An optically controlled probe identifies lipid-gating fenestrations within the TRPC3 channel
Lichtenegger, Michaela, Tiapko, Oleksandra, Svobodova, Barbora, Stockner, Thomas, Glasnov, Toma N., Schreibmayer, Wolfgang, Platzer, Dieter, de la Cruz, Gema Guedes, Krenn, Sarah, Schober, Romana, Shrestha, Niroj, Schindl, Rainer, Romanin, Christoph, Groschner, Klaus
Published in Nature chemical biology (01.04.2018)
Published in Nature chemical biology (01.04.2018)
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Journal Article
PKC-dependent coupling of calcium permeation through transient receptor potential canonical 3 (TRPC3) to calcineurin signaling in HL-1 myocytes
Poteser, Michael, Schleifer, Hannes, Lichtenegger, Michaela, Schernthaner, Michaela, Stockner, Thomas, Kappe, C. Oliver, Glasnov, Toma N, Romanin, Christoph, Groschner, Klaus
Published in Proceedings of the National Academy of Sciences - PNAS (28.06.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (28.06.2011)
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Journal Article
Intensified Microwave-Assisted N-Acylation Procedure -Synthesis and Activity Evaluation of TRPC3 Channel Agonists with a 1,3-Di-hydro-2H-benzo[d] imidazol-2-one Core
de la Cruz, Gema Guedes, Svobodova, Barbora, Lichtenegger, Michaela, Tiapko, Oleksandra, Groschner, Klaus, Glasnov, Toma
Published in Synlett (01.04.2017)
Published in Synlett (01.04.2017)
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Journal Article
TRPC3 contributes to regulation of cardiac contractility and arrhythmogenesis by dynamic interaction with NCX1
Doleschal, Bernhard, Primessnig, Uwe, Wölkart, Gerald, Wolf, Stefan, Schernthaner, Michaela, Lichtenegger, Michaela, Glasnov, Toma N, Kappe, C Oliver, Mayer, Bernd, Antoons, Gudrun, Heinzel, Frank, Poteser, Michael, Groschner, Klaus
Published in Cardiovascular research (01.04.2015)
Published in Cardiovascular research (01.04.2015)
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Journal Article
Intensified Microwave-Assisted N-Acylation Procedure – Synthesis and Activity Evaluation of TRPC3 Channel Agonists with a 1,3-Dihydro-2H-benzo[d]imidazol-2-one Core
Guedes de la Cruz, Gema, Svobodova, Barbora, Lichtenegger, Michaela, Tiapko, Oleksandra, Groschner, Klaus, Glasnov, Toma
Published in Synlett (01.04.2017)
Published in Synlett (01.04.2017)
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Journal Article
Photopharmacological Modulation of Lipid-Gated TRPC Channels as a Strategy to Govern Neuronal Excitability
Tiapko, Oleksandra, Guedes de la Cruz, Gema, Glasnov, Toma, Kubista, Helmut, Lichtenegger, Michaela, Groschner, Klaus
Published in Biophysical journal (03.02.2017)
Published in Biophysical journal (03.02.2017)
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Journal Article
A single point mutation in the TRPC3 lipid-recognition window generates supersensitivity to benzimidazole channel activators
Svobodova, Barbora, Lichtenegger, Michaela, Platzer, Dieter, Di Giuro, Cristiana M.L., de la Cruz, Gema Guedes, Glasnov, Toma, Schreibmayer, Wolfgang, Groschner, Klaus
Published in Cell calcium (Edinburgh) (01.05.2019)
Published in Cell calcium (Edinburgh) (01.05.2019)
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Journal Article
Intensified Microwave-Assisted N-Acylation Procedure - Synthesis and Activity Evaluation of TRPC3 Channel Agonists with a 1,3-Dihydro-2 H -benzo[ d ]imidazol-2-one Core
de la Cruz, Gema Guedes, Svobodova, Barbora, Lichtenegger, Michaela, Tiapko, Oleksandra, Groschner, Klaus, Glasnov, Toma
Published in Synlett (01.04.2017)
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Published in Synlett (01.04.2017)
Journal Article
A novel homology model of TRPC3 reveals allosteric coupling between gate and selectivity filter
Lichtenegger, Michaela, Stockner, Thomas, Poteser, Michael, Schleifer, Hannes, Platzer, Dieter, Romanin, Christoph, Groschner, Klaus
Published in Cell calcium (Edinburgh) (01.09.2013)
Published in Cell calcium (Edinburgh) (01.09.2013)
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Journal Article
TRPC3-Calcineurin Microdomains Govern Orai1 Signaling in Mast Cells
Poteser, Michael, Bacsa, Bernadett, Tiapko, Oleksandra, Lichtenegger, Michaela, Frischauf, Irene, Romanin, Christoph, Groschner, Klaus
Published in Biophysical journal (16.02.2016)
Published in Biophysical journal (16.02.2016)
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Journal Article
Allosteric Coupling Between Gate and Selectivity Filter in TRPC3
Lichtenegger, Michaela, Stockner, Thomas, Poteser, Michael, Groschner, Klaus
Published in Biophysical journal (28.01.2014)
Published in Biophysical journal (28.01.2014)
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Journal Article
Identification of an Essential Structural Element of Lipid Gating Mechanism in the Transient Receptor Potential Canonical Channel Type 3 (TRPC3)
Svobodova, Barbora, Lichtenegger, Michaela, Glasnov, Toma, Stockner, Thomas, Platzer, Dieter, Poteser, Michael, Groschner, Klaus
Published in Biophysical journal (27.01.2015)
Published in Biophysical journal (27.01.2015)
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Journal Article
Photoswitchable Diacylglycerols Identify a Novel Lipid-Gating Mechanism in TRPC3 Channels
Tiapko, Oleksandra, Lichtenegger, Michaela, de la Cruz, Gema Guedes, Glasnov, Toma N., Svobodova, Barbora, Schreibmayer, Wolfgang, Platzer, Dieter, Krenn, Sarah, Shrestha, Niroj, Schindl, Rainer, Stockner, Thomas, Romanin, Christoph, Groschner, Klaus
Published in Biophysical journal (02.02.2018)
Published in Biophysical journal (02.02.2018)
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Journal Article
Analysis of the Functional Determinants of Cation Permeation Through TRPC3
Poteser, Michael, Lichtenegger, Michaela, Schleifer, Hannes, Romanin, Christoph, Groschner, Klaus
Published in Biophysical journal (01.02.2011)
Published in Biophysical journal (01.02.2011)
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Journal Article
Engineering of the TRPC3 Selectivity Filter Identifies a Unique, Dual Signaling Function of TRPC3 in the Heart
Lichtenegger, Michaela, Poteser, Michael, Stockner, Thomas, Schleifer, Hannes, Romanin, Christoph, Groschner, Klaus
Published in Biophysical journal (01.02.2011)
Published in Biophysical journal (01.02.2011)
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Journal Article
Molecular engineering of the TRPC3 pore structure identifies Ca2+ permeation through TRPC3 channels as a key determinant of cardiac calcineurin/NFAT signaling
Lichtenegger, Michaela, Schleifer, Hannes, Stockner, Thomas, Romanin, Christoph, Poteser, Michael, Groschner, Klaus
Published in BMC pharmacology (16.11.2010)
Published in BMC pharmacology (16.11.2010)
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Journal Article