Genome-wide CRISPR–Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1
Crowther, Michael D., Dolton, Garry, Legut, Mateusz, Caillaud, Marine E., Lloyd, Angharad, Attaf, Meriem, Galloway, Sarah A. E., Rius, Cristina, Farrell, Colin P., Szomolay, Barbara, Ager, Ann, Parker, Alan L., Fuller, Anna, Donia, Marco, McCluskey, James, Rossjohn, Jamie, Svane, Inge Marie, Phillips, John D., Sewell, Andrew K.
Published in Nature immunology (01.02.2020)
Published in Nature immunology (01.02.2020)
Get full text
Journal Article
Confirmation of mutation landscape of NF1‐associated malignant peripheral nerve sheath tumors
Sohier, Pierre, Luscan, Armelle, Lloyd, Angharad, Ashelford, Kevin, Laurendeau, Ingrid, Briand‐Suleau, Audrey, Vidaud, Dominique, Ortonne, Nicolas, Pasmant, Eric, Upadhyaya, Meena
Published in Genes chromosomes & cancer (01.05.2017)
Published in Genes chromosomes & cancer (01.05.2017)
Get full text
Journal Article
Conserved allomorphs of MR1 drive the specificity of MR1-restricted TCRs
Cornforth, Terri V, Moyo, Nathifa, Cole, Suzanne, Lam, Emily P S, Lobry, Tatiana, Wolchinsky, Ron, Lloyd, Angharad, Ward, Katarzyna, Denham, Eleanor M, Masi, Giulia, Qing Yun, Phyllis Tea, Moore, Colin, Dhaouadi, Selsabil, Besra, Gurdyal S, Veerapen, Natacha, Illing, Patricia T, Vivian, Julian P, Raynes, Jeremy M, Le Nours, Jérôme, Purcell, Anthony W, Kundu, Samit, Silk, Jonathan D, Williams, Luke, Papa, Sophie, Rossjohn, Jamie, Howie, Duncan, Dukes, Joseph
Published in Frontiers in oncology (03.10.2024)
Published in Frontiers in oncology (03.10.2024)
Get full text
Journal Article
Author Correction: Genome-wide CRISPR–Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1
Crowther, Michael D., Dolton, Garry, Legut, Mateusz, Caillaud, Marine E., Lloyd, Angharad, Attaf, Meriem, Galloway, Sarah A. E., Rius, Cristina, Farrell, Colin P., Szomolay, Barbara, Ager, Ann, Parker, Alan L., Fuller, Anna, Donia, Marco, McCluskey, James, Rossjohn, Jamie, Svane, Inge Marie, Phillips, John D., Sewell, Andrew K.
Published in Nature immunology (01.06.2020)
Published in Nature immunology (01.06.2020)
Get full text
Journal Article
CD4+ T Cells Recognize Conserved Influenza A Epitopes through Shared Patterns of V-Gene Usage and Complementary Biochemical Features
Greenshields-Watson, Alexander, Attaf, Meriem, MacLachlan, Bruce J., Whalley, Thomas, Rius, Cristina, Wall, Aaron, Lloyd, Angharad, Hughes, Hywel, Strange, Kathryn E., Mason, Georgina H., Schauenburg, Andrea J., Hulin-Curtis, Sarah L., Geary, James, Chen, Yuan, Lauder, Sarah N., Smart, Kathryn, Vijaykrishna, Dhanasekaran, Grau, Miguel L., Shugay, Mikhail, Andrews, Robert, Dolton, Garry, Rizkallah, Pierre J., Gallimore, Awen M., Sewell, Andrew K., Godkin, Andrew J., Cole, David K.
