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Alagramam, Kumar N, Gopal, Suhasini R, Geng, Ruishuang, Chen, Daniel H-C, Nemet, Ina, Lee, Richard, Tian, Guilian, Miyagi, Masaru, Malagu, Karine F, Lock, Christopher J, Esmieu, William R K, Owens, Andrew P, Lindsay, Nicola A, Ouwehand, Krista, Albertus, Faywell, Fischer, David F, Bürli, Roland W, MacLeod, Angus M, Harte, William E, Palczewski, Krzysztof, Imanishi, Yoshikazu
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Published in Nature chemical biology (01.06.2016)
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Optimization of permeability in a series of pyrrolotriazine inhibitors of IRAK4
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Published in Bioorganic & medicinal chemistry (15.02.2018)
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Discovery of a Series of 5‑Azaquinazolines as Orally Efficacious IRAK4 Inhibitors Targeting MyD88L265P Mutant Diffuse Large B Cell Lymphoma
Degorce, Sébastien L, Anjum, Rana, Bloecher, Andrew, Carbajo, Rodrigo J, Dillman, Keith S, Drew, Lisa, Halsall, Christopher T, Lenz, Eva M, Lindsay, Nicola A, Mayo, Michele F, Pink, Jennifer H, Robb, Graeme R, Rosen, Alan, Scott, James S, Xue, Yafeng
Published in Journal of medicinal chemistry (14.11.2019)
Published in Journal of medicinal chemistry (14.11.2019)
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Journal Article
Discovery of a Series of 5-Azaquinazolines as Orally Efficacious IRAK4 Inhibitors Targeting MyD88 L265P Mutant Diffuse Large B Cell Lymphoma
Degorce, Sébastien L, Anjum, Rana, Bloecher, Andrew, Carbajo, Rodrigo J, Dillman, Keith S, Drew, Lisa, Halsall, Christopher T, Lenz, Eva M, Lindsay, Nicola A, Mayo, Michele F, Pink, Jennifer H, Robb, Graeme R, Rosen, Alan, Scott, James S, Xue, Yafeng
Published in Journal of medicinal chemistry (14.11.2019)
Published in Journal of medicinal chemistry (14.11.2019)
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Discovery and Optimization of Pyrrolopyrimidine Inhibitors of Interleukin-1 Receptor Associated Kinase 4 (IRAK4) for the Treatment of Mutant MYD88 L265P Diffuse Large B-Cell Lymphoma
Scott, James S, Degorce, Sébastien L, Anjum, Rana, Culshaw, Janet, Davies, Robert D M, Davies, Nichola L, Dillman, Keith S, Dowling, James E, Drew, Lisa, Ferguson, Andrew D, Groombridge, Sam D, Halsall, Christopher T, Hudson, Julian A, Lamont, Scott, Lindsay, Nicola A, Marden, Stacey K, Mayo, Michele F, Pease, J Elizabeth, Perkins, David R, Pink, Jennifer H, Robb, Graeme R, Rosen, Alan, Shen, Minhui, McWhirter, Claire, Wu, Dedong
Published in Journal of medicinal chemistry (28.12.2017)
Published in Journal of medicinal chemistry (28.12.2017)
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Journal Article
Discovery and Optimization of Pyrrolopyrimidine Inhibitors of Interleukin‑1 Receptor Associated Kinase 4 (IRAK4) for the Treatment of Mutant MYD88L265P Diffuse Large B‑Cell Lymphoma
Scott, James S, Degorce, Sébastien L, Anjum, Rana, Culshaw, Janet, Davies, Robert D. M, Davies, Nichola L, Dillman, Keith S, Dowling, James E, Drew, Lisa, Ferguson, Andrew D, Groombridge, Sam D, Halsall, Christopher T, Hudson, Julian A, Lamont, Scott, Lindsay, Nicola A, Marden, Stacey K, Mayo, Michele F, Pease, J. Elizabeth, Perkins, David R, Pink, Jennifer H, Robb, Graeme R, Rosen, Alan, Shen, Minhui, McWhirter, Claire, Wu, Dedong
Published in Journal of medicinal chemistry (28.12.2017)
Published in Journal of medicinal chemistry (28.12.2017)
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Journal Article
Discovery and Optimization of Pyrrolopyrimidine Inhibitors of Interleukin-1 Receptor Associated Kinase 4 (IRAK4) for the Treatment of Mutant MYD88(L265P) Diffuse Large B-Cell Lymphoma
Scott, James S., Degorce, Sebastien L., Anjum, Rana, Culshaw, Janet, Davies, Robert D. M., Davies, Nichola L., Dillman, Keith S., Dowling, James E., Drew, Lisa, Ferguson, Andrew D., Groombridge, Sam D., Halsall, Christopher T., Hudson, Julian A., Lamont, Scott, Lindsay, Nicola A., Marden, Stacey K., Mayo, Michele F., Pease, J. Elizabeth, Perkins, David R., Pink, Jennifer H., Robb, Graeme R., Rosen, Alan, Shen, Minhui, McWhirter, Claire, Wu, Dedong
Published in Journal of medicinal chemistry (28.12.2017)
Published in Journal of medicinal chemistry (28.12.2017)
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Journal Article
Discovery of a Series of 5-Azaquinazolines as Orally Efficacious IRAK4 Inhibitors Targeting MyD88(L265P) Mutant Diffuse Large B Cell Lymphoma
Degorce, Sebastien L., Anjum, Rana, Bloecher, Andrew, Carbajo, Rodrigo J., Dillman, Keith S., Drew, Lisa, Halsall, Christopher T., Lenz, Eva M., Lindsay, Nicola A., Mayo, Michele F., Pink, Jennifer H., Robb, Graeme R., Rosen, Alan, Scott, James S., Xue, Yafeng
Published in Journal of medicinal chemistry (14.11.2019)
Published in Journal of medicinal chemistry (14.11.2019)
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