Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases
Cuadrado, Antonio, Rojo, Ana I., Wells, Geoffrey, Hayes, John D., Cousin, Sharon P., Rumsey, William L., Attucks, Otis C., Franklin, Stephen, Levonen, Anna-Liisa, Kensler, Thomas W., Dinkova-Kostova, Albena T.
Published in Nature reviews. Drug discovery (01.04.2019)
Published in Nature reviews. Drug discovery (01.04.2019)
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Redox regulation of antioxidants, autophagy, and the response to stress: Implications for electrophile therapeutics
Levonen, Anna-Liisa, Hill, Bradford G., Kansanen, Emilia, Zhang, Jianhua, Darley-Usmar, Victor M.
Published in Free radical biology & medicine (01.06.2014)
Published in Free radical biology & medicine (01.06.2014)
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Journal Article
Activation of stress signaling pathways by electrophilic oxidized and nitrated lipids
Kansanen, Emilia, Jyrkkänen, Henna-Kaisa, Levonen, Anna-Liisa
Published in Free radical biology & medicine (15.03.2012)
Published in Free radical biology & medicine (15.03.2012)
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Journal Article
The KEAP1-NRF2 pathway: Targets for therapy and role in cancer
Adinolfi, Simone, Patinen, Tommi, Jawahar Deen, Ashik, Pitkänen, Sini, Härkönen, Jouni, Kansanen, Emilia, Küblbeck, Jenni, Levonen, Anna-Liisa
Published in Redox biology (01.07.2023)
Published in Redox biology (01.07.2023)
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Journal Article
Nrf2 Regulates Neurogenesis and Protects Neural Progenitor Cells Against Aβ Toxicity
Kärkkäinen, Virve, Pomeshchik, Yuriy, Savchenko, Ekaterina, Dhungana, Hiramani, Kurronen, Antti, Lehtonen, Sarka, Naumenko, Nikolay, Tavi, Pasi, Levonen, Anna‐Liisa, Yamamoto, Masayuki, Malm, Tarja, Magga, Johanna, Kanninen, Katja M., Koistinaho, Jari
Published in Stem cells (Dayton, Ohio) (01.07.2014)
Published in Stem cells (Dayton, Ohio) (01.07.2014)
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Journal Article
Nrf2 and SQSTM1/p62 jointly contribute to mesenchymal transition and invasion in glioblastoma
Pölönen, Petri, Jawahar Deen, Ashik, Leinonen, Hanna M., Jyrkkänen, Henna-Kaisa, Kuosmanen, Suvi, Mononen, Mimmi, Jain, Ashish, Tuomainen, Tomi, Pasonen-Seppänen, Sanna, Hartikainen, Jaana M., Mannermaa, Arto, Nykter, Matti, Tavi, Pasi, Johansen, Terje, Heinäniemi, Merja, Levonen, Anna-Liisa
Published in Oncogene (01.12.2019)
Published in Oncogene (01.12.2019)
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Journal Article
NRF2 is a key regulator of endothelial microRNA expression under proatherogenic stimuli
Linna-Kuosmanen, Suvi, Tomas Bosch, Vanesa, Moreau, Pierre R, Bouvy-Liivrand, Maria, Niskanen, Henri, Kansanen, Emilia, Kivelä, Annukka, Hartikainen, Juha, Hippeläinen, Mikko, Kokki, Hannu, Tavi, Pasi, Levonen, Anna-Liisa, Kaikkonen, Minna U
Published in Cardiovascular research (23.04.2021)
Published in Cardiovascular research (23.04.2021)
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Journal Article
NF‐E2‐related factor 2 activation boosts antioxidant defenses and ameliorates inflammatory and amyloid properties in human Presenilin‐1 mutated Alzheimer's disease astrocytes
Oksanen, Minna, Hyötyläinen, Ida, Trontti, Kalevi, Rolova, Taisia, Wojciechowski, Sara, Koskuvi, Marja, Viitanen, Matti, Levonen, Anna‐Liisa, Hovatta, Iiris, Roybon, Laurent, Lehtonen, Šárka, Kanninen, Katja M., Hämäläinen, Riikka H., Koistinaho, Jari
Published in Glia (01.03.2020)
Published in Glia (01.03.2020)
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Journal Article
Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease
Kanninen, Katja, Heikkinen, Riikka, Malm, Tarja, Rolova, Taisia, Kuhmonen, Susanna, Leinonen, Hanna, Ylä-Herttuala, Seppo, Tanila, Heikki, Levonen, Anna-Liisa, Koistinaho, Milla, Koistinaho, Jari
Published in Proceedings of the National Academy of Sciences - PNAS (22.09.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (22.09.2009)
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Journal Article
Dysregulation of the Keap1-Nrf2 pathway in cancer
