Synthetic Approaches to the New Drugs Approved During 2015
Flick, Andrew C, Ding, Hong X, Leverett, Carolyn A, Kyne, Robert E, Liu, Kevin K. -C, Fink, Sarah J, O’Donnell, Christopher J
Published in Journal of medicinal chemistry (10.08.2017)
Published in Journal of medicinal chemistry (10.08.2017)
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Discovery of 1‑{(3R,4R)‑3-[({5-Chloro-2-[(1-methyl‑1H‑pyrazol-4-yl)amino]‑7H‑pyrrolo[2,3‑d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants
Cheng, Hengmiao, Nair, Sajiv K, Murray, Brion W, Almaden, Chau, Bailey, Simon, Baxi, Sangita, Behenna, Doug, Cho-Schultz, Sujin, Dalvie, Deepak, Dinh, Dac M, Edwards, Martin P, Feng, Jun Li, Ferre, Rose Ann, Gajiwala, Ketan S, Hemkens, Michelle D, Jackson-Fisher, Amy, Jalaie, Mehran, Johnson, Ted O, Kania, Robert S, Kephart, Susan, Lafontaine, Jennifer, Lunney, Beth, Liu, Kevin K.-C, Liu, Zhengyu, Matthews, Jean, Nagata, Asako, Niessen, Sherry, Ornelas, Martha A, Orr, Suvi T. M, Pairish, Mason, Planken, Simon, Ren, Shijian, Richter, Daniel, Ryan, Kevin, Sach, Neal, Shen, Hong, Smeal, Tod, Solowiej, Jim, Sutton, Scott, Tran, Khanh, Tseng, Elaine, Vernier, William, Walls, Marlena, Wang, Shuiwang, Weinrich, Scott L, Xin, Shuibo, Xu, Haiwei, Yin, Min-Jean, Zientek, Michael, Zhou, Ru, Kath, John C
Published in Journal of medicinal chemistry (10.03.2016)
Published in Journal of medicinal chemistry (10.03.2016)
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Synthetic approaches to the 2011 new drugs
Ding, Hong X., Liu, Kevin K.-C., Sakya, Subas M., Flick, Andrew C., O’Donnell, Christopher J.
Published in Bioorganic & medicinal chemistry (01.06.2013)
Published in Bioorganic & medicinal chemistry (01.06.2013)
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Identification of Cys255 in HIF‐1α as a novel site for development of covalent inhibitors of HIF‐1α/ARNT PasB domain protein–protein interaction
Cardoso, Rosa, Love, Robert, Nilsson, Carol L., Bergqvist, Simon, Nowlin, Dawn, Yan, Jiangli, Liu, Kevin K.‐C., Zhu, Jing, Chen, Ping, Deng, Ya‐Li, Dyson, H. Jane, Greig, Michael J., Brooun, Alexei
Published in Protein science (01.12.2012)
Published in Protein science (01.12.2012)
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Synthetic approaches to the 2010 new drugs
Liu, Kevin K.-C., Sakya, Subas M., O’Donnell, Christopher J., Flick, Andrew C., Ding, Hong X.
Published in Bioorganic & medicinal chemistry (01.02.2012)
Published in Bioorganic & medicinal chemistry (01.02.2012)
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Synthetic approaches to the 2009 new drugs
Liu, Kevin K.-C., Sakya, Subas M., O’Donnell, Christopher J., Flick, Andrew C., Li, Jin
Published in Bioorganic & medicinal chemistry (01.02.2011)
Published in Bioorganic & medicinal chemistry (01.02.2011)
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Journal Article
Conformationally-restricted cyclic sulfones as potent and selective mTOR kinase inhibitors
Liu, Kevin K.-C., Bailey, Simon, Dinh, Dac M., Lam, Hieu, Li, Chunze, Wells, Peter A., Yin, Min-Jean, Zou, Aihua
Published in Bioorganic & medicinal chemistry letters (01.08.2012)
Published in Bioorganic & medicinal chemistry letters (01.08.2012)
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Discovery of the Highly Potent PI3K/mTOR Dual Inhibitor PF-04979064 through Structure-Based Drug Design
Cheng, Hengmiao, Li, Chunze, Bailey, Simon, Baxi, Sangita M, Goulet, Lance, Guo, Lisa, Hoffman, Jacqui, Jiang, Ying, Johnson, Theodore Otto, Johnson, Ted W, Knighton, Daniel R, Li, John, Liu, Kevin K.-C, Liu, Zhengyu, Marx, Matthew A, Walls, Marlena, Wells, Peter A, Yin, Min-Jean, Zhu, Jinjiang, Zientek, Michael
Published in ACS medicinal chemistry letters (10.01.2013)
Published in ACS medicinal chemistry letters (10.01.2013)
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Synthetic approaches to the 2014 new drugs
Flick, Andrew C., Ding, Hong X., Leverett, Carolyn A., Kyne, Robert E., Liu, Kevin K.-C., Fink, Sarah J., O’Donnell, Christopher J.
