Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition
Wong, Gabrielle S, Zhou, Jin, Liu, Jie Bin, Wu, Zhong, Xu, Xinsen, Li, Tianxia, Xu, David, Schumacher, Steven E, Puschhof, Jens, McFarland, James, Zou, Charles, Dulak, Austin, Henderson, Les, Xu, Peng, O'Day, Emily, Rendak, Rachel, Liao, Wei-Li, Cecchi, Fabiola, Hembrough, Todd, Schwartz, Sarit, Szeto, Christopher, Rustgi, Anil K, Wong, Kwok-Kin, Diehl, J Alan, Jensen, Karin, Graziano, Francesco, Ruzzo, Annamaria, Fereshetian, Shaunt, Mertins, Philipp, Carr, Steven A, Beroukhim, Rameen, Nakamura, Kenichi, Oki, Eiji, Watanabe, Masayuki, Baba, Hideo, Imamura, Yu, Catenacci, Daniel, Bass, Adam J
Published in Nature medicine (01.07.2018)
Published in Nature medicine (01.07.2018)
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Journal Article
A novel GTP-binding inhibitor, FX2149, attenuates LRRK2 toxicity in Parkinson's disease models
Li, Tianxia, He, Xinhua, Thomas, Joseph M, Yang, Dejun, Zhong, Shijun, Xue, Fengtian, Smith, Wanli W
Published in PloS one (27.03.2015)
Published in PloS one (27.03.2015)
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Journal Article
Suppression of Adaptive Responses to Targeted Cancer Therapy by Transcriptional Repression
Rusan, Maria, Li, Kapsok, Li, Yvonne, Christensen, Camilla L, Abraham, Brian J, Kwiatkowski, Nicholas, Buczkowski, Kevin A, Bockorny, Bruno, Chen, Ting, Li, Shuai, Rhee, Kevin, Zhang, Haikuo, Chen, Wankun, Terai, Hideki, Tavares, Tiffany, Leggett, Alan L, Li, Tianxia, Wang, Yichen, Zhang, Tinghu, Kim, Tae-Jung, Hong, Sook-Hee, Poudel-Neupane, Neermala, Silkes, Michael, Mudianto, Tenny, Tan, Li, Shimamura, Takeshi, Meyerson, Matthew, Bass, Adam J, Watanabe, Hideo, Gray, Nathanael S, Young, Richard A, Wong, Kwok-Kin, Hammerman, Peter S
Published in Cancer discovery (01.01.2018)
Published in Cancer discovery (01.01.2018)
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Journal Article
P53-induced GAP-43 Upregulation in Primary Cortical Neurons of Rats
Li, Tianxia, Jia, Yuexin, Fu, Junxian, Fu, Zhuo, Qiao, Zhidong, Liu, Xiaoyang, Lv, Ting, Tang, Rong, Yang, Guanglu
Published in Protein and peptide letters (01.01.2024)
Published in Protein and peptide letters (01.01.2024)
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Journal Article
RAS-MAPK Reactivation Facilitates Acquired Resistance in FGFR1 -Amplified Lung Cancer and Underlies a Rationale for Upfront FGFR-MEK Blockade
Bockorny, Bruno, Rusan, Maria, Chen, Wankun, Liao, Rachel G, Li, Yvonne, Piccioni, Federica, Wang, Jun, Tan, Li, Thorner, Aaron R, Li, Tianxia, Zhang, Yanxi, Miao, Changhong, Ovesen, Therese, Shapiro, Geoffrey I, Kwiatkowski, David J, Gray, Nathanael S, Meyerson, Matthew, Hammerman, Peter S, Bass, Adam J
Published in Molecular cancer therapeutics (01.07.2018)
Published in Molecular cancer therapeutics (01.07.2018)
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Journal Article
From fat fruit fly to human obesity
Smith, Wanli W, Thomas, Joseph, Liu, Jingnan, Li, Tianxia, Moran, Timothy H
Published in Physiology & behavior (01.09.2014)
Published in Physiology & behavior (01.09.2014)
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Journal Article
Conference Proceeding
Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1
Nucifora, Jr, Frederick C, Nucifora, Leslie G, Ng, Chee-Hoe, Arbez, Nicolas, Guo, Yajuan, Roby, Elaine, Shani, Vered, Engelender, Simone, Wei, Dong, Wang, Xiao-Fang, Li, Tianxia, Moore, Darren J, Pletnikova, Olga, Troncoso, Juan C, Sawa, Akira, Dawson, Ted M, Smith, Wanli, Lim, Kah-Leong, Ross, Christopher A
Published in Nature communications (07.06.2016)
Published in Nature communications (07.06.2016)
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Journal Article
