The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models
Kotschy, András, Szlavik, Zoltán, Murray, James, Davidson, James, Maragno, Ana Leticia, Le Toumelin-Braizat, Gaëtane, Chanrion, Maïa, Kelly, Gemma L, Gong, Jia-Nan, Moujalled, Donia M, Bruno, Alain, Csekei, Márton, Paczal, Attila, Szabo, Zoltán B, Sipos, Szabolcs, Radics, Gábor, Proszenyak, Agnes, Balint, Balázs, Ondi, Levente, Blasko, Gábor, Robertson, Alan, Surgenor, Allan, Dokurno, Pawel, Chen, Ijen, Matassova, Natalia, Smith, Julia, Pedder, Christopher, Graham, Christopher, Studeny, Aurélie, Lysiak-Auvity, Gaëlle, Girard, Anne-Marie, Gravé, Fabienne, Segal, David, Riffkin, Chris D, Pomilio, Giovanna, Galbraith, Laura C A, Aubrey, Brandon J, Brennan, Margs S, Herold, Marco J, Chang, Catherine, Guasconi, Ghislaine, Cauquil, Nicolas, Melchiore, Fabien, Guigal-Stephan, Nolwen, Lockhart, Brian, Colland, Frédéric, Hickman, John A, Roberts, Andrew W, Huang, David C S, Wei, Andrew H, Strasser, Andreas, Lessene, Guillaume, Geneste, Olivier
Published in Nature (London) (27.10.2016)
Published in Nature (London) (27.10.2016)
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S49076 is a novel kinase inhibitor of MET, AXL, and FGFR with strong preclinical activity alone and in association with bevacizumab
Burbridge, Mike F, Bossard, Céline J, Saunier, Carine, Fejes, Imre, Bruno, Alain, Léonce, Stéphane, Ferry, Gilles, Da Violante, Georges, Bouzom, François, Cattan, Valérie, Jacquet-Bescond, Anne, Comoglio, Paolo M, Lockhart, Brian P, Boutin, Jean A, Cordi, Alex, Ortuno, Jean-Claude, Pierré, Alain, Hickman, John A, Cruzalegui, Francisco H, Depil, Stéphane
Published in Molecular cancer therapeutics (01.09.2013)
Published in Molecular cancer therapeutics (01.09.2013)
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Neuropilin-1 is upregulated in hepatocellular carcinoma and contributes to tumour growth and vascular remodelling
Bergé, Mathieu, Allanic, David, Bonnin, Philippe, de Montrion, Catherine, Richard, Johann, Suc, Michel, Boivin, Jean-François, Contrerès, Jean-Olivier, Lockhart, Brian P, Pocard, Marc, Lévy, Bernard I, Tucker, Gordon C, Tobelem, Gérard, Merkulova-Rainon, Tatyana
Published in Journal of hepatology (01.10.2011)
Published in Journal of hepatology (01.10.2011)
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Genetic deletion of trace amine 1 receptors reveals their role in auto-inhibiting the actions of ecstasy (MDMA)
Di Cara, Benjamin, Maggio, Roberto, Aloisi, Gabriella, Rivet, Jean-Michel, Lundius, Ebba Gregorsson, Yoshitake, Takashi, Svenningsson, Per, Brocco, Mauricette, Gobert, Alain, De Groote, Lotte, Cistarelli, Laetitia, Veiga, Sylvie, De Montrion, Catherine, Rodriguez, Marianne, Galizzi, Jean-Pierre, Lockhart, Brian P, Cogé, Francis, Boutin, Jean A, Vayer, Philippe, Verdouw, P Monika, Groenink, Lucianne, Millan, Mark J
Published in The Journal of neuroscience (23.11.2011)
Published in The Journal of neuroscience (23.11.2011)
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Nox4 mediates the expression of plasminogen activator inhibitor-1 via p38 MAPK pathway in cultured human endothelial cells
Jaulmes, Amandine, Sansilvestri-Morel, Patricia, Rolland-Valognes, Gaëlle, Bernhardt, Fabienne, Gaertner, Roger, Lockhart, Brian P, Cordi, Alex, Wierzbicki, Michel, Rupin, Alain, Verbeuren, Tony J
Published in Thrombosis research (01.09.2009)
Published in Thrombosis research (01.09.2009)
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Only a subset of Met-activated pathways are required to sustain oncogene addiction
Bertotti, Andrea, Burbridge, Mike F, Gastaldi, Stefania, Galimi, Francesco, Torti, Davide, Medico, Enzo, Giordano, Silvia, Corso, Simona, Rolland-Valognes, Gaëlle, Lockhart, Brian P, Hickman, John A, Comoglio, Paolo M, Trusolino, Livio
Published in Science signaling (08.12.2009)
Published in Science signaling (08.12.2009)
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Specific oncogenic activity of the Src-family tyrosine kinase c-Yes in colon carcinoma cells
Sancier, Florence, Dumont, Aurélie, Sirvent, Audrey, Paquay de Plater, Ludmilla, Edmonds, Thomas, David, Géraldine, Jan, Michel, de Montrion, Catherine, Cogé, Francis, Léonce, Stéphane, Burbridge, Michael, Bruno, Alain, Boutin, Jean A, Lockhart, Brian, Roche, Serge, Cruzalegui, Francisco
