IKs inhibitor JNJ303 prolongs the QT interval and perpetuates arrhythmia when combined with enhanced inotropy in the CAVB dog
van Bavel, Joanne J.A., Beekman, Henriëtte D.M., van Weperen, Valerie Y.H., van der Linde, Henk J., van der Heyden, Marcel A.G., Vos, Marc A.
Published in European journal of pharmacology (15.10.2022)
Published in European journal of pharmacology (15.10.2022)
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Journal Article
The Potential Mechanisms behind Loperamide-Induced Cardiac Arrhythmias Associated with Human Abuse and Extreme Overdose
Lu, Hua Rong, Damiano, Bruce P, Kreir, Mohamed, Rohrbacher, Jutta, van der Linde, Henk, Saidov, Tamerlan, Teisman, Ard, Gallacher, David J
Published in Biomolecules (Basel, Switzerland) (01.09.2023)
Published in Biomolecules (Basel, Switzerland) (01.09.2023)
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Characterization of an anesthetized dog model of transient cardiac ischemia and rapid pacing: A pilot study for preclinical assessment of the potential for proarrhythmic risk of novel drug candidates
Damiano, Bruce P., van der Linde, Henk J., Van Deuren, Bruno, Somers, Yves, Lubomirski, Mariusz, Teisman, Ard, Gallacher, David J.
Published in Journal of pharmacological and toxicological methods (01.03.2015)
Published in Journal of pharmacological and toxicological methods (01.03.2015)
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Journal Article
Interventricular Differences in β‐Adrenergic Responses in the Canine Heart: Role of Phosphodiesterases
Molina, Cristina E., Johnson, Daniel M., Mehel, Hind, Spätjens, Roel L. H. M. G., Mika, Delphine, Algalarrondo, Vincent, Slimane, Zeineb Haj, Lechêne, Patrick, Abi‐Gerges, Najah, Linde, Henk J., Leroy, Jérôme, Volders, Paul G. A., Fischmeister, Rodolphe, Vandecasteele, Grégoire
Published in Journal of the American Heart Association (05.06.2014)
Published in Journal of the American Heart Association (05.06.2014)
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Journal Article
Blockade of the IKs potassium channel: An overlooked cardiovascular liability in drug safety screening?
Towart, Rob, Linders, Joannes T.M., Hermans, An N., Rohrbacher, Jutta, van der Linde, Henk J., Ercken, Martine, Cik, Miroslav, Roevens, Peter, Teisman, Ard, Gallacher, David J.
Published in Journal of pharmacological and toxicological methods (01.07.2009)
Published in Journal of pharmacological and toxicological methods (01.07.2009)
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Journal Article
The fentanyl/etomidate-anaesthetised beagle (FEAB) dog: A versatile in vivo model in Cardiovascular Safety Research
Van Deuren, Bruno, Van Ammel, Karel, Somers, Yves, Cools, Frank, Straetemans, Roel, van der Linde, Henk J., Gallacher, David J.
Published in Journal of pharmacological and toxicological methods (01.07.2009)
Published in Journal of pharmacological and toxicological methods (01.07.2009)
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Journal Article
The FEAB dog-model: Now within reach for everyone
van der Linde, Henk J., Van Deuren, Bruno, Somers, Yves, Teisman, Ard, Gallacher, David J.
Published in Journal of pharmacological and toxicological methods (01.07.2011)
Published in Journal of pharmacological and toxicological methods (01.07.2011)
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Journal Article
Fatal attraction: Exploring the potential value of “attractors” to identify new arrhythmic biomarkers in safety pharmacology
Van Ammel, Karel, Van der Linde, Henk, Nandi, Manasi, Aston, Philip, Teisman, Ard, Gallacher, David J.
Published in Journal of pharmacological and toxicological methods (01.09.2020)
Published in Journal of pharmacological and toxicological methods (01.09.2020)
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Journal Article
B-AB01-03 HIGH-RESOLUTION REAL-TIME LEFT-VENTRICULAR ENDOCARDIAL ACTIVATION-REPOLARIZATION MAPPING IN AN IN-VIVO CANINE MODEL OF DRUG-INDUCED LONG-QT 1 SYNDROME AND TORSADES DE POINTES
ter Bekke, Rachel M.A., Angel, Nathan, Vanderper, Annelies, Corvi, Tim, Gallacher, David J., van der Linde, Henk J., Volders, Paul G.A.
Published in Heart rhythm (01.08.2021)
Published in Heart rhythm (01.08.2021)
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Journal Article
Factors that determine acetylcholine responsiveness of guinea pig tracheal tubes
Folkerts, Gert, Kloek, Joris, Geppetti, Pierangelo, Van der Linde, Henk J, Nijkamp, Frans P
Published in European journal of pharmacology (25.05.2001)
Published in European journal of pharmacology (25.05.2001)
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Journal Article
Virus- and bradykinin-induced airway hyperresponsiveness in guinea pigs
Folkerts, G, Vlieger, J W, de Vries, A, Faas, S, van Der Linde, H, Engels, F, de Jong, J C, Verheyen, F A, Van Heuven-Nolsen, D, Nijkamp, F P
Published in American journal of respiratory and critical care medicine (01.05.2000)
Published in American journal of respiratory and critical care medicine (01.05.2000)
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Journal Article
Diastolic Spontaneous Calcium Release From the Sarcoplasmic Reticulum Increases Beat-to-Beat Variability of Repolarization in Canine Ventricular Myocytes After β-Adrenergic Stimulation
Johnson, Daniel M, Heijman, Jordi, Bode, Elizabeth F, Greensmith, David J, van der Linde, Henk, Abi-Gerges, Najah, Eisner, David A, Trafford, Andrew W, Volders, Paul G.A
Published in Circulation research (18.01.2013)
Published in Circulation research (18.01.2013)
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Journal Article
Is iCEB a universal proarrhythmic biomarker covering TdP to non-TdP arrhythmias? A comparison against existing biomarkers
Urmaliya, Vijay, van der Linde, Henk, Lu, Hua Rong, Van Ammel, Karel, Teisman, Ard, Gallacher, David J.
Published in Journal of pharmacological and toxicological methods (01.09.2018)
Published in Journal of pharmacological and toxicological methods (01.09.2018)
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Journal Article
In vitro cell-based assays to predict drug-induced seizure liability: Rat or human cells?
Kreir, Mohamed, Van Deuren, Bruno, Versweyveld, Sophie, van der Linde, Henk, Lu, Hua Rong, Teuns, Greet, Gallacher, David J.
Published in Journal of pharmacological and toxicological methods (01.09.2018)
Published in Journal of pharmacological and toxicological methods (01.09.2018)
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Journal Article
An integrated translational analysis summary: Prediction of HERG, isolated wedge preparation, anaesthetized guinea pig and dog towards phase I clinical data for drugs with different QT/TdP risk categories
Urmaliya, Vijay, Van Ammel, Karel, Rohrbacher, Jutta, van der Linde, Henk, Lu, Hua Rong, Jansen, Hanne, Gallacher, David J., Teisman, Ard
Published in Journal of pharmacological and toxicological methods (01.09.2019)
Published in Journal of pharmacological and toxicological methods (01.09.2019)
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Journal Article
Translational research: What can we learn from the predictability of anesthetized guinea-pig and dog models for cardiovascular safety findings in man?
Jansen, Hanne, Urmaliya, Vijay, Van Ammel, Karel, van der Linde, Henk, Rohrbacher, Jutta, Teisman, Ard, Gallacher, David J.
Published in Journal of pharmacological and toxicological methods (01.09.2019)
Published in Journal of pharmacological and toxicological methods (01.09.2019)
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