Signaling through cAMP-Epac1 induces metabolic reprogramming to protect podocytes in glomerulonephritis
Abbad, Lilia, Détrait, Maximin, Kavvadas, Panagiotis, Bergonnier, Dorian, Melis, Lisa, Laudette, Marion, Migeon, Tiffany, Verpont, Marie-Christine, Lucas, Alexandre, Chatziantoniou, Christos, Lezoualc’h, Frank
Published in Kidney international (01.09.2024)
Published in Kidney international (01.09.2024)
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Journal Article
Monoamine oxidase‐A is a novel driver of stress‐induced premature senescence through inhibition of parkin‐mediated mitophagy
Manzella, Nicola, Santin, Yohan, Maggiorani, Damien, Martini, Hélène, Douin‐Echinard, Victorine, Passos, Joao F., Lezoualc'h, Frank, Binda, Claudia, Parini, Angelo, Mialet‐Perez, Jeanne
Published in Aging cell (01.10.2018)
Published in Aging cell (01.10.2018)
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Journal Article
Elevated cAMP Protects against Diclofenac-Induced Toxicity in Primary Rat Hepatocytes: A Protective Effect Mediated by the Exchange Protein Directly Activated by cAMP/cAMP-Regulated Guanine Nucleotide Exchange Factors
Aguilar Mora, Fabio Alejandro, Musheshe, Nshunge, Oun, Asmaa, Buist-Homan, Manon, Lezoualc'h, Frank, Cheng, Xiaodong, Schmidt, Martina, Moshage, Han
Published in Molecular pharmacology (01.04.2021)
Published in Molecular pharmacology (01.04.2021)
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Journal Article
Cyclic AMP-binding protein Epac1 acts as a metabolic sensor to promote cardiomyocyte lipotoxicity
Laudette, Marion, Sainte-Marie, Yannis, Cousin, Grégoire, Bergonnier, Dorian, Belhabib, Ismahane, Brun, Stéphanie, Formoso, Karina, Laib, Loubna, Tortosa, Florence, Bergoglio, Camille, Marcheix, Bertrand, Borén, Jan, Lairez, Olivier, Fauconnier, Jérémy, Lucas, Alexandre, Mialet-Perez, Jeanne, Moro, Cédric, Lezoualc’h, Frank
Published in Cell death & disease (01.09.2021)
Published in Cell death & disease (01.09.2021)
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Journal Article
Identification of a pharmacological inhibitor of Epac1 that protects the heart against acute and chronic models of cardiac stress
Laudette, Marion, Coluccia, Antonio, Sainte-Marie, Yannis, Solari, Andrea, Fazal, Loubina, Sicard, Pierre, Silvestri, Romano, Mialet-Perez, Jeanne, Pons, Sandrine, Ghaleh, Bijan, Blondeau, Jean-Paul, Lezoualc’h, Frank
Published in Cardiovascular research (01.10.2019)
Published in Cardiovascular research (01.10.2019)
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Journal Article
Macromolecular Complex Including MLL3, Carabin and Calcineurin Regulates Cardiac Remodeling
Pane, Roberto, Laib, Loubna, Formoso, Karina, Détrait, Maximin, Sainte-Marie, Yannis, Bourgailh, Florence, Ruffenach, Nolan, Faugeras, Hanamée, Simon, Ilias, Lhuillier, Emeline, Lezoualc'h, Frank, Conte, Caroline
Published in Circulation research (05.01.2024)
Published in Circulation research (05.01.2024)
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Journal Article
GRKs and Epac1 Interaction in Cardiac Remodeling and Heart Failure
Laudette, Marion, Formoso, Karina, Lezoualc'h, Frank
Published in Cells (Basel, Switzerland) (14.01.2021)
Published in Cells (Basel, Switzerland) (14.01.2021)
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Journal Article
Mitochondrial 4-HNE derived from MAO-A promotes mitoCa2+ overload in chronic postischemic cardiac remodeling
Santin, Yohan, Fazal, Loubina, Sainte-Marie, Yannis, Sicard, Pierre, Maggiorani, Damien, Tortosa, Florence, Yücel, Yasemin Yücel, Teyssedre, Lise, Rouquette, Jacques, Marcellin, Marlene, Vindis, Cécile, Shih, Jean C., Lairez, Olivier, Burlet-Schiltz, Odile, Parini, Angelo, Lezoualc’h, Frank, Mialet-Perez, Jeanne
Published in Cell death and differentiation (01.06.2020)
Published in Cell death and differentiation (01.06.2020)
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Journal Article
Diabetic cardiomyopathy: the need for adjusting experimental models to meet clinical reality
Lezoualc’h, Frank, Badimon, Lina, Baker, Hana, Bernard, Monique, Czibik, Gabor, de Boer, Rudolf A, D’Humières, Thomas, Kergoat, Micheline, Kowala, Mark, Rieusset, Jennifer, Vilahur, Gemma, Détrait, Maximin, Watson, Chris, Derumeaux, Geneviève A
Published in Cardiovascular research (22.05.2023)
Published in Cardiovascular research (22.05.2023)
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Journal Article
Modeling Epac1 interactions with the allosteric inhibitor AM-001 by co-solvent molecular dynamics
Bufano, Marianna, Laudette, Marion, Blondeau, Jean-Paul, Lezoualc’h, Frank, Nalli, Marianna, Silvestri, Romano, Brancale, Andrea, Coluccia, Antonio
