Connective Tissue Growth Factor Domain 4 Amplifies Fibrotic Kidney Disease through Activation of LDL Receptor-Related Protein 6
Johnson, Bryce G, Ren, Shuyu, Karaca, Gamze, Gomez, Ivan G, Fligny, Cécile, Smith, Benjamin, Ergun, Ayla, Locke, George, Gao, Benbo, Hayes, Sebastian, MacDonnell, Scott, Duffield, Jeremy S
Published in Journal of the American Society of Nephrology (01.06.2017)
Published in Journal of the American Society of Nephrology (01.06.2017)
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Journal Article
Risk assessment of drug–drug interaction potential for bintrafusp alfa with cytochrome P4503A4 substrates: A totality of evidence approach
Vugmeyster, Yulia, Locke, George, Helwig, Christoph, Rolfe, P. Alexander, Dong, Jennifer Q., Venkatakrishnan, Karthik
Published in Clinical and translational science (01.12.2022)
Published in Clinical and translational science (01.12.2022)
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Journal Article
Identification of HMGA2 as a predictive biomarker of response to bintrafusp alfa in a phase 1 trial in patients with advanced triple-negative breast cancer
Spira, Alexander, Awada, Ahmad, Isambert, Nicolas, Lorente, David, Penel, Nicolas, Zhang, Yue, Ojalvo, Laureen S, Hicking, Christine, Rolfe, P Alexander, Ihling, Christian, Dussault, Isabelle, Locke, George, Borel, Christian
Published in Frontiers in oncology (08.12.2022)
Published in Frontiers in oncology (08.12.2022)
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Journal Article
Colocalized targeting of TGF-β and PD-L1 by bintrafusp alfa elicits distinct antitumor responses
Lan, Yan, Yeung, Tsz-Lun, Huang, Hui, Wegener, Ansgar A, Saha, Somdutta, Toister-Achituv, Mira, Jenkins, Molly H, Chiu, Li-Ya, Lazorchak, Adam, Tarcic, Ohad, Wang, Hong, Qi, Jin, Locke, George, Kalimi, Doron, Qin, Guozhong, Marelli, Bo, Yu, Huakui, Gross, Alec W, Derner, Melissa G, Soloviev, Maria, Botte, Mathieu, Sircar, Aroop, Ma, Hong, Sood, Vanita D, Zhang, Dong, Jiang, Feng, Lo, Kin-Ming
Published in Journal for immunotherapy of cancer (01.07.2022)
Published in Journal for immunotherapy of cancer (01.07.2022)
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Journal Article
Enhanced preclinical antitumor activity of M7824, a bifunctional fusion protein simultaneously targeting PD-L1 and TGF-β
Lan, Yan, Zhang, Dong, Xu, Chunxiao, Hance, Kenneth W, Marelli, Bo, Qi, Jin, Yu, Huakui, Qin, Guozhong, Sircar, Aroop, Hernández, Vivian M, Jenkins, Molly H, Fontana, Rachel E, Deshpande, Amit, Locke, George, Sabzevari, Helen, Radvanyi, Laszlo, Lo, Kin-Ming
Published in Science translational medicine (17.01.2018)
Published in Science translational medicine (17.01.2018)
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Simultaneous targeting of TGF-β/PD-L1 synergizes with radiotherapy by reprogramming the tumor microenvironment to overcome immune evasion
Lan, Yan, Moustafa, Mahmoud, Knoll, Maximilian, Xu, Chunxiao, Furkel, Jennifer, Lazorchak, Adam, Yeung, Tsz-Lun, Hasheminasab, Sayed-Mohammad, Jenkins, Molly H., Meister, Sarah, Yu, Huakui, Schlegel, Julian, Marelli, Bo, Tang, Zili, Qin, Guozhong, Klein, Carmen, Qi, Jin, Zhou, Cheng, Locke, George, Krunic, Damir, Derner, Melissa G., Schwager, Christian, Fontana, Rachel E., Kriegsmann, Katharina, Jiang, Feng, Rein, Katrin, Kriegsmann, Mark, Debus, Juergen, Lo, Kin-Ming, Abdollahi, Amir
Published in Cancer cell (11.10.2021)
Published in Cancer cell (11.10.2021)
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Abstract 3290: Evaluation of immune phenotypes and gene expression profiles in tumors from patients treated with bintrafusp alfa
Locke, George, Ihling, Christian, Helwig, Christoph, Ojalvo, Laureen S., Christensen, Olaf, Dussault, Isabelle
