Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form
Nelp, Micah T., Kates, Patrick A., Hunt, John T., Newitt, John A., Balog, Aaron, Maley, Derrick, Zhu, Xiao, Abell, Lynn, Allentoff, Alban, Borzilleri, Robert, Lewis, Hal A., Lin, Zeyu, Seitz, Steven P., Yan, Chunhong, Groves, John T.
Published in Proceedings of the National Academy of Sciences - PNAS (27.03.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (27.03.2018)
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Journal Article
Initial Clinical Guidelines for Co-Occurring Autism Spectrum Disorder and Gender Dysphoria or Incongruence in Adolescents
Strang, John F., Meagher, Haley, Kenworthy, Lauren, de Vries, Annelou L. C., Menvielle, Edgardo, Leibowitz, Scott, Janssen, Aron, Cohen-Kettenis, Peggy, Shumer, Daniel E., Edwards-Leeper, Laura, Pleak, Richard R., Spack, Norman, Karasic, Dan H., Schreier, Herbert, Balleur, Anouk, Tishelman, Amy, Ehrensaft, Diane, Rodnan, Leslie, Kuschner, Emily S., Mandel, Francie, Caretto, Antonia, Lewis, Hal C., Anthony, Laura G.
Published in Journal of clinical child and adolescent psychology (01.01.2018)
Published in Journal of clinical child and adolescent psychology (01.01.2018)
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Journal Article
Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core
Sivaprakasam, Prasanna, Han, Xiaojun, Civiello, Rita L., Jacutin-Porte, Swanee, Kish, Kevin, Pokross, Matt, Lewis, Hal A., Ahmed, Nazia, Szapiel, Nicolas, Newitt, John A., Baldwin, Eric T., Xiao, Hong, Krause, Carol M., Park, Hyunsoo, Nophsker, Michelle, Lippy, Jonathan S., Burton, Catherine R., Langley, David R., Macor, John E., Dubowchik, Gene M.
Published in Bioorganic & medicinal chemistry letters (01.05.2015)
Published in Bioorganic & medicinal chemistry letters (01.05.2015)
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Journal Article
Structure–activity relationship (SAR) studies on substituted N-(pyridin-3-yl)-2-amino-isonicotinamides as highly potent and selective glycogen synthase kinase-3 (GSK-3) inhibitors
Luo, Guanglin, Chen, Ling, Jacutin-Porte, Swanee, Han, Ying, Burton, Catherine R., Xiao, Hong, Krause, Carol M., Cao, Yang, Liu, Nengyin, Kish, Kevin, Lewis, Hal A., Macor, John E., Dubowchik, Gene M.
Published in Bioorganic & medicinal chemistry letters (01.02.2023)
Published in Bioorganic & medicinal chemistry letters (01.02.2023)
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Journal Article
Discovery of Isonicotinamides as Highly Selective, Brain Penetrable, and Orally Active Glycogen Synthase Kinase‑3 Inhibitors
Luo, Guanglin, Chen, Ling, Burton, Catherine R, Xiao, Hong, Sivaprakasam, Prasanna, Krause, Carol M, Cao, Yang, Liu, Nengyin, Lippy, Jonathan, Clarke, Wendy J, Snow, Kimberly, Raybon, Joseph, Arora, Vinod, Pokross, Matt, Kish, Kevin, Lewis, Hal A, Langley, David R, Macor, John E, Dubowchik, Gene M
Published in Journal of medicinal chemistry (11.02.2016)
Published in Journal of medicinal chemistry (11.02.2016)
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Journal Article
5,6,7,8-Tetrahydro-1,6-naphthyridine Derivatives as Potent HIV-1-Integrase-Allosteric-Site Inhibitors
Peese, Kevin M, Allard, Christopher W, Connolly, Timothy, Johnson, Barry L, Li, Chen, Patel, Manoj, Sorensen, Margaret E, Walker, Michael A, Meanwell, Nicholas A, McAuliffe, Brian, Minassian, Beatrice, Krystal, Mark, Parker, Dawn D, Lewis, Hal A, Kish, Kevin, Zhang, Ping, Nolte, Robert T, Simmermacher, Jean, Jenkins, Susan, Cianci, Christopher, Naidu, B. Narasimhulu
Published in Journal of medicinal chemistry (14.02.2019)
Published in Journal of medicinal chemistry (14.02.2019)
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Journal Article
Neutrophil‐predominant bullous pemphigoid induced by checkpoint inhibitors: A case series
Morris, Lisa M., Lewis, Hal A., Cornelius, Lynn A., Chen, David Y., Rosman, Ilana S.
Published in Journal of cutaneous pathology (01.08.2020)
Published in Journal of cutaneous pathology (01.08.2020)
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Journal Article
Channel Gating Regulation by the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) First Cytosolic Loop
Ehrhardt, Annette, Chung, W. Joon, Pyle, Louise C., Wang, Wei, Nowotarski, Krzysztof, Mulvihill, Cory M., Ramjeesingh, Mohabir, Hong, Jeong, Velu, Sadanandan E., Lewis, Hal A., Atwell, Shane, Aller, Steve, Bear, Christine E., Lukacs, Gergely L., Kirk, Kevin L., Sorscher, Eric J.
