PAD4의 공유결합성 억제제
BEAUMONT EDWARD JEAN, LOKE PUI LENG, KERRY PHILIP STEPHEN, KUMARAVEL GNANASAMBANDAM, LECCI CRISTINA, PALFREY JORDAN JOHN, DEVRAJ RAJESH, NORTH CARL, MENICONI MIRCO, TYE HEATHER
Year of Publication 03.04.2019
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Year of Publication 03.04.2019
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6,5-HETEROCYCLIC PROPARGYLIC ALCOHOL COMPOUNDS AND USES THEREFOR
LOKE PUI LENG, MONTALBETTI CHRISTIAN A.G.N, FENG JIANWEN, STABEN STEVEN
Year of Publication 05.12.2013
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Year of Publication 05.12.2013
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OXADIAZOLE INHIBITORS OF LEUKOTRIENE PRODUCTION
BARTOLOZZI ALESSANDRA, BOSANAC TODD, RIETHER DORIS, LIU WEIMIN, ZINDELL RENEE M, OLAGUE ALAN, DE LOMBAERT STEPHANE, LOKE PUI LENG, HUBER JOHN D, WU LIFEN, TYE HEATHER, DINES JONATHON ALAN, CHEN ZHIDONG, MORWICK TINA MARIE
Year of Publication 07.10.2013
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Year of Publication 07.10.2013
Patent
OXADIAZOLE INHIBITORS OF LEUKOTRIENE PRODUCTION
ZINDELL RENEE, BARTOLOZZI ALESSANDRA, BOSANAC TODD, RIETHER DORIS, LIU WEIMIN, OLAGUE ALAN, DE LOMBAERT STEPHANE, LOKE PUI LENG, HUBER JOHN D, LO HO YIN, WU LIFEN, TYE HEATHER, CHEN ZHIDONG, MORWICK TINA MARIE
Year of Publication 09.09.2013
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Year of Publication 09.09.2013
Patent
Synthesis, SAR, and Series Evolution of Novel Oxadiazole-Containing 5‑Lipoxygenase Activating Protein Inhibitors: Discovery of 2‑[4-(3-{(R)‑1-[4-(2-Amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]‑N,N‑dimethyl-acetamide (BI 665915)
Takahashi, Hidenori, Riether, Doris, Bartolozzi, Alessandra, Bosanac, Todd, Berger, Valentina, Binetti, Ralph, Broadwater, John, Chen, Zhidong, Crux, Rebecca, De Lombaert, Stéphane, Dave, Rajvee, Dines, Jonathon A, Fadra-Khan, Tazmeen, Flegg, Adam, Garrigou, Michael, Hao, Ming-Hong, Huber, John, Hutzler, J. Matthew, Kerr, Steven, Kotey, Adrian, Liu, Weimin, Lo, Ho Yin, Loke, Pui Leng, Mahaney, Paige E, Morwick, Tina M, Napier, Spencer, Olague, Alan, Pack, Edward, Padyana, Anil K, Thomson, David S, Tye, Heather, Wu, Lifen, Zindell, Renee M, Abeywardane, Asitha, Simpson, Thomas
Published in Journal of medicinal chemistry (26.02.2015)
Published in Journal of medicinal chemistry (26.02.2015)
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Journal Article
New compounds for treatment of diseases related to DUX4 expression
Foulkes, Gregory, Schnorrenberg, Gerd, Davenport, Adam James, Loke, Pui Leng, De Maeyer, Joris Herman, Pace, Robert David Matthew, Ellwood, Simon Fletcher, Rueda-Zubiaurre, Ainoa, Dickie, Anthony Paul
Year of Publication 16.02.2023
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Year of Publication 16.02.2023
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BICYCLIC TETRAHYDROTHIAZEPINE DERIVATIVES USEFUL FOR THE TREATMENT OF NEOPLASTIC AND/OR INFECTIOUS DISEASES
