Whole Chromosome Instability induces senescence and promotes SASP
Andriani, Grasiella Angelina, Almeida, Vinnycius Pereira, Faggioli, Francesca, Mauro, Maurizio, Tsai, Wanxia Li, Santambrogio, Laura, Maslov, Alexander, Gadina, Massimo, Campisi, Judith, Vijg, Jan, Montagna, Cristina
Published in Scientific reports (12.10.2016)
Published in Scientific reports (12.10.2016)
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Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease
Lalaoui, Najoua, Boyden, Steven E., Oda, Hirotsugu, Wood, Geryl M., Stone, Deborah L., Chau, Diep, Liu, Lin, Stoffels, Monique, Kratina, Tobias, Lawlor, Kate E., Zaal, Kristien J. M., Hoffmann, Patrycja M., Etemadi, Nima, Shield-Artin, Kristy, Biben, Christine, Tsai, Wanxia Li, Blake, Mary D., Kuehn, Hye Sun, Yang, Dan, Anderton, Holly, Silke, Natasha, Wachsmuth, Laurens, Zheng, Lixin, Moura, Natalia Sampaio, Beck, David B., Gutierrez-Cruz, Gustavo, Ombrello, Amanda K., Pinto-Patarroyo, Gineth P., Kueh, Andrew J., Herold, Marco J., Hall, Cathrine, Wang, Hongying, Chae, Jae Jin, Dmitrieva, Natalia I., McKenzie, Mark, Light, Amanda, Barham, Beverly K., Jones, Anne, Romeo, Tina M., Zhou, Qing, Aksentijevich, Ivona, Mullikin, James C., Gross, Andrew J., Shum, Anthony K., Hawkins, Edwin D., Masters, Seth L., Lenardo, Michael J., Boehm, Manfred, Rosenzweig, Sergio D., Pasparakis, Manolis, Voss, Anne K., Gadina, Massimo, Kastner, Daniel L., Silke, John
Published in Nature (London) (02.01.2020)
Published in Nature (London) (02.01.2020)
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Phase 1 double-blind randomized safety trial of the Janus kinase inhibitor tofacitinib in systemic lupus erythematosus
Hasni, Sarfaraz A., Gupta, Sarthak, Davis, Michael, Poncio, Elaine, Temesgen-Oyelakin, Yenealem, Carlucci, Philip M., Wang, Xinghao, Naqi, Mohammad, Playford, Martin P., Goel, Rishi R., Li, Xiaobai, Biehl, Ann J., Ochoa-Navas, Isabel, Manna, Zerai, Shi, Yinghui, Thomas, Donald, Chen, Jinguo, Biancotto, Angélique, Apps, Richard, Cheung, Foo, Kotliarov, Yuri, Babyak, Ashley L., Zhou, Huizhi, Shi, Rongye, Stagliano, Katie, Tsai, Wanxia Li, Vian, Laura, Gazaniga, Nathalia, Giudice, Valentina, Lu, Shajia, Brooks, Stephen R., MacKay, Meggan, Gregersen, Peter, Mehta, Nehal N., Remaley, Alan T., Diamond, Betty, O’Shea, John J., Gadina, Massimo, Kaplan, Mariana J.
