Monoclonal antibodies targeting CD38 in hematological malignancies and beyond
van de Donk, Niels W. C. J., Janmaat, Maarten L., Mutis, Tuna, Lammerts van Bueren, Jeroen J., Ahmadi, Tahamtan, Sasser, A. Kate, Lokhorst, Henk M., Parren, Paul W. H. I.
Published in Immunological reviews (01.03.2016)
Published in Immunological reviews (01.03.2016)
Get full text
Journal Article
A Rational Strategy for Reducing On-Target Off-Tumor Effects of CD38-Chimeric Antigen Receptors by Affinity Optimization
Drent, Esther, Themeli, Maria, Poels, Renée, de Jong-Korlaar, Regina, Yuan, Huipin, de Bruijn, Joost, Martens, Anton C.M., Zweegman, Sonja, van de Donk, Niels W.C.J., Groen, Richard W.J., Lokhorst, Henk M., Mutis, Tuna
Published in Molecular therapy (02.08.2017)
Published in Molecular therapy (02.08.2017)
Get full text
Journal Article
CD38 expression and complement inhibitors affect response and resistance to daratumumab therapy in myeloma
Nijhof, Inger S., Casneuf, Tineke, van Velzen, Jeroen, van Kessel, Berris, Axel, Amy E., Syed, Khaja, Groen, Richard W.J., van Duin, Mark, Sonneveld, Pieter, Minnema, Monique C., Zweegman, Sonja, Chiu, Christopher, Bloem, Andries C., Mutis, Tuna, Lokhorst, Henk M., Sasser, A.Kate, van de Donk, Niels W.C.J.
Published in Blood (18.08.2016)
Published in Blood (18.08.2016)
Get full text
Journal Article
Clinical efficacy and management of monoclonal antibodies targeting CD38 and SLAMF7 in multiple myeloma
van de Donk, Niels W.C.J., Moreau, Philippe, Plesner, Torben, Palumbo, Antonio, Gay, Francesca, Laubach, Jacob P., Malavasi, Fabio, Avet-Loiseau, Hervé, Mateos, Maria-Victoria, Sonneveld, Pieter, Lokhorst, Henk M., Richardson, Paul G.
Published in Blood (11.02.2016)
Published in Blood (11.02.2016)
Get full text
Journal Article
Bortezomib Induction and Maintenance Treatment in Patients With Newly Diagnosed Multiple Myeloma: Results of the Randomized Phase III HOVON-65/ GMMG-HD4 Trial
SONNEVELD, Pieter, SCHMIDT-WOLF, Ingo G. H, WEISEL, Katja C, WITTEBOL, Shulamiet, BOS, Gerard M. J, STEVENS-KROEF, Marian, SCHEID, Christof, PFREUNDSCHUH, Michael, HOSE, Dirk, JAUCH, Anna, DER VELDE, Helgi Van, RAYMAKERS, Reinier, DER HOLT, Bronno Van, SCHAAFSMA, Martijn R, KERSTEN, Marie-Jose, MARWIJK-KOOY, Marinus Van, DUEHRSEN, Ulrich, LINDEMANN, Walter, WIJERMANS, Pierre W, LOKHORST, Henk M, GOLDSCHMIDT, Hartmut M, EL JARARI, Laila, BERTSCH, Uta, SALWENDER, Hans, ZWEEGMAN, Sonja, VELLENGA, Edo, BROYL, Annemiek, BLAU, Igor W
Published in Journal of clinical oncology (20.08.2012)
Published in Journal of clinical oncology (20.08.2012)
Get full text
Journal Article
Bortezomib-Based Versus Nonbortezomib-Based Induction Treatment Before Autologous Stem-Cell Transplantation in Patients With Previously Untreated Multiple Myeloma: A Meta-Analysis of Phase III Randomized, Controlled Trials
