Discovering cell-active BCL6 inhibitors: effectively combining biochemical HTS with multiple biophysical techniques, X-ray crystallography and cell-based assays
Pierrat, Olivier A, Liu, Manjuan, Collie, Gavin W, Shetty, Kartika, Rodrigues, Matthew J, Le Bihan, Yann-Vaï, Gunnell, Emma A, McAndrew, P Craig, Stubbs, Mark, Rowlands, Martin G, Yahya, Norhakim, Shehu, Erald, Talbot, Rachel, Pickard, Lisa, Bellenie, Benjamin R, Cheung, Kwai-Ming J, Drouin, Ludovic, Innocenti, Paolo, Woodward, Hannah, Davis, Owen A, Lloyd, Matthew G, Varela, Ana, Huckvale, Rosemary, Broccatelli, Fabio, Carter, Michael, Galiwango, David, Hayes, Angela, Raynaud, Florence I, Bryant, Christopher, Whittaker, Steven, Rossanese, Olivia W, Hoelder, Swen, Burke, Rosemary, van Montfort, Rob L M
Published in Scientific reports (03.11.2022)
Published in Scientific reports (03.11.2022)
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Journal Article
A Longitudinal Study of the Association of Clinical Indices of Cardiovascular Autonomic Function with Breast Cancer Treatment and Exercise Training
Kirkham, Amy A., Lloyd, Matthew G., Claydon, Victoria E., Gelmon, Karen A., McKenzie, Donald C., Campbell, Kristin L.
Published in The oncologist (Dayton, Ohio) (01.02.2019)
Published in The oncologist (Dayton, Ohio) (01.02.2019)
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Journal Article
Achieving In Vivo Target Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders
Bellenie, Benjamin R, Cheung, Kwai-Ming J, Varela, Ana, Pierrat, Olivier A, Collie, Gavin W, Box, Gary M, Bright, Michael D, Gowan, Sharon, Hayes, Angela, Rodrigues, Matthew J, Shetty, Kartika N, Carter, Michael, Davis, Owen A, Henley, Alan T, Innocenti, Paolo, Johnson, Louise D, Liu, Manjuan, de Klerk, Selby, Le Bihan, Yann-Vaï, Lloyd, Matthew G, McAndrew, P. Craig, Shehu, Erald, Talbot, Rachel, Woodward, Hannah L, Burke, Rosemary, Kirkin, Vladimir, van Montfort, Rob L. M, Raynaud, Florence I, Rossanese, Olivia W, Hoelder, Swen
Published in Journal of medicinal chemistry (23.04.2020)
Published in Journal of medicinal chemistry (23.04.2020)
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Journal Article
Objective Hemodynamic Cardiovascular Autonomic Abnormalities in Post-Acute Sequelae of COVID-19
Hira, Rashmin, Baker, Jacquie R., Siddiqui, Tanya, Ranada, Shaun I., Soroush, Ateyeh, Karalasingham, Kavithra, Ahmad, Hyeqa, Mavai, Vibhuti, Ayala Valani, Luciano Martin, Ambreen, Sakina, Bourne, Kate M., Lloyd, Matthew G., Morillo, Carlos A., Sheldon, Robert S., Raj, Satish R., Ahmad, Hyeqa, Ambreen, Sakina, Ayala Valani, Luciano M., Baker, Jacquie R., Bourne, Kate M., Dunn, Jeff F., Hira, Rashmin, Karalasingham, Kavithra, Lloyd, Matthew G., Mavai, Vibhuti, Morillo, Carlos A., Raj, Satish R., Ranada, Shaun I., Sheldon, Robert S., Siddiqui, Tanya, Soroush, Ateyeh, Guzman, Juan C., Claydon, Victoria, Ayala-Paredes, Felix A., Floras, John, Harvey, Paula, Osuntokun, Oluwatosin
Published in Canadian journal of cardiology (01.06.2023)
Published in Canadian journal of cardiology (01.06.2023)
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Journal Article
Optimizing Shape Complementarity Enables the Discovery of Potent Tricyclic BCL6 Inhibitors
Davis, Owen A., Cheung, Kwai-Ming J., Brennan, Alfie, Lloyd, Matthew G., Rodrigues, Matthew J., Pierrat, Olivier A., Collie, Gavin W., Le Bihan, Yann-Vaï, Huckvale, Rosemary, Harnden, Alice C., Varela, Ana, Bright, Michael D., Eve, Paul, Hayes, Angela, Henley, Alan T., Carter, Michael D., McAndrew, P. Craig, Talbot, Rachel, Burke, Rosemary, van Montfort, Rob L. M., Raynaud, Florence I., Rossanese, Olivia W., Meniconi, Mirco, Bellenie, Benjamin R., Hoelder, Swen
Published in Journal of medicinal chemistry (23.06.2022)
Published in Journal of medicinal chemistry (23.06.2022)
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Journal Article
