A potent class of GPR40 full agonists engages the enteroinsular axis to promote glucose control in rodents
Luo, Jian, Swaminath, Gayathri, Brown, Sean P, Zhang, Jane, Guo, Qi, Chen, Michael, Nguyen, Kathy, Tran, Thanhvien, Miao, Lynn, Dransfield, Paul J, Vimolratana, Marc, Houze, Jonathan B, Wong, Simon, Toteva, Maria, Shan, Bei, Li, Frank, Zhuang, Run, Lin, Daniel C-H
Published in PloS one (09.10.2012)
Published in PloS one (09.10.2012)
Get full text
Journal Article
GPR40 Is Necessary but Not Sufficient for Fatty Acid Stimulation of Insulin Secretion In Vivo
LATOUR, Martin G, ALQUIER, Thierry, OSEID, Elizabeth, TREMBLAY, Caroline, JETTON, Thomas L, JIAN LUO, LIN, Daniel C.-H, POITOUT, Vincent
Published in Diabetes (New York, N.Y.) (01.04.2007)
Published in Diabetes (New York, N.Y.) (01.04.2007)
Get full text
Journal Article
Activation of FFA1 mediates GLP-1 secretion in mice. Evidence for allosterism at FFA1
Xiong, Yumei, Swaminath, Gayathri, Cao, Qiong, Yang, Li, Guo, Qi, Salomonis, Heather, Lu, Jenny, Houze, Jonathan B., Dransfield, Paul J., Wang, Yingcai, Liu, Jiwen (Jim), Wong, Simon, Schwandner, Ralf, Steger, Franziska, Baribault, Helene, Liu, Lily, Coberly, Suzanne, Miao, Lynn, Zhang, Jane, Lin, Daniel C.-H., Schwarz, Margrit
Published in Molecular and cellular endocrinology (30.04.2013)
Published in Molecular and cellular endocrinology (30.04.2013)
Get full text
Journal Article
Identification and pharmacological characterization of multiple allosteric binding sites on the free fatty acid 1 receptor
Lin, Daniel C-H, Guo, Qi, Luo, Jian, Zhang, Jane, Nguyen, Kathy, Chen, Michael, Tran, Thanh, Dransfield, Paul J, Brown, Sean P, Houze, Jonathan, Vimolratana, Marc, Jiao, Xian Yun, Wang, Yingcai, Birdsall, Nigel J M, Swaminath, Gayathri
Published in Molecular pharmacology (01.11.2012)
Published in Molecular pharmacology (01.11.2012)
Get full text
Journal Article
Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors
Ling, Lei, He, Weihai, Miao, Frederick J.-P, Lin, Daniel C.-H, Schwandner, Ralf T, Wang, Zhulun, Gao, Jinhai, Chen, Jin-Long, Tian, Hui
Published in Nature (13.05.2004)
Published in Nature (13.05.2004)
Get full text
Journal Article
AMG 837: a novel GPR40/FFA1 agonist that enhances insulin secretion and lowers glucose levels in rodents
Lin, Daniel C-H, Zhang, Jane, Zhuang, Run, Li, Frank, Nguyen, Kathy, Chen, Michael, Tran, Thanhvien, Lopez, Edwin, Lu, Jenny Ying Lin, Li, Xiaoyan Nina, Tang, Liang, Tonn, George R, Swaminath, Gayathri, Reagan, Jeff D, Chen, Jin-Long, Tian, Hui, Lin, Yi-Jyun, Houze, Jonathan B, Luo, Jian
Published in PloS one (08.11.2011)
