Small molecules targeting γ-secretase and their potential biological applications
Wen, Jiachen, Liu, Dan, Zhao, Linxiang
Published in European journal of medicinal chemistry (15.03.2022)
Published in European journal of medicinal chemistry (15.03.2022)
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Down-regulation of c-FLIP, XIAP and Mcl-1 protein as well as depletion of reduced glutathione contribute to the apoptosis induction of glycyrrhenitic acid derivatives in leukemia cells
Song, Dandan, Gao, Yuan, Wang, Rui, Liu, Dan, Zhao, Linxiang, Jing, Yongkui
Published in Cancer biology & therapy (15.01.2010)
Published in Cancer biology & therapy (15.01.2010)
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Trends in targeting Bcl-2 anti-apoptotic proteins for cancer treatment
Zhang, Zhenwei, Bai, Lijun, Hou, Linghui, Deng, Hongguang, Luan, Shenglin, Liu, Dan, Huang, Min, Zhao, Linxiang
Published in European journal of medicinal chemistry (15.03.2022)
Published in European journal of medicinal chemistry (15.03.2022)
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Targeting Myeloid Leukemia‑1 in Cancer Therapy: Advances and Directions
Deng, Hongguang, Han, Yu, Liu, Liang, Zhang, Hong, Liu, Dan, Wen, Jiachen, Huang, Min, Zhao, Linxiang
Published in Journal of medicinal chemistry (25.04.2024)
Published in Journal of medicinal chemistry (25.04.2024)
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Front Cover: Construction of Diversified Penta‐Spiro‐Heterocyclic and Fused‐Heterocyclic Frameworks with Potent Antitumor Activity (Chem. Eur. J. 54/2023)
Liu, Qi, Liu, Xuyi, Li, Yazhou, Zhou, Yu, Zhao, Linxiang, Liang, Xuewu, Liu, Hong
Published in Chemistry : a European journal (26.09.2023)
Published in Chemistry : a European journal (26.09.2023)
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Discovery of Novel Mcl-1 Inhibitors with a 3-Substituted-1 H -indole-1-yl Moiety Binding to the P1-P3 Pockets to Induce Apoptosis in Acute Myeloid Leukemia Cells
Deng, Hongguang, Zhang, Jingyi, Liu, Liang, Zhang, Hong, Han, Yu, Wu, Linlin, Jing, Yongkui, Huang, Min, Zhao, Linxiang
Published in Journal of medicinal chemistry (22.08.2024)
Published in Journal of medicinal chemistry (22.08.2024)
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Journal Article
Discovery of Novel Mcl‑1 Inhibitors with a 3‑Substituted‑1H‑indole-1-yl Moiety Binding to the P1–P3 Pockets to Induce Apoptosis in Acute Myeloid Leukemia Cells
Deng, Hongguang, Zhang, Jingyi, Liu, Liang, Zhang, Hong, Han, Yu, Wu, Linlin, Jing, Yongkui, Huang, Min, Zhao, Linxiang
Published in Journal of medicinal chemistry (22.08.2024)
Published in Journal of medicinal chemistry (22.08.2024)
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Optimization of BAX trigger site activator BTSA1 with improved antitumor potency and in vitro ADMET properties
Zhang, Zhenwei, Zhao, Shan, Pei, Jiying, Hou, Linghui, Luan, Shenglin, Deng, Hongguang, Liu, Dan, Huang, Min, Zhao, Linxiang
Published in European journal of medicinal chemistry (15.02.2023)
Published in European journal of medicinal chemistry (15.02.2023)
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Design, synthesis and biological evaluation of dual Bcl-2/Mcl-1 inhibitors bearing 2-(1H-indol-4-yl)benzoic acid scaffold
Niu, Qun, Deng, Hongguang, Zhang, Zhenwei, Xu, Qinhao, Luan, Shenglin, Huang, Min, Liu, Dan, Zhao, Linxiang
Published in Bioorganic & medicinal chemistry letters (01.09.2021)
Published in Bioorganic & medicinal chemistry letters (01.09.2021)
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Unlocking the potential: advancements and future horizons in ROR1-targeted cancer therapies
Li, Lin, Huang, Weixue, Ren, Xiaomei, Wang, Zhen, Ding, Ke, Zhao, Linxiang, Zhang, Jinwei
Published in Science China. Life sciences (12.08.2024)
Published in Science China. Life sciences (12.08.2024)
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Abstract 5991: Improved venetoclax therapy by a novel conjugate with artemisinin by NOXA-mediated reduction of Mcl-1 and cyclin D1 protein in myeloid leukemia cells
Zhang, Jingyi, Zhang, Zhenwei, Waxman, Samuel, Zhao, Linxiang, Jing, Yongkui
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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A 18β-glycyrrhetinic acid conjugate with Vorinostat degrades HDAC3 and HDAC6 with improved antitumor effects
Huang, Min, Xie, Xiaorui, Gong, Ping, Wei, Yunfei, Du, Heliang, Xu, Yuanbo, Xu, Qihao, Jing, Yongkui, Zhao, Linxiang
Published in European journal of medicinal chemistry (15.02.2020)
Published in European journal of medicinal chemistry (15.02.2020)
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Design, synthesis and biological evaluation of novel hydroxamic acid based histone deacetylase 6 selective inhibitors bearing phenylpyrazol scaffold as surface recognition motif
Yang, Jinyu, Cheng, Gaoliang, Xu, Qihao, Luan, Shenglin, Wang, Shuxiang, Liu, Dan, Zhao, Linxiang
Published in Bioorganic & medicinal chemistry (01.05.2018)
Published in Bioorganic & medicinal chemistry (01.05.2018)
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