Discovery of a 3‑(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity
Scott, Jack D, DeMong, Duane E, Greshock, Thomas J, Basu, Kallol, Dai, Xing, Harris, Joel, Hruza, Alan, Li, Sarah W, Lin, Sue-Ing, Liu, Hong, Macala, Megan K, Hu, Zhiyong, Mei, Hong, Zhang, Honglu, Walsh, Paul, Poirier, Marc, Shi, Zhi-Cai, Xiao, Li, Agnihotri, Gautam, Baptista, Marco A. S, Columbus, John, Fell, Matthew J, Hyde, Lynn A, Kuvelkar, Reshma, Lin, Yinghui, Mirescu, Christian, Morrow, John A, Yin, Zhizhang, Zhang, Xiaoping, Zhou, Xiaoping, Chang, Ronald K, Embrey, Mark W, Sanders, John M, Tiscia, Heather E, Drolet, Robert E, Kern, Jonathan T, Sur, Sylvie M, Renger, John J, Bilodeau, Mark T, Kennedy, Matthew E, Parker, Eric M, Stamford, Andrew W, Nargund, Ravi, McCauley, John A, Miller, Michael W
Published in Journal of medicinal chemistry (13.04.2017)
Published in Journal of medicinal chemistry (13.04.2017)
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The Discovery of N‑((2H‑Tetrazol-5-yl)methyl)-4-((R)‑1-((5r,8R)‑8‑(tert-butyl)-3-(3,5-dichlorophenyl)-2-oxo-1,4-diazaspiro[4.5]dec-3-en-1-yl)-4,4-dimethylpentyl)benzamide (SCH 900822): A Potent and Selective Glucagon Receptor Antagonist
DeMong, Duane, Dai, Xing, Hwa, Joyce, Miller, Michael, Lin, Sue-Ing, Kang, Ling, Stamford, Andrew, Greenlee, William, Yu, Wensheng, Wong, Michael, Lavey, Brian, Kozlowski, Joseph, Zhou, Guowei, Yang, De-Yi, Patel, Bhuneshwari, Soriano, Aileen, Zhai, Ying, Sondey, Christopher, Zhang, Hongtao, Lachowicz, Jean, Grotz, Diane, Cox, Kathleen, Morrison, Richard, Andreani, Teresa, Cao, Yang, Liang, Mark, Meng, Tao, McNamara, Paul, Wong, Jesse, Bradley, Prudence, Feng, Kung-I, Belani, Jitendra, Chen, Ping, Dai, Peng, Gauuan, Jolicia, Lin, Peishan, Zhao, He
Published in Journal of medicinal chemistry (27.03.2014)
Published in Journal of medicinal chemistry (27.03.2014)
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Piperazine-Based CCR5 Antagonists as HIV-1 Inhibitors. II. Discovery of 1-[(2,4-Dimethyl-3-pyridinyl)carbonyl]-4- methyl-4-[3(S)-methyl-4-[1(S)-[4-(trifluoro- methyl)phenyl]ethyl]-1-piperazinyl]- piperidine N1-Oxide (Sch-350634), an Orally Bioavailable, Potent CCR5 Antagonist
Tagat, Jayaram R, Steensma, Ruo W, McCombie, Stuart W, Nazareno, Dennis V, Lin, Sue-Ing, Neustadt, Bernard R, Cox, Kathleen, Xu, Serena, Wojcik, Lisa, Murray, Michael G, Vantuno, Nicole, Baroudy, Bahige M, Strizki, Julie M
Published in Journal of medicinal chemistry (11.10.2001)
Published in Journal of medicinal chemistry (11.10.2001)
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Tetrahydroquinoline sulfonamides as vasopressin 1b receptor anatgonists
Scott, Jack D., Miller, Michael W., Li, Sarah W., Lin, Sue-Ing, Vaccaro, Henry A., Hong, Liwu, Mullins, Deborra E., Guzzi, Mario, Weinstein, Jay, Hodgson, Robert A., Varty, Geoffrey B., Stamford, Andrew W., Chan, Tin-Yau, McKittrick, Brian A., Greenlee, William J., Priestley, Tony, Parker, Eric M.