Published in PloS one (08.11.2011)
Get full text
Journal Article
Discovery of AM-1638: A Potent and Orally Bioavailable GPR40/FFA1 Full Agonist
Brown, Sean P, Dransfield, Paul J, Vimolratana, Marc, Jiao, XianYun, Zhu, Liusheng, Pattaropong, Vatee, Sun, Ying, Liu, Jinqian, Luo, Jian, Zhang, Jane, Wong, Simon, Zhuang, Run, Guo, Qi, Li, Frank, Medina, Julio C, Swaminath, Gayathri, Lin, Daniel C.-H, Houze, Jonathan B
Published in ACS medicinal chemistry letters (13.09.2012)
Published in ACS medicinal chemistry letters (13.09.2012)
Get full text
Journal Article
Discovery and Optimization of Potent GPR40 Full Agonists Containing Tricyclic Spirocycles
Wang, Yingcai, Liu, Jiwen (Jim), Dransfield, Paul J, Zhu, Liusheng, Wang, Zhongyu, Du, Xiaohui, Jiao, Xianyun, Su, Yongli, Li, An-rong, Brown, Sean P, Kasparian, Annie, Vimolratana, Marc, Yu, Ming, Pattaropong, Vatee, Houze, Jonathan B, Swaminath, Gayathri, Tran, Thanhvien, Nguyen, Khanh, Guo, Qi, Zhang, Jane, Zhuang, Run, Li, Frank, Miao, Lynn, Bartberger, Michael D, Correll, Tiffany L, Chow, David, Wong, Simon, Luo, Jian, Lin, Daniel C.-H, Medina, Julio C
Published in ACS medicinal chemistry letters (13.06.2013)
Published in ACS medicinal chemistry letters (13.06.2013)
Get full text
Journal Article
A scalable organoid model of human autosomal dominant polycystic kidney disease for disease mechanism and drug discovery
Tran, Tracy, Song, Cheng Jack, Nguyen, Trang, Cheng, Shun-Yang, McMahon, Jill A., Yang, Rui, Guo, Qiuyu, Der, Balint, Lindström, Nils O., Lin, Daniel C.-H., McMahon, Andrew P.
Published in Cell stem cell (07.07.2022)
Published in Cell stem cell (07.07.2022)
Get full text
Journal Article
Optimization of GPR40 Agonists for Type 2 Diabetes
Liu, Jiwen (Jim), Wang, Yingcai, Ma, Zhihua, Schmitt, Mike, Zhu, Liusheng, Brown, Sean P, Dransfield, Paul J, Sun, Ying, Sharma, Rajiv, Guo, Qi, Zhuang, Run, Zhang, Jane, Luo, Jian, Tonn, George R, Wong, Simon, Swaminath, Gayathri, Medina, Julio C, Lin, Daniel C.-H, Houze, Jonathan B
Published in ACS medicinal chemistry letters (08.05.2014)
Published in ACS medicinal chemistry letters (08.05.2014)
Get full text
Journal Article
AMG 837: A potent, orally bioavailable GPR40 agonist
Houze, Jonathan B., Zhu, Liusheng, Sun, Ying, Akerman, Michelle, Qiu, Wei, Zhang, Alex J., Sharma, Rajiv, Schmitt, Michael, Wang, Yingcai, Liu, Jiwen, Liu, Jinqian, Medina, Julio C., Reagan, Jeff D., Luo, Jian, Tonn, George, Zhang, Jane, Lu, Jenny Ying-Lin, Chen, Michael, Lopez, Edwin, Nguyen, Kathy, Yang, Li, Tang, Liang, Tian, Hui, Shuttleworth, Steven J., Lin, Daniel C.-H.
