Development and Standardization of an Improved Type 1 Diabetes Genetic Risk Score for Use in Newborn Screening and Incident Diagnosis
Sharp, Seth A, Rich, Stephen S, Wood, Andrew R, Jones, Samuel E, Beaumont, Robin N, Harrison, James W, Schneider, Darius A, Locke, Jonathan M, Tyrrell, Jess, Weedon, Michael N, Hagopian, William A, Oram, Richard A
Published in Diabetes care (01.02.2019)
Published in Diabetes care (01.02.2019)
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Journal Article
Loss of MANF Causes Childhood-Onset Syndromic Diabetes Due to Increased Endoplasmic Reticulum Stress
Montaser, Hossam, Patel, Kashyap A, Balboa, Diego, Ibrahim, Hazem, Lithovius, Väinö, Näätänen, Anna, Chandra, Vikash, Demir, Korcan, Acar, Sezer, Ben-Omran, Tawfeg, Colclough, Kevin, Locke, Jonathan M, Wakeling, Matthew, Lindahl, Maria, Hattersley, Andrew T, Saarimäki-Vire, Jonna, Otonkoski, Timo
Published in Diabetes (New York, N.Y.) (01.04.2021)
Published in Diabetes (New York, N.Y.) (01.04.2021)
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Journal Article
Targeted allelic expression profiling in human islets identifies cis-regulatory effects for multiple variants identified by type 2 diabetes genome-wide association studies
Locke, Jonathan M, Hysenaj, Gerald, Wood, Andrew R, Weedon, Michael N, Harries, Lorna W
Published in Diabetes (New York, N.Y.) (01.04.2015)
Published in Diabetes (New York, N.Y.) (01.04.2015)
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Journal Article
Insights into the genetics of menopausal vasomotor symptoms: genome-wide analyses of routinely-collected primary care health records
Ruth, Katherine S, Beaumont, Robin N, Locke, Jonathan M, Tyrrell, Jessica, Crandall, Carolyn J, Hawkes, Gareth, Frayling, Timothy M, Prague, Julia K, Patel, Kashyap A, Wood, Andrew R, Weedon, Michael N, Murray, Anna
Published in BMC medical genomics (02.10.2023)
Published in BMC medical genomics (02.10.2023)
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Journal Article
The Diabetic Phenotype in HNF4A Mutation Carriers Is Moderated By the Expression of HNF4A Isoforms From the P1 Promoter During Fetal Development
Harries, Lorna W, Locke, Jonathan M, Shields, Beverley, Hanley, Neil A, Hanley, Karen Piper, Steele, Anna, Njølstad, Pål R, Ellard, Sian, Hattersley, Andrew T
Published in Diabetes (New York, N.Y.) (01.06.2008)
Published in Diabetes (New York, N.Y.) (01.06.2008)
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Journal Article
Detection of enterovirus RNA in peripheral blood mononuclear cells correlates with the presence of the predisposing allele of the type 1 diabetes risk gene IFIH1 and with disease stage
Sioofy-Khojine, Amir-Babak, Richardson, Sarah J., Locke, Jonathan M., Oikarinen, Sami, Nurminen, Noora, Laine, Antti-Pekka, Downes, Kate, Lempainen, Johanna, Todd, John A., Veijola, Riitta, Ilonen, Jorma, Knip, Mikael, Morgan, Noel G., Hyöty, Heikki, Peakman, Mark, Eichmann, Martin
Published in Diabetologia (01.10.2022)
Published in Diabetologia (01.10.2022)
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Journal Article
Role of microRNAs in the age-associated decline of pancreatic beta cell function in rat islets
Tugay, Ksenia, Guay, Claudiane, Marques, Ana C., Allagnat, Florent, Locke, Jonathan M., Harries, Lorna W., Rutter, Guy A., Regazzi, Romano
Published in Diabetologia (01.01.2016)
Published in Diabetologia (01.01.2016)
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Journal Article
Association of birthweight and penetrance of diabetes in individuals with HNF4A-MODY: a cohort study
Locke, Jonathan M., Dusatkova, Petra, Colclough, Kevin, Hughes, Alice E., Dennis, John M., Shields, Beverley, Flanagan, Sarah E., Shepherd, Maggie H., Dempster, Emma L., Hattersley, Andrew T., Weedon, Michael N., Pruhova, Stepanka, Patel, Kashyap A.