Published in Bioorganic & medicinal chemistry letters (01.11.2009)
Published in Bioorganic & medicinal chemistry letters (01.11.2009)
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Piperazine-Based CCR5 antagonists as HIV-1 inhibitors. I: 2( S)-methyl piperazine as a key pharmacophore element
Tagat, Jayaram R., McCombie, Stuart W., Steensma, Ruo W., Lin, Sue-Ing, Nazareno, Dennis V., Baroudy, Bahige, Vantuno, Nicole, Xu, Serena, Liu, Jia
Published in Bioorganic & medicinal chemistry letters (20.08.2001)
Published in Bioorganic & medicinal chemistry letters (20.08.2001)
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Piperazine-based CCR5 antagonists as HIV-1 inhibitors. III: synthesis, antiviral and pharmacokinetic profiles of symmetrical heteroaryl carboxamides
McCombie, Stuart W., Tagat, Jayaram R., Vice, Susan F., Lin, Sue-Ing, Steensma, Ruo, Palani, Anandan, Neustadt, Bernard R., Baroudy, Bahige M., Strizki, Julie M., Endres, Michael, Cox, Kathleen, Dan, Niya, Chou, Chuan-Chu
Published in Bioorganic & medicinal chemistry letters (10.02.2003)
Published in Bioorganic & medicinal chemistry letters (10.02.2003)
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Substituted 2-(R)-methyl piperazines as muscarinic M2 selective ligands
KOZLOWSKI, Joseph A, GUOWEI ZHOU, BILLARD, William, BINCH, Herbert III, LACHOWICZ, Jean E, TAGAT, Jayaram R, LIN, Sue-Ing, MCCOMBIE, Stuart W, RUPERTO, Vilma B, DUFFY, Ruth A, MCQUADE, Robert A, CROSBY, Gordon JR, TAYLOR, Lisa A
Published in Bioorganic & medicinal chemistry letters (11.03.2002)
Published in Bioorganic & medicinal chemistry letters (11.03.2002)
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Synthesis and structure-activity relationships of M2-selective muscarinic receptor ligands in the 1-[4-(4-arylsulfonyl)-phenylmethyl]-4-(4-piperidinyl)-piperazine family
MCCOMBIE, Stuart W, LIN, Sue-Ing, RUPERTO, Vilma B, DUFFY, Ruth A, LACHOWICZ, Jean E, TAGAT, Jayaram R, NAZARENO, Dennis, VICE, Susan, FORD, Jennifer, ASBEROM, Theodros, LEONE, Daria, KOZLOWSKI, Joseph A, GUOWEI ZHOU
Published in Bioorganic & medicinal chemistry letters (11.03.2002)
Published in Bioorganic & medicinal chemistry letters (11.03.2002)
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(−)-SCH 57939: synthesis and pharmacological properties of a potent, metabolically stable cholesterol absorption inhibitor
Kirkup, Michael P., Rizvi, Razia, Shankar, Bandarpalle B., Dugar, Sundeep, Clader, John W., McCombie, Stuart W., Lin, Sue-Ing, Yumibe, Nathan, Huie, Keith, Van Heek, Margaret, Compton, Douglas S., Davis, Harry R., McPhail, Andrew T.
Published in Bioorganic & medicinal chemistry letters (03.09.1996)
Published in Bioorganic & medicinal chemistry letters (03.09.1996)
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Indolocarbazoles. 1. Total synthesis and protein kinase inhibiting characteristics of compounds related to K-252c
McCombie, Stuart W, Bishop, Robert W, Carr, Donna, Dobek, Emily, Kirkup, Michael P, Kirschmeier, Paul, Lin, Sue-Ing, Petrin, Joanne, Rosinski, Karen, Shankar, Bandarpalle B, Wilson, Oswald
Published in Bioorganic & medicinal chemistry letters (01.08.1993)
Published in Bioorganic & medicinal chemistry letters (01.08.1993)
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CONTROLLING BENZYLIC FUNCTIONALITY AND STEREOCHEMISTRY .1. SYNTHESIS OF THE SECOPSEUDOPTEROSIN AGLYCONE
MCCOMBIE, SW, COX, B, LIN, SI, GANGULY, AK, MCPHAIL, AT
Published in Tetrahedron letters (06.05.1991)
Published in Tetrahedron letters (06.05.1991)
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New reactions of 2-alkylthiopenems
GIRIJAVALLABHAN, V. M, MCCOMBIE, S. W, PINTO, P, SUE-ING LIN, VERSACE, R