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
Abstract P3-09-13: Identification of a tumor biomarker in advanced triple-negative breast cancer that predicts response to bintrafusp alfa (M7824), a bifunctional fusion protein targeting transforming growth factor-β and programmed death ligand 1
Locke, George, Zhang, Yue, Ojalvo, Laureen S, Helwig, Christoph, Rolfe, Alex, Christensen, Olaf, Dussault, Isabelle
Published in Cancer research (Chicago, Ill.) (15.02.2020)
Published in Cancer research (Chicago, Ill.) (15.02.2020)
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Journal Article
Next-generation Drosophila protein interactome map and its functional implications
Bhat, Guruharsha, Li, Kejie, Locke, George, Theodorou, Marina, Kilambi, Krishna, Hori, Kazuya, Ho, Diana, Obar, Robert, Williams, Leah, Parzen, Hannah, Dephoure, Noah, Braun, Craig, Muskavitch, Marc, Celniker, Susan E., Gygi, Steven, Artavanis-Tsakonas, Spyros
Published in Developmental cell (27.06.2024)
Published in Developmental cell (27.06.2024)
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Bintrafusp Alfa, a Bifunctional Fusion Protein Targeting TGF-[beta] and PD- L1, in Patients with Non-Small Cell Lung Cancer Resistant or Refractory to Immune Checkpoint Inhibitors
Barlesi, Fabrice, Isambert, Nicolas, Felip, Enriqueta, Cho, Byoung Chul, Lee, Dae Ho, Peguero, Julio, Jerusalem, Guy, Penel, Nicolas, Saada-Bouzid, Esma, Garrido, Pilar, Helwig, Christoph, Locke, George, Ojalvo, Laureen S, Gulley, James L
Published in The oncologist (Dayton, Ohio) (01.03.2023)
Published in The oncologist (Dayton, Ohio) (01.03.2023)
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Journal Article
Bintrafusp Alfa, a Bifunctional Fusion Protein Targeting TGF-β and PD-L1, in Patients with Non-Small Cell Lung Cancer Resistant or Refractory to Immune Checkpoint Inhibitors
Barlesi, Fabrice, Isambert, Nicolas, Felip, Enriqueta, Cho, Byoung Chul, Lee, Dae Ho, Peguero, Julio, Jerusalem, Guy, Penel, Nicolas, Saada-Bouzid, Esma, Garrido, Pilar, Helwig, Christoph, Locke, George, Ojalvo, Laureen S, Gulley, James L
Published in The oncologist (Dayton, Ohio) (17.03.2023)
Published in The oncologist (Dayton, Ohio) (17.03.2023)
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Abstract 1573: Association between TGF-β signaling and HMGA2, a potential biomarker for bintrafusp alfa in triple negative breast cancer
Yeung, Tsz-Lun, Locke, George, Lazorchak, Adam, Qin, Guozhong, Yu, Huakui, Qi, Jin, Marelli, Bo, Jenkins, Molly, Rolfe, Alex, Ojalvo, Laureen S., Dussault, Isabelle, Lan, Yan
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
Global remodeling of nucleosome positions in C. elegans
Locke, George, Haberman, Devorah, Johnson, Steven M, Morozov, Alexandre V
Published in BMC genomics (26.04.2013)
Published in BMC genomics (26.04.2013)
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Journal Article
Correlation of electroencephalography and the active and inactive forms of neurocysticercosis
Chayasirisobhon, S, Menoni, R, Chayasirisobhon, W, Locke, G E
Published in Clinical EEG and neuroscience (01.01.1999)
Published in Clinical EEG and neuroscience (01.01.1999)
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Journal Article
Hypervascular acoustic neuroma
LeMay, D R, Sun, J K, Fishback, D, Locke, G E, Giannotta, S L
Published in Neurological research (New York) (01.12.1998)
Published in Neurological research (New York) (01.12.1998)
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Journal Article
Neonatal cocaine-related seizures
Kramer, L D, Locke, G E, Ogunyemi, A, Nelson, L
Published in Journal of child neurology (01.01.1990)
Published in Journal of child neurology (01.01.1990)
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