Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target
Yuthavong, Yongyuth, Tarnchompoo, Bongkoch, Vilaivan, Tirayut, Chitnumsub, Penchit, Kamchonwongpaisan, Sumalee, Charman, Susan A., McLennan, Danielle N., White, Karen L., Vivas, Livia, Bongard, Emily, Thongphanchang, Chawanee, Taweechai, Supannee, Vanichtanankul, Jarunee, Rattanajak, Roonglawan, Arwon, Uthai, Fantauzzi, Pascal, Yuvaniyama, Jirundon, Charman, William N., Matthews, David
Published in Proceedings of the National Academy of Sciences - PNAS (16.10.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (16.10.2012)
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Journal Article
In Vivo and In Vitro Activities and ADME-Tox Profile of a Quinolizidine-Modified 4-Aminoquinoline: A Potent Anti-P. falciparum and Anti-P. vivax Blood-Stage Antimalarial
Basilico, Nicoletta, Parapini, Silvia, Sparatore, Anna, Romeo, Sergio, Misiano, Paola, Vivas, Livia, Yardley, Vanessa, Croft, Simon L, Habluetzel, Annette, Lucantoni, Leonardo, Renia, Laurent, Russell, Bruce, Suwanarusk, Rossarin, Nosten, Francois, Dondio, Giulio, Bigogno, Chiara, Jabes, Daniela, Taramelli, Donatella
Published in Molecules (Basel, Switzerland) (01.12.2017)
Published in Molecules (Basel, Switzerland) (01.12.2017)
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Journal Article
Artemisone-A Highly Active Antimalarial Drug of the Artemisinin Class
Haynes, Richard K., Fugmann, Burkhard, Stetter, Jörg, Rieckmann, Karl, Heilmann, Hans-Dietrich, Chan, Ho-Wai, Cheung, Man-Ki, Lam, Wai-Lun, Wong, Ho-Ning, Croft, Simon L., Vivas, Livia, Rattray, Lauren, Stewart, Lindsay, Peters, Wallace, Robinson, Brian L., Edstein, Michael D., Kotecka, Barbara, Kyle, Dennis E., Beckermann, Bernhard, Gerisch, Michael, Radtke, Martin, Schmuck, Gabriele, Steinke, Wolfram, Wollborn, Ute, Schmeer, Karl, Römer, Axel
Published in Angewandte Chemie (International ed.) (20.03.2006)
Published in Angewandte Chemie (International ed.) (20.03.2006)
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Journal Article
Favorable Preclinical Pharmacological Profile of a Novel Antimalarial Pyrrolizidinylmethyl Derivative of 4-amino-7-chloroquinoline with Potent In Vitro and In Vivo Activities
Basilico, Nicoletta, Parapini, Silvia, D'Alessandro, Sarah, Misiano, Paola, Romeo, Sergio, Dondio, Giulio, Yardley, Vanessa, Vivas, Livia, Nasser, Shereen, Rénia, Laurent, Russell, Bruce M, Suwanarusk, Rossarin, Nosten, François, Sparatore, Anna, Taramelli, Donatella
Published in Biomolecules (Basel, Switzerland) (14.05.2023)
Published in Biomolecules (Basel, Switzerland) (14.05.2023)
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Journal Article
Identification and Activity of a Series of Azole-based Compounds with Lactate Dehydrogenase-directed Anti-malarial Activity
Cameron, Angus, Read, Jon, Tranter, Rebecca, Winter, Victoria J, Sessions, Richard B, Brady, R Leo, Vivas, Livia, Easton, Anna, Kendrick, Howard, Croft, Simon L, Barros, David, Lavandera, Jose Luis, Martin, José Julio, Risco, Felix, García-Ochoa, Silvestre, Gamo, Fracisco Javier, Sanz, Laura, Leon, Luisa, Ruiz, Jose R, Gabarró, Raquel, Mallo, Araceli, Gómez de las Heras, Federico
Published in The Journal of biological chemistry (23.07.2004)
Published in The Journal of biological chemistry (23.07.2004)
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Journal Article
Antioxidant C-Glucosylxanthones from the Leaves of Arrabidaea patellifera
Martin, Frédéric, Hay, Anne-Emmanuelle, Cressend, Delphine, Reist, Marianne, Vivas, Livia, Gupta, Mahabir P, Carrupt, Pierre-Alain, Hostettmann, Kurt
Published in Journal of natural products (Washington, D.C.) (01.11.2008)
Published in Journal of natural products (Washington, D.C.) (01.11.2008)
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Journal Article
Synthesis and antiplasmodial activity of 3-furyl and 3-thienylquinoxaline-2-carbonitrile 1,4-di-N-oxide derivatives
Vicente, Esther, Charnaud, Sarah, Bongard, Emily, Villar, Raquel, Burguete, Asunción, Solano, Beatriz, Ancizu, Saioa, Pérez-Silanes, Silvia, Aldana, Ignacio, Vivas, Livia, Monge, Antonio
Published in Molecules (Basel, Switzerland) (17.01.2008)
Published in Molecules (Basel, Switzerland) (17.01.2008)
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Journal Article
Mapping the binding site for gossypol-like inhibitors of Plasmodium falciparum lactate dehydrogenase
Conners, Rebecca, Schambach, Felix, Read, Jon, Cameron, Angus, Sessions, Richard B., Vivas, Livia, Easton, Anna, Croft, Simon L., Brady, R. Leo
Published in Molecular and biochemical parasitology (01.08.2005)
Published in Molecular and biochemical parasitology (01.08.2005)
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Journal Article
Cyclopalladated complexes containing tridentate thiosemicarbazone ligands of biological significance: Synthesis, structure and antimalarial activity
Chellan, Prinessa, Nasser, Shereen, Vivas, Livia, Chibale, Kelly, Smith, Gregory S.
