AMP-activated protein kinase selectively inhibited by the type II inhibitor SBI-0206965
Dite, Toby A., Langendorf, Christopher G., Hoque, Ashfaqul, Galic, Sandra, Rebello, Richard J., Ovens, Ashley J., Lindqvist, Lisa M., Ngoei, Kevin R.W., Ling, Naomi X.Y., Furic, Luc, Kemp, Bruce E., Scott, John W., Oakhill, Jonathan S.
Published in The Journal of biological chemistry (08.06.2018)
Published in The Journal of biological chemistry (08.06.2018)
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CaMKK2 is inactivated by cAMP-PKA signaling and 14-3-3 adaptor proteins
Langendorf, Christopher G., O'Brien, Matthew T., Ngoei, Kevin R.W., McAloon, Luke M., Dhagat, Urmi, Hoque, Ashfaqul, Ling, Naomi X.Y., Dite, Toby A., Galic, Sandra, Loh, Kim, Parker, Michael W., Oakhill, Jonathan S., Kemp, Bruce E., Scott, John W.
Published in The Journal of biological chemistry (27.11.2020)
Published in The Journal of biological chemistry (27.11.2020)
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The AMPK activator ATX-304 alters cellular metabolism to protect against cisplatin-induced acute kidney injury
Katerelos, Marina, Gleich, Kurt, Harley, Geoff, Loh, Kim, Oakhill, Jonathan S., Kemp, Bruce E., de Souza, David P., Narayana, Vinod K., Coughlan, Melinda T., Laskowski, Adrienne, Ling, Naomi X.Y., Murray-Segal, Lisa, Brink, Robert, Lee, Mardiana, Power, David A., Mount, Peter F.
Published in Biomedicine & pharmacotherapy (01.06.2024)
Published in Biomedicine & pharmacotherapy (01.06.2024)
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Genetic loss of AMPK-glycogen binding destabilises AMPK and disrupts metabolism
Hoffman, Nolan J., Whitfield, Jamie, Janzen, Natalie R., Belhaj, Mehdi R., Galic, Sandra, Murray-Segal, Lisa, Smiles, William J., Ling, Naomi X.Y., Dite, Toby A., Scott, John W., Oakhill, Jonathan S., Brink, Robert, Kemp, Bruce E., Hawley, John A.
Published in Molecular metabolism (Germany) (01.11.2020)
Published in Molecular metabolism (Germany) (01.11.2020)
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CaMKK2 is not involved in contraction-stimulated AMPK activation and glucose uptake in skeletal muscle
Negoita, Florentina, Addinsall, Alex B., Hellberg, Kristina, Bringas, Conchita Fraguas, Hafen, Paul S., Sermersheim, Tyler J., Agerholm, Marianne, Lewis, Christopher T.A., Ahwazi, Danial, Ling, Naomi X.Y., Larsen, Jeppe K., Deshmukh, Atul S., Hossain, Mohammad A., Oakhill, Jonathan S., Ochala, Julien, Brault, Jeffrey J., Sankar, Uma, Drewry, David H., Scott, John W., Witczak, Carol A., Sakamoto, Kei
Published in Molecular metabolism (Germany) (01.09.2023)
Published in Molecular metabolism (Germany) (01.09.2023)
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Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release
Scott, John W., Galic, Sandra, Graham, Kate L., Foitzik, Richard, Ling, Naomi X.Y., Dite, Toby A., Issa, Samah M.A., Langendorf, Chris G., Weng, Qing Ping, Thomas, Helen E., Kay, Thomas W., Birnberg, Neal C., Steinberg, Gregory R., Kemp, Bruce E., Oakhill, Jonathan S.
Published in Chemistry & biology (18.06.2015)
Published in Chemistry & biology (18.06.2015)
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Personalized phosphoproteomics identifies functional signaling
Needham, Elise J., Hingst, Janne R., Parker, Benjamin L., Morrison, Kaitlin R., Yang, Guang, Onslev, Johan, Kristensen, Jonas M., Højlund, Kurt, Ling, Naomi X. Y., Oakhill, Jonathan S., Richter, Erik A., Kiens, Bente, Petersen, Janni, Pehmøller, Christian, James, David E., Wojtaszewski, Jørgen F. P., Humphrey, Sean J.
