Daratumumab depletes CD38+ immune regulatory cells, promotes T-cell expansion, and skews T-cell repertoire in multiple myeloma
Krejcik, Jakub, Casneuf, Tineke, Nijhof, Inger S., Verbist, Bie, Bald, Jaime, Plesner, Torben, Syed, Khaja, Liu, Kevin, van de Donk, Niels W.C.J., Weiss, Brendan M., Ahmadi, Tahamtan, Lokhorst, Henk M., Mutis, Tuna, Sasser, A.Kate
Published in Blood (21.07.2016)
Published in Blood (21.07.2016)
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Monoclonal antibodies targeting CD38 in hematological malignancies and beyond
van de Donk, Niels W. C. J., Janmaat, Maarten L., Mutis, Tuna, Lammerts van Bueren, Jeroen J., Ahmadi, Tahamtan, Sasser, A. Kate, Lokhorst, Henk M., Parren, Paul W. H. I.
Published in Immunological reviews (01.03.2016)
Published in Immunological reviews (01.03.2016)
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A Rational Strategy for Reducing On-Target Off-Tumor Effects of CD38-Chimeric Antigen Receptors by Affinity Optimization
Drent, Esther, Themeli, Maria, Poels, Renée, de Jong-Korlaar, Regina, Yuan, Huipin, de Bruijn, Joost, Martens, Anton C.M., Zweegman, Sonja, van de Donk, Niels W.C.J., Groen, Richard W.J., Lokhorst, Henk M., Mutis, Tuna
Published in Molecular therapy (02.08.2017)
Published in Molecular therapy (02.08.2017)
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CD38 expression and complement inhibitors affect response and resistance to daratumumab therapy in myeloma
Nijhof, Inger S., Casneuf, Tineke, van Velzen, Jeroen, van Kessel, Berris, Axel, Amy E., Syed, Khaja, Groen, Richard W.J., van Duin, Mark, Sonneveld, Pieter, Minnema, Monique C., Zweegman, Sonja, Chiu, Christopher, Bloem, Andries C., Mutis, Tuna, Lokhorst, Henk M., Sasser, A.Kate, van de Donk, Niels W.C.J.
Published in Blood (18.08.2016)
Published in Blood (18.08.2016)
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Feasibility of controlling CD38-CAR T cell activity with a Tet-on inducible CAR design
Drent, Esther, Poels, Renée, Mulders, Manon J, van de Donk, Niels W C J, Themeli, Maria, Lokhorst, Henk M, Mutis, Tuna
Published in PloS one (30.05.2018)
Published in PloS one (30.05.2018)
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Clinical efficacy and management of monoclonal antibodies targeting CD38 and SLAMF7 in multiple myeloma
van de Donk, Niels W.C.J., Moreau, Philippe, Plesner, Torben, Palumbo, Antonio, Gay, Francesca, Laubach, Jacob P., Malavasi, Fabio, Avet-Loiseau, Hervé, Mateos, Maria-Victoria, Sonneveld, Pieter, Lokhorst, Henk M., Richardson, Paul G.
Published in Blood (11.02.2016)
Published in Blood (11.02.2016)
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Combined CD28 and 4-1BB Costimulation Potentiates Affinity-tuned Chimeric Antigen Receptor-engineered T Cells
Drent, Esther, Poels, Renée, Ruiter, Ruud, van de Donk, Niels W C J, Zweegman, Sonja, Yuan, Huipin, de Bruijn, Joost, Sadelain, Michel, Lokhorst, Henk M, Groen, Richard W J, Mutis, Tuna, Themeli, Maria
Published in Clinical cancer research (01.07.2019)
Published in Clinical cancer research (01.07.2019)
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Revised International Staging System for Multiple Myeloma: A Report From International Myeloma Working Group
Palumbo, Antonio, Avet-Loiseau, Hervé, Oliva, Stefania, Lokhorst, Henk M, Goldschmidt, Hartmut, Rosinol, Laura, Richardson, Paul, Caltagirone, Simona, Lahuerta, Juan José, Facon, Thierry, Bringhen, Sara, Gay, Francesca, Attal, Michel, Passera, Roberto, Spencer, Andrew, Offidani, Massimo, Kumar, Shaji, Musto, Pellegrino, Lonial, Sagar, Petrucci, Maria T, Orlowski, Robert Z, Zamagni, Elena, Morgan, Gareth, Dimopoulos, Meletios A, Durie, Brian G M, Anderson, Kenneth C, Sonneveld, Pieter, San Miguel, Jésus, Cavo, Michele, Rajkumar, S Vincent, Moreau, Philippe
