Late-Stage C(sp 2)–C(sp 3) Diversification via Nickel Oxidative Addition Complexes
Odena, Carlota, Santiago, Tomás G., Linares, María Lourdes, Castellanos-Blanco, Nahury, McGuire, Ryan T., Chaves-Arquero, Belén, Alonso, Jose Manuel, Diéguez-Vázquez, Alejandro, Tan, Eric, Alcázar, Jesús, Buijnsters, Peter, Cañellas, Santiago, Martin, Ruben
Published in Journal of the American Chemical Society (07.08.2024)
Published in Journal of the American Chemical Society (07.08.2024)
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Flow chemistry as a tool to access novel chemical space for drug discovery
López, Enol, Linares, María Lourdes, Alcázar, Jesús
Published in Future medicinal chemistry (01.09.2020)
Published in Future medicinal chemistry (01.09.2020)
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Discovery of 3‑Cyclopropylmethyl-7-(4-phenylpiperidin-1-yl)-8-trifluoromethyl[1,2,4]triazolo[4,3‑a]pyridine (JNJ-42153605): A Positive Allosteric Modulator of the Metabotropic Glutamate 2 Receptor
Cid, Jose María, Tresadern, Gary, Vega, Juan Antonio, de Lucas, Ana Isabel, Matesanz, Encarnación, Iturrino, Laura, Linares, María Lourdes, Garcia, Aránzazu, Andrés, José Ignacio, Macdonald, Gregor J, Oehlrich, Daniel, Lavreysen, Hilde, Megens, Anton, Ahnaou, Abdellah, Drinkenburg, Wilhelmus, Mackie, Claire, Pype, Stefan, Gallacher, David, Trabanco, Andrés A
Published in Journal of medicinal chemistry (25.10.2012)
Published in Journal of medicinal chemistry (25.10.2012)
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Discovery of 8‑Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3‑a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM)
Cid, Jose María, Tresadern, Gary, Vega, Juan Antonio, de Lucas, Ana Isabel, del Cerro, Alcira, Matesanz, Encarnación, Linares, María Lourdes, García, Aránzazu, Iturrino, Laura, Pérez-Benito, Laura, Macdonald, Gregor J, Oehlrich, Daniel, Lavreysen, Hilde, Peeters, Luc, Ceusters, Marc, Ahnaou, Abdellah, Drinkenburg, Wilhelmus, Mackie, Claire, Somers, Marijke, Trabanco, Andrés A
Published in Journal of medicinal chemistry (22.09.2016)
Published in Journal of medicinal chemistry (22.09.2016)
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Imidazo[1,2-a]pyridines: Orally Active Positive Allosteric Modulators of the Metabotropic Glutamate 2 Receptor
Trabanco, Andrés A, Tresadern, Gary, Macdonald, Gregor J, Vega, Juan Antonio, de Lucas, Ana Isabel, Matesanz, Encarnación, García, Aránzazu, Linares, María Lourdes, Alonso de Diego, Sergio A, Alonso, José Manuel, Oehlrich, Daniel, Ahnaou, Abdelah, Drinkenburg, Wilhelmus, Mackie, Claire, Andrés, José Ignacio, Lavreysen, Hilde, Cid, José María
Published in Journal of medicinal chemistry (22.03.2012)
Published in Journal of medicinal chemistry (22.03.2012)
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Discovery of 1‑Butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)‑pyridone (JNJ-40411813): A Novel Positive Allosteric Modulator of the Metabotropic Glutamate 2 Receptor
Cid, José María, Tresadern, Gary, Duvey, Guillaume, Lütjens, Robert, Finn, Terry, Rocher, Jean-Philippe, Poli, Sonia, Vega, Juan Antonio, de Lucas, Ana Isabel, Matesanz, Encarnación, Linares, María Lourdes, Andrés, José Ignacio, Alcazar, Jesús, Alonso, José Manuel, Macdonald, Gregor J, Oehlrich, Daniel, Lavreysen, Hilde, Ahnaou, Abdelah, Drinkenburg, Wilhelmus, Mackie, Claire, Pype, Stefan, Gallacher, David, Trabanco, Andrés A
Published in Journal of medicinal chemistry (14.08.2014)
Published in Journal of medicinal chemistry (14.08.2014)
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Discovery of 1,4-Disubstituted 3-Cyano-2-pyridones: A New Class of Positive Allosteric Modulators of the Metabotropic Glutamate 2 Receptor
