The binding and mechanism of a positive allosteric modulator of Kv3 channels
Liang, Qiansheng, Chi, Gamma, Cirqueira, Leonardo, Zhi, Lianteng, Marasco, Agostino, Pilati, Nadia, Gunthorpe, Martin J, Alvaro, Giuseppe, Large, Charles H, Sauer, David B, Treptow, Werner, Covarrubias, Manuel
Published in Nature communications (21.03.2024)
Published in Nature communications (21.03.2024)
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Journal Article
Cryo-EM structure of the human Kv3.1 channel reveals gating control by the cytoplasmic T1 domain
Chi, Gamma, Liang, Qiansheng, Sridhar, Akshay, Cowgill, John B, Sader, Kasim, Radjainia, Mazdak, Qian, Pu, Castro-Hartmann, Pablo, Venkaya, Shayla, Singh, Nanki Kaur, McKinley, Gavin, Fernandez-Cid, Alejandra, Mukhopadhyay, Shubhashish M M, Burgess-Brown, Nicola A, Delemotte, Lucie, Covarrubias, Manuel, Dürr, Katharina L
Published in Nature communications (15.07.2022)
Published in Nature communications (15.07.2022)
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Journal Article
Novel Activation of Voltage-gated K+ Channels by Sevoflurane
Barber, Annika F., Liang, Qiansheng, Covarrubias, Manuel
Published in The Journal of biological chemistry (23.11.2012)
Published in The Journal of biological chemistry (23.11.2012)
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Journal Article
Positive Allosteric Modulation of Kv Channels by Sevoflurane: Insights into the Structural Basis of Inhaled Anesthetic Action
Liang, Qiansheng, Anderson, Warren D, Jones, Shelly T, Souza, Caio S, Hosoume, Juliana M, Treptow, Werner, Covarrubias, Manuel
Published in PloS one (24.11.2015)
Published in PloS one (24.11.2015)
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Role for the Propofol Hydroxyl in Anesthetic Protein Target Molecular Recognition
Woll, Kellie A, Weiser, Brian P, Liang, Qiansheng, Meng, Tao, McKinstry-Wu, Andrew, Pinch, Benika, Dailey, William P, Gao, Wei Dong, Covarrubias, Manuel, Eckenhoff, Roderic G
Published in ACS chemical neuroscience (17.06.2015)
Published in ACS chemical neuroscience (17.06.2015)
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Tanshinone IIA Selectively Enhances Hyperpolarization-Activated Cyclic Nucleotide–Modulated (HCN) Channel Instantaneous Current
Liang, Qiansheng, Yang, Le, Wang, Zhaohua, Huang, Sufang, Li, Shusheng, Yang, Guangtian
Published in Journal of Pharmacological Sciences (2009)
Published in Journal of Pharmacological Sciences (2009)
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Sodium tanshinone IIA sulfonate depresses angiotensin II-induced cardiomyocyte hypertrophy through MEK/ERK pathway
Yang, Le, Zou, Xiaojing, Liang, Qiansheng, Chen, Hao, Feng, Jun, Yan, Li, Wang, Zhaohua, Zhou, Daixing, Li, Shusheng, Yao, Shanglong, Zheng, Zhi
Published in Experimental & molecular medicine (01.02.2007)
Published in Experimental & molecular medicine (01.02.2007)
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A structurally precise mechanism links an epilepsy-associated KCNC2 potassium channel mutation to interneuron dysfunction
Clatot, Jerome, Currin, Christopher B, Liang, Qiansheng, Pipatpolkai, Tanadet, Massey, Shavonne L, Helbig, Ingo, Delemotte, Lucie, Vogels, Tim P, Covarrubias, Manuel, Goldberg, Ethan M
Published in Proceedings of the National Academy of Sciences - PNAS (16.01.2024)
Published in Proceedings of the National Academy of Sciences - PNAS (16.01.2024)
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A New Class of Positive Gating Modulators of hKv3.2 Channels: Insights into the Mechanism of Action
Liang, Qiansheng, Alvaro, Giuseppe, Large, Charles, Covarrubias, Manuel
Published in Biophysical journal (27.01.2015)
Published in Biophysical journal (27.01.2015)
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Journal Article
Sevoflurane: A Potent General Anesthetic Enhancer of Kv Channel Activation
Barber, Annika F., Liang, Qiansheng, Covarrubias, Manuel
Published in Biophysical journal (31.01.2012)
Published in Biophysical journal (31.01.2012)
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Journal Article
Photoaffinity Ligand for the Inhalational Anesthetic Sevoflurane Allows Mechanistic Insight into Potassium Channel Modulation
Woll, Kellie A, Peng, Wesley, Liang, Qiansheng, Zhi, Lianteng, Jacobs, Jack A, Maciunas, Lina, Bhanu, Natarajan, Garcia, Benjamin A, Covarrubias, Manuel, Loll, Patrick J, Dailey, William P, Eckenhoff, Roderic G
Published in ACS chemical biology (19.05.2017)
Published in ACS chemical biology (19.05.2017)
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Journal Article
Molecular Mapping of General Anesthetic Sites in a Voltage-Gated Ion Channel
Barber, Annika F., Liang, Qiansheng, Amaral, Cristiano, Treptow, Werner, Covarrubias, Manuel
Published in Biophysical journal (05.10.2011)
Published in Biophysical journal (05.10.2011)
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Journal Article
Targeted therapy improves cellular dysfunction, ataxia, and seizure susceptibility in a model of a progressive myoclonus epilepsy
Feng, Huijie, Clatot, Jerome, Kaneko, Keisuke, Flores-Mendez, Marco, Wengert, Eric R., Koutcher, Carly, Hoddeson, Emily, Lopez, Emily, Lee, Demetrius, Arias, Leroy, Liang, Qiansheng, Zhang, Xiaohong, Somarowthu, Ala, Covarrubias, Manuel, Gunthorpe, Martin J., Large, Charles H., Akizu, Naiara, Goldberg, Ethan M.
Published in Cell reports. Medicine (20.02.2024)
Published in Cell reports. Medicine (20.02.2024)
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