Published in Journal of the Chemical Society. Chemical communications (1987)
Published in Journal of the Chemical Society. Chemical communications (1987)
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Substituted 2-( R)-Methyl piperazines as muscarinic M 2 selective ligands
Kozlowski, Joseph A, Zhou, Guowei, Tagat, Jayaram R, Lin, Sue-Ing, McCombie, Stuart W, Ruperto, Vilma B, Duffy, Ruth A, McQuade, Robert A, Crosby, Gordon, Taylor, Lisa A, Billard, William, Binch, Herbert, Lachowicz, Jean E
Published in Bioorganic & medicinal chemistry letters (11.03.2002)
Published in Bioorganic & medicinal chemistry letters (11.03.2002)
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Journal Article
Tetrahydroquinoline sulfonamides as vasopressin 1b receptor antagonists
Scott, Jack D, Miller, Michael W, Li, Sarah W, Lin, Sue-Ing, Vaccaro, Henry A, Hong, Liwu, Mullins, Deborra E, Guzzi, Mario, Weinstein, Jay, Hodgson, Robert A, Varty, Geoffrey B, Stamford, Andrew W, Chan, Tin-Yau, McKittrick, Brian A, Greenlee, William J, Priestley, Tony, Parker, Eric M
Published in Bioorganic & medicinal chemistry letters (01.11.2009)
Published in Bioorganic & medicinal chemistry letters (01.11.2009)
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Journal Article
Synthesis and structure–Activity relationships of M 2-Selective muscarinic receptor ligands in the 1-[4-(4-Arylsulfonyl)-phenylmethyl]-4-(4-piperidinyl)-piperazine family
McCombie, Stuart W, Lin, Sue-Ing, Tagat, Jayaram R, Nazareno, Dennis, Vice, Susan, Ford, Jennifer, Asberom, Theodros, Leone, Daria, Kozlowski, Joseph A, Zhou, Guowei, Ruperto, Vilma B, Duffy, Ruth A, Lachowicz, Jean E
Published in Bioorganic & medicinal chemistry letters (11.03.2002)
Published in Bioorganic & medicinal chemistry letters (11.03.2002)
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Journal Article
Piperazine-Based CCR5 Antagonists as HIV-1 Inhibitors. II. Discovery of 1-[(2,4-Dimethyl-3-pyridinyl)carbonyl]-4- methyl-4-[3( S )-methyl-4-[1( S )-[4-(trifluoro- methyl)phenyl]ethyl]-1-piperazinyl]- piperidine N 1-Oxide (Sch-350634), an Orally Bioavailable, Potent CCR5 Antagonist
Tagat, Jayaram R., Steensma, Ruo W., McCombie, Stuart W., Nazareno, Dennis V., Lin, Sue-Ing, Neustadt, Bernard R., Cox, Kathleen, Xu, Serena, Wojcik, Lisa, Murray, Michael G., Vantuno, Nicole, Baroudy, Bahige M., Strizki, Julie M.
Published in Journal of medicinal chemistry (01.10.2001)
Published in Journal of medicinal chemistry (01.10.2001)
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Journal Article
Substituted 2-(R)-methyl piperazines as muscarinic M(2) selective ligands
Kozlowski, Joseph A, Zhou, Guowei, Tagat, Jayaram R, Lin, Sue Ing, McCombie, Stuart W, Ruperto, Vilma B, Duffy, Ruth A, McQuade, Robert A, Crosby, Gordon, Taylor, Lisa A, Billard, William, Binch, Herbert, Lachowicz, Jean E
Published in Bioorganic & medicinal chemistry letters (11.03.2002)
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Published in Bioorganic & medicinal chemistry letters (11.03.2002)
Journal Article
Synthesis and structure-activity relationships of M(2)-selective muscarinic receptor ligands in the 1-[4-(4-arylsulfonyl)-phenylmethyl]-4-(4-piperidinyl)-piperazine family
McCombie, Stuart W, Lin, Sue Ing, Tagat, Jayaram R, Nazareno, Dennis, Vice, Susan, Ford, Jennifer, Asberom, Theodros, Leone, Daria, Kozlowski, Joseph A, Zhou, Guowei, Ruperto, Vilma B, Duffy, Ruth A, Lachowicz, Jean E
Published in Bioorganic & medicinal chemistry letters (11.03.2002)
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Published in Bioorganic & medicinal chemistry letters (11.03.2002)
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