Investigations of the Mode of Action and Resistance Development of Cadazolid, a New Antibiotic for Treatment of Clostridium difficile Infections
LOCHER, Hans H, CASPERS, Patrick, BRUYERE, Thierry, SCHROEDER, Susanne, PFAFF, Philippe, KNEZEVIC, Andreja, KECK, Wolfgang, RITZ, Daniel
Published in Antimicrobial Agents and Chemotherapy (01.02.2014)
Published in Antimicrobial Agents and Chemotherapy (01.02.2014)
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In Vitro and In Vivo Antibacterial Evaluation of Cadazolid, a New Antibiotic for Treatment of Clostridium difficile Infections
LOCHER, Hans H, SEILER, Peter, KELLY, Ciaran P, KECK, Wolfgang, XINHUA CHEN, SCHROEDER, Susanne, PFAFF, Philippe, ENDERLIN, Michel, KLENK, Axel, FOURNIER, Elvire, HUBSCHWERLEN, Christian, RITZ, Daniel
Published in Antimicrobial Agents and Chemotherapy (01.02.2014)
Published in Antimicrobial Agents and Chemotherapy (01.02.2014)
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Structural basis of translation inhibition by cadazolid, a novel quinoxolidinone antibiotic
Scaiola, Alain, Leibundgut, Marc, Boehringer, Daniel, Caspers, Patrick, Bur, Daniel, Locher, Hans H, Rueedi, Georg, Ritz, Daniel
Published in Scientific reports (04.04.2019)
Published in Scientific reports (04.04.2019)
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Identification of Genes Required for Resistance to Peptidomimetic Antibiotics by Transposon Sequencing
Vitale, Alessandra, Pessi, Gabriella, Urfer, Matthias, Locher, Hans H., Zerbe, Katja, Obrecht, Daniel, Robinson, John A., Eberl, Leo
Published in Frontiers in microbiology (23.07.2020)
Published in Frontiers in microbiology (23.07.2020)
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Discovery and Structure–Activity Relationship of Cadazolid: A First-In-Class Quinoxolidinone Antibiotic for the Treatment of Clostridioides difficile Infection
Rueedi, Georg, Panchaud, Philippe, Friedli, Astrid, Specklin, Jean-Luc, Hubschwerlen, Christian, Blumstein, Anne-Catherine, Caspers, Patrick, Enderlin-Paput, Michel, Jacob, Loïc, Kohl, Christopher, Locher, Hans H., Pfaff, Philippe, Schmitt, Christine, Seiler, Peter, Ritz, Daniel
Published in Journal of medicinal chemistry (16.05.2024)
Published in Journal of medicinal chemistry (16.05.2024)
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Journal Article
Different Resistance Mechanisms for Cadazolid and Linezolid in Clostridium difficile Found by Whole-Genome Sequencing Analysis
Caspers, Patrick, Locher, Hans H, Pfaff, Philippe, Diggelmann, Sarah, Rueedi, Georg, Bur, Daniel, Ritz, Daniel
Published in Antimicrobial agents and chemotherapy (01.08.2017)
Published in Antimicrobial agents and chemotherapy (01.08.2017)
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Antimicrobial activity of POL7306 tested against clinical isolates of Gram-negative bacteria collected worldwide
Sader, Helio S, Rhomberg, Paul R, Duncan, Leonard R, Locher, Hans H, Dale, Glenn E, Flamm, Robert K
Published in Journal of antimicrobial chemotherapy (01.06.2020)
Published in Journal of antimicrobial chemotherapy (01.06.2020)
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Optimization of LpxC Inhibitor Lead Compounds Focusing on Efficacy and Formulation for High Dose Intravenous Administration
Panchaud, Philippe, Surivet, Jean-Philippe, Diethelm, Stefan, Blumstein, Anne-Catherine, Gauvin, Jean-Christophe, Jacob, Loïc, Masse, Florence, Mathieu, Gaëlle, Mirre, Azely, Schmitt, Christine, Enderlin-Paput, Michel, Lange, Roland, Gnerre, Carmela, Seeland, Swen, Herrmann, Charlyse, Locher, Hans H, Seiler, Peter, Ritz, Daniel, Rueedi, Georg
Published in Journal of medicinal chemistry (09.01.2020)
Published in Journal of medicinal chemistry (09.01.2020)
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Synthesis and Characterization of Tetrahydropyran-Based Bacterial Topoisomerase Inhibitors with Antibacterial Activity against Gram-Negative Bacteria
Surivet, Jean-Philippe, Zumbrunn, Cornelia, Bruyère, Thierry, Bur, Daniel, Kohl, Christopher, Locher, Hans H, Seiler, Peter, Ertel, Eric A, Hess, Patrick, Enderlin-Paput, Michel, Enderlin-Paput, Stéphanie, Gauvin, Jean-Christophe, Mirre, Azely, Hubschwerlen, Christian, Ritz, Daniel, Rueedi, Georg
Published in Journal of medicinal chemistry (11.05.2017)