Published in Cell reports (Cambridge) (14.07.2020)
Published in Cell reports (Cambridge) (14.07.2020)
Get full text
Journal Article
Peptide Super-Agonist Enhances T-Cell Responses to Melanoma
Galloway, Sarah A E, Dolton, Garry, Attaf, Meriem, Wall, Aaron, Fuller, Anna, Rius, Cristina, Bianchi, Valentina, Theaker, Sarah, Lloyd, Angharad, Caillaud, Marine E, Svane, Inge Marie, Donia, Marco, Cole, David K, Szomolay, Barbara, Rizkallah, Pierre, Sewell, Andrew K
Published in Frontiers in immunology (13.03.2019)
Published in Frontiers in immunology (13.03.2019)
Get full text
Journal Article
362 Allelic variants of MR1 drive cancer and allo-reactivity by MR1-restricted T cells
Howie, Duncan, Cornforth, Terri V, Moyo, Nathifa, Cole, Suzanne, Lam, Emily, Lobry, Tatiana, Wolchinsky, Ron, Lloyd, Angharad, Ward, Katarzyna, Denham, Eleanor M, Besra, Gurdyal S, Illing, Patricia, MacLachlan, Bruce, Vivian, Julian, Raynes, Jeremy, Nours, Jerome Le, Purcell, Anthony, Kundu, Samit, Silk, Jonathan D, Williams, Luke, Papa, Sophie, Rossjohn, Jamie, Dukes, Joseph
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
Get full text
Journal Article
Thermal Stability of Heterotrimeric pMHC Proteins as Determined by Circular Dichroism Spectroscopy
Fuller, Anna, Wall, Aaron, Crowther, Michael D, Lloyd, Angharad, Zhurov, Alexei, Sewell, Andrew K, Cole, David K, Beck, Konrad
Published in Bio-protocol (05.07.2017)
Published in Bio-protocol (05.07.2017)
Get full text
Journal Article
Targeting of multiple tumor-associated antigens by individual T cell receptors during successful cancer immunotherapy
Dolton, Garry, Rius, Cristina, Wall, Aaron, Szomolay, Barbara, Bianchi, Valentina, Galloway, Sarah A.E., Hasan, Md Samiul, Morin, Théo, Caillaud, Marine E., Thomas, Hannah L., Theaker, Sarah, Tan, Li Rong, Fuller, Anna, Topley, Katie, Legut, Mateusz, Attaf, Meriem, Hopkins, Jade R., Behiry, Enas, Zabkiewicz, Joanna, Alvares, Caroline, Lloyd, Angharad, Rogers, Amber, Henley, Peter, Fegan, Christopher, Ottmann, Oliver, Man, Stephen, Crowther, Michael D., Donia, Marco, Svane, Inge Marie, Cole, David K., Brown, Paul E., Rizkallah, Pierre, Sewell, Andrew K.
Published in Cell (03.08.2023)
Published in Cell (03.08.2023)
Get full text
Journal Article
T cell receptor interactions with human leukocyte antigen govern indirect peptide selectivity for the cancer testis antigen MAGE-A4
Coles, Charlotte H., McMurran, Catriona, Lloyd, Angharad, Hock, Miriam, Hibbert, Linda, Raman, Marine C.C., Hayes, Conor, Lupardus, Patrick, Cole, David K., Harper, Stephen
Published in The Journal of biological chemistry (14.08.2020)
Published in The Journal of biological chemistry (14.08.2020)
Get full text
Journal Article
More tricks with tetramers: a practical guide to staining T cells with peptide–MHC multimers
Dolton, Garry, Tungatt, Katie, Lloyd, Angharad, Bianchi, Valentina, Theaker, Sarah M., Trimby, Andrew, Holland, Christopher J., Donia, Marco, Godkin, Andrew J., Cole, David K., Thor Straten, Per, Peakman, Mark, Svane, Inge Marie, Sewell, Andrew K.
