High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: Strategic flexibility explains potency against resistance mutations
Das, Kalyan, Bauman, Joseph D, Clark, Arthur D. Jr, Frenkel, Yulia V, Lewi, Paul J, Shatkin, Aaron J, Hughes, Stephen H, Arnold, Eddy
Published in Proceedings of the National Academy of Sciences - PNAS (05.02.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (05.02.2008)
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Crystallography and the design of anti-AIDS drugs: conformational flexibility and positional adaptability are important in the design of non-nucleoside HIV-1 reverse transcriptase inhibitors
Das, Kalyan, Lewi, Paul J., Hughes, Stephen H., Arnold, Eddy
Published in Progress in biophysics and molecular biology (01.06.2005)
Published in Progress in biophysics and molecular biology (01.06.2005)
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In Search of a Novel Anti-HIV Drug: Multidisciplinary Coordination in the Discovery of 4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, Rilpivirine)
Janssen, Paul A. J, Lewi, Paul J, Arnold, Eddy, Daeyaert, Frits, de Jonge, Marc, Heeres, Jan, Koymans, Luc, Vinkers, Maarten, Guillemont, Jérôme, Pasquier, Elisabeth, Kukla, Mike, Ludovici, Don, Andries, Koen, de Béthune, Marie-Pierre, Pauwels, Rudi, Das, Kalyan, Clark, Art D, Frenkel, Yulia Volovik, Hughes, Stephen H, Medaer, Bart, De Knaep, Fons, Bohets, Hilde, De Clerck, Fred, Lampo, Ann, Williams, Peter, Stoffels, Paul
Published in Journal of medicinal chemistry (24.03.2005)
Published in Journal of medicinal chemistry (24.03.2005)
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The pregnancy and long-term neurodevelopmental outcome of monochorionic diamniotic twin gestations: a multicenter prospective cohort study from the first trimester onward
Ortibus, Els, MD, Lopriore, Enrico, MD, PhD, Deprest, Jan, MD, PhD, Vandenbussche, Frank P., MD, PhD, Walther, Frans J., MD, PhD, Diemert, Anke, MD, Hecher, Kurt, MD, PhD, Lagae, Lieven, MD, PhD, De Cock, Paul, MD, PhD, Lewi, Paul J., PhD, Eng, Lewi, Liesbeth, MD, PhD
Published in American journal of obstetrics and gynecology (01.05.2009)
Published in American journal of obstetrics and gynecology (01.05.2009)
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Conference Proceeding
Concentration and pH Dependent Aggregation of Hydrophobic Drug Molecules and Relevance to Oral Bioavailability
Frenkel, Yulia Volovik, Clark, Arthur D, Das, Kalyan, Wang, Yuh-Hwa, Lewi, Paul J, Janssen, Paul A. J, Arnold, Eddy
Published in Journal of medicinal chemistry (24.03.2005)
Published in Journal of medicinal chemistry (24.03.2005)
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SYNOPSIS: SYNthesize and OPtimize System in Silico
Vinkers, H. Maarten, de Jonge, Marc R, Daeyaert, Frederik F. D, Heeres, Jan, Koymans, Lucien M. H, van Lenthe, Joop H, Lewi, Paul J, Timmerman, Henk, Van Aken, Koen, Janssen, Paul A. J
Published in Journal of medicinal chemistry (19.06.2003)
Published in Journal of medicinal chemistry (19.06.2003)
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Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (Etravirine) and Related Non-nucleoside Reverse Transcriptase Inhibitors That Are Highly Potent and Effective against Wild-Type and Drug-Resistant HIV-1 Variants
Das, Kalyan, Clark, Arthur D, Lewi, Paul J, Heeres, Jan, de Jonge, Marc R, Koymans, Lucien M. H, Vinkers, H. Maarten, Daeyaert, Frederik, Ludovici, Donald W, Kukla, Michael J, De Corte, Bart, Kavash, Robert W, Ho, Chih Y, Ye, Hong, Lichtenstein, Mark. A, Andries, Koen, Pauwels, Rudi, de Béthune, Marie-Pierre, Boyer, Paul L, Clark, Patrick, Hughes, Stephen H, Janssen, Paul A. J, Arnold, Eddy
Published in Journal of medicinal chemistry (06.05.2004)
Published in Journal of medicinal chemistry (06.05.2004)
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Synthesis of Novel Diarylpyrimidine Analogues and Their Antiviral Activity against Human Immunodeficiency Virus Type 1
Guillemont, Jerome, Pasquier, Elisabeth, Palandjian, Patrice, Vernier, Daniel, Gaurrand, Sandrine, Lewi, Paul J, Heeres, Jan, de Jonge, Marc R, Koymans, Lucien M. H, Daeyaert, Frits F. D, Vinkers, Maarten H, Arnold, Eddy, Das, Kalyan, Pauwels, Rudi, Andries, Koen, de Béthune, Marie-Pierre, Bettens, Eva, Hertogs, Kurt, Wigerinck, Piet, Timmerman, Philip, Janssen, Paul A. J
Published in Journal of medicinal chemistry (24.03.2005)
Published in Journal of medicinal chemistry (24.03.2005)
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Evolution of anti-HIV drug candidates. Part 3: diarylpyrimidine (DAPY) analogues
Ludovici, Donald W., De Corte, Bart L., Kukla, Michael J., Ye, Hong, Ho, Chih Y., Lichtenstein, Mark A., Kavash, Robert W., Andries, Koen, de Béthune, Marie-Pierre, Azijn, Hilde, Pauwels, Rudi, Lewi, Paul J., Heeres, Jan, Koymans, Lucien M.H., de Jonge, Marc R., Van Aken, Koen J.A., Daeyaert, Frederik F.D., Das, Kalyan, Arnold, Edward, Janssen, Paul A.J.
