A CRISPR-engineered isogenic model of the 22q11.2 A-B syndromic deletion
Paranjape, Neha, Lin, Yu-Hsiu T., Flores-Ramirez, Quetzal, Sarin, Vishesh, Johnson, Amanda Brooke, Chu, Julia, Paredes, Mercedes, Wiita, Arun P.
Published in Scientific reports (11.05.2023)
Published in Scientific reports (11.05.2023)
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Journal Article
Proteasome inhibitor-induced modulation reveals the spliceosome as a specific therapeutic vulnerability in multiple myeloma
Huang, Hector H., Ferguson, Ian D., Thornton, Alexis M., Bastola, Prabhakar, Lam, Christine, Lin, Yu-Hsiu T., Choudhry, Priya, Mariano, Margarette C., Marcoulis, Makeba D., Teo, Chin Fen, Malato, Julia, Phojanakong, Paul J., Martin, Thomas G., Wolf, Jeffrey L., Wong, Sandy W., Shah, Nina, Hann, Byron, Brooks, Angela N., Wiita, Arun P.
Published in Nature communications (22.04.2020)
Published in Nature communications (22.04.2020)
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Repurposing tofacitinib as an anti-myeloma therapeutic to reverse growth-promoting effects of the bone marrow microenvironment
Lam, Christine, Ferguson, Ian D, Mariano, Margarette C, Lin, Yu-Hsiu T, Murnane, Megan, Liu, Hui, Smith, Geoffrey A, Wong, Sandy W, Taunton, Jack, Liu, Jun O, Mitsiades, Constantine S, Hann, Byron C, Aftab, Blake T, Wiita, Arun P
Published in Haematologica (Roma) (01.07.2018)
Published in Haematologica (Roma) (01.07.2018)
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Journal Article
TMEM16A controls EGF-induced calcium signaling implicated in pancreatic cancer prognosis
Crottès, David, Lin, Yu-Hsiu T., Peters, Christian J., Gilchrist, John M., Wiita, Arun P., Jan, Yuh Nung, Jan, Lily Yeh
Published in Proceedings of the National Academy of Sciences - PNAS (25.06.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (25.06.2019)
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Integrated phosphoproteomics and transcriptional classifiers reveal hidden RAS signaling dynamics in multiple myeloma
Lin, Yu-Hsiu T., Way, Gregory P., Barwick, Benjamin G., Mariano, Margarette C., Marcoulis, Makeba, Ferguson, Ian D., Driessen, Christoph, Boise, Lawrence H., Greene, Casey S., Wiita, Arun P.
Published in Blood advances (12.11.2019)
Published in Blood advances (12.11.2019)
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Journal Article
Allosteric HSP70 inhibitors perturb mitochondrial proteostasis and overcome proteasome inhibitor resistance in multiple myeloma
Ferguson, Ian D., Lin, Yu-Hsiu T., Lam, Christine, Shao, Hao, Tharp, Kevin M., Hale, Martina, Kasap, Corynn, Mariano, Margarette C., Kishishita, Audrey, Patiño Escobar, Bonell, Mandal, Kamal, Steri, Veronica, Wang, Donghui, Phojanakong, Paul, Tuomivaara, Sami T., Hann, Byron, Driessen, Christoph, Van Ness, Brian, Gestwicki, Jason E., Wiita, Arun P.
Published in Cell chemical biology (18.08.2022)
Published in Cell chemical biology (18.08.2022)
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Journal Article
Surface Proteomics Reveals CD72 as a Target for In Vitro -Evolved Nanobody-Based CAR-T Cells in KMT2A/MLL1 -Rearranged B-ALL
Nix, Matthew A, Mandal, Kamal, Geng, Huimin, Paranjape, Neha, Lin, Yu-Hsiu T, Rivera, Jose M, Marcoulis, Makeba, White, Kristie L, Whitman, Jeffrey D, Bapat, Sagar P, Parker, Kevin R, Ramirez, Jonathan, Deucher, Anne, Phojanokong, Paul, Steri, Veronica, Fattahi, Faranak, Hann, Byron C, Satpathy, Ansuman T, Manglik, Aashish, Stieglitz, Elliot, Wiita, Arun P
Published in Cancer discovery (01.08.2021)
Published in Cancer discovery (01.08.2021)
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Journal Article
Human APOBEC3B promotes tumor development in vivo including signature mutations and metastases
Durfee, Cameron, Temiz, Nuri Alpay, Levin-Klein, Rena, Argyris, Prokopios P., Alsøe, Lene, Carracedo, Sergio, Alonso de la Vega, Alicia, Proehl, Joshua, Holzhauer, Anna M., Seeman, Zachary J., Liu, Xingyu, Lin, Yu-Hsiu T., Vogel, Rachel I., Sotillo, Rocio, Nilsen, Hilde, Harris, Reuben S.
