Synaptic defects in the spinal and neuromuscular circuitry in a mouse model of spinal muscular atrophy
Ling, Karen K Y, Lin, Ming-Yi, Zingg, Brian, Feng, Zhihua, Ko, Chien-Ping
Published in PloS one (11.11.2010)
Published in PloS one (11.11.2010)
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Journal Article
SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy
Naryshkin, Nikolai A., Weetall, Marla, Dakka, Amal, Narasimhan, Jana, Zhao, Xin, Feng, Zhihua, Ling, Karen K. Y., Karp, Gary M., Qi, Hongyan, Woll, Matthew G., Chen, Guangming, Zhang, Nanjing, Gabbeta, Vijayalakshmi, Vazirani, Priya, Bhattacharyya, Anuradha, Furia, Bansri, Risher, Nicole, Sheedy, Josephine, Kong, Ronald, Ma, Jiyuan, Turpoff, Anthony, Lee, Chang-Sun, Zhang, Xiaoyan, Moon, Young-Choon, Trifillis, Panayiota, Welch, Ellen M., Colacino, Joseph M., Babiak, John, Almstead, Neil G., Peltz, Stuart W., Eng, Loren A., Chen, Karen S., Mull, Jesse L., Lynes, Maureen S., Rubin, Lee L., Fontoura, Paulo, Santarelli, Luca, Haehnke, Daniel, McCarthy, Kathleen D., Schmucki, Roland, Ebeling, Martin, Sivaramakrishnan, Manaswini, Ko, Chien-Ping, Paushkin, Sergey V., Ratni, Hasane, Gerlach, Irene, Ghosh, Anirvan, Metzger, Friedrich
Published in Science (American Association for the Advancement of Science) (08.08.2014)
Published in Science (American Association for the Advancement of Science) (08.08.2014)
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Journal Article
Pharmacologically induced mouse model of adult spinal muscular atrophy to evaluate effectiveness of therapeutics after disease onset
Feng, Zhihua, Ling, Karen K Y, Zhao, Xin, Zhou, Chunyi, Karp, Gary, Welch, Ellen M, Naryshkin, Nikolai, Ratni, Hasane, Chen, Karen S, Metzger, Friedrich, Paushkin, Sergey, Weetall, Marla, Ko, Chien-Ping
Published in Human molecular genetics (01.03.2016)
Published in Human molecular genetics (01.03.2016)
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Journal Article
ATP Acts via P2Y1 Receptors to Stimulate Acetylcholinesterase and Acetylcholine Receptor Expression: Transduction and Transcription Control
Choi, Roy C. Y, Siow, Nina L, Cheng, Anthony W. M, Ling, Karen K. Y, Tung, Edmund K. K, Simon, Joseph, Barnard, Eric A, Tsim, Karl W. K
Published in The Journal of neuroscience (01.06.2003)
Published in The Journal of neuroscience (01.06.2003)
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Journal Article
SMN protein is required throughout life to prevent spinal muscular atrophy disease progression
Zhao, Xin, Feng, Zhihua, Risher, Nicole, Mollin, Anna, Sheedy, Josephine, Ling, Karen K Y, Narasimhan, Jana, Dakka, Amal, Baird, John D, Ratni, Hasane, Lutz, Catherine, Chen, Karen S, Naryshkin, Nikolai A, Ko, Chien-Ping, Welch, Ellen, Metzger, Friedrich, Weetall, Marla
Published in Human molecular genetics (17.12.2021)
Published in Human molecular genetics (17.12.2021)