Published in Bioorganic & medicinal chemistry letters (03.09.2001)
Published in Bioorganic & medicinal chemistry letters (03.09.2001)
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Novel diarylpyridinones, diarylpyridazinones and diarylphthalazinones as potential HIV-1 nonnucleoside reverse transcriptase inhibitors (NNRTIs)
Venkatraj, Muthusamy, Ariën, Kevin K., Heeres, Jan, Dirié, Bertrand, Joossens, Jurgen, Van Goethem, Sebastiaan, Van der Veken, Pieter, Michiels, Johan, Vande Velde, Christophe M.L., Vanham, Guido, Lewi, Paul J., Augustyns, Koen
Published in Bioorganic & medicinal chemistry (15.10.2011)
Published in Bioorganic & medicinal chemistry (15.10.2011)
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Application of boosting to classification problems in chemometrics
Zhang, M.H., Xu, Q.S., Daeyaert, F., Lewi, P.J., Massart, D.L.
Published in Analytica chimica acta (15.07.2005)
Published in Analytica chimica acta (15.07.2005)
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Conference Proceeding
Evolution of anti-HIV drug candidates. Part 2 : Diaryltriazine (DATA) analogues
LUDOVICI, Donald W, KAVASH, Robert W, MOEREELS, Henry E. L, HEERES, Jan, KOYMANS, Lucien M. H, DE JONGE, Marc R, VAN AKEN, Koen J. A, DAEYAERT, Frederik F. D, LEWI, Paul J, DAS, Kalyan, ARNOLD, Edward, JANSSEN, Paul A. J, KUKLA, Michael J, HO, Chih Y, HONG YE, DE CORTE, Bart L, ANDRIES, Koen, DE BETHUNE, Marie-Pierre, AZIJN, Hilde, PAUWELS, Rudi
Published in Bioorganic & medicinal chemistry letters (03.09.2001)
Published in Bioorganic & medicinal chemistry letters (03.09.2001)
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Novel triazine dimers with potent antitrypanosomal activity
Venkatraj, Muthusamy, Salado, Irene G., Heeres, Jan, Joossens, Jurgen, Lewi, Paul J., Caljon, Guy, Maes, Louis, Van der Veken, Pieter, Augustyns, Koen
Published in European journal of medicinal chemistry (01.01.2018)
Published in European journal of medicinal chemistry (01.01.2018)
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Classification and Regression TreesStudies of HIV Reverse Transcriptase Inhibitors
Daszykowski, M, Walczak, B, Xu, Q.-S, Daeyaert, F, de Jonge, M. R, Heeres, J, Koymans, L. M. H, Lewi, P. J, Vinkers, H. M, Janssen, P. A, Massart, D. L
Published in Journal of Chemical Information and Computer Sciences (01.03.2004)
Published in Journal of Chemical Information and Computer Sciences (01.03.2004)
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Graphical Exploration of Gene Expression Data: A Comparative Study of Three Multivariate Methods
Wouters, Luc, Göhlmann, Hinrich W., Bijnens, Luc, Kass, Stefan U., Molenberghs, Geert, Lewi, Paul J.
Published in Biometrics (01.12.2003)
Published in Biometrics (01.12.2003)
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Improving QSAR models for the biological activity of HIV Reverse Transcriptase inhibitors: Aspects of outlier detection and uninformative variable elimination
Daszykowski, M., Stanimirova, I., Walczak, B., Daeyaert, F., de Jonge, M.R., Heeres, J., Koymans, L.M.H., Lewi, P.J., Vinkers, H.M., Janssen, P.A., Massart, D.L.
Published in Talanta (Oxford) (15.11.2005)
Published in Talanta (Oxford) (15.11.2005)
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Development and in vitro evaluation of a vaginal microbicide gel formulation for UAMC01398, a novel diaryltriazine NNRTI against HIV-1
Grammen, Carolien, Ariën, Kevin K., Venkatraj, Muthusamy, Joossens, Jurgen, Van der Veken, Pieter, Heeres, Jan, Lewi, Paul J., Haenen, Steven, Augustyns, Koen, Vanham, Guido, Augustijns, Patrick, Brouwers, Joachim
Published in Antiviral research (01.01.2014)
Published in Antiviral research (01.01.2014)
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