PI3K signaling in cancer: beyond AKT
Lien, Evan C, Dibble, Christian C, Toker, Alex
Published in Current opinion in cell biology (01.04.2017)
Published in Current opinion in cell biology (01.04.2017)
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Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton
Hu, Hai, Juvekar, Ashish, Lyssiotis, Costas A., Lien, Evan C., Albeck, John G., Oh, Doogie, Varma, Gopal, Hung, Yin Pun, Ullas, Soumya, Lauring, Josh, Seth, Pankaj, Lundquist, Mark R., Tolan, Dean R., Grant, Aaron K., Needleman, Daniel J., Asara, John M., Cantley, Lewis C., Wulf, Gerburg M.
Published in Cell (28.01.2016)
Published in Cell (28.01.2016)
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Journal Article
Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer
Lien, Evan C, Lyssiotis, Costas A, Juvekar, Ashish, Hu, Hai, Asara, John M, Cantley, Lewis C, Toker, Alex
Published in Nature cell biology (01.05.2016)
Published in Nature cell biology (01.05.2016)
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Journal Article
Metabolic Reprogramming by the PI3K-Akt-mTOR Pathway in Cancer
Lien, Evan C, Lyssiotis, Costas A, Cantley, Lewis C
Published in Recent results in cancer research (01.01.2016)
Published in Recent results in cancer research (01.01.2016)
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Journal Article
Low glycaemic diets alter lipid metabolism to influence tumour growth
Lien, Evan C, Westermark, Anna M, Zhang, Yin, Yuan, Chen, Li, Zhaoqi, Lau, Allison N, Sapp, Kiera M, Wolpin, Brian M, Vander Heiden, Matthew G
Published in Nature (London) (11.11.2021)
Published in Nature (London) (11.11.2021)
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Journal Article
MSC-Regulated MicroRNAs Converge on the Transcription Factor FOXP2 and Promote Breast Cancer Metastasis
Cuiffo, Benjamin G., Campagne, Antoine, Bell, George W., Lembo, Antonio, Orso, Francesca, Lien, Evan C., Bhasin, Manoj K., Raimo, Monica, Hanson, Summer E., Marusyk, Andriy, El-Ashry, Dorraya, Hematti, Peiman, Polyak, Kornelia, Mechta-Grigoriou, Fatima, Mariani, Odette, Volinia, Stefano, Vincent-Salomon, Anne, Taverna, Daniela, Karnoub, Antoine E.
Published in Cell stem cell (04.12.2014)
Published in Cell stem cell (04.12.2014)
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Inhibition of Rb Phosphorylation Leads to mTORC2-Mediated Activation of Akt
Zhang, Jinfang, Xu, Kai, Liu, Pengda, Geng, Yan, Wang, Bin, Gan, Wenjian, Guo, Jianping, Wu, Fei, Chin, Y. Rebecca, Berrios, Christian, Lien, Evan C., Toker, Alex, DeCaprio, James A., Sicinski, Piotr, Wei, Wenyi
Published in Molecular cell (16.06.2016)
Published in Molecular cell (16.06.2016)
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Journal Article
Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth
Cox, Andrew G, Hwang, Katie L, Brown, Kristin K, Evason, Kimberley, Beltz, Sebastian, Tsomides, Allison, O'Connor, Keelin, Galli, Giorgio G, Yimlamai, Dean, Chhangawala, Sagar, Yuan, Min, Lien, Evan C, Wucherpfennig, Julia, Nissim, Sahar, Minami, Akihiro, Cohen, David E, Camargo, Fernando D, Asara, John M, Houvras, Yariv, Stainier, Didier Y R, Goessling, Wolfram
Published in Nature cell biology (01.08.2016)
Published in Nature cell biology (01.08.2016)
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Journal Article
Ketogenic HMG‐CoA lyase and its product β‐hydroxybutyrate promote pancreatic cancer progression
Gouirand, Victoire, Gicquel, Tristan, Lien, Evan C, Jaune‐Pons, Emilie, Da Costa, Quentin, Finetti, Pascal, Metay, Elodie, Duluc, Camille, Mayers, Jared R, Audebert, Stephane, Camoin, Luc, Borge, Laurence, Rubis, Marion, Leca, Julie, Nigri, Jeremy, Bertucci, François, Dusetti, Nelson, Lucio Iovanna, Juan, Tomasini, Richard, Bidaut, Ghislain, Guillaumond, Fabienne, Vander Heiden, Matthew G, Vasseur, Sophie
Published in The EMBO journal (02.05.2022)
Published in The EMBO journal (02.05.2022)
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Journal Article
Altered exocrine function can drive adipose wasting in early pancreatic cancer