Synphilin-1 Interacts with AMPK and Increases AMPK Phosphorylation
Li, Tianxia, Liu, Jingnan, Guo, Gongbo, Ning, Bo, Li, Xueping, Zhu, Guangjing, Yang, Dejun, Moran, Timothy H, Smith, Wanli W
Published in International journal of molecular sciences (18.06.2020)
Published in International journal of molecular sciences (18.06.2020)
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Journal Article
LRRK2 kinase activity mediates toxic interactions between genetic mutation and oxidative stress in a Drosophila model: Suppression by curcumin
Yang, Dejun, Li, Tianxia, Liu, Zhaohui, Arbez, Nicolas, Yan, Jianqun, Moran, Timothy H, Ross, Christopher A, Smith, Wanli W
Published in Neurobiology of disease (01.09.2012)
Published in Neurobiology of disease (01.09.2012)
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Journal Article
Case Report: A Case Report and Literature Review of 3p Deletion Syndrome
Fu, Junxian, Wang, Ting, Fu, Zhuo, Li, Tianxia, Zhang, Xiaomeng, Zhao, Jingjing, Yang, Guanglu
Published in Frontiers in pediatrics (10.02.2021)
Published in Frontiers in pediatrics (10.02.2021)
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Journal Article
A LRRK2 GTP Binding Inhibitor, 68, Reduces LPS-Induced Signaling Events and TNF-α Release in Human Lymphoblasts
Li, Tianxia, Ning, Bo, Kong, Lingbo, Dai, Bingling, He, Xiaofei, Thomas, Joseph M, Sawa, Akira, Ross, Christopher A, Smith, Wanli W
Published in Cells (Basel, Switzerland) (23.02.2021)
Published in Cells (Basel, Switzerland) (23.02.2021)
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Journal Article
Developing SHP2-based combination therapy for KRAS-amplified cancer
Li, Tianxia, Kikuchi, Osamu, Zhou, Jin, Wang, Yichen, Pokharel, Babita, Bastl, Klavdija, Gokhale, Prafulla, Knott, Aine, Zhang, Yanxi, Doench, John G, Ho, Zandra V, Catenacci, Daniel Vt, Bass, Adam J
Published in JCI insight (08.02.2023)
Published in JCI insight (08.02.2023)
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Journal Article
CCK Response Deficiency in Synphilin-1 Transgenic Mice
Smith, Wanli W, Smith, Megan, Yang, Dejun, Choi, Pique P, Moghadam, Alexander, Li, Tianxia, Moran, Timothy H
Published in PloS one (16.11.2015)
Published in PloS one (16.11.2015)
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Journal Article
Behavioral characterization of the hyperphagia synphilin-1 overexpressing mice
Li, Xueping, Treesukosol, Yada, Moghadam, Alexander, Smith, Megan, Ofeldt, Erica, Yang, Dejun, Li, Tianxia, Tamashiro, Kellie, Choi, Pique, Moran, Timothy H, Smith, Wanli W
Published in PloS one (14.05.2014)
Published in PloS one (14.05.2014)
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Journal Article
Models for LRRK2-Linked Parkinsonism
Liu, Zhaohui, Sushchky, Sarah, Yang, DeJun, Li, Tianxia, Smith, Wanli W.
Published in Parkinson's disease (01.01.2011)
Published in Parkinson's disease (01.01.2011)
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Journal Article
Protective Effect of Protopine on the Focal Cerebral Ischaemic Injury in Rats
Xiao, Xianghua, Liu, Juntian, Hu, Jingwen, Li, Tianxia, Zhang, Yuanhui
Published in Basic & clinical pharmacology & toxicology (01.08.2007)
Published in Basic & clinical pharmacology & toxicology (01.08.2007)
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Journal Article
225 MODELING THE TUMOR MICROENVIRONMENT OF EARLY AND LATE ONSET COLORECTAL CANCER USING PATIENT-DERIVED ORGANOIDS
Cohen, David, Shin, Alice E., De, Dechokyab, Mitani, Yosuke, Li, Tianxia, Rustgi, Anil K., Pumpalova, Yoanna S., Dionigi, Beatrice, Gabre, Joel T.
Published in Gastroenterology (New York, N.Y. 1943) (18.05.2024)
Published in Gastroenterology (New York, N.Y. 1943) (18.05.2024)
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