Cyclic amide bioisosterism: Strategic application to the design and synthesis of HCV NS5B polymerase inhibitors
Yang, Hanbiao, Hendricks, Robert T., Arora, Nidhi, Nitzan, Dov, Yee, Calvin, Lucas, Matthew C., Yang, Yanli, Fung, Amy, Rajyaguru, Sonal, Harris, Seth F., Leveque, Vincent J.P., Hang, Julie Q., Pogam, Sophie Le, Reuter, Deborah, Tavares, Gisele A.
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
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The Design, Synthesis, and Antiviral Activity of Monofluoro and Difluoro Analogues of 4′-Azidocytidine against Hepatitis C Virus Replication: The Discovery of 4′-Azido-2′-deoxy-2′-fluorocytidine and 4′-Azido-2′-dideoxy-2′,2′-difluorocytidine
Smith, David B, Kalayanov, Genadiy, Sund, Christian, Winqvist, Anna, Maltseva, Tatiana, Leveque, Vincent J.-P, Rajyaguru, Sonal, Pogam, Sophie Le, Najera, Isabel, Benkestock, Kurt, Zhou, Xiao-Xiong, Kaiser, Ann C, Maag, Hans, Cammack, Nick, Martin, Joseph A, Swallow, Steven, Johansson, Nils Gunnar, Klumpp, Klaus, Smith, Mark
Published in Journal of medicinal chemistry (14.05.2009)
Published in Journal of medicinal chemistry (14.05.2009)
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3-Hydroxyisoquinolines as inhibitors of HCV NS5b RNA-dependent RNA polymerase
Hendricks, Robert T., Spencer, Stacey R., Blake, James F., Fell, Jay B., Fischer, John P., Stengel, Peter J., Leveque, Vincent J.P., LePogam, Sophie, Rajyaguru, Sonal, Najera, Isabel, Josey, John A., Swallow, Steven
Published in Bioorganic & medicinal chemistry letters (15.01.2009)
Published in Bioorganic & medicinal chemistry letters (15.01.2009)
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Non-nucleoside inhibitors of HCV NS5B polymerase. Part 1: Synthetic and computational exploration of the binding modes of benzothiadiazine and 1,4-benzothiazine HCV NS5b polymerase inhibitors
Hendricks, Robert T., Fell, Jay B., Blake, James F., Fischer, John P., Robinson, John E., Spencer, Stacey R., Stengel, Peter J., Bernacki, April L., Leveque, Vincent J.P., Pogam, Sophie Le, Rajyaguru, Sonal, Najera, Isabel, Josey, John A., Harris, Jason R., Swallow, Steven
Published in Bioorganic & medicinal chemistry letters (01.07.2009)
Published in Bioorganic & medicinal chemistry letters (01.07.2009)
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Non-nucleoside inhibitors of HCV polymerase NS5B. Part 4: Structure-based design, synthesis, and biological evaluation of benzo[d]isothiazole-1,1-dioxides
de Vicente, Javier, Hendricks, Robert T., Smith, David B., Fell, Jay B., Fischer, John, Spencer, Stacey R., Stengel, Peter J., Mohr, Peter, Robinson, John E., Blake, James F., Hilgenkamp, Ramona K., Yee, Calvin, Adjabeng, George, Elworthy, Todd R., Li, Jim, Wang, Beihan, Bamberg, Joe T., Harris, Seth F., Wong, April, Leveque, Vincent J.P., Najera, Isabel, Pogam, Sophie Le, Rajyaguru, Sonal, Ao-Ieong, Gloria, Alexandrova, Ludmila, Larrabee, Susan, Brandl, Michael, Briggs, Andrew, Sukhtankar, Sunil, Farrell, Robert
Published in Bioorganic & medicinal chemistry letters (01.10.2009)
Published in Bioorganic & medicinal chemistry letters (01.10.2009)
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Non-nucleoside inhibitors of HCV polymerase NS5B. Part 3: Synthesis and optimization studies of benzothiazine-substituted tetramic acids
de Vicente, Javier, Hendricks, Robert T., Smith, David B., Fell, Jay B., Fischer, John, Spencer, Stacey R., Stengel, Peter J., Mohr, Peter, Robinson, John E., Blake, James F., Hilgenkamp, Ramona K., Yee, Calvin, Zhao, Junping, Elworthy, Todd R., Tracy, Jahari, Chin, Elbert, Li, Jim, Lui, Al, Wang, Beihan, Oshiro, Connie, Harris, Seth F., Ghate, Manjiri, Leveque, Vincent J.P., Najera, Isabel, Pogam, Sophie Le, Rajyaguru, Sonal, Ao-Ieong, Gloria, Alexandrova, Ludmila, Fitch, Bill, Brandl, Michael, Masjedizadeh, Mohammad, Wu, Shao-yong, Keczer, Steve de, Voronin, Tatyana
Published in Bioorganic & medicinal chemistry letters (01.10.2009)
Published in Bioorganic & medicinal chemistry letters (01.10.2009)
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Identification of a C-Terminal Regulatory Motif in Hepatitis C Virus RNA-Dependent RNA Polymerase: Structural and Biochemical Analysis
Lévêque, Vincent J.-P., Johnson, Robert B., Parsons, Stephen, Ren, Jianxin, Xie, Congping, Zhang, Faming, Wang, Q. May
Published in Journal of Virology (01.08.2003)
Published in Journal of Virology (01.08.2003)
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Multiple Replacements of Glutamine 143 in Human Manganese Superoxide Dismutase: Effects on Structure, Stability, and Catalysis
Lévêque, Vincent J.-P, Stroupe, M. Elizabeth, Lepock, James R, Cabelli, Diane E, Tainer, John A, Nick, Harry S, Silverman, David N
Published in Biochemistry (Easton) (20.06.2000)
Published in Biochemistry (Easton) (20.06.2000)
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Expression and purification of untagged full-length HCV NS5B RNA-dependent RNA polymerase
May Wang, Q, Johnson, Robert B, Chen, Dayue, Lévêque, Vincent J.-P, Ren, Jianxin, Hockman, Michelle A, Abe, Kenji, Hachisu, Tessho, Kondo, Yutaka, Isaka, Yoshitaka, Sato, Akihiko, Fujiwara, Tamio
Published in Protein expression and purification (01.06.2004)
Published in Protein expression and purification (01.06.2004)
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