Published in Journal of medicinal chemistry (11.05.2017)
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Journal Article
Cadazolid Does Not Promote Intestinal Colonization of Vancomycin-Resistant Enterococci in Mice
Seiler, Peter, Enderlin-Paput, Michel, Pfaff, Philippe, Weiss, Maria, Ritz, Daniel, Clozel, Martine, Locher, Hans H
Published in Antimicrobial agents and chemotherapy (01.01.2016)
Published in Antimicrobial agents and chemotherapy (01.01.2016)
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Author Correction: Chimeric peptidomimetic antibiotics against Gram-negative bacteria
Luther, Anatol, Urfer, Matthias, Zahn, Michael, Müller, Maik, Wang, Shuang-Yan, Mondal, Milon, Vitale, Alessandra, Hartmann, Jean-Baptiste, Sharpe, Timothy, Monte, Fabio Lo, Kocherla, Harsha, Cline, Elizabeth, Pessi, Gabriella, Rath, Parthasarathi, Modaresi, Seyed Majed, Chiquet, Petra, Stiegeler, Sarah, Verbree, Carolin, Remus, Tobias, Schmitt, Michel, Kolopp, Caroline, Westwood, Marie-Anne, Desjonquères, Nicolas, Brabet, Emile, Hell, Sophie, LePoupon, Karen, Vermeulen, Annie, Jaisson, Régis, Rithié, Virginie, Upert, Grégory, Lederer, Alexander, Zbinden, Peter, Wach, Achim, Moehle, Kerstin, Zerbe, Katja, Locher, Hans H, Bernardini, Francesca, Dale, Glenn E, Eberl, Leo, Wollscheid, Bernd, Hiller, Sebastian, Robinson, John A, Obrecht, Daniel
Published in Nature (London) (12.12.2019)
Published in Nature (London) (12.12.2019)
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Journal Article
Biomimetic Total Synthesis and Antimicrobial Evaluation of Anachelin H
Gademann, Karl, Bethuel, Yann, Locher, Hans H, Hubschwerlen, Christian
Published in Journal of organic chemistry (26.10.2007)
Published in Journal of organic chemistry (26.10.2007)
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Journal Article
The Targets of Currently Used Antibacterial Agents: Lessons for Drug Discovery
LANGE, Roland P, LOCHER, Hans H, WYSS, Pierre C, THEN, Rudolf L
Published in Current pharmaceutical design (01.10.2007)
Published in Current pharmaceutical design (01.10.2007)
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Journal Article
Potent Algicides Based on the Cyanobacterial Alkaloid Nostocarboline
Blom, Judith F, Brütsch, Tobias, Barbaras, Damien, Bethuel, Yann, Locher, Hans H, Hubschwerlen, Christian, Gademann, Karl
Published in Organic letters (16.02.2006)
Published in Organic letters (16.02.2006)
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Journal Article
Dimers of Nostocarboline with Potent Antibacterial Activity
Locher, Hans H., Ritz, Daniel, Pfaff, Philippe, Gaertner, Mika, Knezevic, Andreja, Sabato, Daniela, Schroeder, Susanne, Barbaras, Damien, Gademann, Karl
Published in Chemotherapy (Basel) (01.01.2010)
Published in Chemotherapy (Basel) (01.01.2010)
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Structure–activity relationship in the oxazolidinone–quinolone hybrid series: influence of the central spacer on the antibacterial activity and the mode of action
Hubschwerlen, Christian, Specklin, Jean-Luc, Baeschlin, Daniel K., Borer, Yves, Haefeli, Sascha, Sigwalt, Christine, Schroeder, Susanne, Locher, Hans H.
Published in Bioorganic & medicinal chemistry letters (01.12.2003)
Published in Bioorganic & medicinal chemistry letters (01.12.2003)
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Journal Article
Chimeric peptidomimetic antibiotics against Gram-negative bacteria
Luther, Anatol, Urfer, Matthias, Zahn, Michael, Müller, Maik, Wang, Shuang-Yan, Mondal, Milon, Vitale, Alessandra, Hartmann, Jean-Baptiste, Sharpe, Timothy, Monte, Fabio Lo, Kocherla, Harsha, Cline, Elizabeth, Pessi, Gabriella, Rath, Parthasarathi, Modaresi, Seyed Majed, Chiquet, Petra, Stiegeler, Sarah, Verbree, Carolin, Remus, Tobias, Schmitt, Michel, Kolopp, Caroline, Westwood, Marie-Anne, Desjonquères, Nicolas, Brabet, Emile, Hell, Sophie, LePoupon, Karen, Vermeulen, Annie, Jaisson, Régis, Rithié, Virginie, Upert, Grégory, Lederer, Alexander, Zbinden, Peter, Wach, Achim, Moehle, Kerstin, Zerbe, Katja, Locher, Hans H, Bernardini, Francesca, Dale, Glenn E, Eberl, Leo, Wollscheid, Bernd, Hiller, Sebastian, Robinson, John A, Obrecht, Daniel
Published in Nature (London) (01.12.2019)
Published in Nature (London) (01.12.2019)
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