Published in Cell reports. Medicine (17.10.2023)
Published in Cell reports. Medicine (17.10.2023)
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Journal Article
The surfaceome of multiple myeloma cells suggests potential immunotherapeutic strategies and protein markers of drug resistance
Ferguson, Ian D., Patiño-Escobar, Bonell, Tuomivaara, Sami T., Lin, Yu-Hsiu T., Nix, Matthew A., Leung, Kevin K., Kasap, Corynn, Ramos, Emilio, Nieves Vasquez, Wilson, Talbot, Alexis, Hale, Martina, Naik, Akul, Kishishita, Audrey, Choudhry, Priya, Lopez-Girona, Antonia, Miao, Weili, Wong, Sandy W., Wolf, Jeffrey L., Martin, Thomas G., Shah, Nina, Vandenberg, Scott, Prakash, Sonam, Besse, Lenka, Driessen, Christoph, Posey, Avery D., Mullins, R. Dyche, Eyquem, Justin, Wells, James A., Wiita, Arun P.
Published in Nature communications (15.07.2022)
Published in Nature communications (15.07.2022)
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Human APOBEC3B promotes tumor heterogeneity in vivo including signature mutations and metastases
Durfee, Cameron, Temiz, Nuri Alpay, Levin-Klein, Rena, Argyris, Prokopios P, Alsøe, Lene, Carracedo, Sergio, de la Vega, Alicia Alonso, Proehl, Joshua, Holzhauer, Anna M, Seeman, Zachary J, Lin, Yu-Hsiu T, Vogel, Rachel I, Sotillo, Rocio, Nilsen, Hilde, Harris, Reuben S
Published in bioRxiv (25.02.2023)
Published in bioRxiv (25.02.2023)
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Journal Article
Targeting high-risk multiple myeloma genotypes with optimized anti-CD70 CAR-T cells
Kasap, Corynn, Izgutdina, Adila, Patiño-Escobar, Bonell, Kang, Amrik, Chilakapati, Nikhil, Akagi, Naomi, Johnson, Haley, Rashid, Tasfia, Werner, Juwita, Barpanda, Abhilash, Geng, Huimin, Lin, Yu-Hsiu T, Rampersaud, Sham, Gil-Alós, Daniel, Sobh, Amin, Dupéré-Richer, Daphné, Wicaksono, Gianina, Kawehi Kelii, K M, Dalal, Radhika, Ramos, Emilio, Vijayanarayanan, Anjanaa, Salangsang, Fernando, Phojanakong, Paul, Serrano, Juan Antonio Camara, Zakraoui, Ons, Tariq, Isa, Steri, Veronica, Shanmugam, Mala, Boise, Lawrence H, Kortemme, Tanja, Stieglitz, Elliot, Licht, Jonathan D, Karlon, William J, Barwick, Benjamin G, Wiita, Arun P
Published in bioRxiv (28.02.2024)
Published in bioRxiv (28.02.2024)
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Functional Multi-Omics Reveals Genetic and Pharmacologic Regulation of Surface CD38 in Multiple Myeloma
Choudhry, Priya, Gugliemini, Olivia, Geng, Huimin, Sarin, Vishesh, Sarah, Letitia, Lin, Yu-Hsiu T., Paranjape, Neha, Ramkumar, Poornima, Marcoulis, Makeba, Wang, Donghui, Phojanakong, Paul, Steri, Veronica, Hann, Byron, Kampmann, Martin, Wiita, Arun P
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Journal Article
Integrating Phosphoproteomics and Transcriptional Classifiers Reveals “Hidden Signaling” in Multiple Myeloma Including Differential KRAS and NRAS Mutant Effects
Lin, Yu-Hsiu T., Way, Gergory P., Mariano, Margarette C., Marcoulis, Makeba, Ferguson, Ian, Greene, Casey S., Wiita, Arun P
Published in Blood (29.11.2018)
Published in Blood (29.11.2018)
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Journal Article
In Vitro-Selected Nanobody-Based Cellular Therapy Targeting CD72 for Treatment of Refractory B-Cell Malignancies
Nix, Matthew, Lin, Yu-Hsiu T., Geng, Huimin, Marcoulis, Makeba, Phojanakong, Paul, Wang, Donghui, Steri, Veronica, Whitman, Jeffrey, Bapat, Sagar, Stieglitz, Elliot, Deucher, Anne, White, Kristie L, Hann, Byron C, Wiita, Arun P.