Cid, Jose María, Duvey, Guillaume, Tresadern, Gary, Nhem, Vanthea, Furnari, Rocco, Cluzeau, Philippe, Vega, Juan Antonio, de Lucas, Ana Isabel, Matesanz, Encarnación, Alonso, José Manuel, Linares, María Lourdes, Andrés, José Ignacio, Poli, Sonia M, Lutjens, Robert, Himogai, Hassan, Rocher, Jean-Philippe, Macdonald, Gregor J, Oehlrich, Daniel, Lavreysen, Hilde, Ahnaou, Abdelah, Drinkenburg, Wilhelmus, Mackie, Claire, Trabanco, Andrés A
Published in Journal of medicinal chemistry (08.03.2012)
Published in Journal of medicinal chemistry (08.03.2012)
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Scaffold Hopping to Imidazo[1,2‑a]pyrazin-8-one Positive Allosteric Modulators of Metabotropic Glutamate 2 Receptor
de Lucas, Ana I, Vega, Juan A, García Molina, Aránzazu, Linares, María Lourdes, Tresadern, Gary, Lavreysen, Hilde, Oehlrich, Daniel, Trabanco, Andrés A, Cid, José M
Published in ACS omega (07.09.2021)
Published in ACS omega (07.09.2021)
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Discovery of 1,5-Disubstituted Pyridones: A New Class of Positive Allosteric Modulators of the Metabotropic Glutamate 2 Receptor
Cid, Jose María, Duvey, Guillaume, Cluzeau, Philippe, Nhem, Vanthea, Macary, Karim, Raux, Alexandre, Poirier, Nicolas, Muller, Jessica, Boléa, Christelle, Finn, Terry, Poli, Sonia, Epping-Jordan, Mark, Chamelot, Emilie, Derouet, Francis, Girard, Francoise, Macdonald, Gregor J, Vega, Juan Antonio, de Lucas, Ana Isabel, Matesanz, Encarnación, Lavreysen, Hilde, Linares, María Lourdes, Oehlrich, Daniel, Oyarzábal, Julen, Tresadern, Gary, Trabanco, Andrés A, Andrés, Jose Ignacio, Le Poul, Emmanuel, Imogai, Hassan, Lutjens, Robert, Rocher, Jean-Philippe
Published in ACS chemical neuroscience (15.12.2010)
Published in ACS chemical neuroscience (15.12.2010)
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Scaffold hopping from pyridones to imidazo[1,2- a]pyridines. New positive allosteric modulators of metabotropic glutamate 2 receptor
Tresadern, Gary, Cid, Jose María, Macdonald, Gregor J., Vega, Juan Antonio, de Lucas, Ana Isabel, García, Aránzazu, Matesanz, Encarnación, Linares, María Lourdes, Oehlrich, Daniel, Lavreysen, Hilde, Biesmans, Ilse, Trabanco, Andrés A.
Published in Bioorganic & medicinal chemistry letters (2010)
Published in Bioorganic & medicinal chemistry letters (2010)
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Spiro-oxindole Piperidines and 3‑(Azetidin-3-yl)‑1H‑benzimidazol-2-ones as mGlu2 Receptor PAMs
de Lucas, Ana Isabel, Vega, Juan Antonio, Matesanz, Encarnación, Linares, María Lourdes, García Molina, Aránzazu, Tresadern, Gary, Lavreysen, Hilde, Trabanco, Andrés A, Cid, José María
Published in ACS medicinal chemistry letters (12.03.2020)
Published in ACS medicinal chemistry letters (12.03.2020)
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Discovery of 6,7-Dihydropyrazolo1,5-apyrazin-4(5H)-one Derivatives as mGluR2 Negative Allosteric Modulators with In Vivo Activity in a Rodent's Model of Cognition
Alonso de Diego, Sergio A, Linares, María Lourdes, García Molina, Aránzazu, de Lucas, Ana Isabel, Del Cerro, Alcira, Alonso, Jose Manuel, Ver Donck, Luc, Cid, Jose María, Trabanco, Andrés A, Van Gool, Michiel
Published in Journal of medicinal chemistry (12.09.2024)
Published in Journal of medicinal chemistry (12.09.2024)
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Journal Article
Discovery of 6,7-Dihydropyrazolo[1,5- a ]pyrazin-4(5 H )-one Derivatives as mGluR 2 Negative Allosteric Modulators with In Vivo Activity in a Rodent’s Model of Cognition
Alonso de Diego, Sergio A., Linares, María Lourdes, García Molina, Aránzazu, de Lucas, Ana Isabel, del Cerro, Alcira, Alonso, Jose Manuel, Ver Donck, Luc, Cid, Jose María, Trabanco, Andrés A., Van Gool, Michiel
Published in Journal of medicinal chemistry (12.09.2024)
