588 A First-in-patient Phase I Study of the Novel Gamma Secretase Inhibitor PF-03084014 in Patients with Advanced Solid Tumor Malignancies
Messersmith, W.A, LoRusso, P.M, Cleary, J.M, Dasari, A, Huang, B, Shaik, N.M, Cesari, R, McLachlan, K.R, Kern, K.A, Shapiro, G.I
Published in European journal of cancer (1990) (01.11.2012)
Published in European journal of cancer (1990) (01.11.2012)
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189 Preclinical activity of the poly (ADP-ribose) polymerase (PARP) inhibitor ABT-888 in combination with irinotecan in ovarian and triple negative breast cancers
Nechiporchik, N, Lieb, K, Marquette, L, Polin, L, Peters, G.J, Chen, A, Ethier, S.P, LoRusso, P.M, Burger, A.M
Published in European journal of cancer supplements (2010)
Published in European journal of cancer supplements (2010)
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388 Imetelstat sodium (GRN163L), a telomerase inhibitor: tolerability, pharmacokinetics and pharmacodynamic activity using an intermittent once every four weeks dosing schedule in patients with advanced solid tumors
Ratain, M.J, Kelsey, S, Janisch, L, Smith, J, Go, N, Lin, T, Maitland, M.L, Kindler, H.L, LoRusso, P.M
Published in European journal of cancer supplements (2010)
Published in European journal of cancer supplements (2010)
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383 First-in-human study of PF-04691502, a small molecule oral dual inhibitor of PI3K and mTOR in patients with advanced cancer: Preliminary report on safety and pharmacokinetics
Britten, C.D, Adjei, A.A, Millham, R, Houk, B, Wainberg, Z.A, Guthrie, T, Dy, G, LoRusso, P.M
Published in European journal of cancer supplements (2010)
Published in European journal of cancer supplements (2010)
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468 POSTER The role of thymidine kinase and thymidylate synthase in the response of tumor cells to the suicide prodrug 2′-F-ara-deoxyuridine
Phatak, P, Daniels, C.M, Shields, A.F, Collins, J.M, LoRusso, P.M, Burger, A.M
Published in European journal of cancer supplements (2008)
Published in European journal of cancer supplements (2008)
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1029P Dazostinag (TAK-676) alone and in combination with pembrolizumab (pembro) in patients (pts) with advanced or metastatic solid tumors: Preliminary safety, PK/PD, and anti-tumor activity in a phase I dose escalation study supporting a recommended dose for expansion (RDE)
Olszanski, A.J., Luke, J.J., LoRusso, P.M., Falchook, G.S., Bedard, P.L., Sanborn, R.E., Patel, S.P., Orr, D., Gibbs, J.P., Li, C., Huang, Y-C., Gregory, R., Perera, S., Xu, R., Joshi, A., Lee, M.Y., Raizer, J., Gao, X.
Published in Annals of oncology (01.10.2023)
Published in Annals of oncology (01.10.2023)
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1205 A first-in-human Phase I study to evaluate the pan-PI3K inhibitor GDC-0941 administered QD or BID in patients with advanced solid tumours
Von Hoff, D.D, Wagner, A.J, LoRusso, P.M, Tibes, R, Jin, J, Ware, J.A, Yan, Y, Derynck, M.K, Dolezal, M.V, Demetri, G.D
Published in European journal of cancer supplements (2009)
Published in European journal of cancer supplements (2009)
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216 POSTER A phase I dose-escalation study of the safety, pharmacokinetics and pharmacodynamics of XL765, a novel inhibitor of PI3K and mTOR, administered orally to patients with solid tumors
Markman, B, LoRusso, P.M, Patnaik, A, Heath, E, Laird, A.D, van Leeuwen, B, Papadopoulos, K.P, Baselga, J
Published in European journal of cancer supplements (2008)
Published in European journal of cancer supplements (2008)
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A phase I, first in human study of FP-1039 (GSK3052230), a novel FGF ligand trap, in patients with advanced solid tumors
Tolcher, A.W., Papadopoulos, K.P., Patnaik, A., Wilson, K., Thayer, S., Zanghi, J., Gemo, A.T., Kavanaugh, W.M., Keer, H.N., LoRusso, P.M.
