Structural basis for the modulation of MRP2 activity by phosphorylation and drugs
Mazza, Tiziano, Roumeliotis, Theodoros I., Garitta, Elena, Drew, David, Rashid, S. Tamir, Indiveri, Cesare, Choudhary, Jyoti S., Linton, Kenneth J., Beis, Konstantinos
Published in Nature communications (04.03.2024)
Published in Nature communications (04.03.2024)
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ABCB1 Does Not Require the Side-Chain Hydrogen-Bond Donors Gln347, Gln725, Gln990 to Confer Cellular Resistance to the Anticancer Drug Taxol
Sasitharan, Keerthana, Iqbal, Hamzah Asad, Bifsa, Foteini, Olszewska, Aleksandra, Linton, Kenneth J.
Published in International journal of molecular sciences (09.08.2021)
Published in International journal of molecular sciences (09.08.2021)
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Mutations in AQP5, Encoding a Water-Channel Protein, Cause Autosomal-Dominant Diffuse Nonepidermolytic Palmoplantar Keratoderma
Blaydon, Diana C., Lind, Lisbet K., Plagnol, Vincent, Linton, Kenneth J., Smith, Francis J.D., Wilson, Neil J., McLean, W.H. Irwin, Munro, Colin S., South, Andrew P., Leigh, Irene M., O’Toole, Edel A., Lundström, Anita, Kelsell, David P.
Published in American journal of human genetics (08.08.2013)
Published in American journal of human genetics (08.08.2013)
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Journal Article
Canalicular ABC transporters and liver disease
Nicolaou, Michael, Andress, Edward J, Zolnerciks, Joseph K, Dixon, Peter H, Williamson, Catherine, Linton, Kenneth J
Published in The Journal of pathology (01.01.2012)
Published in The Journal of pathology (01.01.2012)
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Missense mutations and single nucleotide polymorphisms in ABCB11 impair bile salt export pump processing and function or disrupt pre‐messenger RNA splicing
Byrne, Jane A., Strautnieks, Sandra S., Ihrke, Gudrun, Pagani, Franco, Knisely, A.S., Linton, Kenneth J., Mieli‐Vergani, Giorgina, Thompson, Richard J.
Published in Hepatology (Baltimore, Md.) (01.02.2009)
Published in Hepatology (Baltimore, Md.) (01.02.2009)
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Complementary Functions of the Flippase ATP8B1 and the Floppase ABCB4 in Maintaining Canalicular Membrane Integrity
Groen, Annemiek, Romero, Marta Rodriguez, Kunne, Cindy, Hoosdally, Sarah J, Dixon, Peter H, Wooding, Carol, Williamson, Catherine, Seppen, Jurgen, van den Oever, Karin, Mok, Kam S, Paulusma, Coen C, Linton, Kenneth J, Oude Elferink, Ronald P.J
Published in Gastroenterology (New York, N.Y. 1943) (01.11.2011)
Published in Gastroenterology (New York, N.Y. 1943) (01.11.2011)
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Pharmacological inhibition of ABCC3 slows tumour progression in animal models of pancreatic cancer
Adamska, Aleksandra, Domenichini, Alice, Capone, Emily, Damiani, Verena, Akkaya, Begum Gokcen, Linton, Kenneth J, Di Sebastiano, Pierluigi, Chen, Xi, Keeton, Adam B, Ramirez-Alcantara, Veronica, Maxuitenko, Yulia, Piazza, Gary A, De Laurenzi, Vincenzo, Sala, Gianluca, Falasca, Marco
Published in Journal of experimental & clinical cancer research (05.08.2019)
Published in Journal of experimental & clinical cancer research (05.08.2019)
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Molecular mechanistic explanation for the spectrum of cholestatic disease caused by the S320F variant of ABCB4
Andress, Edward J., Nicolaou, Michael, Romero, Marta R., Naik, Sandhia, Dixon, Peter H., Williamson, Catherine, Linton, Kenneth J.
Published in Hepatology (Baltimore, Md.) (01.05.2014)
Published in Hepatology (Baltimore, Md.) (01.05.2014)
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The human bile salt export pump: characterization of substrate specificity and identification of inhibitors
Byrne, Jane A, Strautnieks, Sandra S, Mieli-Vergani, Giorgina, Higgins, Christopher F, Linton, Kenneth J, Thompson, Richard J
Published in Gastroenterology (New York, N.Y. 1943) (01.11.2002)
Published in Gastroenterology (New York, N.Y. 1943) (01.11.2002)
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Journal Article
The ATP switch model for ABC transporters
Higgins, Christopher F, Linton, Kenneth J
Published in Nature structural & molecular biology (01.10.2004)
Published in Nature structural & molecular biology (01.10.2004)
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Journal Article
ABCB4 missense mutations D243A, K435T, G535D, I490T, R545C, and S978P significantly impair the lipid floppase and likely predispose to secondary pathologies in the human population
Andress, Edward J., Nicolaou, Michael, McGeoghan, Farrell, Linton, Kenneth J.
Published in Cellular and molecular life sciences : CMLS (01.07.2017)
Published in Cellular and molecular life sciences : CMLS (01.07.2017)
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