Published in Diabetologia (01.01.2022)
Published in Diabetologia (01.01.2022)
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Journal Article
188-LB: Deep Learning–Based Population Screening of Type 1 Diabetes and Celiac Disease Genetic Risk from Blood Spots at Birth
SHARP, SETH A., LOCKE, JONATHAN M., XU, YU, FRASER, DIANE P., FERRAT, LAURIC A., WEEDON, MICHAEL N., INOUYE, MICHAEL, ORAM, RICHARD A., HAGOPIAN, WILLIAM
Published in Diabetes (New York, N.Y.) (01.06.2022)
Published in Diabetes (New York, N.Y.) (01.06.2022)
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Journal Article
The Common HNF1A Variant I27L Is a Modifier of Age at Diabetes Diagnosis in Individuals With HNF1A-MODY
Locke, Jonathan M, Saint-Martin, Cécile, Laver, Thomas W, Patel, Kashyap A, Wood, Andrew R, Sharp, Seth A, Ellard, Sian, Bellanné-Chantelot, Christine, Hattersley, Andrew T, Harries, Lorna W, Weedon, Michael N
Published in Diabetes (New York, N.Y.) (01.09.2018)
Published in Diabetes (New York, N.Y.) (01.09.2018)
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Journal Article
Recessive mutations in the INS gene result in neonatal diabetes through reduced insulin biosynthesis
Garin, Intza, Edghill, Emma L, Akerman, Ildem, Rubio-Cabezas, Oscar, Rica, Itxaso, Locke, Jonathan M, Maestro, Miguel Angel, Alshaikh, Adnan, Bundak, Ruveyde, del Castillo, Gabriel, Deeb, Asma, Deiss, Dorothee, Fernandez, Juan M, Godbole, Koumudi, Hussain, Khalid, O'Connell, Michele, Klupa, Thomasz, Kolouskova, Stanislava, Mohsin, Fauzia, Perlman, Kusiel, Sumnik, Zdenek, Rial, Jose M, Ugarte, Estibaliz, Vasanthi, Thiruvengadam, Johnstone, Karen, Flanagan, Sarah E, Martínez, Rosa, Castaño, Carlos, Patch, Ann-Marie, Fernández-Rebollo, Eduardo, Raile, Klemens, Morgan, Noel, Harries, Lorna W, Castaño, Luis, Ellard, Sian, Ferrer, Jorge, de Nanclares, Guiomar Perez, Hattersley, Andrew T
Published in Proceedings of the National Academy of Sciences - PNAS (16.02.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (16.02.2010)
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Journal Article
Methods for quick, accurate and cost-effective determination of the type 1 diabetes genetic risk score (T1D-GRS)
Locke, Jonathan M., Latten, Mark J., Datta, Renu Y., Wood, Andrew R., Crockard, Martin A., Lamont, John V., Weedon, Michael N., Oram, Richard A.
Published in Clinical chemistry and laboratory medicine (01.04.2020)
Published in Clinical chemistry and laboratory medicine (01.04.2020)
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Journal Article
Genome-Wide Homozygosity Analysis Reveals HADH Mutations as a Common Cause of Diazoxide-Responsive Hyperinsulinemic-Hypoglycemia in Consanguineous Pedigrees
Flanagan, Sarah E, Patch, Ann-Marie, Locke, Jonathan M, Akcay, Teoman, Simsek, Enver, Alaei, Mohammadreza, Yekta, Zeinab, Desai, Meena, Kapoor, Ritika R, Hussain, Khalid, Ellard, Sian
Published in The journal of clinical endocrinology and metabolism (01.03.2011)
Published in The journal of clinical endocrinology and metabolism (01.03.2011)
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Journal Article
A rare SNP in pre-miR-34a is associated with increased levels of miR-34a in pancreatic beta cells
Locke, Jonathan M., Lango Allen, Hana, Harries, Lorna W.
Published in Acta diabetologica (01.04.2014)
Published in Acta diabetologica (01.04.2014)
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Journal Article
The splice site variant rs11078928 may be associated with a genotype-dependent alteration in expression of GSDMB transcripts
Morrison, Faer S, Locke, Jonathan M, Wood, Andrew R, Tuke, Marcus, Pasko, Dorota, Murray, Anna, Frayling, Tim, Harries, Lorna W
Published in BMC genomics (17.09.2013)
Published in BMC genomics (17.09.2013)
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Journal Article
Functional characterisation of ADIPOQ variants using individuals recruited by genotype
Lee, Benjamin P., Lloyd-Laney, Henry O., Locke, Jonathan M., McCulloch, Laura J., Knight, Bridget, Yaghootkar, Hanieh, Cory, Giles, Kos, Katarina, Frayling, Timothy M., Harries, Lorna W.
Published in Molecular and cellular endocrinology (15.06.2016)
Published in Molecular and cellular endocrinology (15.06.2016)
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Journal Article
RNA Processing and mRNA Surveillance in Monogenic Diabetes
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Journal Article
Book Review
Managing Nitrogen, Potassium, and Boron in New Guinea Impatiens: Is More Better?
Pitchay, Dharmalingam S, Frantz, Jonathan M, Locke, Jonathan M, Krause, Charles
Published in HortScience (01.07.2004)
Published in HortScience (01.07.2004)
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Journal Article