Published in Nature communications (07.06.2021)
Published in Nature communications (07.06.2021)
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Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease
Zhou, Qing, Yu, Xiaomin, Demirkaya, Erkan, Deuitch, Natalie, Stone, Deborah, Tsai, Wanxia Li, Kuehn, Hye Sun, Wang, Hongying, Yang, Dan, Park, Yong Hwan, Ombrello, Amanda K., Blake, Mary, Romeo, Tina, Remmers, Elaine F., Chae, Jae Jin, Mullikin, James C., Güzel, Ferhat, Milner, Joshua D., Boehm, Manfred, Rosenzweig, Sergio D., Gadina, Massimo, Welch, Steven B., Özen, Seza, Topaloglu, Rezan, Abinun, Mario, Kastner, Daniel L., Aksentijevich, Ivona
Published in Proceedings of the National Academy of Sciences - PNAS (06.09.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (06.09.2016)
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Journal Article
Pharmacokinetics, Pharmacodynamics, and Proposed Dosing of the Oral JAK1 and JAK2 Inhibitor Baricitinib in Pediatric and Young Adult CANDLE and SAVI Patients
Kim, Hanna, Brooks, Kristina M, Tang, Cheng Cai, Wakim, Paul, Blake, Mary, Brooks, Stephen R, Montealegre Sanchez, Gina A, de Jesus, Adriana A, Huang, Yan, Tsai, Wanxia Li, Gadina, Massimo, Prakash, Apurva, Janes, Jonathan Marcus, Zhang, Xin, Macias, William L, Kumar, Parag, Goldbach-Mansky, Raphaela
Published in Clinical pharmacology and therapeutics (01.08.2018)
Published in Clinical pharmacology and therapeutics (01.08.2018)
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Journal Article
Janus kinase (JAK) inhibition with baricitinib in refractory juvenile dermatomyositis
Kim, Hanna, Dill, Samantha, O'Brien, Michelle, Vian, Laura, Li, Xiaobai, Manukyan, Manuk, Jain, Minal, Adeojo, Lilian W, George, Jomy, Perez, Maria, Grom, Alexei A, Sutter, Michelle, Feldman, Brian M, Yao, Lawrence, Millwood, Michelle, Brundidge, April, Pichard, Dominique C, Cowen, Edward W, Shi, Yinghui, Lu, Shajia, Tsai, Wanxia Li, Gadina, Massimo, Rider, Lisa G, Colbert, Robert A
Published in Annals of the rheumatic diseases (01.03.2021)
Published in Annals of the rheumatic diseases (01.03.2021)
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Pleiotropic consequences of metabolic stress for the major histocompatibility complex class II molecule antigen processing and presentation machinery
Clement, Cristina C., Nanaware, Padma P., Yamazaki, Takahiro, Negroni, Maria Pia, Ramesh, Karthik, Morozova, Kateryna, Thangaswamy, Sangeetha, Graves, Austin, Kim, Hei Jung, Li, Tsai Wanxia, Vigano’, Marco, Soni, Rajesh K., Gadina, Massimo, Tse, Harley Y., Galluzzi, Lorenzo, Roche, Paul A., Denzin, Lisa K., Stern, Lawrence J., Santambrogio, Laura
Published in Immunity (Cambridge, Mass.) (13.04.2021)
Published in Immunity (Cambridge, Mass.) (13.04.2021)
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Interrupting an IFN-γ-dependent feedback loop in the syndrome of pyogenic arthritis with pyoderma gangrenosum and acne
Lee, Wonyong, Stone, Deborah L, Hoffmann, Patrycja, Rosenzweig, Sofia, Tsai, Wanxia Li, Gadina, Massimo, Romeo, Tina, Lee, Chyi-Chia Richard, Randazzo, Davide, Pimpale Chavan, Pallavi, Manthiram, Kalpana, Canna, Scott, Park, Yong Hwan, Ombrello, Amanda K, Aksentijevich, Ivona, Kastner, Daniel L, Chae, Jae Jin
Published in Annals of the rheumatic diseases (01.06.2024)
Published in Annals of the rheumatic diseases (01.06.2024)
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CD11b activation suppresses TLR-dependent inflammation and autoimmunity in systemic lupus erythematosus
Faridi, Mohd Hafeez, Khan, Samia Q, Zhao, Wenpu, Lee, Ha Won, Altintas, Mehmet M, Zhang, Kun, Kumar, Vinay, Armstrong, Andrew R, Carmona-Rivera, Carmelo, Dorschner, Jessica M, Schnaith, Abigail M, Li, Xiaobo, Ghodke-Puranik, Yogita, Moore, Erica, Purmalek, Monica, Irizarry-Caro, Jorge, Zhang, Tingting, Day, Rachael, Stoub, Darren, Hoffmann, Victoria, Khaliqdina, Shehryar Jehangir, Bhargava, Prachal, Santander, Ana M, Torroella-Kouri, Marta, Issac, Biju, Cimbaluk, David J, Zloza, Andrew, Prabhakar, Rajeev, Deep, Shashank, Jolly, Meenakshi, Koh, Kwi Hye, Reichner, Jonathan S, Bradshaw, Elizabeth M, Chen, JianFeng, Moita, Luis F, Yuen, Peter S, Li Tsai, Wanxia, Singh, Bhupinder, Reiser, Jochen, Nath, Swapan K, Niewold, Timothy B, Vazquez-Padron, Roberto I, Kaplan, Mariana J, Gupta, Vineet