CRAFT, RUSSELL STUART, LOIBNER, HANS, AMOUZEGH, PATRICIA LEONIE, JONES, SEVERINE DANIELLE, HANKE, THOMAS, LAMETSCHWANDTNER, GUENTHER, JAMES, TIMOTHY ROBIN, WHITTAKER, MARK, WEHR, ROLAND, ERMANN, MONIKA, STUETZ, ANTON, LOKE, PUI LENG, STERNBERGER, INA
Year of Publication 03.10.2023
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Year of Publication 03.10.2023
Patent
INHIBITOR COMBINATIONS FOR TREATMENT OF DISEASES RELATED TO DUX4 EXPRESSION
DE MAEYER, JORIS, HIRSCH, ROLF, GEESE, MARCUS, LOKE, PUI LENG, MONECKE, SEBASTIAN
Year of Publication 17.12.2020
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Year of Publication 17.12.2020
Patent
Novel compounds for treatment of diseases related to DUX4 expression
Foulkes, Gregory, Anighoro, Andrew, Schnorrenberg, Gerd, Davenport, Adam James, Loke, Pui Leng, De Maeyer, Joris Herman, Pace, Robert David Matthew, Elwood, Simon Fletcher, Richards, Jonathan Philip, Rueda-Zubiaurre, Ainoa, Lecci, Cristina, Dickie, Anthony Paul
Year of Publication 31.08.2023
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Year of Publication 31.08.2023
Patent
NOVEL COMPOUNDS FOR TREATMENT OF DISEASES RELATED TO DUX4 EXPRESSION
ANIGHORO, Andrew, PACE, Robert David Matthew, FOULKES, Gregory, RICHARDS, Jonathan Philip, LOKE, Pui Leng, DE MAEYER, Joris Herman, DAVENPORT, Adam James, DICKIE, Anthony Paul, RUEDA-ZUBIAURRE, Ainoa, ELLWOOD, Simon Fletcher, SCHNORRENBERG, Gerd, LECCI, Cristina
Year of Publication 05.10.2022
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Year of Publication 05.10.2022
Patent
NEW COMPOUNDS FOR TREATMENT OF DISEASES RELATED TO DUX4 EXPRESSION
PACE, Robert David Matthew, FOULKES, Gregory, LOKE, Pui Leng, DE MAEYER, Joris Herman, DAVENPORT, Adam James, DICKIE, Anthony Paul, RUEDA-ZUBIAURRE, Ainoa, ELLWOOD, Simon Fletcher, SCHNORRENBERG, Gerd
Year of Publication 05.10.2022
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Year of Publication 05.10.2022
Patent
HETEROARYL INHIBITORS OF PAD4
Monck, Nathaniel Julius Thomas, North, Carl Leslie, Tye, Heather, Devraj, Rajesh, Kumaravel, Gnanasambandam, Loke, Pui Leng, Ridgill, Mark Peter, Meniconi, Mirco, Lecci, Cristina
Year of Publication 30.09.2021
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Year of Publication 30.09.2021
Patent
Heteroaryl inhibitors of PAD4
Monck, Nathaniel Julius Thomas, North, Carl Leslie, Tye, Heather, Devraj, Rajesh, Kumaravel, Gnanasambandam, Loke, Pui Leng, Ridgill, Mark Peter, Meniconi, Mirco, Lecci, Cristina
Year of Publication 08.06.2021
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Year of Publication 08.06.2021
Patent
compostos de álcool propargílico 6,5-heterocíclico e uso dos mesmos
PUI LENG LOKE, CHRISTIAN A.G.N. MONTALBETTI, JIANWEN FENG, STEVEN STABEN
Year of Publication 13.12.2016
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Year of Publication 13.12.2016
Patent
COVALENT INHIBITORS OF PAD4
DEVRAJ, Rajesh, PALFREY, Jordan John, KERRY, Philip Stephen, MENICONI, Mirco, LOKE, Pui Leng, BEAUMONT, Edward Jean, KUMARAVEL, Gnanasambandam, TYE, Heather, NORTH, Carl, LECCI, Cristina
Year of Publication 09.09.2020
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Year of Publication 09.09.2020
Patent