The Future of Peptide-based Drugs
Craik, David J., Fairlie, David P., Liras, Spiros, Price, David
Published in Chemical biology & drug design (01.01.2013)
Published in Chemical biology & drug design (01.01.2013)
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Journal Article
Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule
Li, Wenfei, Ward, Fred R., McClure, Kim F., Chang, Stacey Tsai-Lan, Montabana, Elizabeth, Liras, Spiros, Dullea, Robert G., Cate, Jamie H. D.
Published in Nature structural & molecular biology (01.06.2019)
Published in Nature structural & molecular biology (01.06.2019)
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Journal Article
Peptidic macrocyclization via palladium-catalyzed chemoselective indole C-2 arylation
Dong, Huijun, Limberakis, Chris, Liras, Spiros, Price, David, James, Keith
Published in Chemical communications (Cambridge, England) (01.01.2012)
Published in Chemical communications (Cambridge, England) (01.01.2012)
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Journal Article
Receptor-Mediated Delivery of CRISPR-Cas9 Endonuclease for Cell-Type-Specific Gene Editing
Rouet, Romain, Thuma, Benjamin A, Roy, Marc D, Lintner, Nathanael G, Rubitski, David M, Finley, James E, Wisniewska, Hanna M, Mendonsa, Rima, Hirsh, Ariana, de Oñate, Lorena, Compte Barrón, Joan, McLellan, Thomas J, Bellenger, Justin, Feng, Xidong, Varghese, Alison, Chrunyk, Boris A, Borzilleri, Kris, Hesp, Kevin D, Zhou, Kaihong, Ma, Nannan, Tu, Meihua, Dullea, Robert, McClure, Kim F, Wilson, Ross C, Liras, Spiros, Mascitti, Vincent, Doudna, Jennifer A
Published in Journal of the American Chemical Society (30.05.2018)
Published in Journal of the American Chemical Society (30.05.2018)
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Journal Article
Nonclassical Size Dependence of Permeation Defines Bounds for Passive Adsorption of Large Drug Molecules
Pye, Cameron R, Hewitt, William M, Schwochert, Joshua, Haddad, Terra D, Townsend, Chad E, Etienne, Lyns, Lao, Yongtong, Limberakis, Chris, Furukawa, Akihiro, Mathiowetz, Alan M, Price, David A, Liras, Spiros, Lokey, R. Scott
Published in Journal of medicinal chemistry (09.03.2017)
Published in Journal of medicinal chemistry (09.03.2017)
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Journal Article
Rational design and synthesis of an orally bioavailable peptide guided by NMR amide temperature coefficients
Wang, Conan K., Northfield, Susan E., Colless, Barbara, Chaousis, Stephanie, Hamernig, Ingrid, Lohman, Rink-Jan, Nielsen, Daniel S., Schroeder, Christina I., Liras, Spiros, Price, David A., Fairlie, David P., Craik, David J.
Published in Proceedings of the National Academy of Sciences - PNAS (09.12.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (09.12.2014)
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Journal Article
Fmoc-Based Synthesis of Disulfide-Rich Cyclic Peptides
Cheneval, Olivier, Schroeder, Christina I, Durek, Thomas, Walsh, Phillip, Huang, Yen-Hua, Liras, Spiros, Price, David A, Craik, David J
Published in Journal of organic chemistry (20.06.2014)
Published in Journal of organic chemistry (20.06.2014)
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Journal Article
On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds
White, Tina R, Renzelman, Chad M, Rand, Arthur C, Rezai, Taha, McEwen, Cayla M, Gelev, Vladimir M, Turner, Rushia A, Linington, Roger G, Leung, Siegfried S F, Kalgutkar, Amit S, Bauman, Jonathan N, Zhang, Yizhong, Liras, Spiros, Price, David A, Mathiowetz, Alan M, Jacobson, Matthew P, Lokey, R Scott
Published in Nature chemical biology (25.09.2011)
Published in Nature chemical biology (25.09.2011)
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Journal Article
Improving on Nature: Making a Cyclic Heptapeptide Orally Bioavailable
Nielsen, Daniel S., Hoang, Huy N., Lohman, Rink-Jan, Hill, Timothy A., Lucke, Andrew J., Craik, David J., Edmonds, David J., Griffith, David A., Rotter, Charles J., Ruggeri, Roger B., Price, David A., Liras, Spiros, Fairlie, David P.
Published in Angewandte Chemie International Edition (03.11.2014)
Published in Angewandte Chemie International Edition (03.11.2014)
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Journal Article
Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain
Lintner, Nathanael G, McClure, Kim F, Petersen, Donna, Londregan, Allyn T, Piotrowski, David W, Wei, Liuqing, Xiao, Jun, Bolt, Michael, Loria, Paula M, Maguire, Bruce, Geoghegan, Kieran F, Huang, Austin, Rolph, Tim, Liras, Spiros, Doudna, Jennifer A, Dullea, Robert G, Cate, Jamie H D
Published in PLoS biology (21.03.2017)
Published in PLoS biology (21.03.2017)
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Journal Article
Probing the Physicochemical Boundaries of Cell Permeability and Oral Bioavailability in Lipophilic Macrocycles Inspired by Natural Products
Bockus, Andrew T, Lexa, Katrina W, Pye, Cameron R, Kalgutkar, Amit S, Gardner, Jarret W, Hund, Kathryn C. R, Hewitt, William M, Schwochert, Joshua A, Glassey, Emerson, Price, David A, Mathiowetz, Alan M, Liras, Spiros, Jacobson, Matthew P, Lokey, R. Scott
Published in Journal of medicinal chemistry (11.06.2015)
Published in Journal of medicinal chemistry (11.06.2015)
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Journal Article
Exploring experimental and computational markers of cyclic peptides: Charting islands of permeability
Wang, Conan K., Northfield, Susan E., Swedberg, Joakim E., Colless, Barbara, Chaousis, Stephanie, Price, David A., Liras, Spiros, Craik, David J.