Published in Journal of organometallic chemistry (01.09.2010)
Published in Journal of organometallic chemistry (01.09.2010)
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Journal Article
Curcumin enhances non-opsonic phagocytosis of Plasmodium falciparum through up-regulation of CD36 surface expression on monocytes/macrophages
MIMCHE, Patrice N, THOMPSON, Eloise, TARAMELLI, Donatella, VIVAS, Livia
Published in Journal of antimicrobial chemotherapy (01.08.2012)
Published in Journal of antimicrobial chemotherapy (01.08.2012)
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Journal Article
Identification of a 1,2,4,5-Tetraoxane Antimalarial Drug-Development Candidate (RKA 182) with Superior Properties to the Semisynthetic Artemisinins
O'Neill, Paul M, Amewu, Richard K, Nixon, Gemma L, Bousejra ElGarah, Fatima, Mungthin, Mathirut, Chadwick, James, Shone, Alison E, Vivas, Livia, Lander, Hollie, Barton, Victoria, Muangnoicharoen, Sant, Bray, Patrick G, Davies, Jill, Park, B. Kevin, Wittlin, Sergio, Brun, Reto, Preschel, Michael, Zhang, Kesheng, Ward, Stephen A
Published in Angewandte Chemie (International ed.) (02.08.2010)
Published in Angewandte Chemie (International ed.) (02.08.2010)
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Journal Article
Antiplasmodial and cytotoxicity evaluation of 3-functionalized 2-azetidinone derivatives
Singh, Pardeep, Sachdeva, Shaveta, Raj, Raghu, Kumar, Vipan, Mahajan, Mohinder P., Nasser, Shereen, Vivas, Livia, Gut, Jiri, Rosenthal, Phillip J., Feng, Tzu-Shean, Chibale, Kelly
Published in Bioorganic & medicinal chemistry letters (01.08.2011)
Published in Bioorganic & medicinal chemistry letters (01.08.2011)
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Journal Article
Potential of Lichen Secondary Metabolites against Plasmodium Liver Stage Parasites with FAS-II as the Potential Target
Lauinger, Ina L, Vivas, Livia, Perozzo, Remo, Stairiker, Christopher, Tarun, Alice, Zloh, Mire, Zhang, Xujie, Xu, Hua, Tonge, Peter J, Franzblau, Scott G, Pham, Duc-Hung, Esguerra, Camila V, Crawford, Alexander D, Maes, Louis, Tasdemir, Deniz
Published in Journal of natural products (Washington, D.C.) (28.06.2013)
Published in Journal of natural products (Washington, D.C.) (28.06.2013)
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Journal Article
Two-Step Synthesis of Achiral Dispiro-1,2,4,5-tetraoxanes with Outstanding Antimalarial Activity, Low Toxicity, and High-Stability Profiles
Ellis, Gemma L, Amewu, Richard, Sabbani, Sunil, Stocks, Paul A, Shone, Alison, Stanford, Deborah, Gibbons, Peter, Davies, Jill, Vivas, Livia, Charnaud, Sarah, Bongard, Emily, Hall, Charlotte, Rimmer, Karen, Lozanom, Sonia, Jesús, María, Gargallo, Domingo, Ward, Stephen A, O’Neill, Paul M
Published in Journal of medicinal chemistry (10.04.2008)
Published in Journal of medicinal chemistry (10.04.2008)
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Journal Article
Synthesis and Antiplasmodial Activity of New Indolone N-Oxide Derivatives
Nepveu, Françoise, Kim, Sothea, Boyer, Jeremie, Chatriant, Olivier, Ibrahim, Hany, Reybier, Karine, Monje, Marie-Carmen, Chevalley, Severine, Perio, Pierre, Lajoie, Barbora H, Bouajila, Jalloul, Deharo, Eric, Sauvain, Michel, Tahar, Rachida, Basco, Leonardo, Pantaleo, Antonella, Turini, Francesco, Arese, Paolo, Valentin, Alexis, Thompson, Eloise, Vivas, Livia, Petit, Serge, Nallet, Jean-Pierre
Published in Journal of medicinal chemistry (28.01.2010)
Published in Journal of medicinal chemistry (28.01.2010)