Published in The Journal of clinical investigation (01.04.2017)
Published in The Journal of clinical investigation (01.04.2017)
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The Aconitate Decarboxylase 1/Itaconate Pathway Modulates Immune Dysregulation and Associates with Cardiovascular Disease Markers and Disease Activity in Systemic Lupus Erythematosus
Patiño-Martinez, Eduardo, Nakabo, Shuichiro, Jiang, Kan, Carmona-Rivera, Carmelo, Tsai, Wanxia Li, Claybaugh, Dillon, Yu, Zu-Xi, Romero, Aracely, Bohrnsen, Eric, Schwarz, Benjamin, Solís-Barbosa, Miguel A, Blanco, Luz P, Naqi, Mohammad, Temesgen-Oyelakin, Yenealem, Davis, Michael, Manna, Zerai, Gupta, Sarthak, Mehta, Nehal, Naz, Faiza, dell'Orso, Stefania, Hasni, Sarfaraz, Kaplan, Mariana J
Published in The Journal of immunology (1950) (15.08.2024)
Published in The Journal of immunology (1950) (15.08.2024)
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3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine
Clement, Cristina C., D’Alessandro, Angelo, Thangaswamy, Sangeetha, Chalmers, Samantha, Furtado, Raquel, Spada, Sheila, Mondanelli, Giada, Ianni, Federica, Gehrke, Sarah, Gargaro, Marco, Manni, Giorgia, Cara, Luisa Carlota Lopez, Runge, Peter, Tsai, Wanxia Li, Karaman, Sinem, Arasa, Jorge, Fernandez-Rodriguez, Ruben, Beck, Amanda, Macchiarulo, Antonio, Gadina, Massimo, Halin, Cornelia, Fallarino, Francesca, Skobe, Mihaela, Veldhoen, Marc, Moretti, Simone, Formenti, Silvia, Demaria, Sandra, Soni, Rajesh K., Galarini, Roberta, Sardella, Roccaldo, Lauvau, Gregoire, Putterman, Chaim, Alitalo, Kari, Grohmann, Ursula, Santambrogio, Laura
Published in Nature communications (21.07.2021)
Published in Nature communications (21.07.2021)
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Second Case of HOIP Deficiency Expands Clinical Features and Defines Inflammatory Transcriptome Regulated by LUBAC
Oda, Hirotsugu, Beck, David B, Kuehn, Hye Sun, Sampaio Moura, Natalia, Hoffmann, Patrycja, Ibarra, Maria, Stoddard, Jennifer, Tsai, Wanxia Li, Gutierrez-Cruz, Gustavo, Gadina, Massimo, Rosenzweig, Sergio D, Kastner, Daniel L, Notarangelo, Luigi D, Aksentijevich, Ivona
Published in Frontiers in immunology (18.03.2019)
Published in Frontiers in immunology (18.03.2019)
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Recruitment of A20 by the C-terminal domain of NEMO suppresses NF-κB activation and autoinflammatory disease
Zilberman-Rudenko, Jevgenia, Shawver, Linda Monaco, Wessel, Alex W., Luo, Yongquan, Pelletier, Martin, Tsai, Wanxia Li, Lee, Younglang, Vonortas, Spiridon, Cheng, Laurence, Ashwell, Jonathan D., Orange, Jordan S., Siegel, Richard M., Hanson, Eric P.
Published in Proceedings of the National Academy of Sciences - PNAS (09.02.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (09.02.2016)
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Journal Article
Divergent roles for STAT4 in shaping differentiation of cytotoxic ILC1 and NK cells during gut inflammation
Scarno, Gianluca, Mazej, Julija, Laffranchi, Mattia, Di Censo, Chiara, Mattiola, Irene, Candelotti, Arianna M, Pietropaolo, Giuseppe, Stabile, Helena, Fionda, Cinzia, Peruzzi, Giovanna, Brooks, Stephen R, Tsai, Wanxia Li, Mikami, Yohei, Bernardini, Giovanni, Gismondi, Angela, Sozzani, Silvano, Di Santo, James P, Vosshenrich, Christian A J, Diefenbach, Andreas, Gadina, Massimo, Santoni, Angela, Sciumè, Giuseppe
Published in Proceedings of the National Academy of Sciences - PNAS (03.10.2023)
Published in Proceedings of the National Academy of Sciences - PNAS (03.10.2023)
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Germline gain-of-function myeloid differentiation primary response gene–88 (MYD88) mutation in a child with severe arthritis
Sikora, Keith A., Bennett, Joshua R., Vyncke, Laurens, Deng, Zuoming, Tsai, Wanxia Li, Pauwels, Ewald, Layh-Schmitt, Gerlinde, Brundidge, April, Navid, Fatemeh, Zaal, Kristien J.M., Hanson, Eric, Gadina, Massimo, Staudt, Louis M., Griffin, Thomas A., Tavernier, Jan, Peelman, Frank, Colbert, Robert A.