Published in Journal of clinical oncology (10.09.2015)
Published in Journal of clinical oncology (10.09.2015)
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Bortezomib Induction and Maintenance Treatment in Patients With Newly Diagnosed Multiple Myeloma: Results of the Randomized Phase III HOVON-65/ GMMG-HD4 Trial
SONNEVELD, Pieter, SCHMIDT-WOLF, Ingo G. H, WEISEL, Katja C, WITTEBOL, Shulamiet, BOS, Gerard M. J, STEVENS-KROEF, Marian, SCHEID, Christof, PFREUNDSCHUH, Michael, HOSE, Dirk, JAUCH, Anna, DER VELDE, Helgi Van, RAYMAKERS, Reinier, DER HOLT, Bronno Van, SCHAAFSMA, Martijn R, KERSTEN, Marie-Jose, MARWIJK-KOOY, Marinus Van, DUEHRSEN, Ulrich, LINDEMANN, Walter, WIJERMANS, Pierre W, LOKHORST, Henk M, GOLDSCHMIDT, Hartmut M, EL JARARI, Laila, BERTSCH, Uta, SALWENDER, Hans, ZWEEGMAN, Sonja, VELLENGA, Edo, BROYL, Annemiek, BLAU, Igor W
Published in Journal of clinical oncology (20.08.2012)
Published in Journal of clinical oncology (20.08.2012)
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Bortezomib-Based Versus Nonbortezomib-Based Induction Treatment Before Autologous Stem-Cell Transplantation in Patients With Previously Untreated Multiple Myeloma: A Meta-Analysis of Phase III Randomized, Controlled Trials
SONNEVELD, Pieter, GOLDSCHMIDT, Hartmut, DESAI, Avinash, CAKANA, Andrew, LIU, Kevin, VAN DE VELDE, Helgi, ESSELTINE, Dixie-Lee, MOREAU, Philippe, ROSIÑOL, Laura, BLADE, Joan, JOSE LAHUERTA, Juan, CAVO, Michele, TACCHETTI, Paola, ZAMAGNI, Elena, ATTAL, Michel, LOKHORST, Henk M
Published in Journal of clinical oncology (10.09.2013)
Published in Journal of clinical oncology (10.09.2013)
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Targeting CD38 with Daratumumab Monotherapy in Multiple Myeloma
Lokhorst, Henk M, Plesner, Torben, Laubach, Jacob P, Nahi, Hareth, Gimsing, Peter, Hansson, Markus, Minnema, Monique C, Lassen, Ulrik, Krejcik, Jakub, Palumbo, Antonio, van de Donk, Niels W.C.J, Ahmadi, Tahamtan, Khan, Imran, Uhlar, Clarissa M, Wang, Jianping, Sasser, A. Kate, Losic, Nedjad, Lisby, Steen, Basse, Linda, Brun, Nikolai, Richardson, Paul G
Published in The New England journal of medicine (24.09.2015)
Published in The New England journal of medicine (24.09.2015)
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Clinical efficacy of daratumumab monotherapy in patients with heavily pretreated relapsed or refractory multiple myeloma
Usmani, Saad Z., Weiss, Brendan M., Plesner, Torben, Bahlis, Nizar J., Belch, Andrew, Lonial, Sagar, Lokhorst, Henk M., Voorhees, Peter M., Richardson, Paul G., Chari, Ajai, Sasser, A.Kate, Axel, Amy, Feng, Huaibao, Uhlar, Clarissa M., Wang, Jianping, Khan, Imran, Ahmadi, Tahamtan, Nahi, Hareth
Published in Blood (07.07.2016)
Published in Blood (07.07.2016)
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Daratumumab, a novel therapeutic human CD38 monoclonal antibody, induces killing of multiple myeloma and other hematological tumors
de Weers, Michel, Tai, Yu-Tzu, van der Veer, Michael S, Bakker, Joost M, Vink, Tom, Jacobs, Daniëlle C H, Oomen, Lukas A, Peipp, Matthias, Valerius, Thomas, Slootstra, Jerry W, Mutis, Tuna, Bleeker, Wim K, Anderson, Kenneth C, Lokhorst, Henk M, van de Winkel, Jan G J, Parren, Paul W H I
Published in The Journal of immunology (1950) (01.02.2011)
