Allosteric activation of an ion channel triggered by modification of mechanosensitive nano-pockets
Kapsalis, Charalampos, Wang, Bolin, El Mkami, Hassane, Pitt, Samantha J, Schnell, Jason R, Smith, Terry K, Lippiat, Jonathan D, Bode, Bela E, Pliotas, Christos
Published in Nature communications (10.10.2019)
Published in Nature communications (10.10.2019)
Get full text
Journal Article
Drosophila expressing mutant human KCNT1 transgenes make an effective tool for targeted drug screening in a whole animal model of KCNT1-epilepsy
Hussain, Rashid, Lim, Chiao Xin, Shaukat, Zeeshan, Islam, Anowarul, Caseley, Emily A, Lippiat, Jonathan D, Rychkov, Grigori Y, Ricos, Michael G, Dibbens, Leanne M
Published in Scientific reports (09.02.2024)
Published in Scientific reports (09.02.2024)
Get full text
Journal Article
TMEM16A/ANO1 calcium-activated chloride channel as a novel target for the treatment of human respiratory syncytial virus infection
Pearson, Hayley, Todd, Eleanor J A A, Ahrends, Mareike, Hover, Samantha E, Whitehouse, Adrian, Stacey, Martin, Lippiat, Jonathan D, Wilkens, Ludwig, Fieguth, Hans-Gerd, Danov, Olga, Hesse, Christina, Barr, John N, Mankouri, Jamel
Published in Thorax (01.01.2021)
Published in Thorax (01.01.2021)
Get full text
Journal Article
Kv1.3 voltage-gated potassium channels link cellular respiration to proliferation through a non-conducting mechanism
Styles, Faye L, Al-Owais, Moza M, Scragg, Jason L, Chuntharpursat-Bon, Eulashini, Hettiarachchi, Nishani T, Lippiat, Jonathan D, Minard, Aisling, Bon, Robin S, Porter, Karen, Sukumar, Piruthivi, Peers, Chris, Roberts, Lee D
Published in Cell death & disease (07.04.2021)
Published in Cell death & disease (07.04.2021)
Get full text
Journal Article
Constitutively Active TRPC Channels of Adipocytes Confer a Mechanism for Sensing Dietary Fatty Acids and Regulating Adiponectin
Sukumar, Piruthivi, Sedo, Alicia, Li, Jing, Wilson, Lesley A, OʼRegan, David, Lippiat, Jonathan D, Porter, Karen E, Kearney, Mark T, Ainscough, Justin F.X, Beech, David J
Published in Circulation research (06.07.2012)
Published in Circulation research (06.07.2012)
Get full text
Journal Article
Receptor-mediated endocytosis and endosomal acidification is impaired in proximal tubule epithelial cells of Dent disease patients
Gorvin, Caroline M., Wilmer, Martijn J., Piret, Sian E., Harding, Brian, van den Heuvel, Lambertus P., Wrong, Oliver, Jat, Parmjit S., Lippiat, Jonathan D., Levtchenko, Elena N., Thakker, Rajesh V.
Published in Proceedings of the National Academy of Sciences - PNAS (23.04.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (23.04.2013)
Get full text
Journal Article
Carrier-mediated transport of quercetin conjugates: Involvement of organic anion transporters and organic anion transporting polypeptides
Wong, Chi Chun, Akiyama, Yasutoshi, Abe, Takaaki, Lippiat, Jonathan D., Orfila, Caroline, Williamson, Gary
Published in Biochemical pharmacology (15.08.2012)
Published in Biochemical pharmacology (15.08.2012)
Get full text
Journal Article
Structure-Based Identification and Characterization of Inhibitors of the Epilepsy-Associated KNa1.1 (KCNT1) Potassium Channel
Cole, Bethan A., Johnson, Rachel M., Dejakaisaya, Hattapark, Pilati, Nadia, Fishwick, Colin W.G., Muench, Stephen P., Lippiat, Jonathan D.
