Lokker, Nathalie A, Lounsbury, Debra L, Robson, Mark E
Published in Cancer research (Chicago, Ill.) (01.05.2015)
Published in Cancer research (Chicago, Ill.) (01.05.2015)
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Block of C/EBP alpha function by phosphorylation in acute myeloid leukemia with FLT3 activating mutations
Radomska, Hanna S, Bassères, Daniela S, Zheng, Rui, Zhang, Pu, Dayaram, Tajhal, Yamamoto, Yukiya, Sternberg, David W, Lokker, Nathalie, Giese, Neill A, Bohlander, Stefan K, Schnittger, Susanne, Delmotte, Marie-Hélène, Davis, Roger J, Small, Donald, Hiddemann, Wolfgang, Gilliland, D Gary, Tenen, Daniel G
Published in The Journal of experimental medicine (20.02.2006)
Published in The Journal of experimental medicine (20.02.2006)
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A phase 2 study (2-stage, 2-cohort) of the oral PARP inhibitor talazoparib (BMN 673) in patients with germline BRCA mutation and locally advanced and/or metastatic breast cancer (ABRAZO)
Turner, Nicholas C., Balmaña, Judith, Fasching, Peter A., Hurvitz, Sara A., Telli, Melinda L., Visco, Fran, Wardley, Andrew M., Zhang, Charlie, Lokker, Nathalie Andrienne, Lounsbury, Debra L., Robson, Mark E.
Published in Journal of clinical oncology (20.05.2015)
Published in Journal of clinical oncology (20.05.2015)
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A phase 3, open-label, randomized, parallel, 2-arm international study of the oral PARP inhibitor talazoparib (BMN 673) in BRCA mutation subjects with locally advanced and/or metastatic breast cancer (EMBRACA)
Litton, Jennifer Keating, Blum, Joanne Lorraine, Im, Young-Hyuck, Martin, Miguel, Mina, Lida A., Roche, Henri Hubert, Rugo, Hope S., Visco, Fran, Zhang, Charlie, Lokker, Nathalie Andrienne, Lounsbury, Debra L., Eiermann, Wolfgang
Published in Journal of clinical oncology (20.05.2015)
Published in Journal of clinical oncology (20.05.2015)
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Abstract OT1-1-12: A phase 3, open-label, randomized, parallel, 2-arm multi-center study of the oral PARP inhibitor BMN 673 versus physician's choice in germline BRCA mutation subjects with locally advanced and/or metastatic breast cancer (EMBRACA study)
Litton, Jennifer K, Blum, Joanne L, Eiermann, Wolfgang, Im, Young-Hyuck, Martin, Miguel, Mina, Lida, Roché, Henri, Rugo, Hope S, Visco, Frances, Zhang, Charlie, Lokker, Nathalie A, Lounsbury, Debra L
Published in Cancer research (Chicago, Ill.) (01.05.2015)
Published in Cancer research (Chicago, Ill.) (01.05.2015)
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Microarray gene expression study of the RESPECT trial for the identification of prognostic and predictive markers
Delorenzi, Mauro, Gerster, Sarah, Tabernero, Josep, Köhne, Claus-Henning, O'Dwyer, Peter J., Sobrero, Alberto F., van Cutsem, Eric, Garcia-Carbonero, Rocio, Salazar, Ramon, Rivera, Fernando, Samuel, Leslie M., Potter, Vanessa Alice, Chang, Yu-Lin, Lokker, Nathalie Andrienne, Tejpar, Sabine
Published in Journal of clinical oncology (20.05.2013)
Published in Journal of clinical oncology (20.05.2013)
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Functional Importance of Platelet-derived Growth Factor (PDGF) Receptor Extracellular Immunoglobulin-like Domains
Lokker, Nathalie A., O'Hare, James P., Barsoumian, Arpy, Tomlinson, James E., Ramakrishnan, Vanitha, Fretto, Larry J., Giese, Neill A.
Published in The Journal of biological chemistry (26.12.1997)
Published in The Journal of biological chemistry (26.12.1997)
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