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Journal Article
Mutant Profilin1 transgenic mice recapitulate cardinal features of motor neuron disease
Fil, Daniel, DeLoach, Abigail, Yadav, Shilpi, Alkam, Duah, MacNicol, Melanie, Singh, Awantika, Compadre, Cesar M, Goellner, Joseph J, O'Brien, Charles A, Fahmi, Tariq, Basnakian, Alexei G, Calingasan, Noel Y, Klessner, Jodi L, Beal, Flint M, Peters, Owen M, Metterville, Jake, Brown, Jr, Robert H, Ling, Karen K Y, Rigo, Frank, Ozdinler, P Hande, Kiaei, Mahmoud
Published in Human molecular genetics (15.02.2017)
Published in Human molecular genetics (15.02.2017)
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Journal Article
Pharmacokinetics, pharmacodynamics, and efficacy of a small-molecule SMN2 splicing modifier in mouse models of spinal muscular atrophy
Zhao, Xin, Feng, Zhihua, Ling, Karen K Y, Mollin, Anna, Sheedy, Josephine, Yeh, Shirley, Petruska, Janet, Narasimhan, Jana, Dakka, Amal, Welch, Ellen M, Karp, Gary, Chen, Karen S, Metzger, Friedrich, Ratni, Hasane, Lotti, Francesco, Tisdale, Sarah, Naryshkin, Nikolai A, Pellizzoni, Livio, Paushkin, Sergey, Ko, Chien-Ping, Weetall, Marla
Published in Human molecular genetics (15.05.2016)
Published in Human molecular genetics (15.05.2016)
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Journal Article
Pathological impact of SMN2 mis‐splicing in adult SMA mice
Sahashi, Kentaro, Ling, Karen K. Y., Hua, Yimin, Wilkinson, John Erby, Nomakuchi, Tomoki, Rigo, Frank, Hung, Gene, Xu, David, Jiang, Ya‐Ping, Lin, Richard Z., Ko, Chien‐Ping, Bennett, C. Frank, Krainer, Adrian R.
Published in EMBO molecular medicine (01.10.2013)
Published in EMBO molecular medicine (01.10.2013)
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Journal Article
TSUNAMI: an antisense method to phenocopy splicing-associated diseases in animals
Sahashi, Kentaro, Hua, Yimin, Ling, Karen K Y, Hung, Gene, Rigo, Frank, Horev, Guy, Katsuno, Masahisa, Sobue, Gen, Ko, Chien-Ping, Bennett, C Frank, Krainer, Adrian R
Published in Genes & development (15.08.2012)
Published in Genes & development (15.08.2012)
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Journal Article
Transcriptional control of different acetylcholinesterase subunits in formation and maintenance of vertebrate neuromuscular junctions
Tsim, Karl W K, Xie, Heidi Q H, Ting, Annie K L, Siow, Nina L, Ling, Karen K Y, Kong, Ling W
Published in Journal of molecular neuroscience (01.01.2006)
Published in Journal of molecular neuroscience (01.01.2006)
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Journal Article
Pathological impact of SMN 2 mis‐splicing in adult SMA mice
Sahashi, Kentaro, Ling, Karen K. Y., Hua, Yimin, Wilkinson, John Erby, Nomakuchi, Tomoki, Rigo, Frank, Hung, Gene, Xu, David, Jiang, Ya‐Ping, Lin, Richard Z., Ko, Chien‐Ping, Bennett, C. Frank, Krainer, Adrian R.
