Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5
Mavrakis, Konstantinos J., McDonald, E. Robert, Schlabach, Michael R., Billy, Eric, Hoffman, Gregory R., deWeck, Antoine, Ruddy, David A., Venkatesan, Kavitha, Yu, Jianjun, McAllister, Gregg, Stump, Mark, deBeaumont, Rosalie, Ho, Samuel, Yue, Yingzi, Liu, Yue, Yan-Neale, Yan, Yang, Guizhi, Lin, Fallon, Yin, Hong, Gao, Hui, Kipp, D. Randal, Zhao, Songping, McNamara, Joshua T., Sprague, Elizabeth R., Zheng, Bing, Lin, Ying, Cho, Young Shin, Gu, Justin, Crawford, Kenneth, Ciccone, David, Vitari, Alberto C., Lai, Albert, Capka, Vladimir, Hurov, Kristen, Porter, Jeffery A., Tallarico, John, Mickanin, Craig, Lees, Emma, Pagliarini, Raymond, Keen, Nicholas, Schmelzle, Tobias, Hofmann, Francesco, Stegmeier, Frank, Sellers, William R.
Published in Science (American Association for the Advancement of Science) (11.03.2016)
Published in Science (American Association for the Advancement of Science) (11.03.2016)
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IDH1 Mutations Alter Citric Acid Cycle Metabolism and Increase Dependence on Oxidative Mitochondrial Metabolism
GRASSIAN, Alexandra R, PARKER, Seth J, JOUD-CALDWELL, Carol, CHUNG, Franklin, HONG YIN, HANDLY, Erika D, STRAUB, Christopher, GROWNEY, Joseph D, HEIDEN, Matthew G. Vander, MURPHY, Anne N, PAGLIARINI, Raymond, METALLO, Christian M, DAVIDSON, Shawn M, DIVAKARUNI, Ajit S, GREEN, Courtney R, XIAMEI ZHANG, SLOCUM, Kelly L, MINYING PU, LIN, Fallon, VICKERS, Chad
Published in Cancer research (Chicago, Ill.) (15.06.2014)
Published in Cancer research (Chicago, Ill.) (15.06.2014)
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ERG signaling in prostate cancer is driven through PRMT5-dependent methylation of the Androgen Receptor
Mounir, Zineb, Korn, Joshua M, Westerling, Thomas, Lin, Fallon, Kirby, Christina A, Schirle, Markus, McAllister, Gregg, Hoffman, Greg, Ramadan, Nadire, Hartung, Anke, Feng, Yan, Kipp, David Randal, Quinn, Christopher, Fodor, Michelle, Baird, Jason, Schoumacher, Marie, Meyer, Ronald, Deeds, James, Buchwalter, Gilles, Stams, Travis, Keen, Nicholas, Sellers, William R, Brown, Myles, Pagliarini, Raymond A
Published in eLife (16.05.2016)
Published in eLife (16.05.2016)
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Allosteric Mutant IDH1 Inhibitors Reveal Mechanisms for IDH1 Mutant and Isoform Selectivity
Xie, Xiaoling, Baird, Daniel, Bowen, Kimberly, Capka, Vladimir, Chen, Jinyun, Chenail, Gregg, Cho, YoungShin, Dooley, Julia, Farsidjani, Ali, Fortin, Pascal, Kohls, Darcy, Kulathila, Raviraj, Lin, Fallon, McKay, Daniel, Rodrigues, Lindsey, Sage, David, Touré, B. Barry, van der Plas, Simon, Wright, Kirk, Xu, Ming, Yin, Hong, Levell, Julian, Pagliarini, Raymond A.
