Discovery of Non-Nucleotide Small-Molecule STING Agonists via Chemotype Hybridization
Cherney, Emily C, Zhang, Liping, Lo, Julian, Huynh, Tram, Wei, Donna, Ahuja, Vijay, Quesnelle, Claude, Schieven, Gary L, Futran, Alan, Locke, Gregory A, Lin, Zeyu, Monereau, Laura, Chaudhry, Charu, Blum, Jordan, Li, Sha, Fereshteh, Mark, Li-Wang, Bifang, Gangwar, Sanjeev, Pan, Chin, Chong, Colin, Zhu, Xiao, Posy, Shana L, Sack, John S, Zhang, Ping, Ruzanov, Max, Harner, Mary, Akhtar, Fahad, Schroeder, Gretchen M, Vite, Gregory, Fink, Brian
Published in Journal of medicinal chemistry (24.02.2022)
Published in Journal of medicinal chemistry (24.02.2022)
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Small molecule and macrocyclic pyrazole derived inhibitors of myeloperoxidase (MPO)
Hu, Carol H., Neissel Valente, Meriah W., Halpern, O. Scott, Jusuf, Sutjano, Khan, Javed A., Locke, Gregory A., Duke, Gerald J., Liu, Xiaoqin, Duclos, Franck J., Wexler, Ruth R., Kick, Ellen K., Smallheer, Joanne M.
Published in Bioorganic & medicinal chemistry letters (15.06.2021)
Published in Bioorganic & medicinal chemistry letters (15.06.2021)
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Discovery and structure activity relationships of 7-benzyl triazolopyridines as stable, selective, and reversible inhibitors of myeloperoxidase
Shaw, Scott A., Vokits, Benjamin P., Dilger, Andrew K., Viet, Andrew, Clark, Charles G., Abell, Lynn M., Locke, Gregory A., Duke, Gerald, Kopcho, Lisa M., Dongre, Ashok, Gao, Ji, Krishnakumar, Arathi, Jusuf, Sutjano, Khan, Javed, Spronk, Steven A., Basso, Michael D., Zhao, Lei, Cantor, Glenn H., Onorato, Joelle M., Wexler, Ruth R., Duclos, Franck, Kick, Ellen K.
Published in Bioorganic & medicinal chemistry (15.11.2020)
Published in Bioorganic & medicinal chemistry (15.11.2020)
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Discovery of Orally Active Isofuranones as Potent, Selective Inhibitors of Hematopoetic Progenitor Kinase 1
Degnan, Andrew P, Kumi, Godwin K, Allard, Christopher W, Araujo, Erika V, Johnson, Walter L, Zimmermann, Kurt, Pearce, Bradley C, Sheriff, Steven, Futran, Alan, Li, Xin, Locke, Gregory A, You, Dan, Morrison, John, Parrish, Karen E, Stromko, Caitlyn, Murtaza, Anwar, Liu, Jinqi, Johnson, Benjamin M, Vite, Gregory D, Wittman, Mark D
Published in ACS medicinal chemistry letters (11.03.2021)
Published in ACS medicinal chemistry letters (11.03.2021)
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Benzothiazole-based compounds as potent endothelial lipase inhibitors
Meng, Wei, Adam, Leonard P., Behnia, Kamelia, Zhao, Lei, Yang, Richard, Kopcho, Lisa M., Locke, Gregory A., Taylor, David S., Yin, Xiaohong, Wexler, Ruth R., Finlay, Heather
Published in Bioorganic & medicinal chemistry letters (15.10.2019)
Published in Bioorganic & medicinal chemistry letters (15.10.2019)
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Potent Triazolopyridine Myeloperoxidase Inhibitors
Wurtz, Nicholas R, Viet, Andrew, Shaw, Scott A, Dilger, Andrew, Valente, Meriah N, Khan, Javed A, Jusuf, Sutjano, Narayanan, Rangaraj, Fernando, Gayani, Lo, Fred, Liu, Xiaoqin, Locke, Gregory A, Kopcho, Lisa, Abell, Lynn M, Sleph, Paul, Basso, Michael, Zhao, Lei, Wexler, Ruth R, Duclos, Franck, Kick, Ellen K
Published in ACS medicinal chemistry letters (13.12.2018)
Published in ACS medicinal chemistry letters (13.12.2018)
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Identification and characterization of TYK2 pseudokinase domain stabilizers that allosterically inhibit TYK2 signaling
Locke, Gregory A, Muckelbauer, Jodi, Tokarski, John S, Barbieri, Christopher M, Belić, Stefan, Falk, Bradley, Tredup, Jeffrey, Wang, Ying-Kai
Published in Methods in enzymology (2022)
Published in Methods in enzymology (2022)
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Triazolopyrimidines identified as reversible myeloperoxidase inhibitors
Duclos, Franck, Abell, Lynn M., Harden, David G., Pike, Kristen, Nowak, Kimberly, Locke, Gregory A., Duke, Gerald J., Liu, Xiaoqin, Fernando, Gayani, Shaw, Scott A., Vokits, Benjamin P., Wurtz, Nicholas R., Viet, Andrew, Valente, Meriah N., Stachura, Sylwia, Sleph, Paul, Khan, Javed A., Gao, Ji, Dongre, Ashok R., Zhao, Lei, Wexler, Ruth R., Gordon, David A., Kick, Ellen K.
