The Bis(1,2,3,4-tetrahydroisoquinoline) Alkaloids Cepharanthine and Berbamine Are Ligands of SK Channels
Vitello, Romain, Taouba, Hossein, Derand, Marine, Liégeois, Jean-François
Published in ACS medicinal chemistry letters (08.02.2024)
Published in ACS medicinal chemistry letters (08.02.2024)
Get full text
Journal Article
Web Resource
The gating pore blocker 1-(2,4-xylyl)guanidinium selectively inhibits pacemaking of midbrain dopaminergic neurons
Jehasse, Kevin, Massotte, Laurent, Hartmann, Sebastian, Vitello, Romain, Ringlet, Sofian, Vitello, Marie, Chua, Han Chow, Pless, Stephan A., Engel, Dominique, Liégeois, Jean-François, Lakaye, Bernard, Roeper, Jochen, Seutin, Vincent
Published in Neuropharmacology (01.10.2021)
Published in Neuropharmacology (01.10.2021)
Get full text
Journal Article
Web Resource
Crucial role of a shared extracellular loop in apamin sensitivity and maintenance of pore shape of small-conductance calcium-activated potassium (SK) channels
Weatherall, Kate L, Seutin, Vincent, Liégeois, Jean-François, Marrion, Neil V
Published in Proceedings of the National Academy of Sciences - PNAS (08.11.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (08.11.2011)
Get full text
Journal Article
Structural Insights into 5‑HT1A/D4 Selectivity of WAY-100635 Analogues: Molecular Modeling, Synthesis, and in Vitro Binding
Dilly, Sébastien, Liégeois, Jean-François
Published in Journal of chemical information and modeling (25.07.2016)
Published in Journal of chemical information and modeling (25.07.2016)
Get full text
Journal Article
Web Resource
Allosteric Block of KCa2 Channels by Apamin
Lamy, Cédric, Goodchild, Samuel J., Weatherall, Kate L., Jane, David E., Liégeois, Jean-François, Seutin, Vincent, Marrion, Neil V.
Published in The Journal of biological chemistry (27.08.2010)
Published in The Journal of biological chemistry (27.08.2010)
Get full text
Journal Article
Web Resource
Bis-(1,2,3,4-tetrahydroisoquinolinium): A Chiral Scaffold for Developing High-Affinity Ligands for SK Channels
Liégeois, Jean-François, Wouters, Johan, Seutin, Vincent, Dilly, Sébastien
Published in ChemMedChem (01.04.2014)
Published in ChemMedChem (01.04.2014)
Get full text
Journal Article
Web Resource
New Pyridobenzoxazepine Derivatives Derived from 5-(4-Methylpiperazin-1-yl)-8-chloro-pyrido[2,3-b][1,5]benzoxazepine (JL13): Chemical Synthesis and Pharmacological Evaluation
Liégeois, Jean-François, Deville, Marine, Dilly, Sébastien, Lamy, Cédric, Mangin, Floriane, Résimont, Mélissa, Tarazi, Frank I
Published in Journal of medicinal chemistry (23.02.2012)
Published in Journal of medicinal chemistry (23.02.2012)
Get full text
Journal Article
Web Resource
Chemical modifications of the N-methyl-laudanosine scaffold point to new directions for SK channels exploration
Badarau, Eduard, Dilly, Sebastien, Wouters, Johan, Seutin, Vincent, Liegeois, Jean-Francois
Published in Bioorganic & medicinal chemistry letters (15.12.2014)
Published in Bioorganic & medicinal chemistry letters (15.12.2014)
Get full text
Journal Article
Web Resource
SK channels control the firing pattern of midbrain dopaminergic neurons in vivo
Waroux, Olivier, Massotte, Laurent, Alleva, Livia, Graulich, Amaury, Thomas, Elizabeth, Liégeois, Jean-François, Scuvée-Moreau, Jacqueline, Seutin, Vincent
Published in The European journal of neuroscience (01.12.2005)
Published in The European journal of neuroscience (01.12.2005)
Get full text
Journal Article
Web Resource
SK channel blockade promotes burst firing in dorsal raphe serotonergic neurons
Rouchet, Nathalie, Waroux, Olivier, Lamy, Cédric, Massotte, Laurent, Scuvée-Moreau, Jacqueline, Liégeois, Jean-François, Seutin, Vincent
Published in The European journal of neuroscience (01.09.2008)
Published in The European journal of neuroscience (01.09.2008)
Get full text
Journal Article