Published in iScience (22.05.2020)
Published in iScience (22.05.2020)
Get full text
Journal Article
Inhibition of the voltage-gated potassium channel Kv1.5 by hydrogen sulfide attenuates remodeling through S-nitrosylation-mediated signaling
Al-Owais, Moza M, Hettiarachchi, Nishani T, Dallas, Mark L, Scragg, Jason L, Lippiat, Jonathan D, Holden, Arun V, Steele, Derek S, Peers, Chris
Published in Communications biology (19.06.2023)
Published in Communications biology (19.06.2023)
Get full text
Journal Article
Cycloalkane-modified amphiphilic polymers provide direct extraction of membrane proteins for CryoEM analysis
Higgins, Anna J, Flynn, Alex J, Marconnet, Anaïs, Musgrove, Laura J, Postis, Vincent L G, Lippiat, Jonathan D, Chung, Chun-Wa, Ceska, Tom, Zoonens, Manuela, Sobott, Frank, Muench, Stephen P
Published in Communications biology (25.11.2021)
Published in Communications biology (25.11.2021)
Get full text
Journal Article
Constitutive Endocytic Recycling and Protein Kinase C-mediated Lysosomal Degradation Control KATP Channel Surface Density
Manna, Paul T., Smith, Andrew J., Taneja, Tarvinder K., Howell, Gareth J., Lippiat, Jonathan D., Sivaprasadarao, Asipu
Published in The Journal of biological chemistry (19.02.2010)
Published in The Journal of biological chemistry (19.02.2010)
Get full text
Journal Article
Characterization of Dent's disease mutations of CLC-5 reveals a correlation between functional and cell biological consequences and protein structure
Smith, Andrew J, Reed, Anita A C, Loh, Nellie Y, Thakker, Rajesh V, Lippiat, Jonathan D
Published in American Journal of Physiology - Renal Physiology (01.02.2009)
Published in American Journal of Physiology - Renal Physiology (01.02.2009)
Get full text
Journal Article
Author Correction: Cycloalkane-modified amphiphilic polymers provide direct extraction of membrane proteins for CryoEM analysis
Higgins, Anna J, Flynn, Alex J, Marconnet, Anaïs, Musgrove, Laura J, Postis, Vincent L G, Lippiat, Jonathan D, Chung, Chun-Wa, Ceska, Tom, Zoonens, Manuela, Sobott, Frank, Muench, Stephen P
Published in Communications biology (05.01.2022)
Published in Communications biology (05.01.2022)
Get full text
Journal Article
CLC-5 and KIF3B interact to facilitate CLC-5 plasma membrane expression, endocytosis, and microtubular transport: relevance to pathophysiology of Dent's disease
Reed, Anita A C, Loh, Nellie Y, Terryn, Sara, Lippiat, Jonathan D, Partridge, Chris, Galvanovskis, Juris, Williams, Siân E, Jouret, Francois, Wu, Fiona T F, Courtoy, Pierre J, Nesbit, M Andrew, Rorsman, Patrik, Devuyst, Olivier, Ashcroft, Frances M, Thakker, Rajesh V
Published in American Journal of Physiology - Renal Physiology (01.02.2010)
Published in American Journal of Physiology - Renal Physiology (01.02.2010)
Get full text
Journal Article
Targeting KNa1.1 channels in KCNT1-associated epilepsy
Cole, Bethan A., Clapcote, Steven J., Muench, Stephen P., Lippiat, Jonathan D.
Published in Trends in pharmacological sciences (Regular ed.) (01.08.2021)
Published in Trends in pharmacological sciences (Regular ed.) (01.08.2021)
Get full text
Journal Article
Mutations at the Same Residue (R50) of Kir6.2 (KCNJ11) That Cause Neonatal Diabetes Produce Different Functional Effects
SHIMOMURA, Kenju, GIRARD, Christophe A. J, ASHCROFT, Frances M, PROKS, Peter, NAZIM, Joanna, LIPPIAT, Jonathan D, CERUTTI, Franco, LORINI, Renata, ELLARD, Sian, HATTERSELY, Andrew T, BARBETTI, Fabrizio
Published in Diabetes (New York, N.Y.) (01.06.2006)
Published in Diabetes (New York, N.Y.) (01.06.2006)
Get full text
Journal Article