Published in Bioorganic & medicinal chemistry letters (15.01.2012)
Published in Bioorganic & medicinal chemistry letters (15.01.2012)
Get full text
Journal Article
Evaluating insulin secretagogues in a humanized mouse model with functional human islets
Luo, Jian, Nguyen, Kathy, Chen, Michael, Tran, Than, Hao, Jianqiang, Tian, Bole, Rulifson, Ingrid C, Zhang, Ying, Tian, Lei, Zhang, Yu, Lopez, Edwin, Lin, Daniel C.-H, Wang, Yingcai, Ma, Zhihua, Houze, Jonathan, Guo, Zhiguang
Published in Metabolism, clinical and experimental (2013)
Published in Metabolism, clinical and experimental (2013)
Get full text
Journal Article
Aminopyrazole–Phenylalanine Based GPR142 Agonists: Discovery of Tool Compound and in Vivo Efficacy Studies
Yu, Ming, Lizarzaburu, Mike, Motani, Alykhan, Fu, Zice, Du, Xiaohui, Liu, Jiwen (Jim), Jiao, Xianyun, Lai, SuJen, Fan, Peter, Fu, Angela, Liu, Qingxiang, Murakoshi, Michiko, Nara, Futoshi, Oda, Kozo, Okuyama, Ryo, Reagan, Jeff D, Watanabe, Nobuaki, Yamazaki, Mami, Xiong, Yumei, Zhang, Ying, Zhuang, Run, Lin, Daniel C.-H, Houze, Jonathan B, Medina, Julio C, Li, Leping
Published in ACS medicinal chemistry letters (12.09.2013)
Published in ACS medicinal chemistry letters (12.09.2013)
Get full text
Journal Article
Discovery of the imidazole-derived GPR40 agonist AM-3189
Ma, Zhihua, Lin, Daniel C.-H., Sharma, Rajiv, Liu, Jinqian, Zhu, Liusheng, Li, An-Rong, Kohn, Todd, Wang, Yingcai, Liu, Jiwen (Jim), Bartberger, Michael D., Medina, Julio C., Zhuang, Run, Li, Frank, Zhang, Jane, Luo, Jian, Wong, Simon, Tonn, George R., Houze, Jonathan B.
Published in Bioorganic & medicinal chemistry letters (01.01.2016)
Published in Bioorganic & medicinal chemistry letters (01.01.2016)
Get full text
Journal Article
Discovery of AM-6226: A Potent and Orally Bioavailable GPR40 Full Agonist That Displays Efficacy in Nonhuman Primates
Brown, Sean P., Dransfield, Paul, Vimolratana, Marc, Zhu, Liusheng, Luo, Jian, Zhang, Jane, Jiao, XianYun, Pattaropong, Vatee, Wong, Simon, Zhuang, Run, Swaminath, Gayathri, Houze, Jonathan B., Lin, Daniel C.-H.
Published in ACS medicinal chemistry letters (12.07.2018)
Published in ACS medicinal chemistry letters (12.07.2018)
Get full text
Journal Article
Improving the Pharmacokinetics of GPR40/FFA1 Full Agonists
Du, Xiaohui, Dransfield, Paul J, Lin, Daniel C.-H, Wong, Simon, Wang, Yingcai, Wang, Zhongyu, Kohn, Todd, Yu, Ming, Brown, Sean P, Vimolratana, Marc, Zhu, Liusheng, Li, An-Rong, Su, Yongli, Jiao, Xianyun, Liu, Jiwen (Jim), Swaminath, Gayathri, Tran, Thanhvien, Luo, Jian, Zhuang, Run, Zhang, Jane, Guo, Qi, Li, Frank, Connors, Richard, Medina, Julio C, Houze, Jonathan B
Published in ACS medicinal chemistry letters (10.04.2014)
Published in ACS medicinal chemistry letters (10.04.2014)
Get full text
Journal Article
Structural basis for pharmacological modulation of the TRPC6 channel
Bai, Yonghong, Yu, Xinchao, Chen, Hao, Horne, Daniel, White, Ryan, Wu, Xiaosu, Lee, Paul, Gu, Yan, Ghimire-Rijal, Sudipa, Lin, Daniel C-H, Huang, Xin
Published in eLife (09.03.2020)
Published in eLife (09.03.2020)
Get full text
Journal Article
HSD17B13 발현을 억제하기 위한 RNAI 작제물 및 이의 사용 방법
COLLINS PATRICK, OLLMANN MICHAEL, HERBERICH BRADLEY J, DAS AMRITA, MURRAY JUSTIN K, LIN DANIEL C. H, HOMANN OLIVER
Year of Publication 11.01.2024
Get full text
Year of Publication 11.01.2024
Patent
SCAP 발현을 저해하기 위한 RNAI 구성체 및 이의 사용 방법
HERBERICH BRADLEY J, OLLMANN MICHAEL, DAS AMRITA, MURRAY JUSTIN K, LIN DANIEL C. H, HOMANN OLIVER
Year of Publication 08.02.2022
Get full text
Year of Publication 08.02.2022
Patent