Published in Bioorganic & medicinal chemistry (01.05.2016)
Published in Bioorganic & medicinal chemistry (01.05.2016)
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Journal Article
Quinazolines with intra-molecular hydrogen bonding scaffold (iMHBS) as PI3K/mTOR dual inhibitors
Liu, Kevin K.C., Huang, Xiaojun, Bagrodia, Shubha, Chen, Jeffrey H., Greasley, Samantha, Cheng, Hengmiao, Sun, Shaoxian, Knighton, Dan, Rodgers, Caroline, Rafidi, Kristina, Zou, Aihua, Xiao, Jiezhan, Yan, Shengyong
Published in Bioorganic & medicinal chemistry letters (15.02.2011)
Published in Bioorganic & medicinal chemistry letters (15.02.2011)
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Synthetic approaches to the 2013 new drugs
Ding, Hong X., Leverett, Carolyn A., Kyne, Robert E., Liu, Kevin K.-C., Fink, Sarah J., Flick, Andrew C., O’Donnell, Christopher J.
Published in Bioorganic & medicinal chemistry (01.05.2015)
Published in Bioorganic & medicinal chemistry (01.05.2015)
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4-Methylpteridinones as orally active and selective PI3K/mTOR dual inhibitors
Liu, Kevin K.-C., Bagrodia, Shubha, Bailey, Simon, Cheng, Hengmiao, Chen, Hui, Gao, Lisa, Greasley, Samantha, Hoffman, Jacqui E., Hu, Qiyue, Johnson, Ted O., Knighton, Dan, Liu, Zhengyu, Marx, Matthew A., Nambu, Mitchell D., Ninkovic, Sacha, Pascual, Bernadette, Rafidi, Kristina, Rodgers, Caroline M.-L., Smith, Graham L., Sun, Shaoxian, Wang, Haitao, Yang, Anle, Yuan, Jing, Zou, Aihua
Published in Bioorganic & medicinal chemistry letters (15.10.2010)
Published in Bioorganic & medicinal chemistry letters (15.10.2010)
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Synthetic approaches to the 2008 new drugs
Liu, Kevin K-C, Sakya, Subas M, O'Donnell, Christopher J, Li, Jin
Published in Mini reviews in medicinal chemistry (01.12.2009)
Published in Mini reviews in medicinal chemistry (01.12.2009)
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Design and synthesis of orally-active and selective azaindane 5HT2c agonist for the treatment of obesity
Liu, Kevin K.-C., Cornelius, Peter, Patterson, Terrell A., Zeng, Yuan, Santucci, Stephanie, Tomlinson, Elizabeth, Gibbons, Colleen, Maurer, Tristan S., Marala, Ravi, Brown, Janice, Kong, Jimmy X., Lee, Eunsun, Werner, Wendy, Wenzel, Zane, Vage, Chandra
Published in Bioorganic & medicinal chemistry letters (2010)
Published in Bioorganic & medicinal chemistry letters (2010)
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Journal Article
Highly Selective and Potent Thiophenes as PI3K Inhibitors with Oral Antitumor Activity
Liu, Kevin K.-C, Zhu, JinJiang, Smith, Graham L, Yin, Min-Jean, Bailey, Simon, Chen, Jeffrey H, Hu, Qiyue, Huang, Qinhua, Li, Chunze, Li, Qing J, Marx, Matthew A, Paderes, Genevieve, Richardson, Paul F, Sach, Neal W, Walls, Marlena, Wells, Peter A, Zou, Aihua
Published in ACS medicinal chemistry letters (10.11.2011)
Published in ACS medicinal chemistry letters (10.11.2011)
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Synthetic approaches to the 2012 new drugs
Ding, Hong X., Leverett, Carolyn A., Kyne, Robert E., Liu, Kevin K.-C., Sakya, Subas M., Flick, Andrew C., O’Donnell, Christopher J.
Published in Bioorganic & medicinal chemistry (01.04.2014)
Published in Bioorganic & medicinal chemistry (01.04.2014)
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Journal Article
Targeting Small Cell Lung Cancer Harboring PIK3CA Mutation with a Selective Oral PI3K Inhibitor PF-4989216
WALLS, Marlena, BAXI, Sangita M, YIN, Min-Jean, MEHTA, Pramod P, LIU, Kevin K.-C, JINJIANG ZHU, ESTRELLA, Heather, CHUNZE LI, ZIENTEK, Michael, QING ZONG, SMEAL, Tod
Published in Clinical cancer research (01.02.2014)
Published in Clinical cancer research (01.02.2014)
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Orally active and brain permeable proline amides as highly selective 5HT2c agonists for the treatment of obesity
Liu, Kevin K.-C., Lefker, Bruce A., Dombroski, Mark A., Chiang, Phoebe, Cornelius, Peter, Patterson, Terrell A., Zeng, Yuan, Santucci, Stephanie, Tomlinson, Elizabeth, Gibbons, Colleen P., Marala, Ravi, Brown, Janice A., Kong, Jimmy X., Lee, Eunsun, Werner, Wendy, Wenzel, Zane, Giragossian, Craig, Chen, Hou, Coffey, Steven B.
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
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