Published in EMBO molecular medicine (01.10.2013)
Published in EMBO molecular medicine (01.10.2013)
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Journal Article
P2Y2 Receptor Activation Regulates the Expression of Acetylcholinesterase and Acetylcholine Receptor Genes at Vertebrate Neuromuscular Junctions
Tung, Edmund K K, Choi, Roy C Y, Siow, Nina L, Jiang, Joy X S, Ling, Karen K Y, Simon, Joseph, Barnard, Eric A, Tsim, Karl W K
Published in Molecular pharmacology (01.10.2004)
Published in Molecular pharmacology (01.10.2004)
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Journal Article
Expression of the P2Y1 Nucleotide Receptor in Chick Muscle: Its Functional Role in the Regulation of Acetylcholinesterase and Acetylcholine Receptor
Choi, Roy C. Y, Man, Menlisa L. S, Ling, Karen K. Y, Ip, Nancy Y, Simon, Joseph, Barnard, Eric A, Tsim, Karl W. K
Published in The Journal of neuroscience (01.12.2001)
Published in The Journal of neuroscience (01.12.2001)
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Journal Article
Corrigendum to: Pharmacologically-induced mouse model of adult spinal muscular atrophy to evaluate effectiveness of therapeutics after disease onset
Feng, Zhihua, Ling, Karen K Y, Zhao, Xin, Zhou, Chunyi, Karp, Gary, Welch, Ellen M, Naryshkin, Nikolai, Ratni, Hasane, Chen, Karen S, Metzger, Friedrich, Paushkin, Sergey, Weetall, Marla, Ko, Chien-Ping
Published in Human molecular genetics (28.05.2021)
Published in Human molecular genetics (28.05.2021)
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Journal Article
Minor snRNA gene delivery improves the loss of proprioceptive synapses on SMA motor neurons
Osman, Erkan Y, Van Alstyne, Meaghan, Yen, Pei-Fen, Lotti, Francesco, Feng, Zhihua, Ling, Karen Ky, Ko, Chien-Ping, Pellizzoni, Livio, Lorson, Christian L
Published in JCI insight (18.06.2020)
Published in JCI insight (18.06.2020)
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Journal Article
ATP potentiates the formation of AChR aggregate in the co-culture of NG108-15 cells with C2C12 myotubes
Ling, Karen K.Y., Siow, Nina L., Choi, Roy C.Y., Tsim, Karl W.K.
Published in FEBS letters (25.04.2005)
Published in FEBS letters (25.04.2005)
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Journal Article
ATP induces post-synaptic gene expressions in vertebrate skeletal neuromuscular junctions
Tsim, Karl W K, Choi, Roy C Y, Siow, Nina L, Cheng, Anthony W M, Ling, Karen K Y, Jiang, Joy X S, Tung, Edmund K K, Lee, Henry H C, Xie, Qun H, Simon, Joseph, Barnard, Eric A
Published in Journal of neurocytology (01.06.2003)
Published in Journal of neurocytology (01.06.2003)
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Journal Article
Motor neuron disease. SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy
Naryshkin, Nikolai A, Weetall, Marla, Dakka, Amal, Narasimhan, Jana, Zhao, Xin, Feng, Zhihua, Ling, Karen K Y, Karp, Gary M, Qi, Hongyan, Woll, Matthew G, Chen, Guangming, Zhang, Nanjing, Gabbeta, Vijayalakshmi, Vazirani, Priya, Bhattacharyya, Anuradha, Furia, Bansri, Risher, Nicole, Sheedy, Josephine, Kong, Ronald, Ma, Jiyuan, Turpoff, Anthony, Lee, Chang-Sun, Zhang, Xiaoyan, Moon, Young-Choon, Trifillis, Panayiota, Welch, Ellen M, Colacino, Joseph M, Babiak, John, Almstead, Neil G, Peltz, Stuart W, Eng, Loren A, Chen, Karen S, Mull, Jesse L, Lynes, Maureen S, Rubin, Lee L, Fontoura, Paulo, Santarelli, Luca, Haehnke, Daniel, McCarthy, Kathleen D, Schmucki, Roland, Ebeling, Martin, Sivaramakrishnan, Manaswini, Ko, Chien-Ping, Paushkin, Sergey V, Ratni, Hasane, Gerlach, Irene, Ghosh, Anirvan, Metzger, Friedrich
Published in Science (American Association for the Advancement of Science) (08.08.2014)
Published in Science (American Association for the Advancement of Science) (08.08.2014)
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Journal Article
ATP potentiates agrin-induced AChR aggregation in cultured myotubes: activation of RhoA in P2Y1 nucleotide receptor signaling at vertebrate neuromuscular junctions
Ling, Karen K Y, Siow, Nina L, Choi, Roy C Y, Ting, Annie K L, Kong, Ling W, Tsim, Karl W K
Published in The Journal of biological chemistry (23.07.2004)
Published in The Journal of biological chemistry (23.07.2004)
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