Published in MedChemComm (01.11.2017)
Published in MedChemComm (01.11.2017)
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Differential activation of recombinant human acetyl-CoA carboxylases 1 and 2 by citrate
Locke, Gregory A., Cheng, Dong, Witmer, Mark R., Tamura, James K., Haque, Tasir, Carney, Robert F., Rendina, Alan R., Marcinkeviciene, Jovita
Published in Archives of biochemistry and biophysics (01.07.2008)
Published in Archives of biochemistry and biophysics (01.07.2008)
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Expression, purification, and characterization of human and rat acetyl coenzyme A carboxylase (ACC) isozymes
Cheng, Dong, Chu, Ching-Hsuen, Chen, Luping, Feder, John N, Mintier, Gabe A, Wu, Yuli, Cook, Joseph W, Harpel, Mark R, Locke, Gregory A, An, Yongmi, Tamura, James K
Published in Protein expression and purification (01.01.2007)
Published in Protein expression and purification (01.01.2007)
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Expression, purification, and characterization of human and rat acetyl cfenzyme A carboxylase (ACC) isozymes
Cheng, Dong, Chu, Ching-Hsuen, Chen, Luping, Feder, John N., Mintier, Gabe A., Wu, Yuli, Cook, Joseph W., Harpel, Mark R., Locke, Gregory A., An, Yongmi, Tamura, James K.
Published in Protein expression and purification (2007)
Published in Protein expression and purification (2007)
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Potent Triazolopyridine Myeloperoxidase Inhibitors
Wurtz, Nicholas R., Viet, Andrew, Shaw, Scott A., Dilger, Andrew, Valente, Meriah N., Khan, Javed A., Jusuf, Sutjano, Narayanan, Rangaraj, Fernando, Gayani, Lo, Fred, Liu, Xiaoqin, Locke, Gregory A., Kopcho, Lisa, Abell, Lynn M., Sleph, Paul, Basso, Michael, Zhao, Lei, Wexler, Ruth R., Duclos, Franck, Kick, Ellen K.
Published in ACS medicinal chemistry letters (09.08.2019)
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Published in ACS medicinal chemistry letters (09.08.2019)
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Triazolopyrimidines identified as reversible myeloperoxidase inhibitorsElectronic supplementary information (ESI) available: General synthetic methods, key compound characterization, assay methods, and crystallographic information are available in the ESI. See DOI: 10.1039/c7md00268h
Duclos, Franck, Abell, Lynn M, Harden, David G, Pike, Kristen, Nowak, Kimberly, Locke, Gregory A, Duke, Gerald J, Liu, Xiaoqin, Fernando, Gayani, Shaw, Scott A, Vokits, Benjamin P, Wurtz, Nicholas R, Viet, Andrew, Valente, Meriah N, Stachura, Sylwia, Sleph, Paul, Khan, Javed A, Gao, Ji, Dongre, Ashok R, Zhao, Lei, Wexler, Ruth R, Gordon, David A, Kick, Ellen K
Year of Publication 16.11.2017
Year of Publication 16.11.2017
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Triazolopyrimidines identified as reversible myeloperoxidase inhibitors† †Electronic supplementary information (ESI) available: General synthetic methods, key compound characterization, assay methods, and crystallographic information are available in the ESI. See DOI: 10.1039/c7md00268h
Duclos, Franck, Abell, Lynn M., Harden, David G., Pike, Kristen, Nowak, Kimberly, Locke, Gregory A., Duke, Gerald J., Liu, Xiaoqin, Fernando, Gayani, Shaw, Scott A., Vokits, Benjamin P., Wurtz, Nicholas R., Viet, Andrew, Valente, Meriah N., Stachura, Sylwia, Sleph, Paul, Khan, Javed A., Gao, Ji, Dongre, Ashok R., Zhao, Lei, Wexler, Ruth R., Gordon, David A., Kick, Ellen K.
Published in MedChemComm (26.10.2017)
Published in MedChemComm (26.10.2017)
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