Published in Nature biotechnology (01.04.2022)
Published in Nature biotechnology (01.04.2022)
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Phosphoproteomics reveals conserved exercise‐stimulated signaling and AMPK regulation of store‐operated calcium entry
Nelson, Marin E, Parker, Benjamin L, Burchfield, James G, Hoffman, Nolan J, Needham, Elise J, Cooke, Kristen C, Naim, Timur, Sylow, Lykke, Ling, Naomi XY, Francis, Deanne, Norris, Dougall M, Chaudhuri, Rima, Oakhill, Jonathan S, Richter, Erik A, Lynch, Gordon S, Stöckli, Jacqueline, James, David E
Published in The EMBO journal (16.12.2019)
Published in The EMBO journal (16.12.2019)
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Hydralazine protects the heart against acute ischaemia/reperfusion injury by inhibiting Drp1-mediated mitochondrial fission
Kalkhoran, Siavash Beikoghli, Kriston-Vizi, Janos, Hernandez-Resendiz, Sauri, Crespo-Avilan, Gustavo E, Rosdah, Ayeshah A, Lees, Jarmon G, Costa, Joana Rodrigues Simoes Da, Ling, Naomi X Y, Holien, Jessica K, Samangouei, Parisa, Chinda, Kroekkiat, Yap, En Ping, Riquelme, Jaime A, Ketteler, Robin, Yellon, Derek M, Lim, Shiang Y, Hausenloy, Derek J
Published in Cardiovascular research (07.01.2022)
Published in Cardiovascular research (07.01.2022)
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The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs
Dite, Toby A., Ling, Naomi X. Y., Scott, John W., Hoque, Ashfaqul, Galic, Sandra, Parker, Benjamin L., Ngoei, Kevin R. W., Langendorf, Christopher G., O’Brien, Matthew T., Kundu, Mondira, Viollet, Benoit, Steinberg, Gregory R., Sakamoto, Kei, Kemp, Bruce E., Oakhill, Jonathan S.
Published in Nature communications (18.09.2017)
Published in Nature communications (18.09.2017)
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The myokine meteorin‐like (metrnl) improves glucose tolerance in both skeletal muscle cells and mice by targeting AMPKα2
Lee, Jung Ok, Byun, Won Seok, Kang, Min Ju, Han, Jeong Ah, Moon, Jiyoung, Shin, Min‐Jeong, Lee, Ho Jun, Chung, Ji Hyung, Lee, Jin‐Seok, Son, Chang‐Gue, Song, Kwon‐Ho, Kim, Tae Woo, Lee, Eun‐Soo, Kim, Hong Min, Chung, Choon Hee, Ngoei, Kevin R. W., Ling, Naomi X. Y., Oakhill, Jonathan S., Galic, Sandra, Murray‐Segal, Lisa, Kemp, Bruce E., Kim, Kyoung Min, Lim, Soo, Kim, Hyeon Soo
Published in The FEBS journal (01.05.2020)
Published in The FEBS journal (01.05.2020)
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Structure-function analysis of the AMPK activator SC4 and identification of a potent pan AMPK activator
Ovens, Ashley J, Gee, Yi Sing, Ling, Naomi X Y, Yu, Dingyi, Hardee, Justin D, Chung, Jin D, Ngoei, Kevin R W, Waters, Nicholas J, Hoffman, Nolan J, Scott, John W, Loh, Kim, Spengler, Katrin, Heller, Regine, Parker, Michael W, Lynch, Gordon S, Huang, Fei, Galic, Sandra, Kemp, Bruce, Baell, Jonathan, Oakhill, Jonathan S, Langendorf, Christopher G
Published in Biochemical journal (17.06.2022)
Published in Biochemical journal (17.06.2022)
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A novel small molecule inhibitor of human Drp1
Rosdah, Ayeshah A., Abbott, Belinda M., Langendorf, Christopher G., Deng, Yali, Truong, Jia Q., Waddell, Helen M. M., Ling, Naomi X. Y., Smiles, William J., Delbridge, Lea M. D., Liu, Guei-Sheung, Oakhill, Jonathan S., Lim, Shiang Y., Holien, Jessica K.