Published in Journal of allergy and clinical immunology (01.05.2018)
Published in Journal of allergy and clinical immunology (01.05.2018)
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PDIA3 epitope-driven immune autoreactivity contributes to hepatic damage in type 2 diabetes
Clement, Cristina C, Osan, Jaspreet, Buque, Aitziber, Nanaware, Padma P, Chang, Yoke-Chen, Perino, Giorgio, Shetty, Madhur, Yamazaki, Takahiro, Tsai, Wanxia Li, Urbanska, Aleksandra M, Calvo-Calle, J Mauricio, Ramsamooj, Shakti, Ramsamooj, Shakti, Vergani, Diego, Mieli-Vergani, Giorgina, Terziroli Beretta-Piccoli, Benedetta, Gadina, Massimo, Montagna, Cristina, Goncalves, Marcus DaSilva, Sallusto, Federica, Galluzzi, Lorenzo, Soni, Rajesh K, Stern, Lawrence J, Santambrogio, Laura
Published in Science immunology (12.08.2022)
Published in Science immunology (12.08.2022)
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Journal Article
Efficacy of topical ruxolitinib for cutaneous dermatomyositis
Lanis, Aviya, Kim, Hanna, Lu, Shajia, Tsai, Wanxia Li, Kaneshiro, Amy, Ehrlich, Alison, Martin, George, Schiffenbauer, Adam, Shenoi, Susan
Published in JAAD Case Reports (01.03.2024)
Published in JAAD Case Reports (01.03.2024)
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Changes in cardiorespiratory function and fatigue following 12 weeks of exercise training in women with systemic lupus erythematosus: a pilot study
Hasni, Sarfaraz, Feng, Li Rebekah, Chapman, Marquis, Gupta, Sarthak, Ahmad, Anam, Munday, Adam, Mazhar, Mir Ali, Li, Xiaobai, Lu, Shajia, Tsai, Wanxia Li, Gadina, Massimo, Davis, Michael, Chu, Jun, Manna, Zerai, Nakabo, Shuichiro, Kaplan, Mariana J, Saligan, Leorey, Keyser, Randall, Chan, Leighton, Chin, Lisa M K
Published in Lupus science & medicine (01.10.2022)
Published in Lupus science & medicine (01.10.2022)
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Journal Article
Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease
Zhou, Qing, Wang, Hongying, Schwartz, Daniella M, Stoffels, Monique, Park, Yong Hwan, Zhang, Yuan, Yang, Dan, Demirkaya, Erkan, Takeuchi, Masaki, Tsai, Wanxia Li, Lyons, Jonathan J, Yu, Xiaomin, Ouyang, Claudia, Chen, Celeste, Chin, David T, Zaal, Kristien, Chandrasekharappa, Settara C, P Hanson, Eric, Yu, Zhen, Mullikin, James C, Hasni, Sarfaraz A, Wertz, Ingrid E, Ombrello, Amanda K, Stone, Deborah L, Hoffmann, Patrycja, Jones, Anne, Barham, Beverly K, Leavis, Helen L, van Royen-Kerkof, Annet, Sibley, Cailin, Batu, Ezgi D, Gül, Ahmet, Siegel, Richard M, Boehm, Manfred, Milner, Joshua D, Ozen, Seza, Gadina, Massimo, Chae, JaeJin, Laxer, Ronald M, Kastner, Daniel L, Aksentijevich, Ivona
Published in Nature genetics (01.01.2016)
Published in Nature genetics (01.01.2016)
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Journal Article
Divergent roles for STAT4 in shaping differentiation of cytotoxic ILC1 and NK cells during gut inflammation
Scarno, Gianluca, Mazej, Julija, Laffranchi, Mattia, Di Censo, Chiara, Mattiola, Irene, Candelotti, Arianna M, Pietropaolo, Giuseppe, Stabile, Helena, Fionda, Cinzia, Peruzzi, Giovanna, Brooks, Stephen R, Tsai, Wanxia Li, Mikami, Yohei, Bernardini, Giovanni, Gismondi, Angela, Sozzani, Silvano, Di Santo, James P, Vosshenrich, Christian A J, Diefenbach, Andreas, Gadina, Massimo, Santoni, Angela, Sciumè, Giuseppe
Published in Proceedings of the National Academy of Sciences - PNAS (03.10.2023)
Published in Proceedings of the National Academy of Sciences - PNAS (03.10.2023)
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