Structural basis for enzymatic photocatalysis in chlorophyll biosynthesis
Zhang, Shaowei, Heyes, Derren J., Feng, Lingling, Sun, Wenli, Johannissen, Linus O., Liu, Huanting, Levy, Colin W., Li, Xuemei, Yang, Ji, Yu, Xiaolan, Lin, Min, Hardman, Samantha J. O., Hoeven, Robin, Sakuma, Michiyo, Hay, Sam, Leys, David, Rao, Zihe, Zhou, Aiwu, Cheng, Qi, Scrutton, Nigel S.
Published in Nature (London) (01.10.2019)
Published in Nature (London) (01.10.2019)
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Journal Article
Redox driven B12-ligand switch drives CarH photoresponse
Poddar, Harshwardhan, Rios-Santacruz, Ronald, Heyes, Derren J., Shanmugam, Muralidharan, Brookfield, Adam, Johannissen, Linus O., Levy, Colin W., Jeffreys, Laura N., Zhang, Shaowei, Sakuma, Michiyo, Colletier, Jacques-Philippe, Hay, Sam, Schirò, Giorgio, Weik, Martin, Scrutton, Nigel S., Leys, David
Published in Nature communications (21.08.2023)
Published in Nature communications (21.08.2023)
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Journal Article
Catalytic Determinants of Alkene Production by the Cytochrome P450 Peroxygenase OleTJE
Matthews, Sarah, Belcher, James D., Tee, Kang Lan, Girvan, Hazel M., McLean, Kirsty J., Rigby, Stephen E.J., Levy, Colin W., Leys, David, Parker, David A., Blankley, Richard T., Munro, Andrew W.
Published in The Journal of biological chemistry (24.03.2017)
Published in The Journal of biological chemistry (24.03.2017)
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Journal Article
Photocobilins integrate B12 and bilin photochemistry for enzyme control
Zhang, Shaowei, Jeffreys, Laura N., Poddar, Harshwardhan, Yu, Yuqi, Liu, Chuanyang, Patel, Kaylee, Johannissen, Linus O., Zhu, Lingyun, Cliff, Matthew J., Yan, Cunyu, Schirò, Giorgio, Weik, Martin, Sakuma, Michiyo, Levy, Colin W., Leys, David, Heyes, Derren J., Scrutton, Nigel S.
Published in Nature communications (28.03.2024)
Published in Nature communications (28.03.2024)
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Journal Article
The major secreted protein of the whipworm parasite tethers to matrix and inhibits interleukin-13 function
Bancroft, Allison J., Levy, Colin W., Jowitt, Thomas A., Hayes, Kelly S., Thompson, Seona, Mckenzie, Edward A., Ball, Matthew D., Dubaissi, Eamon, France, Aidan P., Bellina, Bruno, Sharpe, Catherine, Mironov, Aleksandr, Brown, Sheila L., Cook, Peter C., S. MacDonald, Andrew, Thornton, David J., Grencis, Richard K.
Published in Nature communications (28.05.2019)
Published in Nature communications (28.05.2019)
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Journal Article
Structure and Properties of a Natural Competence-Associated Pilin Suggest a Unique Pilus Tip-Associated DNA Receptor
Salleh, Mohd Zulkifli, Karuppiah, Vijaykumar, Snee, Matthew, Thistlethwaite, Angela, Levy, Colin W, Knight, David, Derrick, Jeremy P
Published in mBio (11.06.2019)
Published in mBio (11.06.2019)
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Journal Article
Biocatalytic Asymmetric Alkene Reduction: Crystal Structure and Characterization of a Double Bond Reductase from Nicotiana tabacum
Mansell, David J, Toogood, Helen S, Waller, John, Hughes, John M. X, Levy, Colin W, Gardiner, John M, Scrutton, Nigel S
Published in ACS catalysis (01.03.2013)
Published in ACS catalysis (01.03.2013)
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Journal Article
Design and Synthesis of Imidazole and Triazole Pyrazoles as Mycobacterium Tuberculosis CYP121A1 Inhibitors
Kishk, Safaa M., McLean, Kirsty J., Sood, Sakshi, Smith, Darren, Evans, Jack W.D., Helal, Mohamed A., Gomaa, Mohamed S., Salama, Ismail, Mostafa, Samia M., de Carvalho, Luiz Pedro S., Levy, Colin W., Munro, Andrew W., Simons, Claire
Published in ChemistryOpen (Weinheim) (01.07.2019)
Published in ChemistryOpen (Weinheim) (01.07.2019)
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Journal Article
A designed photoenzyme for enantioselective [2+2] cycloadditions
Trimble, Jonathan S., Crawshaw, Rebecca, Hardy, Florence J., Levy, Colin W., Brown, Murray J. B., Fuerst, Douglas E., Heyes, Derren J., Obexer, Richard, Green, Anthony P.
