Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor
He, Xingyue, Riceberg, Jessica, Soucy, Teresa, Koenig, Erik, Minissale, James, Gallery, Melissa, Bernard, Hugues, Yang, Xiaofeng, Liao, Hua, Rabino, Claudia, Shah, Pooja, Xega, Kristina, Yan, Zhong-hua, Sintchak, Mike, Bradley, John, Xu, He, Duffey, Matt, England, Dylan, Mizutani, Hirotake, Hu, Zhigen, Guo, Jianping, Chau, Ryan, Dick, Lawrence R, Brownell, James E, Newcomb, John, Langston, Steve, Lightcap, Eric S, Bence, Neil, Pulukuri, Sai M
Published in Nature chemical biology (01.11.2017)
Published in Nature chemical biology (01.11.2017)
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A small-molecule SUMOylation inhibitor activates antitumor immune responses and potentiates immune therapies in preclinical models
Lightcap, Eric S, Yu, Pengfei, Grossman, Stephen, Song, Keli, Khattar, Mithun, Xega, Kristina, He, Xingyue, Gavin, James M, Imaichi, Hisashi, Garnsey, James J, Koenig, Erik, Zhang, Hongru, Lu, Zhen, Shah, Pooja, Fu, Yu, Milhollen, Michael A, Hatton, Beryl A, Riceberg, Jessica, Shinde, Vaishali, Li, Cong, Minissale, James, Yang, Xiaofeng, England, Dylan, Klinghoffer, Richard A, Langston, Steve, Galvin, Katherine, Shapiro, Gary, Pulukuri, Sai M, Fuchs, Serge Y, Huszar, Dennis
Published in Science translational medicine (15.09.2021)
Published in Science translational medicine (15.09.2021)
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Subsets of mononuclear phagocytes are enriched in the inflamed colons of patients with IBD
Liu, Hong, Dasgupta, Suryasarathi, Fu, Yu, Bailey, Brandi, Roy, Christian, Lightcap, Eric, Faustin, Benjamin
Published in BMC immunology (12.11.2019)
Published in BMC immunology (12.11.2019)
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Journal Article
PERK Inhibition by HC-5404 Sensitizes Renal Cell Carcinoma Tumor Models to Antiangiogenic Tyrosine Kinase Inhibitors
Stokes, Michael E, Calvo, Veronica, Fujisawa, Sho, Dudgeon, Crissy, Huang, Sharon, Ballal, Nupur, Shen, Leyi, Gasparek, Jennifer, Betzenhauser, Matthew, Taylor, Simon J, Staschke, Kirk A, Rigby, Alan C, Mulvihill, Mark J, Bose, Nandita, Lightcap, Eric S, Surguladze, David
Published in Clinical cancer research (01.12.2023)
Published in Clinical cancer research (01.12.2023)
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Journal Article
Novel DNA Damage Checkpoints Mediating Cell Death Induced by the NEDD8-Activating Enzyme Inhibitor MLN4924
BLANK, Jonathan L, LIU, Xiaozhen J, MILHOLLEN, Michael A, LIGHTCAP, Eric S, COSMOPOULOS, Katherine, BOUCK, David C, GARCIA, Khristofer, BERNARD, Hugues, TAYBER, Olga, HATHER, Greg, LIU, Ray, NARAYANAN, Usha
Published in Cancer research (Chicago, Ill.) (2013)
Published in Cancer research (Chicago, Ill.) (2013)
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CDC7 inhibition induces replication stress-mediated aneuploid cells with an inflammatory phenotype sensitizing tumors to immune checkpoint blockade
Morita, Tomoko Yamamori, Yu, Jie, Kashima, Yukie, Kamata, Ryo, Yamamoto, Gaku, Minamide, Tatsunori, Mashima, Chiaki, Yoshiya, Miyuki, Sakae, Yuta, Yamauchi, Toyohiro, Hakozaki, Yumi, Kageyama, Shun-ichiro, Nakamura, Akito, Lightcap, Eric, Tanaka, Kosuke, Niu, Huifeng, Kannan, Karuppiah, Ohashi, Akihiro
Published in Nature communications (18.11.2023)
Published in Nature communications (18.11.2023)
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MYC Regulation of a "Poor-Prognosis" Metastatic Cancer Cell State
Wolfer, Anita, Wittner, Ben S., Irimia, Daniel, Flavin, Richard J., Lupien, Mathieu, Gunawardane, Ruwanthi N., Meyer, Clifford A., Lightcap, Eric S., Tamayo, Pablo, Mesirov, Jill P., Liu, X. Shirley, Shioda, Toshi, Toner, Mehmet, Loda, Massimo, Brown, Myles, Brugge, Joan S., Ramaswamy, Sridhar
Published in Proceedings of the National Academy of Sciences - PNAS (23.02.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (23.02.2010)
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Quantitative Proteomic Analysis of Cellular Protein Modulation upon Inhibition of the NEDD8-Activating Enzyme by MLN4924
Liao, Hua, Liu, Xiaozhen J., Blank, Jonathan L., Bouck, David C., Bernard, Hugues, Garcia, Khristofer, Lightcap, Eric S.