Published in Structure (London) (07.03.2017)
Published in Structure (London) (07.03.2017)
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Isocitrate Dehydrogenase (IDH) Mutations Promote a Reversible ZEB1/MicroRNA (miR)-200-dependent Epithelial-Mesenchymal Transition (EMT)
Grassian, Alexandra R., Lin, Fallon, Barrett, Rosemary, Liu, Yue, Jiang, Wei, Korpal, Manav, Astley, Holly, Gitterman, Daniel, Henley, Thomas, Howes, Rob, Levell, Julian, Korn, Joshua M., Pagliarini, Raymond
Published in The Journal of biological chemistry (07.12.2012)
Published in The Journal of biological chemistry (07.12.2012)
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A small molecule that binds and inhibits the ETV1 transcription factor oncoprotein
Pop, Marius S, Stransky, Nicolas, Garvie, Colin W, Theurillat, Jean-Philippe, Hartman, Emily C, Lewis, Timothy A, Zhong, Cheng, Culyba, Elizabeth K, Lin, Fallon, Daniels, Douglas S, Pagliarini, Raymond, Ronco, Lucienne, Koehler, Angela N, Garraway, Levi A
Published in Molecular cancer therapeutics (01.06.2014)
Published in Molecular cancer therapeutics (01.06.2014)
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Patient-derived glioblastoma cultures as a tool for small-molecule drug discovery
Ye, Ling F, Reznik, Eduard, Korn, Joshua M, Lin, Fallon, Yang, Guizhi, Malesky, Kimberly, Gao, Hui, Loo, Alice, Pagliarini, Raymond, Mikkelsen, Tom, Lo, Donald C, deCarvalho, Ana C, Stockwell, Brent R
Published in Oncotarget (28.01.2020)
Published in Oncotarget (28.01.2020)
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Optimization of 3‑Pyrimidin-4-yl-oxazolidin-2-ones as Allosteric and Mutant Specific Inhibitors of IDH1
Levell, Julian R., Caferro, Thomas, Chenail, Gregg, Dix, Ina, Dooley, Julia, Firestone, Brant, Fortin, Pascal D., Giraldes, John, Gould, Ty, Growney, Joseph D., Jones, Michael D., Kulathila, Raviraj, Lin, Fallon, Liu, Gang, Mueller, Arne, van der Plas, Simon, Slocum, Kelly, Smith, Troy, Terranova, Remi, Touré, B. Barry, Tyagi, Viraj, Wagner, Trixie, Xie, Xiaoling, Xu, Ming, Yang, Fan S., Zhou, Liping X., Pagliarini, Raymond, Cho, Young Shin
Published in ACS medicinal chemistry letters (09.02.2017)
Published in ACS medicinal chemistry letters (09.02.2017)
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Journal Article
Abstract 2519: A small molecule that binds and inhibits the ETV1 transcription factor oncoprotein
Pop, Marius, Stransky, Nicolas, Garvie, Colin, Theurillat, Jean-Philippe, Lewis, Timothy, Zhong, Cheng, Culyba, Elizabeth, Lin, Fallon, Daniels, Douglas, Pagliarini, Raymond, Ronco, Lucienne, Koehler, Angela, Garraway, Levi
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Abstract A20: IDH mutations and 2-HG selectively affect histone methylation in the endogenous setting
Lin, Fallon, Saenz-Vash, Veronica, Zhai, Huili, Fletcher, Joy, Acker, Mike, Jiang, David, Gounarides, John, Levell, Julian, Pagliarini, Raymond
Published in Cancer research (Chicago, Ill.) (01.07.2013)
Published in Cancer research (Chicago, Ill.) (01.07.2013)
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Journal Article
Abstract LB-017: Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to marked dependence on PRMT5
Mavrakis, Konstantinos, McDonald, E Robert, Schlabach, Michael R., Billy, Eric, Hoffman, Gregory R., deWeck, Antoine, Ruddy, David A., Venkatesan, Kavitha, McAllister, Greg, deBeaumont, Rosalie, Ho, Samuel, Liu, Yue, Yan-Neale, Yan, Yang, Guizhi, Lin, Fallon, Yin, Hong, Gao, Hui, Kipp, David Randal, Zhao, Songping, McNamara, Joshua T., Sprague, Elizabeth R., Cho, Young Shin, Gu, Justin, Crawford, Ken, Capka, Vladimir, Hurov, Kristen, Porter, Jeffrey A., Tallarico, John, Mickanin, Craig, Lees, Emma, Pagliarini, Raymond, Keen, Nicholas, Schmelzle, Tobias, Hofmann, Francesco, Stegmeier, Frank, Sellers, William R.