Web Resource
Ion-Channel Modulators: More Diversity Than Previously Thought
Dilly, Sébastien, Lamy, Cédric, Marrion, Neil V., Liégeois, Jean-François, Seutin, Vincent
Published in Chembiochem : a European journal of chemical biology (16.08.2011)
Published in Chembiochem : a European journal of chemical biology (16.08.2011)
Get full text
Journal Article
Web Resource
The sigma agonist 1,3-di- o-tolyl-guanidine directly blocks SK channels in dopaminergic neurons and in cell lines
Lamy, Cédric, Scuvée-Moreau, Jacqueline, Dilly, Sébastien, Liégeois, Jean-François, Seutin, Vincent
Published in Colloids and surfaces. A, Physicochemical and engineering aspects (01.09.2010)
Published in Colloids and surfaces. A, Physicochemical and engineering aspects (01.09.2010)
Get full text
Journal Article
The 5-HT1A Agonism Potential of Substituted Piperazine-Ethyl-Amide Derivatives Is Conserved in the Hexyl Homologues: Molecular Modeling and Pharmacological Evaluation
Dilly, Sébastien, Scuvée-Moreau, Jacqueline, Wouters, Johan, Liégeois, Jean-François
Published in Journal of chemical information and modeling (28.11.2011)
Published in Journal of chemical information and modeling (28.11.2011)
Get full text
Journal Article
Web Resource
M-type channels selectively control bursting in rat dopaminergic neurons
Drion, Guillaume, Bonjean, Maxime, Waroux, Olivier, Scuvée-Moreau, Jacqueline, Liégeois, Jean-François, Sejnowski, Terrence J., Sepulchre, Rodolphe, Seutin, Vincent
Published in The European journal of neuroscience (01.03.2010)
Published in The European journal of neuroscience (01.03.2010)
Get full text
Journal Article
Web Resource
Implementation of a design space approach for enantiomeric separations in polar organic solvent chromatography
Nistor, Iolanda, Lebrun, Pierre, Ceccato, Attilio, Lecomte, Frédéric, Slama, Ines, Oprean, Radu, Badarau, Eduard, Dufour, Fabien, Dossou, Katina Sourou Sylvestre, Fillet, Marianne, Liégeois, Jean-François, Hubert, Philippe, Rozet, Eric
Published in Journal of pharmaceutical and biomedical analysis (23.02.2013)
Published in Journal of pharmaceutical and biomedical analysis (23.02.2013)
Get full text
Journal Article
Web Resource
Synthesis and in vitro binding studies of piperazine-alkyl-naphthamides: Impact of homology and sulphonamide/carboxamide bioisosteric replacement on the affinity for 5-HT1A, α2A, D4.2, D3 and D2L receptors
RESIMONT, Mélissa, LIEGEOIS, Jean-François
Published in Bioorganic & medicinal chemistry letters (01.09.2010)
Published in Bioorganic & medicinal chemistry letters (01.09.2010)
Get full text
Journal Article
The interactions of apamin and tetraethylammonium are differentially affected by single mutations in the pore mouth of small conductance calcium-activated potassium (SK) channels
Dilly, Sébastien, Philippart, Fabian, Lamy, Cédric, Poncin, Sylvie, Snyders, Dirk, Seutin, Vincent, Liégeois, Jean-François
Published in Biochemical pharmacology (15.02.2013)
Published in Biochemical pharmacology (15.02.2013)
Get full text
Journal Article
Web Resource
Molecular modeling study of 4-phenylpiperazine and 4-phenyl-1,2,3,6-tetrahydropyridine derivatives: A new step towards the design of high-affinity 5-HT1A ligands
DILLY, Sébastien, GRAULICH, Amaury, LIEGEOIS, Jean-François
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
Get full text
Journal Article
Web Resource
Structural analysis of some bis-(8-isopropyl-isoquinolinium) derivatives reveals a preferential folded conformation leading to a stereoselective attack by sodium borohydride
Dilly, Sébastien, Badarau, Eduard, Dufour, Fabien, Nistor, Iolanda, Hubert, Philippe, Seutin, Vincent, Wouters, Johan, Liégeois, Jean-François
Published in Journal of molecular structure (25.09.2014)
Published in Journal of molecular structure (25.09.2014)
Get full text
Journal Article
Web Resource