Danai, Laura V, Babic, Ana, Rosenthal, Michael H, Dennstedt, Emily A, Muir, Alexander, Lien, Evan C, Mayers, Jared R, Tai, Karen, Lau, Allison N, Jones-Sali, Paul, Prado, Carla M, Petersen, Gloria M, Takahashi, Naoki, Sugimoto, Motokazu, Yeh, Jen Jen, Lopez, Nicole, Bardeesy, Nabeel, Fernandez-Del Castillo, Carlos, Liss, Andrew S, Koong, Albert C, Bui, Justin, Yuan, Chen, Welch, Marisa W, Brais, Lauren K, Kulke, Matthew H, Dennis, Courtney, Clish, Clary B, Wolpin, Brian M, Vander Heiden, Matthew G
Published in Nature (London) (01.06.2018)
Published in Nature (London) (01.06.2018)
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Journal Article
Tumor lipid metabolism: a mechanistic link between diet and cancer progression
Jeong, Yu-Jin, Rogers, Thomas J, Anderson, Carolyn E, Lien, Evan C
Published in Current opinion in biotechnology (01.12.2023)
Published in Current opinion in biotechnology (01.12.2023)
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Journal Article
A CRISPRi/a screening platform to study cellular nutrient transport in diverse microenvironments
Chidley, Christopher, Darnell, Alicia M, Gaudio, Benjamin L, Lien, Evan C, Barbeau, Anna M, Vander Heiden, Matthew G, Sorger, Peter K
Published in Nature cell biology (01.05.2024)
Published in Nature cell biology (01.05.2024)
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Journal Article
REV1 inhibitor JH-RE-06 enhances tumor cell response to chemotherapy by triggering senescence hallmarks
Chatterjee, Nimrat, Whitman, Matthew A., Harris, Cynthia A., Min, Sophia M., Jonas, Oliver, Lien, Evan C., Luengo, Alba, Vander Heiden, Matthew G., Hong, Jiyong, Zhou, Pei, Hemann, Michael T., Walker, Graham C.
Published in Proceedings of the National Academy of Sciences - PNAS (17.11.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (17.11.2020)
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Journal Article
Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion
Juvekar, Ashish, Hu, Hai, Yadegarynia, Sina, Lyssiotis, Costas A., Ullas, Soumya, Lien, Evan C., Bellinger, Gary, Son, Jaekyoung, Hok, Rosanna C., Seth, Pankaj, Daly, Michele B., Kim, Baek, Scully, Ralph, Asara, John M., Cantley, Lewis C., Wulf, Gerburg M.
Published in Proceedings of the National Academy of Sciences - PNAS (26.07.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (26.07.2016)
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Journal Article
PI3K drives the de novo synthesis of coenzyme A from vitamin B5
Dibble, Christian C., Barritt, Samuel A., Perry, Grace E., Lien, Evan C., Geck, Renee C., DuBois-Coyne, Sarah E., Bartee, David, Zengeya, Thomas T., Cohen, Emily B., Yuan, Min, Hopkins, Benjamin D., Meier, Jordan L., Clohessy, John G., Asara, John M., Cantley, Lewis C., Toker, Alex
Published in Nature (London) (04.08.2022)
Published in Nature (London) (04.08.2022)
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Journal Article
Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth
Cox, Andrew G, Tsomides, Allison, Yimlamai, Dean, Hwang, Katie L, Miesfeld, Joel, Galli, Giorgio G, Fowl, Brendan H, Fort, Michael, Ma, Kimberly Y, Sullivan, Mark R, Hosios, Aaron M, Snay, Erin, Yuan, Min, Brown, Kristin K, Lien, Evan C, Chhangawala, Sagar, Steinhauser, Matthew L, Asara, John M, Houvras, Yariv, Link, Brian, Vander Heiden, Matthew G, Camargo, Fernando D, Goessling, Wolfram
Published in The EMBO journal (15.11.2018)
Published in The EMBO journal (15.11.2018)
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Journal Article
Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma
Lau, Allison N, Li, Zhaoqi, Danai, Laura V, Westermark, Anna M, Darnell, Alicia M, Ferreira, Raphael, Gocheva, Vasilena, Sivanand, Sharanya, Lien, Evan C, Sapp, Kiera M, Mayers, Jared R, Biffi, Giulia, Chin, Christopher R, Davidson, Shawn M, Tuveson, David A, Jacks, Tyler, Matheson, Nicholas J, Yilmaz, Omer, Vander Heiden, Matthew G
Published in eLife (10.07.2020)
Published in eLife (10.07.2020)
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