Discovery of Ledipasvir (GS-5885): A Potent, Once-Daily Oral NS5A Inhibitor for the Treatment of Hepatitis C Virus Infection
Link, John O., Taylor, James G., Xu, Lianhong, Mitchell, Michael, Guo, Hongyan, Liu, Hongtao, Kato, Darryl, Kirschberg, Thorsten, Sun, Jianyu, Squires, Neil, Parrish, Jay, Keller, Terry, Yang, Zheng-Yu, Yang, Chris, Matles, Mike, Wang, Yujin, Wang, Kelly, Cheng, Guofeng, Tian, Yang, Mogalian, Erik, Mondou, Elsa, Cornpropst, Melanie, Perry, Jason, Desai, Manoj C.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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Journal Article
Clinical Resistance to Velpatasvir (GS-5816), a Novel Pan-Genotypic Inhibitor of the Hepatitis C Virus NS5A Protein
Lawitz, Eric J, Dvory-Sobol, Hadas, Doehle, Brian P, Worth, Angela S, McNally, John, Brainard, Diana M, Link, John O, Miller, Michael D, Mo, Hongmei
Published in Antimicrobial agents and chemotherapy (01.09.2016)
Published in Antimicrobial agents and chemotherapy (01.09.2016)
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Journal Article
Discovery of the pan-genotypic hepatitis C virus NS3/4A protease inhibitor voxilaprevir (GS-9857): A component of Vosevi
Taylor, James G., Zipfel, Sheila, Ramey, Kyla, Vivian, Randy, Schrier, Adam, Karki, Kapil K., Katana, Ashley, Kato, Darryl, Kobayashi, Tetsuya, Martinez, Ruben, Sangi, Michael, Siegel, Dustin, Tran, Chinh V., Yang, Zheng-Yu, Zablocki, Jeff, Yang, Cheng Y., Wang, Yujin, Wang, Kelly, Chan, Katie, Barauskas, Ona, Cheng, Guofeng, Jin, Debi, Schultz, Brian E., Appleby, Todd, Villaseñor, Armando G., Link, John O.
Published in Bioorganic & medicinal chemistry letters (15.08.2019)
Published in Bioorganic & medicinal chemistry letters (15.08.2019)
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Journal Article
Direct binding of ledipasvir to HCV NS5A: mechanism of resistance to an HCV antiviral agent
Kwon, Hyock Joo, Xing, Weimei, Chan, Katie, Niedziela-Majka, Anita, Brendza, Katherine M, Kirschberg, Thorsten, Kato, Darryl, Link, John O, Cheng, Guofeng, Liu, Xiaohong, Sakowicz, Roman
Published in PloS one (09.04.2015)
Published in PloS one (09.04.2015)
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Journal Article
Discovery of velpatasvir (GS-5816): A potent pan-genotypic HCV NS5A inhibitor in the single-tablet regimens Vosevi® and Epclusa
Link, John O., Taylor, James G., Trejo-Martin, Alejandra, Kato, Darryl, Katana, Ashley A., Krygowski, Evan S., Yang, Zheng-Yu, Zipfel, Sheila, Cottell, Jeromy J., Bacon, Elizabeth M., Tran, Chinh V., Yang, Cheng Y., Wang, Yujin, Wang, Kelly W., Zhao, Guangyu, Cheng, Guofeng, Tian, Yang, Gong, Ruoyu, Lee, Yu-Jen, Yu, Mei, Gorman, Eric, Mogalian, Erik, Perry, Jason K.
Published in Bioorganic & medicinal chemistry letters (15.08.2019)
Published in Bioorganic & medicinal chemistry letters (15.08.2019)
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Journal Article
Correction to Discovery of Ledipasvir (GS-5885): A Potent, Once-Daily Oral NS5A Inhibitor for the Treatment of Hepatitis C Virus Infection
Link, John O, Taylor, James G, Xu, Lianhong, Mitchell, Michael, Guo, Hongyan, Liu, Hongtao, Kato, Darryl, Kirschberg, Thorsten, Sun, Jianyu, Squires, Neil, Parrish, Jay, Kellar, Terry, Yang, Zheng-Yu, Yang, Chris, Matles, Mike, Wang, Yujin, Wang, Kelly, Cheng, Guofeng, Tian, Yang, Mogalian, Erik, Mondou, Elsa, Cornpropst, Melanie, Perry, Jason, Desai, Manoj C
Published in Journal of medicinal chemistry (25.08.2016)
Published in Journal of medicinal chemistry (25.08.2016)
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Journal Article
A highly potent long-acting small-molecule HIV-1 capsid inhibitor with efficacy in a humanized mouse model
Yant, Stephen R, Mulato, Andrew, Hansen, Derek, Tse, Winston C, Niedziela-Majka, Anita, Zhang, Jennifer R, Stepan, George J, Jin, Debi, Wong, Melanie H, Perreira, Jill M, Singer, Eric, Papalia, Giuseppe A, Hu, Eric Y, Zheng, Jim, Lu, Bing, Schroeder, Scott D, Chou, Kevin, Ahmadyar, Shekeba, Liclican, Albert, Yu, Helen, Novikov, Nikolai, Paoli, Eric, Gonik, Daniel, Ram, Renee R, Hung, Magdeleine, McDougall, William M, Brass, Abraham L, Sundquist, Wesley I, Cihlar, Tomas, Link, John O
Published in Nature medicine (01.09.2019)
Published in Nature medicine (01.09.2019)
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Journal Article