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Abstract LB-017: Disordered methionine metabolism in MTAPCDKN2A-deleted cancers leads to marked dependence on PRMT5
Mavrakis, Konstantinos, McDonald, E Robert, Schlabach, Michael R, Billy, Eric, Hoffman, Gregory R, deWeck, Antoine, Ruddy, David A, Venkatesan, Kavitha, McAllister, Greg, deBeaumont, Rosalie, Ho, Samuel, Liu, Yue, Yan-Neale, Yan, Yang, Guizhi, Lin, Fallon, Yin, Hong, Gao, Hui, Kipp, David Randal, Zhao, Songping, McNamara, Joshua T, Sprague, Elizabeth R, Cho, Young Shin, Gu, Justin, Crawford, Ken, Capka, Vladimir, Hurov, Kristen, Porter, Jeffrey A, Tallarico, John, Mickanin, Craig, Lees, Emma, Pagliarini, Raymond, Keen, Nicholas, Schmelzle, Tobias, Hofmann, Francesco, Stegmeier, Frank, Sellers, William R
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Abstract B159: Heterozygous IDH1 mutations modify the citric acid (TCA) cycle metabolism and sensitize cells to inhibition of mitochondrial respiration/oxidative phosphorylation
Grassian, Alexandra R., Parker, Seth, Davidson, Shawn, Green, Courtney, Lin, Fallon, Joud-Caldwell, Carol, Yin, Hong, Chung, Franklin, Straub, Christopher, Vander Heiden, Matthew, Pagliarini, Raymond, Metallo, Christian
Published in Molecular cancer therapeutics (01.11.2013)
Published in Molecular cancer therapeutics (01.11.2013)
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Abstract B23: Identification of TMPRSS2:ERG-dependent regulators of AR function and differentiation status in prostate cancer
Mounir, Zineb, Pagliarini, Raymond, Lin, Fallon, Schirle, Markus, Klekota, Justin, Feng, Yan, Hartung, Anke, Jaffe, Aron, Buchwalter, Gilles, Brown, Myles
Published in Cancer research (Chicago, Ill.) (06.02.2012)
Published in Cancer research (Chicago, Ill.) (06.02.2012)
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Journal Article
Abstract LB-139: IDH1 mutations alter citric acid cycle metabolism and increase dependence on oxidative mitochondrial metabolism
Grassian, Alexandra R., Parker, Seth, Davidson, Shawn, Divakaruni, Ajit, Green, Courtney, Zhang, Xiamei, Slocum, Kelly, Pu, Minying, Lin, Fallon, Vickers, Chad, Joud-Caldwell, Carol, Chung, Franklin, Yin, Hong, Handly, Erika, Straub, Christopher, Growney, Joseph D., Heiden, Matt Vander, Murphy, Anne, Pagliarini, Raymond, Metallo, Christian
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Journal Article
MARKERS FOR ISOCITRATE DEHYDROGENASE INHIBITORS
McLaughlin Margaret Elise, Meyer Ronald, Levell Julian Roy, Zhai Huili, Pagliarini Raymond, Cho Young Shin, Lin Fallon, Saenz-Vash Veronica, Shebanova Olga
Year of Publication 27.10.2016
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Year of Publication 27.10.2016
Patent
MARKERS FOR ISOCITRATE DEHYDROGENASE INHIBITORS
SAENZ-VASH, VERONICA, LIN, FALLON, SHEBANOVA, OLGA, MEYER, RONALD, ZHAI, HUILI, CHO, YOUNG SHIN, MCLAUGHLIN, MARGARET ELISE, PAGLIARINI, RAYMOND, LEVELL, JULIAN ROY
Year of Publication 20.01.2016
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Year of Publication 20.01.2016
Patent
MARKERS FOR ISOCITRATE DEHYDROGENASE INHIBITORS
SAENZ-VASH, VERONICA, LIN, FALLON, SHEBANOVA, OLGA, MEYER, RONALD, ZHAI, HUILI, CHO, YOUNG SHIN, MCLAUGHLIN, MARGARET ELISE, PAGLIARINI, RAYMOND, LEVELL, JULIAN ROY
Year of Publication 09.10.2014
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Year of Publication 09.10.2014
Patent