Identification of small molecule inhibitors of the hepatitis C virus RNA-dependent RNA polymerase from a pyrrolidine combinatorial mixture
Burton, George, Ku, Thomas W., Carr, Thomas J., Kiesow, Terry, Sarisky, Robert T., Lin-Goerke, Juili, Baker, Audrey, Earnshaw, David L., Hofmann, Glenn A., Keenan, Richard M., Dhanak, Dashyant
Published in Bioorganic & medicinal chemistry letters (15.03.2005)
Published in Bioorganic & medicinal chemistry letters (15.03.2005)
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An efficient, asymmetric solid-phase synthesis of benzothiadiazine-substituted tetramic acids: Potent inhibitors of the hepatitis C virus RNA-dependent RNA polymerase
Evans, Karen A., Chai, Deping, Graybill, Todd L., Burton, George, Sarisky, Robert T., Lin-Goerke, Juili, Johnston, Victor K., Rivero, Ralph A.
Published in Bioorganic & medicinal chemistry letters (15.04.2006)
Published in Bioorganic & medicinal chemistry letters (15.04.2006)
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RNA helicase and nucleotide triphosphatase activities of the bovine viral diarrhea virus NS3 protein are essential viral replication
Gu, B, Liu, C, Lin-Goerke, J, Maley, D.R, Gutshall, L.L, Feltenberger, C.A, Del Vecchio, A.M
Published in Journal of Virology (01.02.2000)
Published in Journal of Virology (01.02.2000)
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3-(1,1-Dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones, Potent Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase
Tedesco, Rosanna, Shaw, Antony N, Bambal, Ramesh, Chai, Deping, Concha, Nestor O, Darcy, Michael G, Dhanak, Dashyant, Fitch, Duke M, Gates, Adam, Gerhardt, Warren G, Halegoua, Dina L, Han, Chao, Hofmann, Glenn A, Johnston, Victor K, Kaura, Arun C, Liu, Nannan, Keenan, Richard M, Lin-Goerke, Juili, Sarisky, Robert T, Wiggall, Kenneth J, Zimmerman, Michael N, Duffy, Kevin J
Published in Journal of medicinal chemistry (09.02.2006)
Published in Journal of medicinal chemistry (09.02.2006)
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Substituted benzothiadizine inhibitors of Hepatitis C virus polymerase
Shaw, Antony N., Tedesco, Rosanna, Bambal, Ramesh, Chai, Deping, Concha, Nestor O., Darcy, Michael G., Dhanak, Dashyant, Duffy, Kevin J., Fitch, Duke M., Gates, Adam, Johnston, Victor K., Keenan, Richard M., Lin-Goerke, Juili, Liu, Nannan, Sarisky, Robert T., Wiggall, Kenneth J., Zimmerman, Michael N.
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
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Identification and Biological Characterization of Heterocyclic Inhibitors of the Hepatitis C Virus RNA-dependent RNA Polymerase
Dhanak, Dashyant, Duffy, Kevin J., Johnston, Victor K., Lin-Goerke, Juili, Darcy, Michael, Shaw, Antony N., Gu, Baohua, Silverman, Carol, Gates, Adam T., Nonnemacher, Michael R., Earnshaw, David L., Casper, David J., Kaura, Arun, Baker, Audrey, Greenwood, Cathy, Gutshall, Lester L., Maley, Derrick, DelVecchio, Alfred, Macarron, Ricardo, Hofmann, Glenn A., Alnoah, Zaid, Cheng, Hung-Yuan, Chan, George, Khandekar, Sanjay, Keenan, Richard M., Sarisky, Robert T.
Published in The Journal of biological chemistry (11.10.2002)
Published in The Journal of biological chemistry (11.10.2002)
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Studies on acyl pyrrolidine inhibitors of HCV RNA-dependent RNA polymerase to identify a molecule with replicon antiviral activity
Burton, George, Ku, Thomas W., Carr, Thomas J., Kiesow, Terry, Sarisky, Robert T., Lin-Goerke, Juili, Hofmann, Glenn A., Slater, Martin J., Haigh, David, Dhanak, Dashyant, Johnson, Victor K., Parry, Nigel R., Thommes, Pia
Published in Bioorganic & medicinal chemistry letters (01.04.2007)
Published in Bioorganic & medicinal chemistry letters (01.04.2007)
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Synthesis and biological activity of heteroaryl 3-(1,1-dioxo-2H-(1,2,4)-benzothiadizin-3-yl)-4-hydroxy-2(1H)-quinolinone derivatives as hepatitis C virus NS5B polymerase inhibitors
Tedesco, Rosanna, Chai, Deping, Darcy, Michael G., Dhanak, Dashyant, Fitch, Duke M., Gates, Adam, Johnston, Victor K., Keenan, Richard M., Lin-Goerke, Juili, Sarisky, Robert T., Shaw, Antony N., Valko, Klara L., Wiggall, Kenneth J., Zimmerman, Michael N., Duffy, Kevin J.
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
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Synthesis and biological activity of heteroaryl 3-(1,1-dioxo-2H-(1,2,4)-benzo-thiadizin-3-yl)-4-hydroxy-2(1H)-quinolinone derivatives as hepatitis C virus NS5B polymerase inhibitors
TEDESCO, Rosanna, DEPING CHAI, SHAW, Antony N, VALKO, Klara L, WIGGALL, Kenneth J, ZIMMERMAN, Michael N, DUFFY, Kevin J, DARCY, Michael G, DHANAK, Dashyant, FITCH, Duke M, GATES, Adam, JOHNSTON, Victor K, KEENAN, Richard M, LIN-GOERKE, Juili, SARISKY, Robert T
Published in Bioorganic & medicinal chemistry letters (2009)
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Published in Bioorganic & medicinal chemistry letters (2009)
Journal Article
Enzymatic activities of the GB virus-B RNA-dependent RNA polymerase
Ranjith-Kumar, C.T, Santos, Jan Lee, Gutshall, Lester L, Johnston, Victor K, Lin-Goerke, Juili, Kim, Min-Ju, Porter, David J, Maley, Derrick, Greenwood, Cathy, Earnshaw, David L, Baker, Audrey, Gu, Baohua, Silverman, Carol, Sarisky, Robert T, Kao, Cheng
Published in Virology (New York, N.Y.) (01.08.2003)
Published in Virology (New York, N.Y.) (01.08.2003)
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Mapping cooperative activity of the hepatitis C virus RNA-dependent RNA polymerase using genotype 1a–1b chimeras
Gu, Baohua, Gutshall, Lester L., Maley, Derrick, Pruss, Cynthia M., Nguyen, Tammy T., Silverman, Carol L., Lin-Goerke, Juili, Khandekar, Sanjay, Liu, Changbao, Baker, Audrey E., Casper, David J., Sarisky, Robert T.
Published in Biochemical and biophysical research communications (09.01.2004)
Published in Biochemical and biophysical research communications (09.01.2004)
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