Published in Journal of computer-aided molecular design (01.11.2020)
Published in Journal of computer-aided molecular design (01.11.2020)
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Journal Article
Atrial Natriuretic Peptide Orchestrates a Coordinated Physiological Response to Fuel Non-shivering Thermogenesis
Carper, Deborah, Coué, Marine, Nascimento, Emmani B.M., Barquissau, Valentin, Lagarde, Damien, Pestourie, Carine, Laurens, Claire, Petit, Justine Vily, Soty, Maud, Monbrun, Laurent, Marques, Marie-Adeline, Jeanson, Yannick, Sainte-Marie, Yannis, Mairal, Aline, Déjean, Sébastien, Tavernier, Geneviève, Viguerie, Nathalie, Bourlier, Virginie, Lezoualc’h, Frank, Carrière, Audrey, Saris, Wim H.M., Astrup, Arne, Casteilla, Louis, Mithieux, Gilles, van Marken Lichtenbelt, Wouter, Langin, Dominique, Schrauwen, Patrick, Moro, Cedric
Published in Cell reports (Cambridge) (25.08.2020)
Published in Cell reports (Cambridge) (25.08.2020)
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Journal Article
Oxidative Stress by Monoamine Oxidase-A Impairs Transcription Factor EB Activation and Autophagosome Clearance, Leading to Cardiomyocyte Necrosis and Heart Failure
Santin, Yohan, Sicard, Pierre, Vigneron, François, Guilbeau-Frugier, Céline, Dutaur, Marianne, Lairez, Olivier, Couderc, Bettina, Manni, Diego, Korolchuk, Viktor I, Lezoualc'h, Frank, Parini, Angelo, Mialet-Perez, Jeanne
Published in Antioxidants & redox signaling (01.07.2016)
Published in Antioxidants & redox signaling (01.07.2016)
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Journal Article
Role of EPAC1 Signalosomes in Cell Fate: Friends or Foes?
Formoso, Karina, Lezoualc'h, Frank, Mialet-Perez, Jeanne
Published in Cells (Basel, Switzerland) (25.08.2020)
Published in Cells (Basel, Switzerland) (25.08.2020)
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Journal Article
Epac Function and cAMP Scaffolds in the Heart and Lung
Laudette, Marion, Zuo, Haoxiao, Lezoualc'h, Frank, Schmidt, Martina
Published in Journal of cardiovascular development and disease (03.02.2018)
Published in Journal of cardiovascular development and disease (03.02.2018)
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Journal Article
Large Extracellular Vesicle-Associated Rap1 Accumulates in Atherosclerotic Plaques, Correlates With Vascular Risks and Is Involved in Atherosclerosis
Perdomo, Liliana, Vidal-Gómez, Xavier, Soleti, Raffaella, Vergori, Luisa, Duluc, Lucie, Chwastyniak, Maggy, Bisserier, Malik, Le Lay, Soazig, Villard, Alexandre, Simard, Gilles, Meilhac, Olivier, Lezoualc’h, Frank, Khantalin, Ilya, Veerapen, Reuben, Dubois, Séverine, Boursier, Jérôme, Henni, Samir, Gagnadoux, Frédéric, Pinet, Florence, Andriantsitohaina, Ramaroson, Martínez, M. Carmen
Published in Circulation research (28.08.2020)
Published in Circulation research (28.08.2020)
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Journal Article
Identification of a Tetrahydroquinoline Analog as a Pharmacological Inhibitor of the cAMP-binding Protein Epac
Courilleau, Delphine, Bisserier, Malik, Jullian, Jean-Christophe, Lucas, Alexandre, Bouyssou, Pascal, Fischmeister, Rodolphe, Blondeau, Jean-Paul, Lezoualc'h, Frank
Published in The Journal of biological chemistry (28.12.2012)
Published in The Journal of biological chemistry (28.12.2012)
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Journal Article
Exchange protein directly activated by cAMP 1 promotes autophagy during cardiomyocyte hypertrophy
Laurent, Anne-Coline, Bisserier, Malik, Lucas, Alexandre, Tortosa, Florence, Roumieux, Marie, De Régibus, Annélie, Swiader, Audrey, Sainte-Marie, Yannis, Heymes, Christophe, Vindis, Cécile, Lezoualc'h, Frank
Published in Cardiovascular research (01.01.2015)
Published in Cardiovascular research (01.01.2015)
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Journal Article
Acute heart failure: mechanisms and pre-clinical models—a Scientific Statement of the ESC Working Group on Myocardial Function
Ciccarelli, Michele, Pires, Inês Falcão, Bauersachs, Johann, Bertrand, Luc, Beauloye, Christophe, Dawson, Dana, Hamdani, Nazha, Hilfiker-Kleiner, Denise, van Laake, Linda W, Lezoualc’h, Frank, Linke, Wolfgang A, Lunde, Ida G, Rainer, Peter P, Rispoli, Antonella, Visco, Valeria, Carrizzo, Albino, Ferro, Matteo Dal, Stolfo, Davide, van der Velden, Jolanda, Zacchigna, Serena, Heymans, Stephane, Thum, Thomas, Tocchetti, Carlo Gabriele
Published in Cardiovascular research (15.11.2023)
Published in Cardiovascular research (15.11.2023)
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