Published in PloS one (24.02.2011)
Published in PloS one (24.02.2011)
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Exploring functional beta-cell heterogeneity in vivo using PSA-NCAM as a specific marker
Karaca, Melis, Castel, Julien, Tourrel-Cuzin, Cécile, Brun, Manuel, Géant, Anne, Dubois, Mathilde, Catesson, Sandra, Rodriguez, Marianne, Luquet, Serge, Cattan, Pierre, Lockhart, Brian, Lang, Jochen, Ktorza, Alain, Magnan, Christophe, Kargar, Catherine
Published in PloS one (18.05.2009)
Published in PloS one (18.05.2009)
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RhoA guanine exchange factor expression profile in arteries: evidence for a Rho kinase-dependent negative feedback in angiotensin II-dependent hypertension
Cario-Toumaniantz, Chrystelle, Ferland-McCollough, David, Chadeuf, Gilliane, Toumaniantz, Gilles, Rodriguez, Marianne, Galizzi, Jean-Pierre, Lockhart, Brian, Bril, Antoine, Scalbert, Elizabeth, Loirand, Gervaise, Pacaud, Pierre
Published in American Journal of Physiology: Cell Physiology (01.05.2012)
Published in American Journal of Physiology: Cell Physiology (01.05.2012)
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Tree species exhibit complex patterns of distribution in bottomland hardwood forests
Dimov, Luben D., Chambers, Jim L., Lockhart, Brian Roy
Published in Annals of forest science. (01.12.2013)
Published in Annals of forest science. (01.12.2013)
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Lindera melissifolia responses to flood durations and light regimes suggest strategies for recovery and conservation
Lockhart, Brian Roy, Gardiner, Emile S., Leininger, Theodor D., Hamel, Paul B., Connor, Kristina F., Devall, Margaret S., Schiff, Nathan M., Wilson, A. Dan
Published in Plant ecology (01.07.2013)
Published in Plant ecology (01.07.2013)
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Implications of Mitochondrial Dysfunction for the Anesthetic and Perioperative Management: A Case Report of Spinal Fusion, Genetic Confusion, and a Patient's Perspective
Aglio, Linda S, Lockhart, Brian T, Lunshof, Jeantine E, Nabzdyk, Christoph S
Published in A&A practice (01.03.2018)
Published in A&A practice (01.03.2018)
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Shallow Whole-Genome Sequencing from Plasma Identifies FGFR1 Amplified Breast Cancers and Predicts Overall Survival
Bourrier, Chantal, Pierga, Jean-Yves, Xuereb, Laura, Salaun, Hélène, Proudhon, Charlotte, Speicher, Michael R., Belic, Jelena, Heitzer, Ellen, Lockhart, Brian Paul, Guigal-Stephan, Nolwen
Published in Cancers (06.06.2020)
Published in Cancers (06.06.2020)
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Targeting Bcl-2/Bcl-XL induces antitumor activity in uveal melanoma patient-derived xenografts
Némati, Fariba, de Montrion, Catherine, Lang, Guillaume, Kraus-Berthier, Laurence, Carita, Guillaume, Sastre-Garau, Xavier, Berniard, Aurélie, Vallerand, David, Geneste, Olivier, de Plater, Ludmilla, Pierré, Alain, Lockhart, Brian, Desjardins, Laurence, Piperno-Neumann, Sophie, Depil, Stéphane, Decaudin, Didier
Published in PloS one (2014)
Published in PloS one (2014)
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Intensity and mode of Lindera melissifolia reproduction are affected by flooding and light availability
Leininger, Theodor D., Gardiner, Emile S., Lockhart, Brian Roy, Schiff, Nathan M., Wilson, Alphus Dan, Devall, Margaret S., Hamel, Paul B., Connor, Kristina F.
Published in Ecology and evolution (01.10.2021)
Published in Ecology and evolution (01.10.2021)
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New quinolinic derivatives as centrally active antioxidants
Dorey, G, Lockhart, B, Lestage, P, Casara, P
Published in Bioorganic & medicinal chemistry letters (01.05.2000)
Published in Bioorganic & medicinal chemistry letters (01.05.2000)
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Bone Marrow Fibrosis Is Associated with Non-Response to CD19 CAR-T Therapy
Anil, Joshua, Lytle, Andrew, Alnemri, Ahab, Lockhart, Brian, Pillai, Vinodh
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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