Reductive Metabolism Influences the Toxicity and Pharmacokinetics of the Hypoxia-Targeted Benzotriazine Di-Oxide Anticancer Agent SN30000 in Mice
Gu, Yongchuan, Chang, Tony T-A, Wang, Jingli, Jaiswal, Jagdish K, Edwards, David, Downes, Noel J, Liyanage, H D Sarath, Lynch, Courtney R H, Pruijn, Frederik B, Hickey, Anthony J R, Hay, Michael P, Wilson, William R, Hicks, Kevin O
Published in Frontiers in pharmacology (11.08.2017)
Published in Frontiers in pharmacology (11.08.2017)
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Spatially-resolved pharmacokinetic/pharmacodynamic modelling of bystander effects of a nitrochloromethylbenzindoline hypoxia-activated prodrug
Hong, Cho Rong, Mehta, Sunali Y., Liyanage, H. D. Sarath, McManaway, Sarah P., Lee, Ho H., Jaiswal, Jagdish K., Bogle, Gib, Tercel, Moana, Pruijn, Frederik B., Wilson, William R., Hicks, Kevin O.
Published in Cancer chemotherapy and pharmacology (01.10.2021)
Published in Cancer chemotherapy and pharmacology (01.10.2021)
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Pharmacokinetic/Pharmacodynamic Modeling Identifies SN30000 and SN29751 as Tirapazamine Analogues with Improved Tissue Penetration and Hypoxic Cell Killing in Tumors
HICKS, Kevin O, SIIM, Bronwyn G, DENNY, William A, HAY, Michael P, WILSON, William R, JAISWAL, Jagdish K, PRUIJN, Frederik B, FRASER, Annie M, PATEL, Rita, HOGG, Alison, SARATH LIYANAGE, H. D, JO DORIE, Mary, BROWN, J. Martin
Published in Clinical cancer research (15.10.2010)
Published in Clinical cancer research (15.10.2010)
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Mechanism of Action of AminoCBIs: Highly Reactive but Highly Cytotoxic Analogues of the Duocarmycins
Tercel, Moana, Pruijn, Frederik B., O'Connor, Patrick D., Liyanage, H. D. Sarath, Atwell, Graham J., Alix, Sonia M.
Published in Chembiochem : a European journal of chemical biology (05.09.2014)
Published in Chembiochem : a European journal of chemical biology (05.09.2014)
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Influence of a Basic Side Chain on the Properties of Hypoxia-Selective Nitro Analogues of the Duocarmycins: Demonstration of Substantial Anticancer Activity in Combination with Irradiation or Chemotherapy
Tercel, Moana, Lee, Ho H, Mehta, Sunali Y, Youte Tendoung, Jean-Jacques, Bai, Sally Y, Liyanage, H. D. Sarath, Pruijn, Frederik B
Published in Journal of medicinal chemistry (13.07.2017)
Published in Journal of medicinal chemistry (13.07.2017)
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The Cytotoxicity of Duocarmycin Analogues is Mediated through Alkylation of DNA, not Aldehyde Dehydrogenase 1: A Comment
Tercel, Moana, McManaway, Sarah P., Leung, Euphemia, Liyanage, H. D. Sarath, Lu, Guo-Liang, Pruijn, Frederik B.
Published in Angewandte Chemie (International ed.) (17.05.2013)
Published in Angewandte Chemie (International ed.) (17.05.2013)
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The flavoprotein FOXRED2 reductively activates nitro-chloromethylbenzindolines and other hypoxia-targeting prodrugs
Hunter, Francis W., Jaiswal, Jagdish K., Hurley, Daniel G., Liyanage, H.D. Sarath, McManaway, Sarah P., Gu, Yongchuan, Richter, Susan, Wang, Jingli, Tercel, Moana, Print, Cristin G., Wilson, William R., Pruijn, Frederik B.
Published in Biochemical pharmacology (15.05.2014)
Published in Biochemical pharmacology (15.05.2014)
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Nitro-chloromethylbenzindolines: hypoxia-activated prodrugs of potent adenine N3 DNA minor groove alkylators
Wilson, William R, Stribbling, Stephen M, Pruijn, Frederik B, Syddall, Sophie P, Patterson, Adam V, Liyanage, H D Sarath, Smith, Eileen, Botting, K Jane, Tercel, Moana
Published in Molecular cancer therapeutics (01.10.2009)
Published in Molecular cancer therapeutics (01.10.2009)
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Extravascular Transport of Drugs in Tumor Tissue: Effect of Lipophilicity on Diffusion of Tirapazamine Analogues in Multicellular Layer Cultures
Pruijn, Frederik B, Sturman, Joanna R, Liyanage, H. D. Sarath, Hicks, Kevin O, Hay, Michael P, Wilson, William R
Published in Journal of medicinal chemistry (24.02.2005)
Published in Journal of medicinal chemistry (24.02.2005)
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DNA-Targeted 1,2,4-Benzotriazine 1,4-Dioxides: Potent Analogues of the Hypoxia-Selective Cytotoxin Tirapazamine
Hay, Michael P, Pruijn, Frederik B, Gamage, Swarna A, Liyanage, H. D. Sarath, Kovacs, Mary S, Patterson, Adam V, Wilson, William R, Brown, J. Martin, Denny, William A
Published in Journal of medicinal chemistry (15.01.2004)
Published in Journal of medicinal chemistry (15.01.2004)
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Preparation and Antitumour Properties of the Enantiomers of a Hypoxia-Selective Nitro Analogue of the Duocarmycins
Tercel, Moana, Lee, Ho H., Yang, Shangjin, Liyanage, H. D. Sarath, Mehta, Sunali Y., Boyd, Peter D. W., Jaiswal, Jagdish K., Tan, Karin L., Pruijn, Frederik B.
Published in ChemMedChem (04.10.2011)
Published in ChemMedChem (04.10.2011)
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Drug-DNA adducts as biomarkers for metabolic activation of the nitro-aromatic nitrogen mustard prodrug PR-104A
Stornetta, Alessia, Deng, Kai-Cheng Kieren, Danielli, Sara, Liyanage, H.D. Sarath, Sturla, Shana J., Wilson, William R., Gu, Yongchuan
Published in Biochemical pharmacology (01.08.2018)
Published in Biochemical pharmacology (01.08.2018)
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The Cytotoxicity of Duocarmycin Analogues is Mediated through Alkylation of DNA, not Aldehyde Dehydrogenase 1: A Comment
Tercel, Moana, McManaway, Sarah P., Leung, Euphemia, Liyanage, H. D. Sarath, Lu, Guo-Liang, Pruijn, Frederik B.
Published in Angewandte Chemie (17.05.2013)
Published in Angewandte Chemie (17.05.2013)
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