Published in Nature (London) (24.11.2022)
Published in Nature (London) (24.11.2022)
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Journal Article
Glutamate-haem ester bond formation is disfavoured in flavocytochrome P450 BM3: characterization of glutamate substitution mutants at the haem site of P450 BM3
Girvan, Hazel M, Levy, Colin W, Williams, Paul, Fisher, Karl, Cheesman, Myles R, Rigby, Stephen E J, Leys, David, Munro, Andrew W
Published in Biochemical journal (01.05.2010)
Published in Biochemical journal (01.05.2010)
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Journal Article
Utilization of dietary mixed-linkage β-glucans by the Firmicute Blautia producta
Singh, Ravindra Pal, Niharika, Jayashree, Thakur, Raksha, Wagstaff, Ben A., Kumar, Gulshan, Kurata, Rikuya, Patel, Dhaval, Levy, Colin W., Miyazaki, Takatsugu, Field, Robert A.
Published in The Journal of biological chemistry (01.06.2023)
Published in The Journal of biological chemistry (01.06.2023)
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Journal Article
Biocatalysis in Drug Design: Engineered Reductive Aminases (RedAms) Are Used to Access Chiral Building Blocks with Multiple Stereocenters
Casamajo, Arnau Rué, Yu, Yuqi, Schnepel, Christian, Morrill, Charlotte, Barker, Rhys, Levy, Colin W., Finnigan, James, Spelling, Victor, Westerlund, Kristina, Petchey, Mark, Sheppard, Robert J., Lewis, Richard J., Falcioni, Francesco, Hayes, Martin A., Turner, Nicholas J.
Published in Journal of the American Chemical Society (11.10.2023)
Published in Journal of the American Chemical Society (11.10.2023)
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Journal Article
How a 10-epi-Cubebol Synthase Avoids Premature Reaction Quenching to Form a Tricyclic Product at High Purity
Whitehead, Joshua N., Leferink, Nicole G. H., Komati Reddy, Gajendar, Levy, Colin W., Hay, Sam, Takano, Eriko, Scrutton, Nigel S.
Published in ACS catalysis (07.10.2022)
Published in ACS catalysis (07.10.2022)
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Journal Article
Structure Based Discovery of Inhibitors of CYP125 and CYP142 from Mycobacterium tuberculosis
Katariya, Mona M., Snee, Matthew, Tunnicliffe, Richard B., Kavanagh, Madeline E., Boshoff, Helena I. M., Amadi, Cecilia N., Levy, Colin W., Munro, Andrew W., Abell, Chris, Leys, David, Coyne, Anthony G., McLean, Kirsty J.
Published in Chemistry : a European journal (22.05.2023)
Published in Chemistry : a European journal (22.05.2023)
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Journal Article
The Dual PDZ Domain from Postsynaptic Density Protein 95 Forms a Scaffold with Peptide Ligand
Rodzli, Nazahiyah A., Lockhart-Cairns, Michael P., Levy, Colin W., Chipperfield, John, Bird, Louise, Baldock, Clair, Prince, Stephen M.
Published in Biophysical journal (04.08.2020)
Published in Biophysical journal (04.08.2020)
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Journal Article
Structure–Activity Relationships of cyclo(l‑Tyrosyl‑l‑tyrosine) Derivatives Binding to Mycobacterium tuberculosis CYP121: Iodinated Analogues Promote Shift to High-Spin Adduct
Rajput, Sunnia, McLean, Kirsty J, Poddar, Harshwardhan, Selvam, Irwin R, Nagalingam, Gayathri, Triccas, James A, Levy, Colin W, Munro, Andrew W, Hutton, Craig A
Published in Journal of medicinal chemistry (14.11.2019)
Published in Journal of medicinal chemistry (14.11.2019)
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Journal Article
The crystal structure of P450-TT heme-domain provides the first structural insights into the versatile class VII P450s
Tavanti, Michele, Porter, Joanne L., Levy, Colin W., Gómez Castellanos, J. Rubén, Flitsch, Sabine L., Turner, Nicholas J.
Published in Biochemical and biophysical research communications (02.07.2018)
Published in Biochemical and biophysical research communications (02.07.2018)
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Journal Article
A designed photoenzyme for enantioselective [2+2] cycloadditions
Trimble, Jonathan S., Crawshaw, Rebecca, Hardy, Florence J., Levy, Colin W., Brown, Murray J. B., Fuerst, Douglas E., Heyes, Derren J., Obexer, Richard, Green, Anthony P.
Published in Nature (London) (24.11.2022)
Published in Nature (London) (24.11.2022)
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Journal Article