TTK Inhibitors as a Targeted Therapy for CTNNB1 ( β -catenin) Mutant Cancers
Zaman, Guido J R, de Roos, Jeroen A D M, Libouban, Marion A A, Prinsen, Martine B W, de Man, Jos, Buijsman, Rogier C, Uitdehaag, Joost C M
Published in Molecular cancer therapeutics (01.11.2017)
Published in Molecular cancer therapeutics (01.11.2017)
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Journal Article
Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity
Uitdehaag, Joost C.M., de Man, Jos, Willemsen-Seegers, Nicole, Prinsen, Martine B.W., Libouban, Marion A.A., Sterrenburg, Jan Gerard, de Wit, Joeri J.P., de Vetter, Judith R.F., de Roos, Jeroen A.D.M., Buijsman, Rogier C., Zaman, Guido J.R.
Published in Journal of molecular biology (07.07.2017)
Published in Journal of molecular biology (07.07.2017)
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Stable aneuploid tumors cells are more sensitive to TTK inhibition than chromosomally unstable cell lines
Libouban, Marion A A, de Roos, Jeroen A D M, Uitdehaag, Joost C M, Willemsen-Seegers, Nicole, Mainardi, Sara, Dylus, Jelle, de Man, Jos, Tops, Bastiaan, Meijerink, Jules P P, Storchová, Zuzana, Buijsman, Rogier C, Medema, René H, Zaman, Guido J R
Published in Oncotarget (13.06.2017)
Published in Oncotarget (13.06.2017)
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74 a-TIGIT mAb belrestotug in combination with anti-PD1 induces an immunocompetent tumor microenvironment (TME)
Cuende, Julia, Ma, Stephanie, Welsby, Iain, Rosewick, Nicolas, Wald, Noemie, Vezzu, Anais, Mercier, Marjorie, Tieppo, Paola, Claes, Bart, McGrath, Yvonne, Henau, Olivier De, Driessens, Gregory, Ceppi, Maurizio, Libouban, Marion
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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The transcription factor Spi-B regulates human plasmacytoid dendritic cell survival through direct induction of the antiapoptotic gene BCL2-A1
Karrich, Julien J., Balzarolo, Melania, Schmidlin, Heike, Libouban, Marion, Nagasawa, Maho, Gentek, Rebecca, Kamihira, Shimeru, Maeda, Takahiro, Amsen, Derk, Wolkers, Monika C., Blom, Bianca
Published in Blood (31.05.2012)
Published in Blood (31.05.2012)
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Abstract B065: TTK inhibitors as a targeted therapy for β-catenin mutant cancers
Zaman, Guido, de Roos, Jeroen, Libouban, Marion, Prinsen, Martine, de Man, Jos, Buijsman, Rogier, Uitdehaag, Joost
Published in Molecular cancer therapeutics (01.01.2018)
Published in Molecular cancer therapeutics (01.01.2018)
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MicroRNA-146a regulates survival and maturation of human plasmacytoid dendritic cells
Karrich, Julien J., Jachimowski, Loes C.M., Libouban, Marion, Iyer, Anand, Brandwijk, Kim, Taanman-Kueter, Esther W., Nagasawa, Maho, de Jong, Esther C., Uittenbogaart, Christel H., Blom, Bianca
Published in Blood (24.10.2013)
Published in Blood (24.10.2013)
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Differentiated pharmacokinetic and pharmacodynamic properties of a highly selective MET kinase inhibitor, OMO-1: Implications for efficacy and safety
Perera, Timothy Pietro Suren, Libouban, Marion, Jansen, Ellen, Tjwa, Marc, Ciamporcero, Eric, Meulemans, Ann, Van der Aa, Annegret, Clack, Glen, Lolkema, Martijn P.
Published in Journal of clinical oncology (20.05.2019)
Published in Journal of clinical oncology (20.05.2019)
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Abstract 4791: OMO-1, a potent, highly selective, orally bioavailable, MET kinase inhibitor with a favorable preclinical toxicity profile, shows both monotherapy activity, against MET pathway-driven tumors, and EGFR TKI combination activity in acquired resistance models
Libouban, Marion, Jovcehva, Eleonora, Lange, Desiree De, Janssens, Boudewijn, Verhulst, Tinne, Ogata, Souichi, Wroblowski, Berthold, Mevellec, Laurence, Lu, Tianbao, Clack, Glen, Perera, Timothy
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Modular phase I/II clinical trial evaluating the selective MET-kinase inhibitor OMO-1 in patients with advanced malignancies: Safety and proof of mechanism
Lolkema, Martijn P., Plummer, Elizabeth Ruth, De Vos, Filip Yves Francine Leon, Forster, Martin David, Angevin, Eric, Libouban, Marion, Jansen, Ellen, Tjwa, Marc, Ciamporcero, Eric, Meulemans, Ann, Van der Aa, Annegret, Perera, Timothy Pietro Suren, Clack, Glen, Krebs, Matthew, Blagden, Sarah Patricia
Published in Journal of clinical oncology (20.05.2019)
Published in Journal of clinical oncology (20.05.2019)
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Abstract 3457: Stable aneuploid cells are more sensitive to TTK inhibition than chromosome instable cell lines
Libouban, Marion A.A., Roos, Jeroen A.D.M. de, Uitdehaag, Joost C.M., Willemsen-Seegers, Nicole, Mainardi, Sara, Dylus, Jelle, Man, Jos de, Tops, Bastiaan, Meijerink, Jules P.P., Storchová, Zuzana, Buijsman, Rogier C., Medema, René H., Zaman, Guido J.R.
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Abstract 4185: NTRC 1501-0, a TTK kinase inhibitor selected for its long target residence time, completely inhibits tumor growth in the MDA-MB-231 xenograft model for triple-negative breast cancer
Uitdehaag, Joost C., Man, Jos de, Libouban, Marion, Willemsen-Seegers, Nicole, Sterrenburg, Jan Gerard, Wit, Joeri J. de, Roos, Jeroen A.D de, Prinsen, Martine B., Buijsman, Rogier C., Zaman, Guido J.
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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A modular, multi-arm, multi-part, first time in patient study to evaluate the safety and tolerability of the dual MET kinase/OCT2 inhibitor, OMO-1, alone and in combination with anti-cancer treatments, in patients with locally advanced, unresectable or metastatic solid malignancies
Plummer, Elizabeth Ruth, Lolkema, Martijn P., Aerts, Joachim G.J.V., De Vos, Filip Yves Francine Leon, Forster, Martin, ANGEVIN, ERIC, Kristeleit, Rebecca Sophie, Perera, Tim, Clack, Glen, Meulemans, Ann, Libouban, Marion, Hari Dass, Prashanth, Drew, Yvette, Tinsley, Nadina, Balaratnam, Shankar, Blagden, Sarah Patricia, Krebs, Matthew
Published in Journal of clinical oncology (20.05.2018)
Published in Journal of clinical oncology (20.05.2018)
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Abstract LB189: Pharmacodynamic assessment of a-TIGIT mAb EOS-448 highlights multiple FcγR-mediated mode-of-actions in blood and tumor of patients with advanced solid tumors
Cuende, Julia, Preillon, Julie, Wald, Noemie, Mercier, Marjorie, Tieppo, Paola, Welsby, Iain, Bodo, Veronique, McGrath, Yvonne, Van Den Mooter, Tom F., Machiels, Jean-Pascal, Truong, Clarisse, De Henau, Olivier, Driessens, Gregory, Libouban, Marion
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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