Phytosterol accumulation results in ventricular arrhythmia, impaired cardiac function and death in mice
Ge, Hongfei, Liu, Gongxin, Yamawaki, Tracy M., Tao, Caroline, Alexander, Shawn T., Ly, Kimberly, Fordstrom, Preston, Shkumatov, Artem A., Li, Chi-Ming, Rajamani, Sridharan, Zhou, Mingyue, Ason, Brandon
Published in Scientific reports (31.08.2021)
Published in Scientific reports (31.08.2021)
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A novel, potent, and selective inhibitor of cardiac late sodium current suppresses experimental arrhythmias
Belardinelli, Luiz, Liu, Gongxin, Smith-Maxwell, Cathy, Wang, Wei-Qun, El-Bizri, Nesrine, Hirakawa, Ryoko, Karpinski, Serge, Li, Cindy Hong, Hu, Lufei, Li, Xiao-Jun, Crumb, William, Wu, Lin, Koltun, Dmitry, Zablocki, Jeff, Yao, Lina, Dhalla, Arvinder K, Rajamani, Sridharan, Shryock, John C
Published in The Journal of pharmacology and experimental therapeutics (01.01.2013)
Published in The Journal of pharmacology and experimental therapeutics (01.01.2013)
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If inhibition in the atrioventricular node by ivabradine causes rate-dependent slowing of conduction and reduces ventricular rate during atrial fibrillation
Verrier, Richard L., PhD, Bonatti, Rodolfo, BS, Silva, Ana F.G., BS, Batatinha, Julio A.P., BS, Nearing, Bruce D., PhD, Liu, Gongxin, PhD, Rajamani, Sridharan, PhD, Zeng, Dewan, PhD, Belardinelli, Luiz, MD
Published in Heart rhythm (01.12.2014)
Published in Heart rhythm (01.12.2014)
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Correction: Spatially Discordant Alternans and Arrhythmias in Tachypacing-Induced Cardiac Myopathy in Transgenic LQT1 Rabbits: The Importance of IKs and Ca2+ Cycling
Lau, Emily, Kossidas, Konstantinos, Kim, Tae Yun, Kunitomo, Yukiko, Ziv, Ohad, Song, Zhen, Taylor, Chantel, Schofield, Lorraine, Yammine, Joe, Liu, Gongxin, Peng, Xuwen, Qu, Zhilin, Koren, Gideon, Choi, Bum-Rak
Published in PloS one (01.07.2015)
Published in PloS one (01.07.2015)
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Spatially Discordant Alternans and Arrhythmias in Tachypacing-Induced Cardiac Myopathy in Transgenic LQT1 Rabbits: The Importance of IKs and Ca2+ Cycling
Lau, Emily, Kossidas, Konstantinos, Kim, Tae Yun, Kunitomo, Yukiko, Ziv, Ohad, Song, Zhen, Zhen, Song, Taylor, Chantel, Schofield, Lorraine, Yammine, Joe, Liu, Gongxin, Peng, Xuwen, Qu, Zhilin, Koren, Gideon, Choi, Bum-Rak
Published in PloS one (2015)
Published in PloS one (2015)
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Phosphatidylinositol 3-phosphate indirectly activates KCa3.1 via 14 amino acids in the carboxy terminus of KCa3.1
Srivastava, Shekhar, Choudhury, Papiya, Li, Zhai, Liu, Gongxin, Nadkarni, Vivek, Ko, Kyung, Coetzee, William A, Skolnik, Edward Y
Published in Molecular biology of the cell (01.01.2006)
Published in Molecular biology of the cell (01.01.2006)
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The Phosphatidylinositol 3-Phosphate Phosphatase Myotubularin- Related Protein 6 (MTMR6) Is a Negative Regulator of the Ca2+-Activated K+ Channel KCa3.1
Srivastava, Shekhar, Li, Zhai, Lin, Lin, Liu, GongXin, Ko, Kyung, Coetzee, William A., Skolnik, Edward Y.