SONNEVELD, Pieter, GOLDSCHMIDT, Hartmut, DESAI, Avinash, CAKANA, Andrew, LIU, Kevin, VAN DE VELDE, Helgi, ESSELTINE, Dixie-Lee, MOREAU, Philippe, ROSIÑOL, Laura, BLADE, Joan, JOSE LAHUERTA, Juan, CAVO, Michele, TACCHETTI, Paola, ZAMAGNI, Elena, ATTAL, Michel, LOKHORST, Henk M
Published in Journal of clinical oncology (10.09.2013)
Published in Journal of clinical oncology (10.09.2013)
Get full text
Journal Article
Daratumumab, a novel therapeutic human CD38 monoclonal antibody, induces killing of multiple myeloma and other hematological tumors
de Weers, Michel, Tai, Yu-Tzu, van der Veer, Michael S, Bakker, Joost M, Vink, Tom, Jacobs, Daniëlle C H, Oomen, Lukas A, Peipp, Matthias, Valerius, Thomas, Slootstra, Jerry W, Mutis, Tuna, Bleeker, Wim K, Anderson, Kenneth C, Lokhorst, Henk M, van de Winkel, Jan G J, Parren, Paul W H I
Published in The Journal of immunology (1950) (01.02.2011)
Published in The Journal of immunology (1950) (01.02.2011)
Get full text
Journal Article
Preclinical Evidence for the Therapeutic Potential of CD38-Targeted Immuno-Chemotherapy in Multiple Myeloma Patients Refractory to Lenalidomide and Bortezomib
Nijhof, Inger S, Groen, Richard W J, Noort, Willy A, van Kessel, Berris, de Jong-Korlaar, Regina, Bakker, Joost, van Bueren, Jeroen J L, Parren, Paul W H I, Lokhorst, Henk M, van de Donk, Niels W C J, Martens, Anton C M, Mutis, Tuna
Published in Clinical cancer research (15.06.2015)
Published in Clinical cancer research (15.06.2015)
Get full text
Journal Article
Feasibility of controlling CD38-CAR T cell activity with a Tet-on inducible CAR design
Drent, Esther, Poels, Renée, Mulders, Manon J, van de Donk, Niels W C J, Themeli, Maria, Lokhorst, Henk M, Mutis, Tuna
Published in PloS one (30.05.2018)
Published in PloS one (30.05.2018)
Get full text
Journal Article
Phase 1/2 study of daratumumab, lenalidomide, and dexamethasone for relapsed multiple myeloma
Plesner, Torben, Arkenau, Hendrik-Tobias, Gimsing, Peter, Krejcik, Jakub, Lemech, Charlotte, Minnema, Monique C., Lassen, Ulrik, Laubach, Jacob P., Palumbo, Antonio, Lisby, Steen, Basse, Linda, Wang, Jianping, Sasser, A. Kate, Guckert, Mary E., de Boer, Carla, Khokhar, Nushmia Z., Yeh, Howard, Clemens, Pamela L., Ahmadi, Tahamtan, Lokhorst, Henk M., Richardson, Paul G.
Published in Blood (06.10.2016)
Published in Blood (06.10.2016)
Get full text
Journal Article
Pre-clinical evaluation of CD38 chimeric antigen receptor engineered T cells for the treatment of multiple myeloma
Drent, Esther, Groen, Richard W J, Noort, Willy A, Themeli, Maria, Lammerts van Bueren, Jeroen J, Parren, Paul W H I, Kuball, Jürgen, Sebestyen, Zsolt, Yuan, Huipin, de Bruijn, Joost, van de Donk, Niels W C J, Martens, Anton C M, Lokhorst, Henk M, Mutis, Tuna
Published in Haematologica (Roma) (01.05.2016)
Published in Haematologica (Roma) (01.05.2016)
Get full text
Journal Article
How I treat plasma cell leukemia
van de Donk, Niels W.C.J., Lokhorst, Henk M., Anderson, Kenneth C., Richardson, Paul G.