Leinonen, Hanna M, Kansanen, Emilia, Pölönen, Petri, Heinäniemi, Merja, Levonen, Anna-Liisa
Published in Biochemical Society transactions (01.08.2015)
Published in Biochemical Society transactions (01.08.2015)
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Journal Article
MicroRNA profiling of pericardial fluid samples from patients with heart failure
Kuosmanen, Suvi M, Hartikainen, Juha, Hippeläinen, Mikko, Kokki, Hannu, Levonen, Anna-Liisa, Tavi, Pasi
Published in PloS one (12.03.2015)
Published in PloS one (12.03.2015)
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Journal Article
PI3Kβ inhibition enhances ALK‐inhibitor sensitivity in ALK‐rearranged lung cancer
Talwelkar, Sarang S., Mäyränpää, Mikko I., Schüler, Julia, Linnavirta, Nora, Hemmes, Annabrita, Adinolfi, Simone, Kankainen, Matti, Sommergruber, Wolfgang, Levonen, Anna‐Liisa, Räsänen, Jari, Knuuttila, Aija, Verschuren, Emmy W., Wennerberg, Krister
Published in Molecular oncology (01.05.2023)
Published in Molecular oncology (01.05.2023)
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Journal Article
Electrophilic Nitro-fatty Acids Activate NRF2 by a KEAP1 Cysteine 151-independent Mechanism
Kansanen, Emilia, Bonacci, Gustavo, Schopfer, Francisco J., Kuosmanen, Suvi M., Tong, Kit I., Leinonen, Hanna, Woodcock, Steven R., Yamamoto, Masayuki, Carlberg, Carsten, Ylä-Herttuala, Seppo, Freeman, Bruce A., Levonen, Anna-Liisa
Published in The Journal of biological chemistry (22.04.2011)
Published in The Journal of biological chemistry (22.04.2011)
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Journal Article
HAS3-induced extracellular vesicles from melanoma cells stimulate IHH mediated c-Myc upregulation via the hedgehog signaling pathway in target cells
Arasu, Uma Thanigai, Deen, Ashik Jawahar, Pasonen-Seppänen, Sanna, Heikkinen, Sami, Lalowski, Maciej, Kärnä, Riikka, Härkönen, Kai, Mäkinen, Petri, Lázaro-Ibáñez, Elisa, Siljander, Pia R-M, Oikari, Sanna, Levonen, Anna-Liisa, Rilla, Kirsi
Published in Cellular and molecular life sciences : CMLS (01.10.2020)
Published in Cellular and molecular life sciences : CMLS (01.10.2020)
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Journal Article
The EDCMET Project: Metabolic Effects of Endocrine Disruptors
Küblbeck, Jenni, Vuorio, Taina, Niskanen, Jonna, Fortino, Vittorio, Braeuning, Albert, Abass, Khaled, Rautio, Arja, Hakkola, Jukka, Honkakoski, Paavo, Levonen, Anna-Liisa
Published in International journal of molecular sciences (24.04.2020)
Published in International journal of molecular sciences (24.04.2020)
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Journal Article
Regulation of stress signaling pathways by protein lipoxidation
Patinen, Tommi, Adinolfi, Simone, Cortés, Carlos Cruz, Härkönen, Jouni, Jawahar Deen, Ashik, Levonen, Anna-Liisa
Published in Redox biology (01.05.2019)
Published in Redox biology (01.05.2019)
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Journal Article
MicroRNAs mediate the senescence-associated decline of NRF2 in endothelial cells
Kuosmanen, Suvi M., Sihvola, Virve, Kansanen, Emilia, Kaikkonen, Minna U., Levonen, Anna-Liisa
Published in Redox biology (01.09.2018)
Published in Redox biology (01.09.2018)
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Journal Article
Characterizing valve dynamics in mice by high‐resolution cine‐MRI
Weisell, Jonna, Ruotsalainen, Anna‐Kaisa, Laakso, Hanne, Ylä‐Herttuala, Elias, Näpänkangas, Juha, Levonen, Anna‐Liisa, Liimatainen, Timo, Rysä, Jaana
Published in NMR in biomedicine (01.08.2019)
Published in NMR in biomedicine (01.08.2019)
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Journal Article
The absence of macrophage Nrf2 promotes early atherogenesis
Ruotsalainen, Anna-Kaisa, Inkala, Matias, Partanen, Mervi E, Lappalainen, Jari P, Kansanen, Emilia, Mäkinen, Petri I, Heinonen, Suvi E, Laitinen, Heidi M, Heikkilä, Janne, Vatanen, Tero, Hörkkö, Sohvi, Yamamoto, Masayuki, Ylä-Herttuala, Seppo, Jauhiainen, Matti, Levonen, Anna-Liisa
Published in Cardiovascular research (01.04.2013)
Published in Cardiovascular research (01.04.2013)
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