Published in European journal of medicinal chemistry (05.06.2015)
Published in European journal of medicinal chemistry (05.06.2015)
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Journal Article
Identification of a Brain Penetrant PDE9A Inhibitor Utilizing Prospective Design and Chemical Enablement as a Rapid Lead Optimization Strategy
Verhoest, Patrick R, Proulx-Lafrance, Caroline, Corman, Michael, Chenard, Lois, Helal, Christopher J, Hou, Xinjun, Kleiman, Robin, Liu, Shenping, Marr, Eric, Menniti, Frank S, Schmidt, Christopher J, Vanase-Frawley, Michelle, Schmidt, Anne W, Williams, Robert D, Nelson, Frederick R, Fonseca, Kari R, Liras, Spiros
Published in Journal of medicinal chemistry (24.12.2009)
Published in Journal of medicinal chemistry (24.12.2009)
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Journal Article
Discovery of Potent and Orally Bioavailable Macrocyclic Peptide–Peptoid Hybrid CXCR7 Modulators
Boehm, Markus, Beaumont, Kevin, Jones, Rhys, Kalgutkar, Amit S., Zhang, Liying, Atkinson, Karen, Bai, Guoyun, Brown, Janice A., Eng, Heather, Goetz, Gilles H., Holder, Brian R., Khunte, Bhagyashree, Lazzaro, Sarah, Limberakis, Chris, Ryu, Sangwoo, Shapiro, Michael J., Tylaska, Laurie, Yan, Jiangli, Turner, Rushia, Leung, Siegfried S. F., Ramaseshan, Mahesh, Price, David A., Liras, Spiros, Jacobson, Matthew P., Earp, David J., Lokey, R. Scott, Mathiowetz, Alan M., Menhaji-Klotz, Elnaz
Published in Journal of medicinal chemistry (14.12.2017)
Published in Journal of medicinal chemistry (14.12.2017)
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Journal Article
Peptide to Peptoid Substitutions Increase Cell Permeability in Cyclic Hexapeptides
Schwochert, Joshua, Turner, Rushia, Thang, Melissa, Berkeley, Ray F, Ponkey, Alexandra R, Rodriguez, Kelsie M, Leung, Siegfried S F, Khunte, Bhagyashree, Goetz, Gilles, Limberakis, Chris, Kalgutkar, Amit S, Eng, Heather, Shapiro, Michael J, Mathiowetz, Alan M, Price, David A, Liras, Spiros, Jacobson, Matthew P, Lokey, R. Scott
Published in Organic letters (19.06.2015)
Published in Organic letters (19.06.2015)
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Journal Article
Medicinal chemistry design principles for liver targeting through OATP transporters
Tu, Meihua, Mathiowetz, Alan M, Pfefferkorn, Jeffrey A, Cameron, Kimberly O, Dow, Robert L, Litchfield, John, Di, Li, Feng, Bo, Liras, Spiros
Published in Current topics in medicinal chemistry (01.04.2013)
Published in Current topics in medicinal chemistry (01.04.2013)
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Journal Article
Functionalization of Aromatic Amino Acids via Direct C−H Activation: Generation of Versatile Building Blocks for Accessing Novel Peptide Space
Meyer, Falco-Magnus, Liras, Spiros, Guzman-Perez, Angel, Perreault, Christian, Bian, Jianwei, James, Keith
Published in Organic letters (03.09.2010)
Published in Organic letters (03.09.2010)
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Journal Article
Translational Diffusion of Cyclic Peptides Measured Using Pulsed-Field Gradient NMR
Wang, Conan K, Northfield, Susan E, Swedberg, Joakim E, Harvey, Peta J, Mathiowetz, Alan M, Price, David A, Liras, Spiros, Craik, David J
Published in The journal of physical chemistry. B (25.09.2014)
Published in The journal of physical chemistry. B (25.09.2014)
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Journal Article
Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance()
Rand, Arthur C, Leung, Siegfried S F, Eng, Heather, Rotter, Charles J, Sharma, Raman, Kalgutkar, Amit S, Zhang, Yizhong, Varma, Manthena V, Farley, Kathleen A, Khunte, Bhagyashree, Limberakis, Chris, Price, David A, Liras, Spiros, Mathiowetz, Alan M, Jacobson, Matthew P, Lokey, R Scott
Published in MedChemComm (01.10.2012)
Published in MedChemComm (01.10.2012)
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