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Journal Article
Synthesis and structure–activity relationship of 3-phenylquinoxaline 1,4-di- N-oxide derivatives as antimalarial agents
Vicente, Esther, Lima, Lidia M., Bongard, Emily, Charnaud, Sarah, Villar, Raquel, Solano, Beatriz, Burguete, Asunción, Perez-Silanes, Silvia, Aldana, Ignacio, Vivas, Livia, Monge, Antonio
Published in European journal of medicinal chemistry (01.09.2008)
Published in European journal of medicinal chemistry (01.09.2008)
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Journal Article
Synthesis and evaluation of the antimalarial, anticancer, and caspase 3 activities of tetraoxane dimers
Amewu, Richard K., Chadwick, James, Hussain, Afthab, Panda, Somnath, Rinki, Rinki, Janneh, Omar, Ward, Stephen A., Miguel, Candel, Burrell-Saward, Hollie, Vivas, Livia, O’Neill, Paul M.
Published in Bioorganic & medicinal chemistry (01.12.2013)
Published in Bioorganic & medicinal chemistry (01.12.2013)
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Journal Article
Modular Synthesis and in Vitro and in Vivo Antimalarial Assessment of C-10 Pyrrole Mannich Base Derivatives of Artemisinin
Pacorel, Bénédicte, Leung, Suet C, Stachulski, Andrew V, Davies, Jill, Vivas, Livia, Lander, Hollie, Ward, Stephen A, Kaiser, Marcel, Brun, Reto, O’Neill, Paul M
Published in Journal of medicinal chemistry (28.01.2010)
Published in Journal of medicinal chemistry (28.01.2010)
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Journal Article
Long-term efficacy and safety of a treatment strategy for HIV infection using protease inhibitor monotherapy: 8-year routine clinical care follow-up from a randomised, controlled, open-label pragmatic trial (PIVOT)Research in context
Nicholas I. Paton, Alejandro Arenas-Pinto, Chloe Orkin, Vincent Lee, Mark Gompels, Wendy Hadley, David Stacey, Margaret Johnson, Pat Byrne, Ian Williams, Pierre Pellegrino, Lewis Haddow, Alejandro Arenas-Pinto, Chloe Orkin, James Hand, Carl De Souza, Lisa Murthen, Fabian Chen, Ruth Wilson, Elizabeth Green, John Masterson, Kamlesh Patel, Rebecca Howe, Alan Winston, Scott Mullaney, Mark Gompels, Louise Jennings, Nicholas Beeching, Rebecca Tamaklo, Julie Fox, Isabelle Jendrulek, Juan Manuel Tiraboschi, Yvonne Clowes, Andrew Thompson, Gary Brook, Manoj Trivedi, Martin Jones, Andrew DeBurgh-Thomas, Liz Jones, David Chadwick, Pauline Spence, Nellie Nkhoma, Zoe Warwick, Suzanne Price, Sally Read, Elbushra Herieka, John Day, Helen Blackman, Wendy Mejewska, Olanike Okolo, Edmund Ong, Karen Martin, Lee Munro, David Dockrell, Jonathan Ainsworth, Anele Waters, Stephen Kegg, Steve Taylor, Gerry Gilleran, Brian Gazzard, Jane Rowlands, Sris Allan, Rumun Sandhu, Nigel O'Farrell, Sheena Quaid, Moses Kapembwa, Jane Minton, James Calderwood, Frank Post, Lucy Campbell, Emily Wandolo, Adrian Palfreeman, Thambiah Balachandran, Rebecca O'Connell, Say Quah, Sarah Douglas, Sarah Russell-Sharpe, Christine Brewer, Clifford Leen, Sheila Morris, Sharmin Obeyesekera, Shirley Williams, Nelson David, Mark Roberts, Nicholas Paton, Karen Scott, Susie Hennings, Ischa Kummeling, Sara Martins, Ellen Owen-Powell, Karen Sanders, Ellen White, Ben Cromerty, Danielle Mercey, Sarah Fidler, Estee Torok, Tim Peto, David Lalloo, Andrew Phillips, Robert James
Published in EClinicalMedicine (01.03.2024)
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Published in EClinicalMedicine (01.03.2024)
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