Published in Journal of medicinal chemistry (12.09.2024)
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Spiro-oxindole Piperidines and 3-(Azetidin-3-yl)-1 H -benzimidazol-2-ones as mGlu 2 Receptor PAMs
de Lucas, Ana Isabel, Vega, Juan Antonio, Matesanz, Encarnación, Linares, María Lourdes, García Molina, Aránzazu, Tresadern, Gary, Lavreysen, Hilde, Trabanco, Andrés A, Cid, José María
Published in ACS medicinal chemistry letters (12.03.2020)
Published in ACS medicinal chemistry letters (12.03.2020)
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End-to-End Automated Synthesis of C(sp3)‑Enriched Drug-like Molecules via Negishi Coupling and Novel, Automated Liquid–Liquid Extraction
Abdiaj, Irini, Cañellas, Santiago, Dieguez, Alejandro, Linares, Maria Lourdes, Pijper, Brenda, Fontana, Alberto, Rodriguez, Raquel, Trabanco, Andres, Palao, Eduardo, Alcázar, Jesus
Published in Journal of medicinal chemistry (12.01.2023)
Published in Journal of medicinal chemistry (12.01.2023)
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Fully Automated Flow Protocol for C(sp3)–C(sp3) Bond Formation from Tertiary Amides and Alkyl Halides
Pijper, Brenda, Martín, Raúl, Huertas-Alonso, Alberto J., Linares, Maria Lourdes, López, Enol, Llaveria, Josep, Díaz-Ortiz, Ángel, Dixon, Darren J., de la Hoz, Antonio, Alcázar, Jesús
Published in Organic letters (12.04.2024)
Published in Organic letters (12.04.2024)
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Multistep and multivectorial assembly line library synthesis in flow
Pijper, Brenda, Abdiaj, Irini, Mazuela, Javier, Linares, Maria Lourdes, Gómez, José Enrique, Rodriguez, Raquel, Arquero, Belén Chaves, Palao, Eduardo, Cañellas, Santiago, Alcázar, Jesús
Published in Chem catalysis (01.09.2024)
Published in Chem catalysis (01.09.2024)
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Discovery of 1-Buty1-3-chloro-4-(4-pheny1-1-piperidiny1)(1H)-pyridone (JNJ-40411813): A Novel Positive Allosteric Modulator of the Metabotropic Glutamate 2 Receptor
Maria Cid, Jose, Tresadern, Gary, Duvey, Guillaume, Lutjens, Robert, Finn, Terry, Rocher, Jean-Philippe, Poli, Sonia, Antonio Vega, Juan, Isabel de Lucas, Ana, Matesanz, Encarnacion, Lourdes Linares, Maria, Ignacio Andres, Jose, Alcazar, Jesus, Manuel Alonso, Jose, Macdonald, Gregor J., Oehlrich, Daniel, Lavreysen, Hilde, Ahnaou, Abdelah, Drinkenburg, Wilhelmus, Mackie, Claire, Pype, Stefan, Gallacher, David, Trabanco, Andres A.
Published in Journal of medicinal chemistry (14.08.2014)
Published in Journal of medicinal chemistry (14.08.2014)
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Journal Article
Spiro-oxindole Piperidines and 3-(Azetidin-3-yl)-1H-benzimidazol-2-ones as mGlu(2) Receptor PAMs
de Lucas, Ana Isabel, Vega, Juan Antonio, Matesanz, Encarnacion, Linares, Maria Lourdes, Molina, Aranzazu Garcia, Tresadern, Gary, Lavreysen, Hilde, Trabanco, Andres A., Cid, Jose Maria
Published in ACS medicinal chemistry letters (12.03.2020)
Published in ACS medicinal chemistry letters (12.03.2020)
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Journal Article
Scaffold hopping from pyridones to imidazo[1,2-a]pyridines. New positive allosteric modulators of metabotropic glutamate 2 receptor The authors dedicate this Letter to the memory of Dr. Hassan Imogai, Addex Pharmaceuticals SA
Tresadern, Gary, Cid, Jose Maria, Macdonald, Gregor J, Vega, Juan Antonio, De Lucas, Ana Isabel, Garcia, Aranzazu, Matesanz, Encarnacion, Linares, Maria Lourdes, Oehlrich, Daniel, Lavreysen, Hilde, Biesmans, Ilse, Trabanco, Andres A
Published in Bioorganic & medicinal chemistry letters (01.01.2010)
Published in Bioorganic & medicinal chemistry letters (01.01.2010)
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