Published in Molecular & cellular proteomics (01.11.2011)
Published in Molecular & cellular proteomics (01.11.2011)
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Journal Article
Functional role and oncogene-regulated expression of the BH3-only factor Bmf in mammary epithelial anoikis and morphogenesis
Schmelzle, Tobias, Mailleux, Arnaud A, Overholtzer, Michael, Carroll, Jason S, Solimini, Nicole L, Lightcap, Eric S, Veiby, Ole P, Brugge, Joan S
Published in Proceedings of the National Academy of Sciences - PNAS (06.03.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (06.03.2007)
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Nedd8-activating enzyme inhibitor MLN4924 provides synergy with mitomycin C through interactions with ATR, BRCA1/BRCA2, and chromatin dynamics pathways
Garcia, Khristofer, Blank, Jonathan L, Bouck, David C, Liu, Xiaozhen J, Sappal, Darshan S, Hather, Greg, Cosmopoulos, Katherine, Thomas, Michael P, Kuranda, Mike, Pickard, Michael D, Liu, Ray, Bandi, Syamala, Smith, Peter G, Lightcap, Eric S
Published in Molecular cancer therapeutics (01.06.2014)
Published in Molecular cancer therapeutics (01.06.2014)
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Journal Article
Genome-Wide siRNA Screen for Modulators of Cell Death Induced by Proteasome Inhibitor Bortezomib
SIQUAN CHEN, BLANK, Jonathan L, BURKHARDT, Anne L, WEI CHEN, GARCIA, Khristofer, SAPPAL, Darshan S, GRAY, Jesse, HALES, Paul, LEROY, Patrick J, RINGELING, John, RABINO, Claudia, SPELMAN, James J, PETERS, Theodore, MORGENSTERN, Jay P, LIGHTCAP, Eric S, LIU, Xiaozhen J, RAPPOLI, David M, PICKARD, Michael D, MENON, Saurabh, JIE YU, DRISCOLL, Denise L, LINGARAJ, Trupti
Published in Cancer research (Chicago, Ill.) (01.06.2010)
Published in Cancer research (Chicago, Ill.) (01.06.2010)
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Journal Article
Acoustic Liquid Handling for Rapid siRNA Transfection Optimization
Xiao, Andrew S, Lightcap, Eric S, Bouck, David C
Published in Journal of biomolecular screening (01.09.2015)
Published in Journal of biomolecular screening (01.09.2015)
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Journal Article
Complementary Whole-Genome Technologies Reveal the Cellular Response to Proteasome Inhibition by PS-341
Fleming, James A., Lightcap, Eric S., Sadis, Seth, Thoroddsen, Vala, Bulawa, Christine E., Blackman, Ronald K.
Published in Proceedings of the National Academy of Sciences - PNAS (05.02.2002)
Published in Proceedings of the National Academy of Sciences - PNAS (05.02.2002)
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Journal Article
Proteasome Inhibition Measurements: Clinical Application
Lightcap, Eric S, McCormack, Teresa A, Pien, Christine S, Chau, Vincent, Adams, Julian, Elliott, Peter J
Published in Clinical chemistry (Baltimore, Md.) (01.05.2000)
Published in Clinical chemistry (Baltimore, Md.) (01.05.2000)
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Akt and ERK control the proliferative response of mammary epithelial cells to the growth factors IGF-1 and EGF through the cell cycle inhibitor p57Kip2
Worster, Devin T, Schmelzle, Tobias, Solimini, Nicole L, Lightcap, Eric S, Millard, Bjorn, Mills, Gordon B, Brugge, Joan S, Albeck, John G
Published in Science signaling (06.03.2012)
Published in Science signaling (06.03.2012)
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Purification and inactivation of 3-hydroxyanthranilic acid 3,4-dioxygenase from beef liver
Nandi, Dhirendra, Lightcap, Eric S, Koo, Yumee Kim, Lu, Xingliang, Quancard, Jean, Silverman, Richard B
Published in The international journal of biochemistry & cell biology (01.07.2003)
Published in The international journal of biochemistry & cell biology (01.07.2003)
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Journal Article
Assays for proteasome inhibition
Elliott, Peter J, Soucy, Teresa A, Pien, Christine S, Adams, Julian, Lightcap, Eric S
Published in Methods in molecular medicine (2003)
Published in Methods in molecular medicine (2003)
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5 A Phase 1b, Open-Label, Safety, Tolerability, and Efficacy Study of HC-7366 in Combination with Belzutifan (WELIREGTM) in Patients with Advanced or Metastatic Renal Cell Carcinoma, NCT06234605
McKay, Rana R, Garmezy, Ben, Barata, Pedro, Ornstein, Moshe, Shah, Neil J, Hammers, Hans, Hutson, Thomas E, Chisamore, Michael, Karim, Dhamina, Mattson, Paulette, Lightcap, Eric, Drees, Jeremy, Harrison, Ben, Holm, Megan, Bose, Nandita, Thomas, Cherry T, Motzer, Robert J
Published in The oncologist (Dayton, Ohio) (06.08.2024)
Published in The oncologist (Dayton, Ohio) (06.08.2024)
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Activation of GCN2 By HC-7366 Results in Significant Anti-Tumor Efficacy As Monotherapy and Overcomes Resistance Mechanisms When Combined with Venetoclax in AML
Tameire, Feven, Collette, Nicholas, Fujisawaa, Sho, Bieging-Rolett, Kathryn, Dudgeon, Crissy, Stokes, Michael E., Harrison, Ben, LaCayo, Ashley, Wojnarowicz, Paulina, Drees, Jeremy, Staschke, Kirk A., Surguladze, David, Lightcap, Eric S., Bose, Nandita
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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