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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Journal Article
Profiling the Cell Surface Landscape of Proteasome Inhibitor-Treated and -Resistant Multiple Myeloma to Guide Immunotherapy Targeting, Diagnosis, and Biology
Ferguson, Ian, Lin, Yu-Hsiu T., Tuomivaara, Sami, Wolf, Jeffrey L., Martin, Thomas G., Wong, Sandy W., Shah, Nina D., Driessen, Christoph, Van Ness, Brian G., Wiita, Arun P.
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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Journal Article
Functional multiomics reveals genetic and pharmacologic regulation of surface CD38 in multiple myeloma
Choudhry, Priya, Kasap, Corynn, Patiño-Escobar, Bonell, Gugliemini, Olivia, Geng, Huimin, Sarin, Vishesh, Kang, Amrik, Kishishita, Audrey, Rampersaud, Sham, Sarah, Letitia, Lin, Yu-Hsiu T., Paranjape, Neha, Ramkumar, Poornima, Patton, Jonathan C., Marcoulis, Makeba, Wang, Donghui, Phojanakong, Paul, Steri, Veronica, Hann, Byron, Barwick, Benjamin G., Kampmann, Martin, Wiita, Arun P.
Published in Blood Neoplasia (01.09.2024)
Published in Blood Neoplasia (01.09.2024)
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Journal Article
Autophagy cargo receptors are secreted via extracellular vesicles and particles in response to endolysosomal inhibition or impaired autophagosome maturation
Solvik, Tina A, Nguyen, Tan A, Lin, Yu-Hsiu T, Marsh, Timothy, Huang, Eric J, Wiita, Arun P, Debnath, Jayanta, Leidal, Andrew M
Published in bioRxiv (12.08.2021)
Published in bioRxiv (12.08.2021)
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Paper
Allosteric HSP70 inhibitors perturb mitochondrial proteostasis and overcome proteasome inhibitor resistance in multiple myeloma
Ferguson, Ian D, Lin, Yu-Hsiu T, Lam, Christine, Shao, Hao, Hale, Martina, Tharp, Kevin M, Mariano, Margarette C, Steri, Veronica, Wang, Donghui, Phojanokong, Paul, Tuomivaara, Sami T, Hann, Byron, Driessen, Christoph, Brian Van Ness, Gestwicki, Jason E, Wiita, Arun P
Published in bioRxiv (23.04.2020)
Published in bioRxiv (23.04.2020)
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Defining the cell surface proteomic landscape of multiple myeloma reveals immunotherapeutic strategies and biomarkers of drug resistance
Ferguson, Ian D, Bonell Patiño Escobar, Tuomivaara, Sami T, Lin, Yu-Hsiu T, Nix, Matthew A, Leung, Kevin K, Hale, Martina, Choudhry, Priya, Lopez-Girona, Antonia, Ramos, Emilio, Wong, Sandy W, Wolf, Jeffrey L, Martin, Thomas G, Shah, Nina, Vandenberg, Scott, Prakash, Sonam, Besse, Lenka, Driessen, Christoph, Wells, James A, Wiita, Arun P
Published in bioRxiv (19.01.2021)
Published in bioRxiv (19.01.2021)
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