Published in Immunology (01.09.2015)
Published in Immunology (01.09.2015)
Get full text
Journal Article
Specificity of bispecific T cell receptors and antibodies targeting peptide-HLA
Holland, Christopher J, Crean, Rory M, Pentier, Johanne M, de Wet, Ben, Lloyd, Angharad, Srikannathasan, Velupillai, Lissin, Nikolai, Lloyd, Katy A, Blicher, Thomas H, Conroy, Paul J, Hock, Miriam, Pengelly, Robert J, Spinner, Thomas E, Cameron, Brian, Potter, Elizabeth A, Jeyanthan, Anitha, Molloy, Peter E, Sami, Malkit, Aleksic, Milos, Liddy, Nathaniel, Robinson, Ross A, Harper, Stephen, Lepore, Marco, Pudney, Chris R, van der Kamp, Marc W, Rizkallah, Pierre J, Jakobsen, Bent K, Vuidepot, Annelise, Cole, David K
Published in The Journal of clinical investigation (01.05.2020)
Published in The Journal of clinical investigation (01.05.2020)
Get full text
Journal Article
Promiscuous recognition of MR1 drives self-reactive mucosal-associated invariant T cell responses
Chancellor, Andrew, Alan Simmons, Robert, Khanolkar, Rahul C, Nosi, Vladimir, Beshirova, Aisha, Berloffa, Giuliano, Colombo, Rodrigo, Karuppiah, Vijaykumar, Pentier, Johanne M, Tubb, Vanessa, Ghadbane, Hemza, Suckling, Richard J, Page, Keith, Crean, Rory M, Vacchini, Alessandro, De Gregorio, Corinne, Schaefer, Verena, Constantin, Daniel, Gligoris, Thomas, Lloyd, Angharad, Hock, Miriam, Srikannathasan, Velupillai, Robinson, Ross A, Besra, Gurdyal S, van der Kamp, Marc W, Mori, Lucia, Calogero, Raffaele, Cole, David K, De Libero, Gennaro, Lepore, Marco
Published in The Journal of experimental medicine (04.09.2023)
Published in The Journal of experimental medicine (04.09.2023)
Get full text
Journal Article
TCRs with Distinct Specificity Profiles Use Different Binding Modes to Engage an Identical Peptide-HLA Complex
Coles, Charlotte H, Mulvaney, Rachel M, Malla, Sunir, Walker, Andrew, Smith, Kathrine J, Lloyd, Angharad, Lowe, Kate L, McCully, Michelle L, Martinez Hague, Ruth, Aleksic, Milos, Harper, Jane, Paston, Samantha J, Donnellan, Zoe, Chester, Fiona, Wiederhold, Katrin, Robinson, Ross A, Knox, Andrew, Stacey, Andrea R, Dukes, Joseph, Baston, Emma, Griffin, Sue, Jakobsen, Bent K, Vuidepot, Annelise, Harper, Stephen
Published in The Journal of immunology (1950) (01.04.2020)
Published in The Journal of immunology (1950) (01.04.2020)
Get full text
Journal Article
A Molecular Switch Abrogates Glycoprotein 100 (gp100) T-cell Receptor (TCR) Targeting of a Human Melanoma Antigen
Bianchi, Valentina, Bulek, Anna, Fuller, Anna, Lloyd, Angharad, Attaf, Meriem, Rizkallah, Pierre J., Dolton, Garry, Sewell, Andrew K., Cole, David K.
Published in The Journal of biological chemistry (22.04.2016)
Published in The Journal of biological chemistry (22.04.2016)
Get full text
Journal Article
T-cell libraries allow simple parallel generation of multiple peptide-specific human T-cell clones
Theaker, Sarah M., Rius, Cristina, Greenshields-Watson, Alexander, Lloyd, Angharad, Trimby, Andrew, Fuller, Anna, Miles, John J., Cole, David K., Peakman, Mark, Sewell, Andrew K., Dolton, Garry
Published in Journal of immunological methods (01.03.2016)
Published in Journal of immunological methods (01.03.2016)
Get full text
Journal Article
Engineering of Isogenic Cells Deficient for MR1 with a CRISPR/Cas9 Lentiviral System: Tools To Study Microbial Antigen Processing and Presentation to Human MR1-Restricted T Cells
Laugel, Bruno, Lloyd, Angharad, Meermeier, Erin W, Crowther, Michael D, Connor, Thomas R, Dolton, Garry, Miles, John J, Burrows, Scott R, Gold, Marielle C, Lewinsohn, David M, Sewell, Andrew K
Published in The Journal of immunology (1950) (01.08.2016)
Published in The Journal of immunology (1950) (01.08.2016)
Get full text
Journal Article
Structural Mechanism Underpinning Cross-reactivity of a CD8+ T-cell Clone That Recognizes a Peptide Derived from Human Telomerase Reverse Transcriptase
Cole, David K., van den Berg, Hugo A., Lloyd, Angharad, Crowther, Michael D., Beck, Konrad, Ekeruche-Makinde, Julia, Miles, John J., Bulek, Anna M., Dolton, Garry, Schauenburg, Andrea J., Wall, Aaron, Fuller, Anna, Clement, Mathew, Laugel, Bruno, Rizkallah, Pierre J., Wooldridge, Linda, Sewell, Andrew K.
Published in The Journal of biological chemistry (20.01.2017)
Published in The Journal of biological chemistry (20.01.2017)
Get full text
Journal Article