Erratum to "Objective Hemodynamic Cardiovascular Autonomic Abnormalities in Post-Acute Sequelae of COVID-19" [Can J Cardiol 39 (2023):767-775]
Hira, Rashmin, Baker, Jacquie R, Siddiqui, Tanya, Ranada, Shaun I, Soroush, Ateyeh, Karalasingham, Kavithra, Ahmad, Hyeqa, Mavai, Vibhuti, Valani, Luciano Martin Ayala, Ambreen, Sakina, Bourne, Kate M, Lloyd, Matthew G, Morillo, Carlos A, Sheldon, Robert S, Raj, Satish R
Published in Canadian journal of cardiology (01.11.2023)
Published in Canadian journal of cardiology (01.11.2023)
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Journal Article
Into Deep Water: Optimizing BCL6 Inhibitors by Growing into a Solvated Pocket
Lloyd, Matthew G, Huckvale, Rosemary, Cheung, Kwai-Ming J, Rodrigues, Matthew J, Collie, Gavin W, Pierrat, Olivier A, Gatti Iou, Mahad, Carter, Michael, Davis, Owen A, McAndrew, P. Craig, Gunnell, Emma, Le Bihan, Yann-Vaï, Talbot, Rachel, Henley, Alan T, Johnson, Louise D, Hayes, Angela, Bright, Michael D, Raynaud, Florence I, Meniconi, Mirco, Burke, Rosemary, van Montfort, Rob L. M, Rossanese, Olivia W, Bellenie, Benjamin R, Hoelder, Swen
Published in Journal of medicinal chemistry (09.12.2021)
Published in Journal of medicinal chemistry (09.12.2021)
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Journal Article
A One-Pot C–H Insertion/Olefination Sequence for the Formation of α‑Alkylidene-γ-butyrolactones
Lloyd, Matthew G, Taylor, Richard J. K, Unsworth, William P
Published in Organic letters (16.05.2014)
Published in Organic letters (16.05.2014)
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Journal Article
Phosphorylated cyclopropanes in the synthesis of alpha-alkylidene-gamma-butyrolactones: total synthesis of (+/-)-savinin, (+/-)-gadain and (+/-)-peperomin E
Lloyd, Matthew G., Taylor, Richard J. K., Unsworth, William P.
Published in Organic & biomolecular chemistry (01.01.2016)
Published in Organic & biomolecular chemistry (01.01.2016)
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Journal Article
New indices from microneurography to investigate the arterial baroreflex
Laurin, Alexandre, Lloyd, Matthew G., Hachiya, Tesshin, Saito, Mitsuru, Claydon, Victoria E., Blaber, Andrew
Published in Physiological reports (01.06.2017)
Published in Physiological reports (01.06.2017)
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Journal Article
Carotid sinus hypersensitivity: block of the sternocleidomastoid muscle does not affect responses to carotid sinus massage in healthy young adults
Lloyd, Matthew G., Wakeling, James M., Koehle, Michael S., Drapala, Robert J., Claydon, Victoria E.
Published in Physiological reports (01.10.2017)
Published in Physiological reports (01.10.2017)
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Journal Article
α-Alkylidene-γ-butyrolactone synthesis via one-pot C–H insertion/olefination: substrate scope and the total synthesis of (±)-cedarmycins A and B
Lloyd, Matthew G., D'Acunto, Mariantonietta, Taylor, Richard J.K., Unsworth, William P.
Published in Tetrahedron (30.09.2015)
Published in Tetrahedron (30.09.2015)
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Journal Article
Phosphorylated cyclopropanes in the synthesis of α-alkylidene-γ-butyrolactones: total synthesis of (±)-savinin, (±)-gadain and (±)-peperomin EElectronic supplementary information (ESI) available. CCDC 1465173. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6ob01527a
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A selective C-H insertion/olefination protocol for the synthesis of α-methylene-γ-butyrolactone natural productsElectronic supplementary information (ESI) available: Experimental, spectral and crystallographic data. CCDC 1421154, 1421158 and 1421164. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5ob02579f
Lloyd, Matthew G, D'Acunto, Mariantonietta, Taylor, Richard J. K, Unsworth, William P
Year of Publication 27.01.2016
Year of Publication 27.01.2016
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