Published in Annals of oncology (01.03.2016)
Published in Annals of oncology (01.03.2016)
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355 POSTER Updated safety and efficacy data from a first-in-human, first-in-class, phase I study of Hedgehog pathway antagonist, GDC-0449
Rudin, C.M, Von Hoff, D.D, LoRusso, P.M, Vernillet, L, Yauch, R, Darbonne, W.C, Mackey, H, de Sauvage, F.J, Low, J.A, Reddy, J.C
Published in European journal of cancer supplements (2008)
Published in European journal of cancer supplements (2008)
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Phase I study of the checkpoint kinase 1 inhibitor GDC-0575 in combination with gemcitabine in patients with refractory solid tumors
Italiano, A., Infante, J.R., Shapiro, G.I., Moore, K.N., LoRusso, P.M., Hamilton, E., Cousin, S., Toulmonde, M., Postel-Vinay, S., Tolaney, S., Blackwood, E.M., Mahrus, S., Peale, F.V., Lu, X., Moein, A., Epler, J., DuPree, K., Tagen, M., Murray, E.R., Schutzman, J.L., Lauchle, J.O., Hollebecque, A., Soria, J.-C.
Published in Annals of oncology (01.05.2018)
Published in Annals of oncology (01.05.2018)
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Dose-Escalation Phase I Study of Cabazitaxel (CBZ) + Gemcitabine (GEM) in Patients (PTS) with Metastatic or Unresectable Advanced Solid Malignancy
Rixe, O., Puzanov, I., LoRusso, P.M., Yin, J., Doroumian, S., Zhi, X., Olszanski, A.J.
Published in Annals of oncology (01.09.2012)
Published in Annals of oncology (01.09.2012)
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497P - Dose-Escalation Phase I Study of Cabazitaxel (CBZ) + Gemcitabine (GEM) in Patients (PTS) with Metastatic or Unresectable Advanced Solid Malignancy
Rixe, O., Puzanov, I., LoRusso, P.M., Yin, J., Doroumian, S., Zhi, X., Olszanski, A.J.
Published in Annals of oncology (01.09.2012)
Published in Annals of oncology (01.09.2012)
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Expanded Access Study of Advanced Bcc Patients Treated with the Hedgehog-Pathway Inhibitor Vismodegib
Weiss, G.J., Oro, A., Chang, A.L.S., Solomon, J.A., LoRusso, P.M., Hamid, O., Chen, D.M., McKenna, E., Feng, S., Hainsworth, J.D.
Published in Annals of oncology (01.09.2012)
Published in Annals of oncology (01.09.2012)
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1111PD - Expanded Access Study of Advanced Bcc Patients Treated with the Hedgehog-Pathway Inhibitor Vismodegib
Weiss, G.J., Oro, A., Chang, A.L.S., Solomon, J.A., LoRusso, P.M., Hamid, O., Chen, D.M., McKenna, E., Feng, S., Hainsworth, J.D.
Published in Annals of oncology (01.09.2012)
Published in Annals of oncology (01.09.2012)
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Multicenter, Dose-Escalation Study of the Investigational Drug Tak-733, An Oral Mek inhibitor, in Patients (PTS) with Advanced Solid Tumors: Preliminary Phase 1 Results
Adjei, A.A., LoRusso, P.M., Ribas, A., Sosman, J.A., Dy, G.K., Chmielowski, B., Lipman, P., Zhou, X., Gangolli, E., Bozón, V.
Published in Annals of oncology (01.09.2012)
Published in Annals of oncology (01.09.2012)
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Phase 1/2 Study of Oral Rucaparib: Updated Phase 1 and Preliminary Phase 2 Results
Kristeleit, R., Shapira-Frommer, R., Burris, H., Patel, M.R., Lorusso, P.M., Oza, A.M., Balmaña, J., Domchek, S.M., Chen, L., Montes, A., Plummer, R., Arkenau, H., Maloney, L., Dominy, E., Shapiro, G.
Published in Annals of oncology (01.09.2014)
Published in Annals of oncology (01.09.2014)
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