Published in Blood (20.09.2012)
Published in Blood (20.09.2012)
Get full text
Journal Article
Effects of daratumumab on natural killer cells and impact on clinical outcomes in relapsed or refractory multiple myeloma
Casneuf, Tineke, Xu, Xu Steven, Adams, Homer C., Axel, Amy E., Chiu, Christopher, Khan, Imran, Ahmadi, Tahamtan, Yan, Xiaoyu, Lonial, Sagar, Plesner, Torben, Lokhorst, Henk M., van de Donk, Niels W.C.J., Clemens, Pamela L., Sasser, A. Kate
Published in Blood advances (24.10.2017)
Published in Blood advances (24.10.2017)
Get full text
Journal Article
Towards effective immunotherapy of myeloma: enhanced elimination of myeloma cells by combination of lenalidomide with the human CD38 monoclonal antibody daratumumab
VAN DER VEER, Michael S, DE WEERS, Michel, VAN KESSEL, Berris, BAKKER, Joost M, WITTEBOL, Shulamiet, PARREN, Paul W. H. I, LOKHORST, Henk M, MUTIS, Tuna
Published in Haematologica (Roma) (01.02.2011)
Published in Haematologica (Roma) (01.02.2011)
Get full text
Journal Article
The clinical relevance and management of monoclonal gammopathy of undetermined significance and related disorders: recommendations from the European Myeloma Network
van de Donk, Niels W C J, Palumbo, Antonio, Johnsen, Hans Erik, Engelhardt, Monika, Gay, Francesca, Gregersen, Henrik, Hajek, Roman, Kleber, Martina, Ludwig, Heinz, Morgan, Gareth, Musto, Pellegrino, Plesner, Torben, Sezer, Orhan, Terpos, Evangelos, Waage, Anders, Zweegman, Sonja, Einsele, Hermann, Sonneveld, Pieter, Lokhorst, Henk M
Published in Haematologica (Roma) (01.06.2014)
Published in Haematologica (Roma) (01.06.2014)
Get full text
Journal Article
Daratumumab-mediated lysis of primary multiple myeloma cells is enhanced in combination with the human anti-KIR antibody IPH2102 and lenalidomide
Nijhof, Inger S, Lammerts van Bueren, Jeroen J, van Kessel, Berris, Andre, Pascale, Morel, Yannis, Lokhorst, Henk M, van de Donk, Niels W C J, Parren, Paul W H I, Mutis, Tuna
Published in Haematologica (Roma) (01.02.2015)
Published in Haematologica (Roma) (01.02.2015)
Get full text
Journal Article
Mechanisms of peripheral neuropathy associated with bortezomib and vincristine in patients with newly diagnosed multiple myeloma: a prospective analysis of data from the HOVON-65/GMMG-HD4 trial
Broyl, Annemiek, Dr, Corthals, Sophie L, MSc, Jongen, Joost LM, MD, van der Holt, Bronno, PhD, Kuiper, Rowan, BSc, de Knegt, Yvonne, BSc, van Duin, Mark, PhD, el Jarari, Laila, MSc, Bertsch, Uta, MD, Lokhorst, Henk M, Prof, Durie, Brian G, MD, Goldschmidt, Hartmut, Prof, Sonneveld, Pieter, Prof
Published in The lancet oncology (01.11.2010)
Published in The lancet oncology (01.11.2010)
Get full text
Journal Article
Misfolded proteins activate factor XII in humans, leading to kallikrein formation without initiating coagulation
Maas, Coen, Govers-Riemslag, José W P, Bouma, Barend, Schiks, Bettina, Hazenberg, Bouke P C, Lokhorst, Henk M, Hammarström, Per, ten Cate, Hugo, de Groot, Philip G, Bouma, Bonno N, Gebbink, Martijn F B G
Published in The Journal of clinical investigation (01.09.2008)
Published in The Journal of clinical investigation (01.09.2008)
Get full text
Journal Article
Immunotherapy in myeloma: how far have we come?
Franssen, Laurens E., Mutis, Tuna, Lokhorst, Henk M., van de Donk, Niels W. C. J.
Published in Therapeutic Advances in Hematology (2019)
Published in Therapeutic Advances in Hematology (2019)
Get full text
Book Review
Journal Article
Reconstructing the human hematopoietic niche in immunodeficient mice: opportunities for studying primary multiple myeloma
Groen, Richard W.J., Noort, Willy A., Raymakers, Reinier A., Prins, Henk-Jan, Aalders, Linda, Hofhuis, Frans M., Moerer, Petra, van Velzen, Jeroen F., Bloem, Andries C., van Kessel, Berris, Rozemuller, Henk, van Binsbergen, Ellen, Buijs, Arjan, Yuan, Huipin, de Bruijn, Joost D., de Weers, Michel, Parren, Paul W.H.I., Schuringa, Jan Jacob, Lokhorst, Henk M., Mutis, Tuna, Martens, Anton C.M.
Published in Blood (19.07.2012)
Published in Blood (19.07.2012)
Get full text
Journal Article