Proteasome-associated deubiquitinases and cancer
Mofers, Arjan, Pellegrini, Paola, Linder, Stig, D’Arcy, Pádraig
Published in Cancer and metastasis reviews (01.12.2017)
Published in Cancer and metastasis reviews (01.12.2017)
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Targeting Mitochondria for Treatment of Chemoresistant Ovarian Cancer
Emmings, Edith, Mullany, Sally, Chang, Zenas, Landen, Jr, Charles N, Linder, Stig, Bazzaro, Martina
Published in International journal of molecular sciences (01.01.2019)
Published in International journal of molecular sciences (01.01.2019)
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A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance
Tian, Ze, D'Arcy, Padraig, Wang, Xin, Ray, Arghya, Tai, Yu-Tzu, Hu, Yiguo, Carrasco, Ruben D., Richardson, Paul, Linder, Stig, Chauhan, Dharminder, Anderson, Kenneth C.
Published in Blood (30.01.2014)
Published in Blood (30.01.2014)
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Inhibition of proteasome deubiquitinating activity as a new cancer therapy
D'Arcy, Pádraig, Brnjic, Slavica, Olofsson, Maria Hägg, Fryknäs, Mårten, Lindsten, Kristina, De Cesare, Michelandrea, Perego, Paola, Sadeghi, Behnam, Hassan, Moustapha, Larsson, Rolf, Linder, Stig
Published in Nature medicine (01.12.2011)
Published in Nature medicine (01.12.2011)
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Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy
Stafford, William C, Peng, Xiaoxiao, Olofsson, Maria Hägg, Zhang, Xiaonan, Luci, Diane K, Lu, Li, Cheng, Qing, Trésaugues, Lionel, Dexheimer, Thomas S, Coussens, Nathan P, Augsten, Martin, Ahlzén, Hanna-Stina Martinsson, Orwar, Owe, Östman, Arne, Stone-Elander, Sharon, Maloney, David J, Jadhav, Ajit, Simeonov, Anton, Linder, Stig, Arnér, Elias S J
Published in Science translational medicine (14.02.2018)
Published in Science translational medicine (14.02.2018)
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Three-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer
Senkowski, Wojciech, Zhang, Xiaonan, Olofsson, Maria Hägg, Isacson, Ruben, Höglund, Urban, Gustafsson, Mats, Nygren, Peter, Linder, Stig, Larsson, Rolf, Fryknäs, Mårten
Published in Molecular cancer therapeutics (01.06.2015)
Published in Molecular cancer therapeutics (01.06.2015)
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The proteasome deubiquitinase inhibitor VLX1570 shows selectivity for ubiquitin-specific protease-14 and induces apoptosis of multiple myeloma cells
Wang, Xin, Mazurkiewicz, Magdalena, Hillert, Ellin-Kristina, Olofsson, Maria Hägg, Pierrou, Stefan, Hillertz, Per, Gullbo, Joachim, Selvaraju, Karthik, Paulus, Aneel, Akhtar, Sharoon, Bossler, Felicitas, Khan, Asher Chanan, Linder, Stig, D’Arcy, Padraig
Published in Scientific reports (06.06.2016)
Published in Scientific reports (06.06.2016)
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Phase 1 study of the protein deubiquitinase inhibitor VLX1570 in patients with relapsed and/or refractory multiple myeloma
Rowinsky, Eric K., Paner, Agne, Berdeja, Jesus G., Paba-Prada, Claudia, Venugopal, Parameswaran, Porkka, Kimmo, Gullbo, Joachim, Linder, Stig, Loskog, Angelica, Richardson, Paul G., Landgren, Ola
Published in Investigational new drugs (01.10.2020)
Published in Investigational new drugs (01.10.2020)
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Identification of proteasome inhibitors using analysis of gene expression profiles
Mofers, Arjan, Selvaraju, Karthik, Gubat, Johannes, D'Arcy, Padraig, Linder, Stig
Published in European journal of pharmacology (15.12.2020)
Published in European journal of pharmacology (15.12.2020)