Published in The Journal of immunology (1950) (01.02.2011)
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Preclinical Evidence for the Therapeutic Potential of CD38-Targeted Immuno-Chemotherapy in Multiple Myeloma Patients Refractory to Lenalidomide and Bortezomib
Nijhof, Inger S, Groen, Richard W J, Noort, Willy A, van Kessel, Berris, de Jong-Korlaar, Regina, Bakker, Joost, van Bueren, Jeroen J L, Parren, Paul W H I, Lokhorst, Henk M, van de Donk, Niels W C J, Martens, Anton C M, Mutis, Tuna
Published in Clinical cancer research (15.06.2015)
Published in Clinical cancer research (15.06.2015)
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Phase 1/2 study of daratumumab, lenalidomide, and dexamethasone for relapsed multiple myeloma
Plesner, Torben, Arkenau, Hendrik-Tobias, Gimsing, Peter, Krejcik, Jakub, Lemech, Charlotte, Minnema, Monique C., Lassen, Ulrik, Laubach, Jacob P., Palumbo, Antonio, Lisby, Steen, Basse, Linda, Wang, Jianping, Sasser, A. Kate, Guckert, Mary E., de Boer, Carla, Khokhar, Nushmia Z., Yeh, Howard, Clemens, Pamela L., Ahmadi, Tahamtan, Lokhorst, Henk M., Richardson, Paul G.
Published in Blood (06.10.2016)
Published in Blood (06.10.2016)
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Pre-clinical evaluation of CD38 chimeric antigen receptor engineered T cells for the treatment of multiple myeloma
Drent, Esther, Groen, Richard W J, Noort, Willy A, Themeli, Maria, Lammerts van Bueren, Jeroen J, Parren, Paul W H I, Kuball, Jürgen, Sebestyen, Zsolt, Yuan, Huipin, de Bruijn, Joost, van de Donk, Niels W C J, Martens, Anton C M, Lokhorst, Henk M, Mutis, Tuna
Published in Haematologica (Roma) (01.05.2016)
Published in Haematologica (Roma) (01.05.2016)
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Pharmacokinetics of Daratumumab Following Intravenous Infusion in Relapsed or Refractory Multiple Myeloma After Prior Proteasome Inhibitor and Immunomodulatory Drug Treatment
Clemens, Pamela L., Yan, Xiaoyu, Lokhorst, Henk M., Lonial, Sagar, Losic, Nedjad, Khan, Imran, Jansson, Richard, Ahmadi, Tahamtan, Lantz, Kristen, Zhou, Honghui, Puchalski, Thomas, Xu, Xu Steven
Published in Clinical pharmacokinetics (01.08.2017)
Published in Clinical pharmacokinetics (01.08.2017)
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Journal Article
Monocytes and Granulocytes Reduce CD38 Expression Levels on Myeloma Cells in Patients Treated with Daratumumab
Krejcik, Jakub, Frerichs, Kris A, Nijhof, Inger S, van Kessel, Berris, van Velzen, Jeroen F, Bloem, Andries C, Broekmans, Marloes E C, Zweegman, Sonja, van Meerloo, Johan, Musters, René J P, Poddighe, Pino J, Groen, Richard W J, Chiu, Christopher, Plesner, Torben, Lokhorst, Henk M, Sasser, A Kate, Mutis, Tuna, van de Donk, Niels W C J
Published in Clinical cancer research (15.12.2017)
Published in Clinical cancer research (15.12.2017)
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High‐Parameter Mass Cytometry Evaluation of Relapsed/Refractory Multiple Myeloma Patients Treated with Daratumumab Demonstrates Immune Modulation as a Novel Mechanism of Action
Adams, Homer C., Stevenaert, Frederik, Krejcik, Jakub, Van der Borght, Koen, Smets, Tina, Bald, Jaime, Abraham, Yann, Ceulemans, Hugo, Chiu, Christopher, Vanhoof, Greet, Usmani, Saad Z., Plesner, Torben, Lonial, Sagar, Nijhof, Inger, Lokhorst, Henk M., Mutis, Tuna, Donk, Niels W.C.J., Sasser, Amy Kate, Casneuf, Tineke
Published in Cytometry. Part A (01.03.2019)
Published in Cytometry. Part A (01.03.2019)
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