Published in Scientific reports (13.12.2022)
Published in Scientific reports (13.12.2022)
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Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1 isoforms
Pinkosky, Stephen L, Scott, John W, Desjardins, Eric M, Smith, Brennan K, Day, Emily A, Ford, Rebecca J, Langendorf, Christopher G, Ling, Naomi X Y, Nero, Tracy L, Loh, Kim, Galic, Sandra, Hoque, Ashfaqul, Smiles, William J, Ngoei, Kevin R W, Parker, Michael W, Yan, Yan, Melcher, Karsten, Kemp, Bruce E, Oakhill, Jonathan S, Steinberg, Gregory R
Published in Nature metabolism (01.09.2020)
Published in Nature metabolism (01.09.2020)
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Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding
Langendorf, Christopher G., Ngoei, Kevin R. W., Scott, John W., Ling, Naomi X. Y., Issa, Sam M. A., Gorman, Michael A., Parker, Michael W., Sakamoto, Kei, Oakhill, Jonathan S., Kemp, Bruce E.
Published in Nature communications (08.03.2016)
Published in Nature communications (08.03.2016)
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Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK α2β2γ1 by the Glucose Importagog SC4
Ngoei, Kevin R.W., Langendorf, Christopher G., Ling, Naomi X.Y., Hoque, Ashfaqul, Varghese, Swapna, Camerino, Michelle A., Walker, Scott R., Bozikis, Ylva E., Dite, Toby A., Ovens, Ashley J., Smiles, William J., Jacobs, Roxane, Huang, He, Parker, Michael W., Scott, John W., Rider, Mark H., Foitzik, Richard C., Kemp, Bruce E., Baell, Jonathan B., Oakhill, Jonathan S.
Published in Cell chemical biology (21.06.2018)
Published in Cell chemical biology (21.06.2018)
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mTORC1 directly inhibits AMPK to promote cell proliferation under nutrient stress
Ling, Naomi X Y, Kaczmarek, Adrian, Hoque, Ashfaqul, Davie, Elizabeth, Ngoei, Kevin R W, Morrison, Kaitlin R, Smiles, William J, Forte, Gabriella M, Wang, Tingting, Lie, Shervi, Dite, Toby A, Langendorf, Christopher G, Scott, John W, Oakhill, Jonathan S, Petersen, Janni
Published in Nature metabolism (01.01.2020)
Published in Nature metabolism (01.01.2020)
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An AMPKα2-specific phospho-switch controls lysosomal targeting for activation
Morrison, Kaitlin R., Smiles, William J., Ling, Naomi X.Y., Hoque, Ashfaqul, Shea, Gabrielle, Ngoei, Kevin R.W., Yu, Dingyi, Murray-Segal, Lisa, Scott, John W., Galic, Sandra, Kemp, Bruce.E., Petersen, Janni, Oakhill, Jonathan S.
Published in Cell reports (Cambridge) (15.02.2022)
Published in Cell reports (Cambridge) (15.02.2022)
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Blocking AMPK β1 myristoylation enhances AMPK activity and protects mice from high-fat diet-induced obesity and hepatic steatosis
Neopane, Katyayanee, Kozlov, Natalie, Negoita, Florentina, Murray-Segal, Lisa, Brink, Robert, Hoque, Ashfaqul, Ovens, Ashley J., Tjin, Gavin, McAloon, Luke M., Yu, Dingyi, Ling, Naomi X.Y., Sanders, Matthew J., Oakhill, Jonathan S., Scott, John W., Steinberg, Gregory R., Loh, Kim, Kemp, Bruce E., Sakamoto, Kei, Galic, Sandra
Published in Cell reports (Cambridge) (20.12.2022)
Published in Cell reports (Cambridge) (20.12.2022)
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