Published in Molecular and Cellular Biology (01.05.2005)
Published in Molecular and Cellular Biology (01.05.2005)
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Journal Article
Conduction liability of cardiac sodium channel binding sites
Li, Cindy, Yin, Ryan, Liu, Gongxin, Li, Ning, Rajamani, Sridharan
Published in Journal of pharmacological and toxicological methods (01.09.2021)
Published in Journal of pharmacological and toxicological methods (01.09.2021)
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The novel late Na+ current inhibitor, GS‐6615 (eleclazine) and its anti‐arrhythmic effects in rabbit isolated heart preparations
Rajamani, Sridharan, Liu, Gongxin, El‐Bizri, Nesrine, Guo, Donglin, Li, Cindy, Chen, Xiao‐Liang, Kahlig, Kristopher M, Mollova, Nevena, Elzein, Elfatih, Zablocki, Jeff, Belardinelli, Luiz
Published in British journal of pharmacology (01.11.2016)
Published in British journal of pharmacology (01.11.2016)
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Discovery of Dihydrobenzoxazepinone (GS-6615) Late Sodium Current Inhibitor (Late I Nai), a Phase II Agent with Demonstrated Preclinical Anti-Ischemic and Antiarrhythmic Properties
Zablocki, Jeff A, Elzein, Elfatih, Li, Xiaofen, Koltun, Dmitry O, Parkhill, Eric Q, Kobayashi, Tetsuya, Martinez, Ruben, Corkey, Britton, Jiang, Haibo, Perry, Thao, Kalla, Rao, Notte, Gregory T, Saunders, Oliver, Graupe, Michael, Lu, Yafan, Venkataramani, Chandru, Guerrero, Juan, Perry, Jason, Osier, Mark, Strickley, Robert, Liu, Gongxin, Wang, Wei-Qun, Hu, Lufei, Li, Xiao-Jun, El-Bizri, Nesrine, Hirakawa, Ryoko, Kahlig, Kris, Xie, Cheng, Li, Cindy Hong, Dhalla, Arvinder K, Rajamani, Sridharan, Mollova, Nevena, Soohoo, Daniel, Lepist, Eve-Irene, Murray, Bernard, Rhodes, Gerry, Belardinelli, Luiz, Desai, Manoj C
Published in Journal of medicinal chemistry (13.10.2016)
Published in Journal of medicinal chemistry (13.10.2016)
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Abstract 16882: Over Expression of Scn5a in Mouse Heart Mimics Human Syndrome of Enhanced Atrioventricular Nodal Conduction
Liu, Gongxin, Belardinelli, Luiz, Rajamani, Sridharan, Remme, Carol Ann, Boukens, Bastiaan J.D.
Published in Circulation (New York, N.Y.) (25.11.2014)
Published in Circulation (New York, N.Y.) (25.11.2014)
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Combined Actions of Ivabradine and Ranolazine Reduce Ventricular Rate During Atrial Fibrillation
VERRIER, RICHARD L., SILVA, ANA F.G., BONATTI, RODOLFO, BATATINHA, JULIO A.P., NEARING, BRUCE D., LIU, GONGXIN, RAJAMANI, SRIDHARAN, ZENG, DEWAN, BELARDINELLI, LUIZ
Published in Journal of cardiovascular electrophysiology (01.03.2015)
Published in Journal of cardiovascular electrophysiology (01.03.2015)
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Journal Article
Discovery of Dihydrobenzoxazepinone (GS-6615) Late Sodium Current Inhibitor (Late I(Na)i), a Phase II Agent with Demonstrated Preclinical Anti-Ischemic and Antiarrhythmic Properties
Zablocki, Jeff A., Elzein, Elfatih, Li, Xiaofen, Koltun, Dmitry O., Parkhill, Eric Q., Kobayashi, Tetsuya, Martinez, Ruben, Corkey, Britton, Jiang, Haibo, Perry, Thao, Kalla, Rao, Notte, Gregory T., Saunders, Oliver, Graupe, Michael, Lu, Yafan, Venkataramani, Chandru, Guerrero, Juan, Perry, Jason, Osier, Mark, Strickley, Robert, Liu, Gongxin, Wang, Wei-Qun, Hu, Lufei, Li, Xiao-Jun, El-Bizri, Nesrine, Hirakawa, Ryoko, Kahlig, Kris, Xie, Cheng, Li, Cindy Hong, Dhalla, Arvinder K., Rajamani, Sridharan, Mollova, Nevena, Soohoo, Daniel, Lepist, Eve-Irene, Murray, Bernard, Rhodes, Gerry, Belardinelle, Luiz, Desai, Manoj C.