Published in The Journal of biological chemistry (22.01.2016)
Published in The Journal of biological chemistry (22.01.2016)
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Journal Article
Dermatology ECHO - an innovative solution to address limited access to dermatology expertise
Lewis, Hal, Becevic, Mirna, Myers, Danny, Helming, Dyann, Mutrux, Rachel, Fleming, David, Edison, Karen
Published in Rural and remote health (01.02.2018)
Published in Rural and remote health (01.02.2018)
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Journal Article
Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant
Atwell, Shane, Brouillette, Christie G., Conners, Kris, Emtage, Spencer, Gheyi, Tarun, Guggino, William B., Hendle, Jorg, Hunt, John F., Lewis, Hal A., Lu, Frances, Protasevich, Irina I., Rodgers, Logan A., Romero, Rich, Wasserman, Stephen R., Weber, Patricia C., Wetmore, Diana, Zhang, Feiyu F., Zhao, Xun
Published in Protein engineering, design and selection (01.05.2010)
Published in Protein engineering, design and selection (01.05.2010)
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Journal Article
Impact of the ΔF508 Mutation in First Nucleotide-binding Domain of Human Cystic Fibrosis Transmembrane Conductance Regulator on Domain Folding and Structure
Lewis, Hal A., Zhao, Xun, Wang, Chi, Sauder, J. Michael, Rooney, Isabelle, Noland, Brian W., Lorimer, Don, Kearins, Margaret C., Conners, Kris, Condon, Brad, Maloney, Peter C., Guggino, William B., Hunt, John F., Emtage, Spencer
Published in The Journal of biological chemistry (14.01.2005)
Published in The Journal of biological chemistry (14.01.2005)
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Journal Article
Overuse of Magnetic Resonance Imaging in the Diagnosis and Treatment of Moderate to Severe Osteoarthritis
Sherman, Seth L, Gulbrandsen, Trevor R, Lewis, Hal A, Gregory, Martin H, Capito, Nicholas M, Gray, Aaron D, Bal, B Sonny
Published in The Iowa orthopaedic journal (2018)
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Published in The Iowa orthopaedic journal (2018)
Journal Article
Human Apolipoprotein E4 Worsens Acute Axonal Pathology but Not Amyloid-β Immunoreactivity After Traumatic Brain Injury in 3xTG-AD Mice
Bennett, Rachel E, Esparza, Thomas J, Lewis, Hal A, Kim, Eddie, Mac Donald, Christine L, Sullivan, Patrick M, Brody, David L
Published in Journal of neuropathology and experimental neurology (01.05.2013)
Published in Journal of neuropathology and experimental neurology (01.05.2013)
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Journal Article
Methotrexate-induced cutaneous ulceration in 3 nonpsoriatic patients: Report of a rare side effect
Lewis, Hal A., Nemer, Kathleen M., Chibnall, Rebecca J., Musiek, Amy C.
Published in JAAD Case Reports (01.05.2017)
Published in JAAD Case Reports (01.05.2017)
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Journal Article
Inhibition of influenza virus replication via small molecules that induce the formation of higher-order nucleoprotein oligomers
Gerritz, Samuel W, Cianci, Christopher, Kim, Sean, Pearce, Bradley C, Deminie, Carol, Discotto, Linda, McAuliffe, Brian, Minassian, Beatrice F, Shi, Shuhao, Zhu, Shirong, Zhai, Weixu, Pendri, Annapurna, Li, Guo, Poss, Michael A, Edavettal, Suzanne, McDonnell, Patricia A, Lewis, Hal A, Maskos, Klaus, Mörtl, Mario, Kiefersauer, Reiner, Steinbacher, Stefan, Baldwin, Eric T, Metzler, William, Bryson, James, Healy, Matthew D, Philip, Thomas, Zoeckler, Mary, Schartman, Richard, Sinz, Michael, Leyva-Grado, Victor H, Hoffmann, Hans-Heinrich, Langley, David R, Meanwell, Nicholas A, Krystal, Mark
Published in Proceedings of the National Academy of Sciences - PNAS (13.09.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (13.09.2011)
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Journal Article
Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator
Lewis, Hal A, Buchanan, Sean G, Burley, Stephen K, Conners, Kris, Dickey, Mark, Dorwart, Michael, Fowler, Richard, Gao, Xia, Guggino, William B, Hendrickson, Wayne A, Hunt, John F, Kearins, Margaret C, Lorimer, Don, Maloney, Peter C, Post, Kai W, Rajashankar, Kanagalaghatta R, Rutter, Marc E, Sauder, J Michael, Shriver, Stephanie, Thibodeau, Patrick H, Thomas, Philip J, Zhang, Marie, Zhao, Xun, Emtage, Spencer
Published in The EMBO journal (28.01.2004)
Published in The EMBO journal (28.01.2004)
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Journal Article