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Journal Article
Autophagy Is a Protective Mechanism for Human Melanoma Cells under Acidic Stress
Marino, Maria Lucia, Pellegrini, Paola, Di Lernia, Giuseppe, Djavaheri-Mergny, Mojgan, Brnjic, Slavica, Zhang, Xiaonan, Hägg, Maria, Linder, Stig, Fais, Stefano, Codogno, Patrice, De Milito, Angelo
Published in The Journal of biological chemistry (31.08.2012)
Published in The Journal of biological chemistry (31.08.2012)
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Proteasome inhibitor b-AP15 induces enhanced proteotoxicity by inhibiting cytoprotective aggresome formation
Hillert, Ellin-Kristina, Brnjic, Slavica, Zhang, Xiaonan, Mazurkiewicz, Magdalena, Saei, Amir Ata, Mofers, Arjan, Selvaraju, Karthik, Zubarev, Roman, Linder, Stig, D'Arcy, Padraig
Published in Cancer letters (28.04.2019)
Published in Cancer letters (28.04.2019)
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The deubiquitinase inhibitor b-AP15 induces strong proteotoxic stress and mitochondrial damage
Zhang, Xiaonan, Pellegrini, Paola, Saei, Amir Ata, Hillert, Ellin-Kristina, Mazurkiewicz, Magdalena, Olofsson, Maria Hägg, Zubarev, Roman A., D'Arcy, Pádraig, Linder, Stig
Published in Biochemical pharmacology (01.10.2018)
Published in Biochemical pharmacology (01.10.2018)
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Pharmacokinetics and Toxicity of Sodium Selenite in the Treatment of Patients with Carcinoma in a Phase I Clinical Trial: The SECAR Study
Brodin, Ola, Eksborg, Staffan, Wallenberg, Marita, Asker-Hagelberg, Charlotte, Larsen, Erik H, Mohlkert, Dag, Lenneby-Helleday, Clara, Jacobsson, Hans, Linder, Stig, Misra, Sougat, Björnstedt, Mikael
Published in Nutrients (19.06.2015)
Published in Nutrients (19.06.2015)
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Pseudomonas aeruginosa N-3-Oxo-Dodecanoyl-Homoserine Lactone Impacts Mitochondrial Networks Morphology, Energetics, and Proteome in Host Cells
Josephson, Henrik, Ntzouni, Maria, Skoglund, Camilla, Linder, Stig, Turkina, Maria V., Vikström, Elena
Published in Frontiers in microbiology (25.05.2020)
Published in Frontiers in microbiology (25.05.2020)
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Analysis of determinants for in vitro resistance to the small molecule deubiquitinase inhibitor b-AP15
Mofers, Arjan, Perego, Paola, Selvaraju, Karthik, Gatti, Laura, Gullbo, Joachim, Linder, Stig, D'Arcy, Padraig
Published in PloS one (22.10.2019)
Published in PloS one (22.10.2019)
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Cisplatin Induces Endoplasmic Reticulum Stress and Nucleus-independent Apoptotic Signaling
Mandic, Aleksandra, Hansson, Johan, Linder, Stig, Shoshan, Maria C
Published in The Journal of biological chemistry (14.03.2003)
Published in The Journal of biological chemistry (14.03.2003)
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Corrigendum: Antiproliferative effects of the natural oxadiazine Nocuolin A are associated with impairment of mitochondrial oxidative phosphorylation
Sousa, Maria Lígia, Preto, Marco, Vasconcelos, Vítor, Linder, Stig, Urbatzka, Ralph
Published in Frontiers in oncology (2023)
Published in Frontiers in oncology (2023)
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Induction of ER Stress in Acute Lymphoblastic Leukemia Cells by the Deubiquitinase Inhibitor VLX1570
Pellegrini, Paola, Selvaraju, Karthik, Faustini, Elena, Mofers, Arjan, Zhang, Xiaonan, Ternerot, Jens, Schubert, Alice, Linder, Stig, D Arcy, Pádraig
Published in International journal of molecular sciences (04.07.2020)
Published in International journal of molecular sciences (04.07.2020)
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