Published in Journal of medicinal chemistry (13.10.2016)
Published in Journal of medicinal chemistry (13.10.2016)
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Journal Article
The novel late Na super(+) current inhibitor, GS-6615 (eleclazine) and its anti-arrhythmic effects in rabbit isolated heart preparations
Rajamani, Sridharan, Liu, Gongxin, El-Bizri, Nesrine, Guo, Donglin, Li, Cindy, Chen, Xiao-Liang, Kahlig, Kristopher M, Mollova, Nevena, Elzein, Elfatih, Zablocki, Jeff, Belardinelli, Luiz
Published in British journal of pharmacology (01.11.2016)
Published in British journal of pharmacology (01.11.2016)
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Journal Article
Selective inhibition of the late sodium current has no adverse effect on electrophysiological or contractile function of the normal heart
Fernandes, Sarah, Hoyer, Kirsten, Liu, Gongxin, Wang, Wei-Qun, Dhalla, Arvinder K, Belardinelli, Luiz, Rajamani, Sridharan
Published in Journal of cardiovascular pharmacology (01.06.2014)
Published in Journal of cardiovascular pharmacology (01.06.2014)
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Journal Article
Correction: Spatially Discordant Alternans and Arrhythmias in Tachypacing-Induced Cardiac Myopathy in Transgenic LQT1 Rabbits: The Importance of I.sub.Ks and Ca.sup.2+ Cycling
Lau, Emily, Kossidas, Konstantinos, Kim, Tae Yun, Kunitomo, Yukiko, Ziv, Ohad, Song, Zhen, Taylor, Chantel, Schofield, Lorraine, Yammine, Joe, Liu, Gongxin, Peng, Xuwen, Qu, Zhilin, Koren, Gideon, Choi, Bum-Rak
Published in PloS one (01.07.2015)
Published in PloS one (01.07.2015)
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Journal Article
Spatially Discordant Alternans and Arrhythmias in Tachypacing-Induced Cardiac Myopathy in Transgenic LQT1 Rabbits: The Importance of I.sub.Ks and Ca.sup.2+ Cycling
Lau, Emily, Kossidas, Konstantinos, Kim, Tae Yun, Kunitomo, Yukiko, Ziv, Ohad, Zhen, Song, Taylor, Chantel, Schofield, Lorraine, Yammine, Joe, Liu, Gongxin, Peng, Xuwen, Qu, Zhilin, Koren, Gideon, Choi, Bum-Rak
Published in PloS one (13.05.2015)
Published in PloS one (13.05.2015)
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Journal Article
Abstract 9171: An Increase in Late Sodium Current Causes Junctional Tachycardia in Mice Expressing an LQT3 SCN5A Mutant Na + Channel
Wu, Lin, Liu, Gongxin, Yang, Bo, Li, Hong, Hoyer, Kirsten, Shryock, John C, Belardinelli, Luiz
Published in Circulation (New York, N.Y.) (22.11.2011)
Published in Circulation (New York, N.Y.) (22.11.2011)
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Journal Article
Consequences of cardiac myocyte-specific ablation of KATP channels in transgenic mice expressing dominant negative Kir6 subunits
Tong, XiaoYong, Porter, Lisa M, Liu, GongXin, Dhar-Chowdhury, Piyali, Srivastava, Shekhar, Pountney, David J, Yoshida, Hidetada, Artman, Michael, Fishman, Glenn I, Yu, Cindy, Iyer, Ramesh, Morley, Gregory E, Gutstein, David E, Coetzee, William A
Published in American journal of physiology. Heart and circulatory physiology (01.08.2006)
Published in American journal of physiology. Heart and circulatory physiology (01.08.2006)
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