Lenacapavir Exhibits Atropisomerism - Mechanistic Pharmacokinetics and Disposition Studies of Lenacapavir Reveal Intestinal Excretion as a Major Clearance Pathway
Zheng, Jim, Lu, Bing, Carr, Gavin, Mwangi, Judy, Wang, Kelly, Hao, Jia, Staiger, Kelly MacLennan, Kozon, Nathan, Murray, Bernard P., Bashir, Mohammad, Gohdes, Mark A., Tse, Winston C., Schroeder, Scott, Graupe, Michael, Link, John O., Yoon, Jungjoo, Chiu, Anna, Rowe, William, Smith, Bill J, Subramanian, Raju
Published in The Journal of pharmacology and experimental therapeutics (18.09.2024)
Published in The Journal of pharmacology and experimental therapeutics (18.09.2024)
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Journal Article
A phase 1, randomized, placebo-controlled, 3-day, dose-ranging study of GS-5885, an NS5A inhibitor, in patients with genotype 1 hepatitis C
Lawitz, Eric J, Gruener, Daniel, Hill, John M, Marbury, Thomas, Moorehead, Lisa, Mathias, Anita, Cheng, Guofeng, Link, John O, Wong, Kelly A, Mo, Hongmei, McHutchison, John G, Brainard, Diana M
Published in Journal of hepatology (01.07.2012)
Published in Journal of hepatology (01.07.2012)
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Journal Article
In Vitro Antiviral Activity and Resistance Profile Characterization of the Hepatitis C Virus NS5A Inhibitor Ledipasvir
Cheng, Guofeng, Tian, Yang, Doehle, Brian, Peng, Betty, Corsa, Amoreena, Lee, Yu-Jen, Gong, Ruoyu, Yu, Mei, Han, Bin, Xu, Simin, Dvory-Sobol, Hadas, Perron, Michel, Xu, Yili, Mo, Hongmei, Pagratis, Nikos, Link, John O, Delaney, William
Published in Antimicrobial agents and chemotherapy (01.03.2016)
Published in Antimicrobial agents and chemotherapy (01.03.2016)
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Journal Article
Discovery of Hepatitis B Virus Surface Antigen Suppressor GS-8873
Kato, Darryl, Choy, Regina Wai-Yan, Canales, Eda, Dick, Ryan A., Lake, April D., Shapiro, Nathan D., Chin, Elbert, Li, Jiayao, Zhang, Jennifer R., Wu, Qiaoyin, Saito, Roland D., Metobo, Sammy, Aktoudianakis, Evangelos, Schroeder, Scott D., Yang, Zheng-Yu, Glatt, Dylan M., Balsitis, Scott, Gamelin, Lindsay, Yu, Mei, Cheng, Guofeng, Delaney, William E., Link, John O.
Published in ACS medicinal chemistry letters (11.04.2024)
Published in ACS medicinal chemistry letters (11.04.2024)
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Journal Article
ZIKA 바이러스 감염 치료용 테트라사이클릭 화합물
LINK JOHN O, YANG ZHENG YU, TAYLOR JAMES G, CHIN ELBERT, ROBERTS EZRA
Year of Publication 29.01.2024
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Year of Publication 29.01.2024
Patent
539. GS-CA2: A Novel, Potent, and Selective First-In-class Inhibitor of HIV-1 Capsid Function Displays Nonclinical Pharmacokinetics Supporting Long-Acting Potential in Humans
Zheng, Jim, Yant, Stephen R, Ahmadyar, Shekeba, Chan, Tiffany Y, Chiu, Anna, Cihlar, Tomas, Link, John O, Lu, Bing, Mwangi, Judy, Rowe, William, Schroeder, Scott D, Stepan, George J, Wang, Kelly Wei, Subramanian, Raju, Tse, Winston C
Published in Open forum infectious diseases (26.11.2018)
Published in Open forum infectious diseases (26.11.2018)
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Journal Article
HIV 바이러스 감염 치료용 화합물
KATO DARRYL, WATKINS WILLIAM J, GUNEY TEZCAN, LINK JOHN O, MUN DONG MIN, MACK JAMES B. C, DU ZHIMIN, ZHANG JENNIFER R, FARAND JULIE
Year of Publication 01.08.2024
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Year of Publication 01.08.2024
Patent
HIV THERAPEUTIC COMPOUNDS USEFUL FOR THE PROPHYLACTIC OR THERAPEUTIC TREATMENT OF AN HIV VIRUS INFECTION
STEFANIDIS DIMITRIOS, ROWE CHARLES WILLIAM, SAITO ROLAND D, LINK JOHN O, SCHROEDER SCOTT D, HENRY STEVEN J, TSE WINSTON C, ZHANG JENNIFER R, GRAUPE MICHAEL
Year of Publication 21.05.2024
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Year of Publication 21.05.2024
Patent
HIV 바이러스 감염 치료용 화합물
MACK JAMES B.C, WATKINS WILLIAM J, BRIZGYS GEDIMINAS J, GUNEY TEZCAN, LINK JOHN O, SCHROEDER SCOTT D, CHU HANG, MUN DONG MIN, FARAND JULIE, KATO DARRYL, LI JIAYAO, CHOU CHIENHUNG, WU QIAOYIN, ZHANG JENNIFER R, GRAUPE MICHAEL
Year of Publication 23.07.2024
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Year of Publication 23.07.2024
Patent
HIV 바이러스 감염 치료용 화합물
MACK JAMES B.C, KATO DARRYL, WATKINS WILLIAM J, SAITO ROLAND D, GUNEY TEZCAN, LINK JOHN O, LI JIAYAO, MUN DONG MIN, ZHANG JENNIFER R, GRAUPE MICHAEL, FARAND JULIE
Year of Publication 22.07.2024
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Year of Publication 22.07.2024
Patent